Acta oto-laryngologica. Supplementum最新文献_第5页

Estimation of factors influencing the results of tinnitus retraining therapy. 耳鸣再训练治疗效果影响因素的评估。

Acta oto-laryngologica. Supplementum Pub Date : 2009-06-01 DOI: 10.1080/00016480902933072

Toshizo Koizumi, Tadashi Nishimura, Takefumi Sakaguchi, Masanori Okamoto, Hiroshi Hosoi

{"title":"Estimation of factors influencing the results of tinnitus retraining therapy.","authors":"Toshizo Koizumi, Tadashi Nishimura, Takefumi Sakaguchi, Masanori Okamoto, Hiroshi Hosoi","doi":"10.1080/00016480902933072","DOIUrl":"https://doi.org/10.1080/00016480902933072","url":null,"abstract":"Conclusion: The factors of tinnitus loudness and Tinnitus Handicap Inventory (THI) score in tinnitus patients have the potential to relate to therapeutic results of tinnitus retraining therapy (TRT).Objectives: To confirm what factors in tinnitus influence the results of TRT.Patients and methods: Twelve factors were investigated in 53 patients with tinnitus, examining the relationship between these factors and the results of TRT. A THI score was determined before and 6 months after TRT introduction (pre- and post-TRT). Moreover, the change of THI score from pre- to post-TRT (delta THI) was referred to as the therapeutic effect of TRT. Based on the 12 factors, subjects were respectively divided into two groups, comparing delta THI between groups.Results: Two groups of greater tinnitus loudness and higher THI score showed significant increases in delta THI, indicating that two factors of tinnitus loudness and THI score were related to the therapeutic effect of TRT.","PeriodicalId":7027,"journal":{"name":"Acta oto-laryngologica. Supplementum","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/00016480902933072","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28453699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Localization of aquaporins, water channel proteins, in the mouse eustachian tube. 水通道蛋白(水通道蛋白)在小鼠耳咽管中的定位。

Acta oto-laryngologica. Supplementum Pub Date : 2009-06-01 DOI: 10.1080/00016480902964317

Etsu Takahashi, Toshihiko Kikuchi, Yukio Katori, Toshimitsu Kobayashi

{"title":"Localization of aquaporins, water channel proteins, in the mouse eustachian tube.","authors":"Etsu Takahashi, Toshihiko Kikuchi, Yukio Katori, Toshimitsu Kobayashi","doi":"10.1080/00016480902964317","DOIUrl":"https://doi.org/10.1080/00016480902964317","url":null,"abstract":"Conclusion: Immunolocalization of the subtypes of water channel proteins, aquaporins (AQPs), was detected in the mouse eustachian tube (ET). AQPs are located continuously from the serous glands and the capillary vessels to the luminal side in the ET epithelium and may play an important role in the transportation of water to the surface of the ET lumen through the epithelium.Objectives: Although the water supply to the surface of the ET lumen is considered to be essential for closing of the ET, the pathway of the water in the ET is not fully understood. Since AQPs, a group of water transport proteins, have been reported to regulate water homeostasis, we examined the location of AQPs in the mouse ET.Materials and methods: Nine subtypes of AQPs were examined in paraffin embedded ETs of adult mice using the avidin-biotin peroxidase complex method of immunohistochemistry.Results: Four subtypes of AQPs were detected in the mouse ET. AQP-1 was detected in fibroblasts, endothelial cells of capillary vessels and cartilage cells. AQP-3 was distinctly detected in the basal membrane of epithelial cells. AQP-4 was detected in the basal membrane of epithelial cells. AQP-5 was expressed in the luminal side of the ET epithelial cells and also in the apical surface of the cells of the serous glands.","PeriodicalId":7027,"journal":{"name":"Acta oto-laryngologica. Supplementum","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/00016480902964317","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28454672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Neuromuscular junctions of the posterior cricoarytenoid muscle in multiple system atrophy: a case study. 多系统萎缩中后环杓肌的神经肌肉连接:一个案例研究。

Acta oto-laryngologica. Supplementum Pub Date : 2009-06-01 DOI: 10.1080/00016480902911987

Toshio Yoshihara, Yukie Yamamura, Fumie Kaneko, Naoko Abo, Minoru Nomoto

{"title":"Neuromuscular junctions of the posterior cricoarytenoid muscle in multiple system atrophy: a case study.","authors":"Toshio Yoshihara, Yukie Yamamura, Fumie Kaneko, Naoko Abo, Minoru Nomoto","doi":"10.1080/00016480902911987","DOIUrl":"https://doi.org/10.1080/00016480902911987","url":null,"abstract":"Conclusion: The present study showed a variety of stages of neurogenic degeneration of the muscle fibers and the neuromuscular junctions (NMJs) of the posterior cricoarytenoid (PCA) muscle in multiple system atrophy (MSA). These findings coincide with abductor paralysis of vocal cords. Ultrastructural features of the NMJs of the PCA muscle in MSA were different from those of previous studies on experimental resection of recurrent nerve and amyotrophic lateral sclerosis (ALS).Objectives: MSA may influence various respiratory functions. Upper airway tracts including larynx are affected without exception during its clinical course. Morphological changes of NMJs of the intrinsic laryngeal muscle in MSA were examined ultrastructurally.Patient and methods: The patient was a 68-year-old male complaining of recurrent aspiration pneumonia, dysphagia, respiratory disturbance, and abductor paralysis of vocal cords. The motor nerve terminals of the PCA muscle in a patient with MSA were investigated electron microscopically.Results: The NMJs showed varying degrees of ultrastructural changes by motor nerve degeneration. They were seen in the pre- and post-synaptic regions. Muscle fibers losing nerve terminals showed severe damage in their cytoplasm.","PeriodicalId":7027,"journal":{"name":"Acta oto-laryngologica. Supplementum","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/00016480902911987","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28452427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Cutting edge of inner ear MRI. 内耳MRI切面。

Acta oto-laryngologica. Supplementum Pub Date : 2009-02-01 DOI: 10.1080/00016480902729819

Shinji Naganawa, Tsutomu Nakashima

{"title":"Cutting edge of inner ear MRI.","authors":"Shinji Naganawa, Tsutomu Nakashima","doi":"10.1080/00016480902729819","DOIUrl":"https://doi.org/10.1080/00016480902729819","url":null,"abstract":"Conclusion: Recent advances in clinical MR imagers, such as the 3-Tesla, multi-channel phased-array coil and novel pulse sequences, allow the evaluation of subtle alterations in the inner ear fluid environments and breakdown of the blood-labyrinthine barrier. Intratympanic injection of Gd-DTPA allows the imaging detection of endolymphatic hydrops in patients.Objectives: To describe the current status of inner ear MRI and future directions for imaging.Materials and methods: Based on our experiences and literature research, a brief review of the history and recent developments of inner ear MRI is presented.Results: The 3D-FLAIR technique can detect abnormalities that could not be visualized previously in many inner ear diseases, such as sudden deafness, otosclerosis, lupus erythematosus, mumps, and Ramsay-Hunt syndrome. Imaging techniques, indications, and findings for the visualization of endolymphatic hydrops after intratympanic injection of Gd-DTPA are also discussed. This procedure enabled the visualization of endolymphatic hydrops in vivo. Newly developed 3D-real IR techniques and utilities of 32 channel coil are also presented.","PeriodicalId":7027,"journal":{"name":"Acta oto-laryngologica. Supplementum","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/00016480902729819","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27990377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 40

A comparison of two methods of using transtympanic electrocochleography for the diagnosis of Meniere's disease: click summating potential/action potential ratio measurements and tone burst summating potential measurements. 经鼓室超声诊断梅尼埃病两种方法的比较:点击合电位/动作电位比值测量和音突合电位测量。

Acta oto-laryngologica. Supplementum Pub Date : 2009-02-01 DOI: 10.1080/00016480902729843

William P R Gibson

{"title":"A comparison of two methods of using transtympanic electrocochleography for the diagnosis of Meniere's disease: click summating potential/action potential ratio measurements and tone burst summating potential measurements.","authors":"William P R Gibson","doi":"10.1080/00016480902729843","DOIUrl":"https://doi.org/10.1080/00016480902729843","url":null,"abstract":"Conclusion: Transtympanic electrocochleography (TT ECochG) is helpful for the confirmation of Meniere's disease using tone burst stimuli to measure the amplitude of the frequency specific summating potentials (SP) but not when using the click evoked summating potential versus action potential ratio (SP/AP).Objectives: To evaluate the effectiveness of TT ECochG as a means of confirming the clinical diagnosis of Meniere's disease.Patients and methods: A total of 2,717 patients were referred for TT ECochG between August 1998 and September 2008. Each patient was assessed prospectively on clinical grounds according to the AAOHNS criteria and a scale devised by the author. A Meniere's group and a non-Meniere's group were determined and the TT ECochG results were compared between the groups that had similar hearing levels for the particular stimulus employed.Results: Click SP/AP measurements did not significantly differentiate between populations of Meniere's ears and non-Meniere's ears. Tone burst SP amplitude measurements were significantly different between the populations, especially using frequencies at 500 Hz, 1 kHz, and 2 kHz.","PeriodicalId":7027,"journal":{"name":"Acta oto-laryngologica. Supplementum","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/00016480902729843","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27990380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 54

3D computerized model of endolymphatic hydrops from specimens of temporal bone. 颞骨标本内淋巴积液的三维计算机模型。

Acta oto-laryngologica. Supplementum Pub Date : 2009-02-01 DOI: 10.1080/00016480902729868

Masaaki Teranishi, Tadao Yoshida, Naomi Katayama, Hideo Hayashi, Hironao Otake, Seiichi Nakata, Michihiko Sone, Patricia A Schachern, Michael M Paparella, Tsutomu Nakashima

{"title":"3D computerized model of endolymphatic hydrops from specimens of temporal bone.","authors":"Masaaki Teranishi, Tadao Yoshida, Naomi Katayama, Hideo Hayashi, Hironao Otake, Seiichi Nakata, Michihiko Sone, Patricia A Schachern, Michael M Paparella, Tsutomu Nakashima","doi":"10.1080/00016480902729868","DOIUrl":"https://doi.org/10.1080/00016480902729868","url":null,"abstract":"Conclusion: The 3D models of endolymphatic and perilymphatic spaces enabled us to obtain normal and pathological volumes of each space and helped us to understand the 3D structure of various parts of the inner ear and of endolymphatic hydrops.Objective: To make a 3D model of the inner ear using sections of temporal bone with and without hydrops.Materials and methods: Every 10th 20 microm thick section of temporal bone was collected from two ears with endolymphatic hydrops and five ears without hydrops. Using ZedView, 3D Doctor, FreeForm as analytical software, a 3D model of the inner ear was obtained by reconstruction of these sections. The volumes of the endolymphatic (EV) and perilymphatic spaces (PV) were calculated in each part of the cochlea and vestibular apparatus including the semicircular canals, but the endolymphatic duct and sac were not included.Results: In normal ears (controls), the average cochlear EV was 5.1 microl and the PV was 41.9 microl, and the average vestibular EV was 24.0 microl and the PV 75.7 microl. In one hydropic ear, the cochlear EV was 17.5 microl, cochlear PV 30.7 microl, vestibular EV 42.5 microl, and vestibular PV 33.4 microl. In the other hydropic ear, cochlear EV was 31.2 microl, cochlear PV 30.1 microl, vestibular EV 25.6 microl, and vestibular PV 71.8 microl.","PeriodicalId":7027,"journal":{"name":"Acta oto-laryngologica. Supplementum","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/00016480902729868","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27990381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Clinical significance of endolymphatic imaging after intratympanic gadolinium injection. 鼓腔内注射钆后淋巴内显像的临床意义。

Acta oto-laryngologica. Supplementum Pub Date : 2009-02-01 DOI: 10.1080/00016480902729801

Tsutomu Nakashima, Shinji Naganawa, Naomi Katayama, Masaaki Teranishi, Seiichi Nakata, Makoto Sugiura, Michihiko Sone, Sachio Kasai, Mayumi Yoshioka, Masako Yamamoto

{"title":"Clinical significance of endolymphatic imaging after intratympanic gadolinium injection.","authors":"Tsutomu Nakashima, Shinji Naganawa, Naomi Katayama, Masaaki Teranishi, Seiichi Nakata, Makoto Sugiura, Michihiko Sone, Sachio Kasai, Mayumi Yoshioka, Masako Yamamoto","doi":"10.1080/00016480902729801","DOIUrl":"https://doi.org/10.1080/00016480902729801","url":null,"abstract":"Conclusion: Using three-dimensional real inversion recovery (3D-real IR) and three-dimensional fluid-attenuated inversion recovery (3D-FLAIR) magnetic resonance imaging (MRI), various degrees of endolymphatic hydrops were observed in the basal and upper turns of the cochlea and in the vestibular apparatus after intratympanic gadolinium (Gd) injection. MRI may contribute to our understanding of inner ear diseases and may be a useful addition to intratympanic drug therapy in the management of inner ear diseases.Objective: To evaluate 3D-real IR MRI and 3D-FLAIR MRI with clinical symptoms and signs in patients with inner ear disease.Patients and methods: Gd was diluted in saline and injected intratympanically in 73 patients with inner ear disease. The endolymphatic space was evaluated with 3-Tesla MRI at 1 day after the intratympanic Gd injection.Results: 3D-real IR MRI was generally better than 3D-FLAIR MRI in discriminating between the perilymphatic space and endolymphatic space in the cochlear turns and in the vestibular apparatus. However, when Gd concentration was insufficient in the perilymph, it was more difficult to visualize the Gd with 3D-real IR MRI than with 3D-FLAIR MRI. Endolymphatic hydrops was observed using MRI in patients with 'probable' Meniere's disease based on the criteria.","PeriodicalId":7027,"journal":{"name":"Acta oto-laryngologica. Supplementum","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/00016480902729801","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27990376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 56

Visualization of inner ear disorders with MRI in vivo: from animal models to human application. 内耳疾病的活体MRI可视化:从动物模型到人类应用。

Acta oto-laryngologica. Supplementum Pub Date : 2009-02-01 DOI: 10.1080/00016480902729850

Jing Zou, Dennis Poe, Bolje Bjelke, Ilmari Pyykko

{"title":"Visualization of inner ear disorders with MRI in vivo: from animal models to human application.","authors":"Jing Zou, Dennis Poe, Bolje Bjelke, Ilmari Pyykko","doi":"10.1080/00016480902729850","DOIUrl":"https://doi.org/10.1080/00016480902729850","url":null,"abstract":"Conclusion: The inner ear membranous permeability and leakiness and endolymphatic hydrops can be visualized using gadolinium-enhanced MRI in both rodents and man. Intratympanic administration of contrast agent gives greater perilymphatic loading of gadolinium.Objectives: Visualization of different types of inner ear dysfunction in MRI with intravenous or intratympanic administration of contrast agent.Materials and methods: In the animal study, gadolinium was administered intravenously or intratympanically and imaged with 4.7 T MRI. In man, gadolinium was delivered intratympanically and studied with 1.5 T or 3 T MRI.Results: In the animals, intravenous delivery of gadolinium demonstrated uptake in the perilymph of normal inner ears. The cochlear modiolus appeared to be a critical site for the secretion of perilymph and the location of fluid communication between the perilymphatic scalae. Intense noise exposure and immune reaction caused cochlear injury and accelerated gadolinium passage through the blood-perilymph and blood-endolymph barriers. In man, perilymphatic uptake of gadolinium was only observed in the impaired inner ear when administered intravenously. However, the signal-to-noise ratio of images was improved when gadolinium was delivered intratympanically. MRI demonstrated endolymphatic hydrops in both animal models and patients with Meniere's disease.","PeriodicalId":7027,"journal":{"name":"Acta oto-laryngologica. Supplementum","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/00016480902729850","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27990378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 52

Grading of endolymphatic hydrops using magnetic resonance imaging. 磁共振成像对内淋巴积液的分级。

Acta oto-laryngologica. Supplementum Pub Date : 2009-02-01 DOI: 10.1080/00016480902729827

Tsutomu Nakashima, Shinji Naganawa, Ilmari Pyykko, William P R Gibson, Michihiko Sone, Seiichi Nakata, Masaaki Teranishi

{"title":"Grading of endolymphatic hydrops using magnetic resonance imaging.","authors":"Tsutomu Nakashima, Shinji Naganawa, Ilmari Pyykko, William P R Gibson, Michihiko Sone, Seiichi Nakata, Masaaki Teranishi","doi":"10.1080/00016480902729827","DOIUrl":"https://doi.org/10.1080/00016480902729827","url":null,"abstract":"Conclusion: Grading of endolymphatic hydrops in the vestibule and the cochlea using magnetic resonance imaging (MRI) is proposed (2008 Nagoya scale).Objective: To standardize the evaluation of endolymphatic hydrops in both the vestibule and the cochlea using MRI.Patients and methods: The endolymphatic space was evaluated after intratympanic gadolinium injection using three-dimensional fluid attenuated (3D-FLAIR) MRI and three-dimensional real inversion recovery (3D-real IR) MRI.Results: A simple three-stage grading system was acceptable for hydrops in both the vestibule and the cochlea: none, mild, and significant. In the vestibule, the grading was determined by the ratio of the area of endolymphatic space to the vestibular fluid space (sum of the endolymphatic and perilymphatic spaces). Patients with no hydrops have a ratio of one-third or less, those with mild hydrops have between one-third and a half, and those with significant hydrops have a ratio of more than 50%. In the cochlea, patients classified as having no hydrops show no displacement of Reissner's membrane; those with mild hydrops show displacement of Reissner's membrane but the area of the endolymphatic space does not exceed the area of the scala vestibuli; and in those with significant hydrops the area of the endolymphatic space exceeds the area of the scala vestibuli.","PeriodicalId":7027,"journal":{"name":"Acta oto-laryngologica. Supplementum","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/00016480902729827","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27990375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 303

Chronological changes in the eighth cranial nerve compound action potential (CAP) in experimental endolymphatic hydrops: the effects of altering the polarity of click sounds. 实验性内淋巴积液中第八脑神经复合动作电位(CAP)的时间变化:改变咔哒声极性的影响。

Acta oto-laryngologica. Supplementum Pub Date : 2009-02-01 DOI: 10.1080/00016480902729835

Tetsuo Morizono, Tsuyoshi Kondo, Takafumi Yamano, Morimichi Miyagi, Kimio Shiraishi

{"title":"Chronological changes in the eighth cranial nerve compound action potential (CAP) in experimental endolymphatic hydrops: the effects of altering the polarity of click sounds.","authors":"Tetsuo Morizono, Tsuyoshi Kondo, Takafumi Yamano, Morimichi Miyagi, Kimio Shiraishi","doi":"10.1080/00016480902729835","DOIUrl":"https://doi.org/10.1080/00016480902729835","url":null,"abstract":"Conclusion: Using a guinea pig model of experimental endolymphatic hydrops, click sounds of altered polarity showed different latencies and amplitudes in hydropic compared with normal cochleae. Latency changes appeared as early as 1 week after endolymphatic obstruction. This method can help diagnose endolymphatic hydrops.Objective: The goal of the study was to develop an objective electrophysiological diagnosis of endolymphatic hydrops.Materials and methods: Endolymphatic hydrops were created surgically in guinea pigs. The latency and the amplitude of the eighth cranial nerve compound action potential (CAP) for click sounds of altered polarity were measured up to 8 weeks after the surgery.Results: At early stages after surgery, the latency for condensation clicks became longer, and at later stages the latencies for both condensation and rarefaction became longer. The discrepancy in the latencies for rarefaction and condensation click sounds (rarefaction minus condensation) became larger by the first week after surgery, but no further discrepancy occurred thereafter. Compared with latency changes, amplitude changes in the CAP were rapid and progressive following surgery, suggesting ongoing damage to hair cells.","PeriodicalId":7027,"journal":{"name":"Acta oto-laryngologica. Supplementum","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/00016480902729835","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27990379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0