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Adult hypophosphatasia. 成人低磷酸盐血症。
Acta medica Scandinavica Pub Date : 2020-02-10 DOI: 10.32388/ag8ws5
E. Sorensen, H. Flodgaard
{"title":"Adult hypophosphatasia.","authors":"E. Sorensen, H. Flodgaard","doi":"10.32388/ag8ws5","DOIUrl":"https://doi.org/10.32388/ag8ws5","url":null,"abstract":"A case of adult hypophosphatasia under treatment with a high orthophosphate (P1) intake is described. The patient is a 53-year-old woman. Her symptoms have progressed for seven years, and it has been necessary to perform osteosynthesis of both crura. The diagnosis rests upon a characteristic clinical picture, low serum alkaline phosphatase activity, high urinary excretion of phosphoethanolamine, and an invariably elevated concentration of inorganic pyrophosphate (PP1) in plasma accompanied by a very high excretion of this compound in the urine. An improved technique allowed specific determinations of microquantities of PP1 in biologic materials. The concentrations of PP1 in the plasma and urine remained unchanged when the patient's intake of phosphorus was increased to 1.98 g/day. The PP1/P1 ratio in the urine was 10-20 before treatment. During treatment P1 excretion increased. PP1 excretion did not change, and the ratio decreased to around 7. The renal tubular transport of PP1 probably was saturated, and therefore PP1, which was circulating in abnormally high concentrations in the patient's fluids, could not be removed by loading with P1. Four months of treatment did not benefit the patient.","PeriodicalId":7011,"journal":{"name":"Acta medica Scandinavica","volume":"197 5 1","pages":"357-60"},"PeriodicalIF":0.0,"publicationDate":"2020-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49407184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Thiazide prophylaxis of urolithiasis. A double-blind study in general practice. 噻嗪预防尿石症。一般情况下的双盲研究。
Acta medica Scandinavica Pub Date : 2009-04-24 DOI: 10.1007/978-1-4684-7272-1_101
E. Lærum, Stig Larsen
{"title":"Thiazide prophylaxis of urolithiasis. A double-blind study in general practice.","authors":"E. Lærum, Stig Larsen","doi":"10.1007/978-1-4684-7272-1_101","DOIUrl":"https://doi.org/10.1007/978-1-4684-7272-1_101","url":null,"abstract":"","PeriodicalId":7011,"journal":{"name":"Acta medica Scandinavica","volume":"61 1","pages":"383-9"},"PeriodicalIF":0.0,"publicationDate":"2009-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51021998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 163
Assessment of D-dimer in plasma: diagnostic value in suspected deep venous thrombosis of the leg. 血浆d -二聚体的评估:对疑似下肢深静脉血栓的诊断价值。
Acta medica Scandinavica Pub Date : 2009-04-24 DOI: 10.1016/0268-9499(88)90432-8
P. Ott, L. Astrup, R. Jensen, B. Nyeland, B. Pedersen
{"title":"Assessment of D-dimer in plasma: diagnostic value in suspected deep venous thrombosis of the leg.","authors":"P. Ott, L. Astrup, R. Jensen, B. Nyeland, B. Pedersen","doi":"10.1016/0268-9499(88)90432-8","DOIUrl":"https://doi.org/10.1016/0268-9499(88)90432-8","url":null,"abstract":"","PeriodicalId":7011,"journal":{"name":"Acta medica Scandinavica","volume":"79 1","pages":"263-7"},"PeriodicalIF":0.0,"publicationDate":"2009-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0268-9499(88)90432-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53600142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 53
Plasma and skeletal muscle electrolytes in patients on long-term diuretic therapy for arterial hypertension and/or congestive heart failure. 长期利尿剂治疗动脉高血压和/或充血性心力衰竭患者血浆和骨骼肌电解质的变化
Acta medica Scandinavica Pub Date : 1988-10-01 DOI: 10.1097/00132586-198810000-00008
T. Dyckner, P. Wester
{"title":"Plasma and skeletal muscle electrolytes in patients on long-term diuretic therapy for arterial hypertension and/or congestive heart failure.","authors":"T. Dyckner, P. Wester","doi":"10.1097/00132586-198810000-00008","DOIUrl":"https://doi.org/10.1097/00132586-198810000-00008","url":null,"abstract":"Investigations regarding plasma and skeletal muscle electrolytes were carried out in 537 patients on long-term diuretic treatment (greater than 1 year) for arterial hypertension (n = 240) and/or congestive heart failure (n = 297). In both groups there were significant decreases in both plasma and skeletal muscle K and Mg, while the muscle Na values as well as the total and extracellular water content of skeletal muscle were increased.","PeriodicalId":7011,"journal":{"name":"Acta medica Scandinavica","volume":"222 3 1","pages":"231-6"},"PeriodicalIF":0.0,"publicationDate":"1988-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/00132586-198810000-00008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61636178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 34
Fats and diet. 脂肪和饮食。
Acta medica Scandinavica Pub Date : 1988-01-01
K R Norum, C A Drevon
{"title":"Fats and diet.","authors":"K R Norum, C A Drevon","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7011,"journal":{"name":"Acta medica Scandinavica","volume":"224 4","pages":"289-91"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14319430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bartter's syndrome. A review of 28 patients followed for 10 years. 巴特氏综合症。对28名患者进行了10年的随访。
Acta medica Scandinavica Pub Date : 1988-01-01
A Rudin
{"title":"Bartter's syndrome. A review of 28 patients followed for 10 years.","authors":"A Rudin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Twenty-eight patients with Bartter's syndrome diagnosed during the years 1964-86 and followed for an average of 9.9 years have been reviewed. Their mean age at the time of diagnosis was 32.9 years. As a group they were shorter than normal subjects. In 19 patients hypokalaemia was detected incidentally. Neuromuscular symptoms, usually minor, had occurred in 19 subjects. Pregnancies and deliveries were unremarkable. One patient has died from malignant lymphoma, the others are alive. Of these, one patient has developed renal failure and received a renal transplant. The other patients have preserved a normal renal function and the majority have been healthy and working full time. Treatment rarely resulted in normokalaemia. The annual incidence of the syndrome has been estimated at 1.2 per million people.</p>","PeriodicalId":7011,"journal":{"name":"Acta medica Scandinavica","volume":"224 2","pages":"165-71"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14546467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Social isolation and mortality in ischemic heart disease. A 10-year follow-up study of 150 middle-aged men. 社会孤立与缺血性心脏病的死亡率对150名中年男性进行了为期10年的跟踪研究。
Acta medica Scandinavica Pub Date : 1988-01-01
K Orth-Gomér, A L Undén, M E Edwards
{"title":"Social isolation and mortality in ischemic heart disease. A 10-year follow-up study of 150 middle-aged men.","authors":"K Orth-Gomér,&nbsp;A L Undén,&nbsp;M E Edwards","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effects of psychosocial and clinical factors on mortality in ischemic heart disease (IHD) were examined in a 10-year follow-up of 150 middle-aged men. Three groups of men were included: men with clinically manifest IHD, men with risk factors and healthy men. Psychosocial factors were assessed by means of standardized questionnaires. They comprised educational level, social class, marital status and a comprehensive assessment of the daily rounds of life of these men. Furthermore, a subjective rating of the own general health status was obtained. The clinical investigation included a standard physical examination, fasting serum lipids, glucose and urate, a frontal and sagittal chest X-ray and a 24-hour ambulatory ECG monitoring. During follow-up 37 men died, 20 of them from IHD. Non-survivors were discriminated from survivors by the following factors: older age, lower education, lower social class, higher systolic blood pressure, increased ventricular irritability and cardiac enlargement. Furthermore, a relative social isolation as indicated by a low social activity level and a poor self-rated general health status was characteristic of non-survivors. In multivariate analyses three factors emerged as the equally strong predictors of mortality, both from all causes and from IHD: social isolation, a poor self-rated health status and ventricular irritability. The psychosocial mortality predictors were independent of and of similar strength as the clinical predictors.</p>","PeriodicalId":7011,"journal":{"name":"Acta medica Scandinavica","volume":"224 3","pages":"205-15"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14367849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyperuricaemia and risk of cardiovascular disease and overall death. A 12-year follow-up of participants in the population study of women in Gothenburg, Sweden. 高尿酸血症与心血管疾病和总体死亡的风险。对瑞典哥德堡妇女人口研究的参与者进行了为期12年的随访。
Acta medica Scandinavica Pub Date : 1988-01-01
C Bengtsson, L Lapidus, C Stendahl, J Waldenström
{"title":"Hyperuricaemia and risk of cardiovascular disease and overall death. A 12-year follow-up of participants in the population study of women in Gothenburg, Sweden.","authors":"C Bengtsson,&nbsp;L Lapidus,&nbsp;C Stendahl,&nbsp;J Waldenström","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Serum uric concentration was determined in a series of 1462 women, aged 38-60 when first examined in 1968-69, as the first phase of a longitudinal population study in Gothenburg, Sweden. Serum uric acid concentration was positively correlated to the 12-year overall mortality in univariate analysis. No relationship was observed between initial serum uric acid values and incidence of myocardial infarction, angina pectoris, ECG changes indicating ischaemic heart disease or stroke. The association between serum uric acid concentration and mortality was independent of age, body mass index, systolic blood pressure, adipose tissue distribution, smoking habits, serum cholesterol concentration, serum triglyceride concentration, serum creatinine concentration, serum calcium concentration, use of diuretics, and haematological disease. The increased mortality could not be explained by any increase in malignant neoplastic disease.</p>","PeriodicalId":7011,"journal":{"name":"Acta medica Scandinavica","volume":"224 6","pages":"549-55"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14334424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reduction of blood pressure by treatment with alphacalcidol. A double-blind, placebo-controlled study in subjects with impaired glucose tolerance. 用α骨化醇治疗降低血压。糖耐量受损患者的双盲、安慰剂对照研究。
Acta medica Scandinavica Pub Date : 1988-01-01
L Lind, H Lithell, E Skarfors, L Wide, S Ljunghall
{"title":"Reduction of blood pressure by treatment with alphacalcidol. A double-blind, placebo-controlled study in subjects with impaired glucose tolerance.","authors":"L Lind,&nbsp;H Lithell,&nbsp;E Skarfors,&nbsp;L Wide,&nbsp;S Ljunghall","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Disturbances of calcium or vitamin D metabolism have been suggested to be of pathogenetic importance both for hypertension and impaired glucose tolerance, two disorders that are commonly associated. In the present study 65 men, aged 61-65 years, with impaired glucose tolerance were enrolled in a prospective, double-blind, placebo-controlled study over 12 weeks evaluating the effects of 0.75 microgram alphacalcidol, a synthetic analog to the active metabolite of vitamin D. In the 26 patients with blood pressure greater than or equal to 150/90 mmHg before treatment a significant reduction (p less than 0.01) of both the systolic (SBP) and diastolic (DBP) blood pressure was found after therapy (from 171/95 to 150/88 mmHg). The effect was additive to concomitant antihypertensive treatment and was correlated (p = 0.03) to a reduction of serum levels of parathyroid hormone. Also in the whole group of patients given alphacalcidol blood pressure was moderately lowered from a mean of 152/87 +/- 22/10 (SD) to 143/84 +/- 17/8 mmHg. There were no relationships between the changes in body weight, blood glucose or insulin parameters and the changes in blood pressure during the trial. The findings are compatible with the concept that calcium metabolism influences blood pressure regulation and suggest that supplementation with a physiologic dose of active vitamin D could be beneficial for patients with high blood pressure.</p>","PeriodicalId":7011,"journal":{"name":"Acta medica Scandinavica","volume":"223 3","pages":"211-7"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14408308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coronary thrombolysis. Principles and practice. 冠状动脉溶栓。原则和实践。
Acta medica Scandinavica Pub Date : 1988-01-01
L Erhardt, H Emanuelsson, M Hartford, H Johnsson, L E Strandberg
{"title":"Coronary thrombolysis. Principles and practice.","authors":"L Erhardt,&nbsp;H Emanuelsson,&nbsp;M Hartford,&nbsp;H Johnsson,&nbsp;L E Strandberg","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7011,"journal":{"name":"Acta medica Scandinavica","volume":"224 5","pages":"413-24"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14108589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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