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Gossypol.
Acta Europaea fertilitatis Pub Date : 2020-02-07 DOI: 10.32388/xz65pm
N. Kalla
{"title":"Gossypol.","authors":"N. Kalla","doi":"10.32388/xz65pm","DOIUrl":"https://doi.org/10.32388/xz65pm","url":null,"abstract":"\u0000 The male contraceptive gossypol was developed by Chinese workers and tested on 10,000 male volunteers over a period of 5-8 years. It was effective in 99.8% of the cases. It acts also as an antiviral and antifungal agent inhibiting Trypnosone and Plasmodium, which cause Chagas and malaria respectively. This study also supports the efficacy of gossypol. Cellular and molecular lesions in the testis occurred with gossypol. Animal models have shown spermatogenesis after drug withdrawal. Bonnet monkey results support significantly reduced fertility. In vivo and in vitro work has been conducted in order to isolate the differential effects of optical isomers. The current results of unwanted side effects are 1) failure of recovery of spermatogenesis, and 2) hypokalemia. An operational model of action of gossypol on the testis is under development.\u0000","PeriodicalId":7016,"journal":{"name":"Acta Europaea fertilitatis","volume":"95 1","pages":"5-6"},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88972020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preimplantation genetic diagnosis. 胚胎植入前遗传学诊断。
Acta Europaea fertilitatis Pub Date : 2005-01-01 DOI: 10.1159/000082225
A. Safran, N. Laufer
{"title":"Preimplantation genetic diagnosis.","authors":"A. Safran, N. Laufer","doi":"10.1159/000082225","DOIUrl":"https://doi.org/10.1159/000082225","url":null,"abstract":"Preimplantation genetic diagnosis (PGD) involves testing for specific genetic conditions prior to the implantation [5] of an embryo in the uterine wall. This form of genetic screening has been made possible by the growth of in-vitro fertilization [6] (IVF) technology, which allows for the early stages of development to occur in a laboratory dish rather than in vivo [7]. The purpose of PGD is to identify what are considered to be abnormal embryos in order to select the most desirable embryos for implantation [5]. Diagnosis is comprised of two steps: extraction of one or two cells from an IVF-produced embryo, and application of the PGD test. PGD is important to embryology [8] because it has advanced IVF results and allowed couples more opportunities to deliver a child to term; however, it has also created much controversy.","PeriodicalId":7016,"journal":{"name":"Acta Europaea fertilitatis","volume":"10 1","pages":"166-201"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84688543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
New therapeutic possibilities handling residual azoospermia. 处理残余无精子症的新治疗方法。
Acta Europaea fertilitatis Pub Date : 1995-07-01
R Schoysman, B Lejeune, L Segal, E van Roosendaal, P Vanderzwalmen, M Nijs, S G Bertin, B Vandamme
{"title":"New therapeutic possibilities handling residual azoospermia.","authors":"R Schoysman,&nbsp;B Lejeune,&nbsp;L Segal,&nbsp;E van Roosendaal,&nbsp;P Vanderzwalmen,&nbsp;M Nijs,&nbsp;S G Bertin,&nbsp;B Vandamme","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Obviously, medical therapy of secretory azoospermia or microsurgical therapy of excretory azoospermia are not always successful. The unsolvable cases therefore can be grouped as residual azoospermias. Both the medical and microsurgical approaches are reviewed and their success rates analyzed. Some problems are unsolvable after work-up of the diagnosis. Till the early nineties, such patients were discouraged to undergo further medical therapeutic approaches and were advised to consider either adoption or donor insemination. At the present time, new possibilities have risen since the use of epididymal spermatozoa for performing assisted fertilization has considerably altered the picture. Furthermore, the last breakthrough of using testicular spermatozoa combined with the ICSI procedures have offered solutions that were unthinkable only a few years ago. The impact of these new approaches is discussed and the future development of microsurgery versus assisted reproduction techniques is also considered.</p>","PeriodicalId":7016,"journal":{"name":"Acta Europaea fertilitatis","volume":"26 4","pages":"131-6"},"PeriodicalIF":0.0,"publicationDate":"1995-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20048892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Activation of the acrosome reaction after treatment with human follicular fluid. A morphofunctional evaluation useful for in vitro fertilization. 人卵泡液处理后顶体反应的激活。对体外受精有用的形态功能评价。
Acta Europaea fertilitatis Pub Date : 1995-07-01
G Ruvolo, G Cassarà, M A Di Bella, D Parrinello, M Manno, C Cimino, M Bajamonte, E Cittadini, G De Leo
{"title":"Activation of the acrosome reaction after treatment with human follicular fluid. A morphofunctional evaluation useful for in vitro fertilization.","authors":"G Ruvolo,&nbsp;G Cassarà,&nbsp;M A Di Bella,&nbsp;D Parrinello,&nbsp;M Manno,&nbsp;C Cimino,&nbsp;M Bajamonte,&nbsp;E Cittadini,&nbsp;G De Leo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Studies aided by transmission electron microscopy were made in order to evaluate the occurrence and efficiency of the human follicular fluid in the activation of the processes leading to the acrosome reaction; quantitative, qualitative and morphological data and relative evaluations are here presented. The effects of the human follicular fluid were compared with those determined by other types of treatment, semen untreated, Pellet-Swim-up, and Centrifugation on Discontinuous Percoll Gradient. The transmission electron microscope observations permitted to evaluate the percentage of sperm with an activation of the acrosome reaction in the different groups. The analysis of the data showed a statistically relevant difference (P < 0.001) among the first group (Control group) and the SU group, the MP group and the hFF group, regarding the sperm with AR activation. The sperm treatment with 50% diluted hFF represents an important option to the preparation protocols of the semen samples useful for ART.</p>","PeriodicalId":7016,"journal":{"name":"Acta Europaea fertilitatis","volume":"26 4","pages":"125-30"},"PeriodicalIF":0.0,"publicationDate":"1995-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20048888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of female hyperandrogenism: estroprogestinic therapy at low dose in an inversal sequential scheme. 女性高雄激素症的治疗:低剂量的逆序贯雌激素治疗方案。
Acta Europaea fertilitatis Pub Date : 1995-07-01
F P Ragonesi, F Lo Mastro, V Arena, M Ermini
{"title":"Treatment of female hyperandrogenism: estroprogestinic therapy at low dose in an inversal sequential scheme.","authors":"F P Ragonesi,&nbsp;F Lo Mastro,&nbsp;V Arena,&nbsp;M Ermini","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>to investigate the effects of treatment with low dose of cyproterone acetate and ethynyl-estradiol on chemical and hormonal parameters in female hyperandrogenism.</p><p><strong>Design: </strong>twenty patients, affected by clinical manifestations of hyperandrogenism, were studied basally and during treatment with 10 mg of cyproterone acetate associated with ethynyl-estradiol (20 m g) in an inversal sequential scheme for six months. Safety parameters were assessed throughout the study. Hirsutism was graded by Ferriman and Gallway score, and hormonal parameters were evaluated basally and after six months of therapy.</p><p><strong>Results: </strong>after six months of therapy all patients showed a significant decrease of clinical and biochemical signs of hyperandrogenism, and normalization of ovarian parameters in seventeen women affected by PCOS.</p><p><strong>Conclusions: </strong>this treatment is an effective and well tolerated therapy. It is reasonable to consider this treatment as a safe procedure especially in view of a long-term administration.</p>","PeriodicalId":7016,"journal":{"name":"Acta Europaea fertilitatis","volume":"26 4","pages":"141-3"},"PeriodicalIF":0.0,"publicationDate":"1995-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20048217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human sperm cryopreservation and reactive oxygen species (ROS) production. 人类精子低温保存和活性氧(ROS)的产生。
Acta Europaea fertilitatis Pub Date : 1995-07-01
F Mazzilli, T Rossi, L Sabatini, F M Pulcinelli, S Rapone, F Dondero, P P Gazzaniga
{"title":"Human sperm cryopreservation and reactive oxygen species (ROS) production.","authors":"F Mazzilli,&nbsp;T Rossi,&nbsp;L Sabatini,&nbsp;F M Pulcinelli,&nbsp;S Rapone,&nbsp;F Dondero,&nbsp;P P Gazzaniga","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The aim of this work was to establish whether cryopreservation procedure can trigger the production of Reactive Oxygen Species (ROS) in selected sperm populations. Semen samples were obtained from 45 subjects attending our Department of Medical Pathophysiology. Motile sperm suspensions were obtained by swim-up in Tyrode's salt solution. After dilution with TEST yolk buffer freezing medium, they were cryopreserved in liquid nitrogen. In addition to motility assessment, in basal and freeze/thaw conditions ROS detection and the Hypoosmotic Viability Test were also carried out. In 19 subjects (42.2%) there was already evidence of ROS production prior to cryopreservation, which increased after thawing. In 9 subjects (20.0%) there was no ROS production prior to cryopreservation, however, after freezing/thawing we detected evidence of the presence of ROS. It seems, therefore, that cryoprocedure can indeed provoke or increase ROS production in some semen samples. In ROS producing subjects, the post-show recovery of sperm motility and vitality was significantly lower compared to ROS-free subjects. This was probably due to damage by oxidative stress leading to lipid peroxidation of the sperm membrane. Moreover, in some ejaculates, ROS overproduction or scavenger system failure can be regarded as a cryopathogenetic factor affecting \"sperm quality\" recovery.</p>","PeriodicalId":7016,"journal":{"name":"Acta Europaea fertilitatis","volume":"26 4","pages":"145-8"},"PeriodicalIF":0.0,"publicationDate":"1995-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20048221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidence of Chlamydia trachomatis in women with PID: effectiveness of therapy. 女性PID患者沙眼衣原体发病率:治疗效果。
Acta Europaea fertilitatis Pub Date : 1995-07-01
C De Punzio, E Neri, G Guazzelli, R Gremigni
{"title":"Incidence of Chlamydia trachomatis in women with PID: effectiveness of therapy.","authors":"C De Punzio,&nbsp;E Neri,&nbsp;G Guazzelli,&nbsp;R Gremigni","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The pelvic inflammatory disease (PID) can be caused by various germs. Of the two thousand seven hundred thirty one women screened for different microbiological agents in the genitourinary tract and for PID, three hundred sixty nine patients were Chlamydia trachomatis (Ct) positive; one hundred and three patients were affected by PID. Seventy out of them were resulted to be Ct positive. One hundred twenty two women were Ct positive but not affected by PID. The antibiotic treatment resulted to be less effective in women Ct positive but affected by PID. Results of the present study demonstrate that Ct is the primary cause of PID.</p>","PeriodicalId":7016,"journal":{"name":"Acta Europaea fertilitatis","volume":"26 4","pages":"149-51"},"PeriodicalIF":0.0,"publicationDate":"1995-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20048223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of new biologic markers in the ovulation induction. 新生物标志物在促排卵中的应用。
Acta Europaea fertilitatis Pub Date : 1995-07-01
A Silvestri, F Scarpellini, N Dino, L Scarselli
{"title":"Use of new biologic markers in the ovulation induction.","authors":"A Silvestri,&nbsp;F Scarpellini,&nbsp;N Dino,&nbsp;L Scarselli","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Biological markers of ovulation, after a great in the past, have been fallen into disuse for the large diffusion of biochemical and biophysical ones. However, the real effect of hormones involved in ovulation is expressed by biological modifications on target tissues. To explore the modifications of not reproductive target tissues as ovulation markers we studied the behaviour of Albuminemia, Platelet Factor IV (as indicator of Platelet Aggregation), Type II estrogenic receptors in 42 ovulation induced women, undergoing our observation. 33 of them had ovulation and 9 developed a LUF syndrome, constituting two biological models of an opposite situation for the three markers observed. All the markers considered were sufficiently sensitive, but among them, Platelet Factor IV was the most reliable to the hormonal ovulatory situation.</p>","PeriodicalId":7016,"journal":{"name":"Acta Europaea fertilitatis","volume":"26 4","pages":"137-9"},"PeriodicalIF":0.0,"publicationDate":"1995-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20048894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cabergoline treatment in a case of macroprolactinoma after delivery. 卡麦角林治疗产后巨泌乳素瘤1例。
Acta Europaea fertilitatis Pub Date : 1995-05-01
L Falsetti
{"title":"Cabergoline treatment in a case of macroprolactinoma after delivery.","authors":"L Falsetti","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We present a case of microprolactinoma (3 mm) grown into macroprolactinoma (21 mm) during pregnancy. This patient was admitted in our hospital for left hemianopsia 13 days after delivery. Through Magnetic Resonance Imaging (MRI) a macroprolactinoma (21 mm in diameter) was diagnosed. The Prolactin (PRL) serum levels were 152 ng/ml. The patient started Cabergoline treatment with good results: normalization of PRL levels after 5 days, of the visual field after 58 days and complete disappearance of prolactinoma within 180 days from the beginning of treatment.</p>","PeriodicalId":7016,"journal":{"name":"Acta Europaea fertilitatis","volume":"26 3","pages":"105-7"},"PeriodicalIF":0.0,"publicationDate":"1995-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20048885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adrenal androgen-secreting carcinoma in a fertile woman. 育龄妇女肾上腺雄激素分泌癌。
Acta Europaea fertilitatis Pub Date : 1995-05-01
L Falsetti, F Salinaro, M Chiaramonte
{"title":"Adrenal androgen-secreting carcinoma in a fertile woman.","authors":"L Falsetti,&nbsp;F Salinaro,&nbsp;M Chiaramonte","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The article reports on a case of functioning adrenal carcinoma in a woman of 40 with concomitant in situ carcinoma of the portio (CIN 3). She had had amenorrhoea for 14 months and early menopause was suspected. Hirsutism and other signs of virilization such as clitoromegaly and voice changes were detected upon hospitalization.. The characteristic of the clinical case is given by hormone production involving not only androgens of prevalently adrenal genesis (dehydroepiandrosterone, dehydroepiandrosterone sulphate and androstenedione), but also testosterone, more suggestive of a gonadal neoplasm. The adrenal carcinoma only produced androgens, as plasma cortisol and aldosterone concentrations were normal. Diagnosis of adrenal carcinoma was first made with hormone assays and then with the adrenal block test using dexamethasone, with adrenal ecography and abdomino-pelvic computed tomography (CT). When amenorrhoea is present and hirsutism and other signs of virilization occur ex-novo in a short period, in a woman of fertile age, a thorough endocrine study must be carried out. According to the hormone profile, the next diagnostic step should be aimed at detecting a prospective ovarian or adrenal neoplasm.</p>","PeriodicalId":7016,"journal":{"name":"Acta Europaea fertilitatis","volume":"26 3","pages":"117-21"},"PeriodicalIF":0.0,"publicationDate":"1995-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20048889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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