Elsa Catalina Villanueva Yave, Alexandra Ximena Banda Baltodano, Natalie Gabriela García Cam, Sandra Patricia Diaz Santiago, Esmeralda Liccethy Torres Soto
{"title":"Características tomográficas del seno frontal en un hospital público de Perú","authors":"Elsa Catalina Villanueva Yave, Alexandra Ximena Banda Baltodano, Natalie Gabriela García Cam, Sandra Patricia Diaz Santiago, Esmeralda Liccethy Torres Soto","doi":"10.1016/j.otorri.2025.512315","DOIUrl":"10.1016/j.otorri.2025.512315","url":null,"abstract":"<div><h3>Introduction and aim of the study</h3><div>The frontal sinus is the paranasal cavity with the greatest anatomical variability. Since the level of difficulty in dissecting the frontal recess during surgery is directly related to these anatomical variations, identifying them in the preoperative stage is crucial. This study aims to determine the most prevalent tomographic characteristics of the frontal sinus in paranasal sinus CT scans performed at a tertiary-level hospital in Lima, Peru, during the period 2023-2024.</div></div><div><h3>Materials and methods</h3><div>This is an observational, descriptive, cross-sectional study. Paranasal sinus CT scans obtained between July 2023 and June 2024 were analyzed. Sinus morphology, anteroposterior diameter of the frontal <em>ostium</em>, frontal angle, and frontal <em>ostium</em> grade were evaluated. Identification of ethmoidal cells and measurement of the distance from the columella to the frontal beak and to the anterior skull base were also included. Data was collected using Excel spreadsheets, and frequency tabulations were performed using IBM SPSS Statistics software.</div></div><div><h3>Results</h3><div>A total of 328 CT scans were included. In our sample, the most frequent age group was 30–59 years (54.6%), and the female sex predominated (55.2%). The most frequent morphology of the frontal sinus was medium size (66.5% on the right side and 59.5% on the left side). Hyperplasia predominated in males. More than 60% of the analyzed CT scans presented an anteroposterior distance of the frontal <em>ostium</em> between 5-10<!--> <!-->mm (64.63% on the right side and 60.98% on the left). Adults over 30 years of age showed a diameter >10<!--> <!-->mm more frequently than those aged 18-29 years. The frontal angle between 45° and <<!--> <!-->60° was the most frequent (65.55% on the right side and 62.80% on the left), and the most common grade was positive (62.80% on the right side and 65.55% on the left). The mean D-CFB was approximately 5.6<!--> <!-->mm on the right side and 5.7<!--> <!-->mm on the left side. Males presented greater measurements (approximately 0.5<!--> <!-->mm more) than females. The mean D-CASB was 6.39<!--> <!-->mm (right) and 6.53<!--> <!-->mm (left). Males presented a significantly greater distance (∼0.5-0.6<!--> <!-->mm more) than females (<em>P</em><.001). The most prevalent cells were the agger nasi cell (90.55% on the right side and 92.38% on the left side) and the suprabullar cell (67.68% on the right side and 72.26% on the left side).</div></div><div><h3>Conclusions</h3><div>This study provides a detailed tomographic characterization of the frontal sinus in a Peruvian population, serving as a theoretical basis to optimize surgical planning and anticipate potential challenges in the endoscopic approach to this anatomical region. The IFAC classification, frontal <em>ostium</em> diameter, and frontal angle are key factors to consider in surgical decision-making.</di","PeriodicalId":7019,"journal":{"name":"Acta otorrinolaringologica espanola","volume":"77 3","pages":"Article 512315"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148003068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sex differences in prognosis of oral cavity carcinoma","authors":"Júlia Gayà , Xavier Moix , Cristina Valero , Mattia Todaro , Federico Perquoti , Miquel Quer , Xavier León","doi":"10.1016/j.otorri.2026.512326","DOIUrl":"10.1016/j.otorri.2026.512326","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the impact of sex on survival outcomes in patients diagnosed with oral cavity squamous cell carcinoma in a region characterized by high exposure to toxic substances.</div></div><div><h3>Materials and methods</h3><div>A retrospective analysis was conducted on 857 patients diagnosed and treated between 1985 and 2020. Survival outcomes were assessed based on sex, considering variables such as age, toxic substance exposure, tumor location, and type of treatment received.</div></div><div><h3>Results</h3><div>Five-year CSS was significantly lower in women (52.3%, 95% CI: 3.2) compared with men (67.0%, 95% CI: 2.0; <em>P</em> <!-->=<!--> <!-->0.0001). No significant difference was found in 5-year OS between men (53.4%) and women (45.8%; <em>P</em> <!-->=<!--> <!-->0.238). In multivariable analysis, female sex remained an independent negative prognostic factor for CSS (HR 1.55, 95% CI: 1.14–2.10; <em>P</em> <!-->=<!--> <!-->0.005<strong>)</strong>. Other variables associated with poorer CSS included age >80 years (HR 3.78, 95% CI: 2.38–5.82; <em>P</em> <!-->=<!--> <!-->0.0001), tongue tumor location (HR 3.10, 95% CI: 1.43–6.70; <em>P</em> <!-->=<!--> <!-->0.004), buccal mucosa tumors (HR 3.14, 95% CI: 1.35–7.32; <em>P</em> <!-->=<!--> <!-->0.008), and advanced stage (stage IV vs I: HR 8.93, 95% CI: 6.04–13.20; <em>P</em> <!-->=<!--> <!-->0.0001). Women showed a higher proportion of tumors in the tongue and upper gingiva/palate and were more frequently managed with palliative treatment.</div></div><div><h3>Conclusions</h3><div>Female patients exhibited significantly worse cancer-specific survival despite lower exposure to tobacco and alcohol. The persistently higher risk of cancer-related mortality among women after multivariable adjustment (HR 1.55) suggests underlying biological or hormonal differences influencing disease behavior. These findings highlight the importance of incorporating sex-specific prognostic considerations in the management of oral cavity carcinoma.</div></div>","PeriodicalId":7019,"journal":{"name":"Acta otorrinolaringologica espanola","volume":"77 3","pages":"Article 512326"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148003072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura Gálvez-Gafo , Franklin Mariño-Sánchez , Laura Yeguas-Ramírez , María Muñoz-García , Silvia Sánchez-Cuéllar , Darío Antolín-Amérigo , David González-De-Olano , Alfonso Santamaría-Gadea
{"title":"Evaluating mepolizumab and dupilumab for severe chronic rhinosinusitis with nasal polyps: insights from a real-life study","authors":"Laura Gálvez-Gafo , Franklin Mariño-Sánchez , Laura Yeguas-Ramírez , María Muñoz-García , Silvia Sánchez-Cuéllar , Darío Antolín-Amérigo , David González-De-Olano , Alfonso Santamaría-Gadea","doi":"10.1016/j.otorri.2026.512328","DOIUrl":"10.1016/j.otorri.2026.512328","url":null,"abstract":"<div><h3>Introduction</h3><div>Monoclonal antibodies (mAbs) have been effective in managing chronic rhinosinusitis with nasal polyps (CRSwNP) for over two decades, primarily as secondary treatments for severe asthma or nonsteroidal anti-inflammatory drug-exacerbated respiratory disease (N-ERD). Recent approvals of biologics like mepolizumab (anti-IL5) and dupilumab (anti-IL4/IL13) now allow their use as add-on therapies for severe CRSwNP, regardless of comorbidities. However, limited data exist on their efficacy as standalone primary treatments for CRSwNP. This rea-life study investigates the potential of biologic therapies as a primary treatment for CRSwNP, focusing on multiple clinical and patient-reported outcomes.</div></div><div><h3>Materials and methods</h3><div>This prospective real-life study included 25 patients with severe CRSwNP, treated with mepolizumab and dupilumab indicated specifically for CRSwNP rather than associated comorbidities. Evaluations occurred at baseline and 1, 3, 6, and 12 months post-treatment, using VAS, SNOT22, and NOSE questionnaires, nasal polyp size (NPS), Lund–Kennedy scores, and BOT-8 smell tests. We also collect the data of the blood eosinophils levels before and after the treatment. Adverse events were monitored.</div></div><div><h3>Results</h3><div>Patients (mean age 49; 75% male; 75% N-ERD) experienced significant improvements. By 12 months, VAS scores decreased from 8.5 to 2.1, SNOT22 from 61.3 to 11, and NOSE from 69.5 to 8. Other measures, including NPS and BOT-8, also improved substantially. Specific descriptive results for each drug are also presented separately. No adverse effects were reported.</div></div><div><h3>Conclusions</h3><div>Biologic therapy (mepolizumab and dupilumab) as a primary treatment for CRSwNP demonstrated significant efficacy, reducing the need for surgical interventions and signaling a shift toward non-surgical management.</div></div>","PeriodicalId":7019,"journal":{"name":"Acta otorrinolaringologica espanola","volume":"77 3","pages":"Article 512328"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148003049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Remzi Dogan, Emre Polat, Erol Senturk, Alper Yenigun, Sabri Baki Eren, Fadlullah Aksoy, Ramazan Bahadir Kucuk, Orhan Ozturan
{"title":"Intratympanic steroid for residual dizziness after benign paroxysmal positional vertigo: a randomized controlled study","authors":"Remzi Dogan, Emre Polat, Erol Senturk, Alper Yenigun, Sabri Baki Eren, Fadlullah Aksoy, Ramazan Bahadir Kucuk, Orhan Ozturan","doi":"10.1016/j.otorri.2026.512330","DOIUrl":"10.1016/j.otorri.2026.512330","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigates the effectiveness of intratympanic steroid treatment in managing residual dizziness after benign paroxysmal positional vertigo (BPPV) and its impact on quality of life.</div></div><div><h3>Methods</h3><div>Fifty-six patients with unilateral posterior canal BPPV without nystagmus after the Epley maneuver were randomized into two groups. Group 1 received intratympanic steroids (two sessions) with the canalith repositioning maneuver, while Group 2 received only the maneuver. Patients were assessed using the Dizziness Handicap Inventory (DHI), Visual Analog Scale (VAS), and residual dizziness evaluation on Day 1 and Day 10.</div></div><div><h3>Results</h3><div>Baseline assessments showed no significant differences between groups. On Day 10, Group 1 showed significantly greater improvement in residual dizziness (p = 0.036) and Physical DHI scores (p = 0.047), while other DHI and VAS scores remained similar.</div></div><div><h3>Conclusion</h3><div>This study is the first to show that intratympanic steroids significantly reduce residual dizziness, potentially accelerating recovery and improving quality of life in BPPV patients.</div></div>","PeriodicalId":7019,"journal":{"name":"Acta otorrinolaringologica espanola","volume":"77 3","pages":"Article 512330"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148003051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ramón Moreno-Luna , Julissa Vizcarra Melgar , Daniel Martín Jiménez , Meritxell Clari Comes , Pedro Infante Cossio , Serafín Sánchez Gómez
{"title":"Diagnostic challenges of central compartment atopic disease in type-2 chronic rhinosinusitis","authors":"Ramón Moreno-Luna , Julissa Vizcarra Melgar , Daniel Martín Jiménez , Meritxell Clari Comes , Pedro Infante Cossio , Serafín Sánchez Gómez","doi":"10.1016/j.otorri.2025.512290","DOIUrl":"10.1016/j.otorri.2025.512290","url":null,"abstract":"<div><h3>Background</h3><div>Central compartment atopic disease (CCAD) is an emerging phenotype of type-2 chronic rhinosinusitis (CRS), characterized by inflammation involving the central nasal structures. The absence of standardized diagnostic criteria has hindered its recognition. This study aims to describe the first European cohort of CCAD patients and compare its features with previously published international data.</div></div><div><h3>Materials and methods</h3><div>A retrospective observational study was conducted including adult patients diagnosed with CCAD at a tertiary rhinology unit (2021–2024), based on predefined endoscopic and radiologic criteria. Demographic, clinical, exploratory, analytical and quality-of-life data were collected. Descriptive statistics were used to characterize the baseline profile of the study population.</div></div><div><h3>Results</h3><div>The cohort of 93 CCAD patients was predominantly male (65.6%) with a mean age of 48.7 ± 12.2 years. The baseline SNOT-22 score averaged 61.5 ± 24.3, with marked olfactory impairment. Asthma and N-ERD were reported in 40.9% and 7.5% of cases, respectively; allergic sensitization was confirmed in 60.2%. The mean endoscopic scores were 4.0 ± 2.2 for the nasal polyp score and 7.5 ± 2.5 for the modified Lund-Kennedy scale, while the mean CT-scan score was 11.7 ± 3.8. Blood eosinophilia >150 cells/μL was present in 77.4% of patients, and tissue eosinophil counts averaged 49.9 ± 43.8 eosinophils per high-power field.</div></div><div><h3>Conclusion</h3><div>This study reinforces CCAD as a localized type-2 CRS phenotype with a distinctive atopic signature. Findings underscore the need for standardized diagnostic criteria to improve its recognition and guide more personalized therapeutic strategies.</div></div>","PeriodicalId":7019,"journal":{"name":"Acta otorrinolaringologica espanola","volume":"77 3","pages":"Article 512290"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148003069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Waleed Moneir, Ahmed Hamed Fouda, Mohamed Moustafa Elshaer, Ahmed Hemdan
{"title":"The impact of anatomical variations of chorda tympani nerve on taste outcome after endoscopic stapedotomy","authors":"Waleed Moneir, Ahmed Hamed Fouda, Mohamed Moustafa Elshaer, Ahmed Hemdan","doi":"10.1016/j.otorri.2026.512323","DOIUrl":"10.1016/j.otorri.2026.512323","url":null,"abstract":"<div><h3>Objectives</h3><div>To assess the impact of anatomical variations of chorda tympani on postoperative taste sensation following stapedotomy.</div></div><div><h3>Materials and methods</h3><div>A prospective cohort study that was conducted among 80 patients with otosclerosis who underwent endoscopic stapedotomy. The anatomical type of chorda tympani was identified. Postoperative taste outcome was assessed using both subjective questionnaire and chemical testing using taste strips.</div></div><div><h3>Results</h3><div>The most common anatomical variant of chorda tympani was the attached long type. There were statistically significant differences between the anatomical variants of chorda tympani in postoperative taste disturbance by both subjective (<em>P</em> = .034) and chemical testing (<em>P</em> = .008) with the ultrashort type being the most common type associated with postoperative taste disturbance.</div></div><div><h3>Conclusion</h3><div>The anatomical variations of chorda tympani affect the nerve handling and manipulation which results in variation in postoperative taste sensation. The ultrashort type is the most common type associated with postoperative taste disturbance. Accordingly, facing this type during the surgery necessitates careful nerve handling and manipulation to avoid postoperative taste disturbance.</div></div>","PeriodicalId":7019,"journal":{"name":"Acta otorrinolaringologica espanola","volume":"77 3","pages":"Article 512323"},"PeriodicalIF":1.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148003071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
María Alharilla Montilla-Ibáñez , Javier Modesto García-Fernández , María Soledad Sánchez-Torices , María Pilar Gómez-Gallego , Miguel Angel Feliz-Fernández , Rafael Lomas-Vega
{"title":"Adaptación transcultural y validación psicométrica de la versión en español del cuestionario Nasal Polyposis Quality of Life (NPQ)","authors":"María Alharilla Montilla-Ibáñez , Javier Modesto García-Fernández , María Soledad Sánchez-Torices , María Pilar Gómez-Gallego , Miguel Angel Feliz-Fernández , Rafael Lomas-Vega","doi":"10.1016/j.otorri.2025.512310","DOIUrl":"10.1016/j.otorri.2025.512310","url":null,"abstract":"<div><h3>Introduction</h3><div>To perform the cross-cultural adaptation into Spanish and the psychometric validation of the Nasal Polyposis Quality of Life Questionnaire (NPQ) for use in patients with chronic rhinosinusitis with nasal polyps (CRSwNP).</div></div><div><h3>Methods</h3><div>A total of 140 adult patients diagnosed with CRSwNP were included. The original NPQ was adapted from Italian into Spanish following established international guidelines. Construct validity was assessed through exploratory factor analysis (EFA) with principal components. Internal consistency was analyzed using Cronbach's alpha coefficient. Test-retest reliability was determined by the intraclass correlation coefficient (ICC). Concurrent validity was examined using Pearson correlations with the SNOT-22 and NOSE-E questionnaires. Discriminant validity was analyzed using ROC curves.</div></div><div><h3>Results</h3><div>EFA revealed a five-factor structure explaining 67% of the total variance. The Spanish NPQ showed excellent internal consistency (Cronbach's α<!--> <!-->=<!--> <!-->0.917) and high test-retest reliability (ICC<!--> <!-->=<!--> <!-->0.991; 95% CI: 0.983-0.996). The standard error of measurement (SEM) was 2 points, and the minimal detectable change (MDC95) was 5 points. Strong correlations were observed with the NOSE-E (r<!--> <!-->=<!--> <!-->0.802) and SNOT-22 (r<!--> <!-->=<!--> <!-->0.870). The NPQ total score demonstrated high discriminative ability for severe symptoms (AUC<!--> <!-->=<!--> <!-->0.947), with a cutoff point >41 providing 88.9% sensitivity and 93.3% specificity.</div></div><div><h3>Conclusions</h3><div>The Spanish version of the NPQ is a valid, reliable, and clinically useful instrument for assessing symptom burden in patients with CRSwNP. Its multidimensional structure allows capturing the specific impact of this phenotype and supports its use in both clinical practice and research.</div></div>","PeriodicalId":7019,"journal":{"name":"Acta otorrinolaringologica espanola","volume":"77 2","pages":"Article 512310"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147552583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hussein Sherif Hamdy, Abeir Osman Dabbous, Enas Magdy Ahmed, Dina Fouad Osman
{"title":"Auditory attention ability in normal hearing patients with chronic subjective tinnitus","authors":"Hussein Sherif Hamdy, Abeir Osman Dabbous, Enas Magdy Ahmed, Dina Fouad Osman","doi":"10.1016/j.otorri.2025.512305","DOIUrl":"10.1016/j.otorri.2025.512305","url":null,"abstract":"<div><h3>Background</h3><div>Tinnitus is the perception of sounds in the absence of an external acoustic signal. Many patients with tinnitus complain of attention and concentration difficulties that affect their daily life activities.</div></div><div><h3>Objectives</h3><div>This study was done to assess the auditory attention ability in normal hearing patients with subjective chronic tinnitus, and to study the relation between auditory attention and the degree of tinnitus handicap and the psychoacoustic characterization of tinnitus.</div></div><div><h3>Subjects and methods</h3><div>This is a case control study that included 35 normal hearing chronic (>6 months duration) tinnitus patients, between 18–50 years of age, of both genders, compared to 35 normal hearing controls without tinnitus. Tinnitus severity was assessed by the Tinnitus Handicap Inventory, and the Hospital Anxiety and Depression Scale was used to assess the psychological status of the patients. Auditory attention was evaluated by behavioral measures: The vigilance test of the Montreal Cognitive Assessment (VMoCA), the Digit forward span test (DFST), Speech-in-noise (SPIN) test, and the Dichotic digits test (DDT).</div></div><div><h3>Results</h3><div>Tinnitus cases in the current study performed significantly worse than their controls on the behavioral measures of auditory attention measured (<em>P</em> value <.05). The vigilance test of the Montreal Cognitive Assessment (VMOCA) was significantly affected with a mean of 1.49 (SD ± 0.66) as compared to controls (Mean: 2 ± 0). There was a statistically significant (<em>P</em> < .05) negative correlation between functional subscale of THI with DDT test right ear (r = −0.415) and left ear (r = −0.354). There was a statistically significant (<em>P</em> < .05) negative correlation between catastrophic subscale of THI with DDT test left ear (r = −0.387). There was a statistically significant (<em>P</em> < .05) negative correlation between total score of THI with DDT test right ear (r = −0.347). Also, there was a statistically significant (<em>P</em> < .05) negative correlation between functional subscale of THI and SPIN test results in the left ear (r = −0.39), and between total score of THI and SPIN test in the left ear (r = −0.382).</div></div><div><h3>Conclusion</h3><div>Chronic tinnitus is linked to anxiety, depression, and impaired auditory attention. These findings suggest that therapies for tinnitus should include cognitive and emotional support.</div></div>","PeriodicalId":7019,"journal":{"name":"Acta otorrinolaringologica espanola","volume":"77 2","pages":"Article 512305"},"PeriodicalIF":1.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147552587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}