Acta Medica Alanya最新文献

{"title":"Otizm Spektrum Bozukluğu Olan Hastalarda Öğrenme ve Hafıza Bozukluklarının NEURL1 ve RGS14 Genleri ile İlişkisi","authors":"Hamiyet Eciroglu, E. Şener, D. Öztop, Sevgi Özmen, Dilek Kaan, Yusuf Özkul","doi":"10.30565/medalanya.1136820","DOIUrl":"https://doi.org/10.30565/medalanya.1136820","url":null,"abstract":"Aim: We aimed to evaluate the relationship between learning-memory difficulties and NEURL1 and RGS14 genes in patients with autism spectrum disorders (ASD). \u0000Method: Forty children with ASD (20 ASD, 20 high functioning autism (HFA)) and 20 healthy controls were enrolled in this study. NEURL1 and RGS14 gene expressions in the blood samples of volunteers were assessed by quantitative Real-Time PCR (qRT-PCR). The clinical and demographical findings in patients were determined and examined relation with the gene expressions. \u0000Results: According to our findings, NEURL1 gene expression was decreased in both patient groups compared to the control (p0.05). A statistically significant correlation was found between learning and memory difficulties and RGS14 gene expression in HFA patients (p = 0.045). There was a positive correlation between between NEURL1 and RGS14 gene expressions of ASD patients (p=0.032, r=0,59). \u0000Conclusion: According to this study, NEURL1 gene may be proposed as a candidate gene for ASD. Nonetheless, we recommend that both genes be studied with more patients and preferably with brain tissues. These genes were evaluated for the first time in a clinical study on autism, and we believe that they will contribute to the literature in this respect.","PeriodicalId":7003,"journal":{"name":"Acta Medica Alanya","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86162582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FRONTAL QRS-T AÇISI İLE AMBULATUAR 24 SAAT HOLTERDE PREMATÜR VENTRİKÜLER KONTRAKSİYON YÜKÜ ARASINDAKİ İLİŞKİ","authors":"Görkem Kuş, Göksel Çağirci","doi":"10.30565/medalanya.1131541","DOIUrl":"https://doi.org/10.30565/medalanya.1131541","url":null,"abstract":"AMAÇ \u0000Sık prematür ventriküler kontraksiyonlar (PVK), ventriküler fonksiyonun bozulmasına veya ventriküler kavitelerin genişlemesine neden olabilir. Frontal düzlem QRS-T [f(QRS-T)] açısı, miyokardın elektrofizyolojik özelliklerindeki kararsızlığın bir göstergesidir ve aritmilerle ilişkilidir. Bu çalışma, ventriküler repolarizasyon heterojenitesinin bir belirteci olarak f(QRS-T) açısının, ambulatuar 24 saatlik holterde prematüre ventriküler kontraksiyon yükünü tahmin edip etmediğini araştırmayı amaçlamıştır. \u0000METHOD \u0000Çalışmada 100 hasta mevcuttu. Hastalar 24 saatlik Holter izleminde PVK yüklerine göre “sık PVK” ve “nadir PVK” olarak iki gruba ayrıldı. Laboratuar ve frontal plan QRS-T açısı dahil olmak üzere bazı ambulatuar elektrokardiyografi parametreleri iki grup arasında karşılaştırıldı. \u0000BULGULAR \u0000Frontal QRS-T açısı (63.34±37.86°'ye karşı 23.46±14.29° p","PeriodicalId":7003,"journal":{"name":"Acta Medica Alanya","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80220507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temel Duygusal Durumların Hemodinamik Karşılıklarının Taşınabilir bir İşlevsel Yakın Kızılaltı Spektroskopi Sistemi ile Tanımlanması","authors":"S. Erdoğan","doi":"10.30565/medalanya.1120497","DOIUrl":"https://doi.org/10.30565/medalanya.1120497","url":null,"abstract":"Objective: The aim of this study was to test the feasibility of a functional near infrared spectroscopy (fNIRS) system for quantification of the similarities and differences in the spatial localization of cerebral hemodynamic activation induced by visual presentation of neutral, negative and positive valence emotional stimuli. Method: 13 healthy subjects viewed neutral, pleasant and unpleasant pictures from the International Affective Picture System (IAPS) database in a block design experiment while the prefrontal cortical hemodynamic changes induced by emotional stimuli were continuously recorded with a 20 channel fNIRS system that covered the forehead region. Results: Negative valence pictures induced higher hemodynamic activity in right lateralized regions involving dorsolateral and oribtofrontal cortex when compared to neutral and positive valence stimuli (pFDR","PeriodicalId":7003,"journal":{"name":"Acta Medica Alanya","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84712786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the Effect of Antiepileptics on Vitamin D and Calcium Levels","authors":"B. Yulug, Ahmet Özşimşek, Ece ÖZDEMİR ÖKTEM","doi":"10.30565/medalanya.1116431","DOIUrl":"https://doi.org/10.30565/medalanya.1116431","url":null,"abstract":"Purpose: The purpose of our study is to investigate Vitamin D and calcium levels in epilepsy patients using different antiepileptic agents and to investigate the relationship between vitamin D levels and various factors such as the type of antiepileptic agent, patient age and gender. \u0000Methodology: This retrospective case-control study enrolled a total of 290 participants, including 141 epilepsy patients followed up in AlanyaAlaaddinKeykubat University neurology outpatient clinic and 150 healthy individuals who applied to the neurology outpatient clinic for different reasons from January 2018 to January 2021. Demographics, detailed history, use of medications, duration of antiepileptic use, plasma 25-hydroxy Vitamin D and calcium levels of all participants were recorded. \u0000Results: The average Vitamin D level was 15.46 in the epilepsy group and 16.95 in the control group. Vitamin D level did not differ significantly by group (p>0.05). No significant relationship was found between age and vitamin D levels in both groups, and Vitamin D levels were statistically significantly lower in women in the epilepsy group. Vitamin D level was below 20 in 69.6% of healthy control group, 78.9% of carbamazepine users, 62.5% of lacosamide users, all lamotrigine users, 66.7% of levatiracetam users, and 72.4% of sodium valproate users. There was no significant relationship between Vitamin D level and the drug used (p>0.05).There was a significant relationship only between calcium level and carbamazepine (p","PeriodicalId":7003,"journal":{"name":"Acta Medica Alanya","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91293015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"APIXABAN'ın DOZA BAĞLI ANTİANJİYOJENİK POTANSİYELİ: Deneysel bir bakış","authors":"Özgür Akkaya, Eyüp Aydoğan","doi":"10.30565/medalanya.1129978","DOIUrl":"https://doi.org/10.30565/medalanya.1129978","url":null,"abstract":"Amaç: Direkt oral antikoagülanlar (DOAK'lar), tromboembolizmin tedavisi ve önlenmesi için geleneksel tıbbi rejimlere iyi alternatiflerdir. Apixaban, bu yeni geliştirilen ilaçların daha popüler varyasyonlarından biridir. Antikoagülan potansiyelinin yanı sıra, olası hücresel etkiler gelecekteki çalışmaların konusu olmaya devam etmektedir. Bu çalışmanın amacı, korioallantoik membran (CAM) modelinde apiksaban'ın olası antianjiyogenik etkilerini araştırmaktı. \u0000 \u0000Yöntem: Apixaban'ın 10-4, 10-5 ve 10-6 M konsantrasyonlarında ilaç peletleri hazırlandı ve yumurta inkübasyonunun dördüncü gününde korioallantoik membrana yerleştirildi. Sekizinci günde, membranların tüm vasküler yoğunlukları, bilinen bir monoklonal, insanlaştırılmış, vasküler endotelyal büyüme faktörü inhibitörü olan 10-6 M'lik bir bevacizumab konsantrasyonu ile karşılaştırıldı. \u0000 \u0000Sonuçlar: 10-4 M apiksaban konsantrasyonunun, bevacizumabınkine benzer güçlü bir antianjiyogenik potansiyele sahip olduğunu bulduk. Bununla birlikte, daha düşük bir apiksaban dozunda (10-5 M, 10-6 M) orta düzeyde antianjiyogenik potansiyel vardı. Daha yüksek antianjiyogenik potansiyel dozlarının (10-4 M konsantrasyon) daha düşük dozlarda apiksaban (10-5 M, 10-6 M) ile karşılaştırılması, önemli istatistiksel farklılıklar ortaya çıkardı (p < 0.05). \u0000 \u0000Sonuç: Sonuçlarımız, yüksek doz apiksaban'ın güçlü antianjiyogenik potansiyele sahip olduğunu göstermektedir. Bu etkinin kesin mekanizması bilinmemektedir. Bu pilot sonuçlar, DOAK'lara yeni bir bakış elde etmek için daha ileri çalışmalarla doğrulanmalıdır.","PeriodicalId":7003,"journal":{"name":"Acta Medica Alanya","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85382284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NR-2 antikor peptid düzeyinin akut iskemik inmede tanı, prognoz ve koma skorları ile ilişkisi var mıdır?","authors":"Alpay Tuncar, Başar Cander, Kadir Küçükceran, Fatma Hümryra Yerli̇kaya","doi":"10.30565/medalanya.1116544","DOIUrl":"https://doi.org/10.30565/medalanya.1116544","url":null,"abstract":"Aim: This study aimed to demonstrate the diagnostic and prognostic value of NR-2 peptides as a biomarker in acute ischemic stroke and to evaluate their correlation with the Glasgow Coma Scale (GCS) and the National Institutes of Health Stroke Scale (NIHSS). \u0000Materials and Methods: This is a prospective study evaluating the value of NR-2 peptide levels in the diagnosis and prognosis of acute stroke. The study included 101 patients, who presented to a tertiary healthcare facility and were diagnosed with acute stroke, and 57 healthy controls. In the whole study population, serum NR-2 peptide levels were measured using the ELISA method. \u0000Results: The NR-2 peptide level was 6.32 ± 8.30 in the patient group and 3.91 ± 1.64 in the study group. The NR-2 peptide level was significantly higher in the patient group (p = 0.006). No correlation was detected between NR-2 peptide levels and scores in the GCS or NIHSS. The results indicated that NR-2 was a potential biomarker elevated in the early phase of acute stroke, but had no correlation with the prognosis of acute stroke. \u0000Conclusion: Although our data shed light on the use of the NR-2 peptide level as a biomarker in the acute phase in patients with stroke, data are insufficient to predict prognosis. We think that larger, multicentre studies with longer follow-up periods are needed.","PeriodicalId":7003,"journal":{"name":"Acta Medica Alanya","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90462991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Çocuk Hastanesinde Perioperatif Hipotermi Sıklığı ve Predispozan Faktörler","authors":"Kübra EVREN ŞAHİN, M. Sözbilen","doi":"10.30565/medalanya.1122479","DOIUrl":"https://doi.org/10.30565/medalanya.1122479","url":null,"abstract":"Background/Aim: Perioperative hypothermia is more common in pediatric patients than in adult patients due to increased body surface area/weight ratio and limited subcutaneous fat deposits. Therefore, active and passive warming techniques are used more frequently in the surgeries applied to pediatric patients. This study presents the prevalence of perioperative hypothermia and the predisposing conditions for perioperative hypothermia in pediatric orthopedic surgeries in which active and passive warming techniques are applied. \u0000Methods: This cross-sectional, descriptive, and observational study included 102 children admitted to the pediatric orthopedic clinic of a children’s hospital. Temperature measurements were made with a calibrated infrared tympanic thermometer in all cases while they were waiting in the service room, when they entered the operation theater, when they left the operation theater, and when they left the postoperative care unit. Their demographic data, hemogram, and thyroid hormone parameters, preoperative fasting times related to the procedure, and temperature were recorded. Also, the humidity and temperature values of the operating theater, the operation type performed, the anesthesia method applied during the operation, the complications encountered, and the time spent in the operating theater were all recorded in their follow-up forms. Data analysis was done using SPSS V21.0 and was conducted at a 95% confidence interval. \u0000Results: Hypothermia was observed in 20,58% of 102 patients included in the study. Predisposing factors were determined for perioperative hypothermia as follows; the patient's American Society of Anesthesiologists risk score is above 1, concomitant diagnosis of cerebral palsy, low hemoglobin level in the preoperative period, fasting longer than 8 hours, the low body temperature of the patient in the service room, long time stayed in the operating room, and different humidity values of the operating theatre. \u0000Conclusion: Although active and passive warming techniques are applied during the operation, perioperative hypothermia was observed in 20,58% of pediatric patients who underwent the orthopedic operation. Consideration of predisposing factors together with active and passive warming techniques may reduce the incidence of perioperative hypothermia.","PeriodicalId":7003,"journal":{"name":"Acta Medica Alanya","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81850750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Omuz bölgesi yağ kalınlığının rotator manşet operasyonlarının süresine etkisi var mıdır?","authors":"Sefa Akti, Serdar Akti, Daghan Dogruyol, Selin Haver, Hakan Zeybek, Deniz Çankaya","doi":"10.30565/medalanya.1101349","DOIUrl":"https://doi.org/10.30565/medalanya.1101349","url":null,"abstract":"Objective: Accurate estimation of operation time will reduce operating room costs and increase patient satisfaction. In recent studies, authors have found that thicker adipose tissue at the operation site is associated with higher rate of complications. However, there is no study in the literature investigating the effect on operation time of an increase in adipose tissue thickness. This present study hypothesised that thicker adipose tissue in the shoulder surgery would prolong the operation time, so the study was planned accordingly. \u0000Material and Methods: Preoperative magnetic resonance images of patients applied with rotator cuff repair between 2015 and 2020 were independently evaluated by two observers. The acromial fat thickness was measured as the fat thickness of the operation area, and the scapular fat tissue thickness as the fat thickness of the region relatively far from the operation area. The data obtained were evaluated using multivariate analysis and a binary logistic regression model. \u0000Results: Evaluation was made of a total of 106 patients. The mean total operation time was 89±33 mins. The mean acromial fat thickness was 12.2±4.89 mm and mean scapular fat thickness was 27.9±12.5mm. The increase in acromial fat thickness was determined to have extended the operation time (OR=5.75, 29.21, p","PeriodicalId":7003,"journal":{"name":"Acta Medica Alanya","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88356331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dikkat Eksikliği ve Hiperaktivite Bozukluğunda Yağ Asitlerinin Rolü","authors":"Sümeyye Akin, Fatih Gültekin, Eray Metin Güler","doi":"10.30565/medalanya.1059552","DOIUrl":"https://doi.org/10.30565/medalanya.1059552","url":null,"abstract":"Attention deficit hyperactivity disorder (ADHD) is a childhood-onset disorder that affects 5% to 12% of children worldwide. Etiological factors, including nutrition, are involved in this disease, which is characterized by inattention, impulsivity, and hyperactivity symptoms. Fats, which form an important part of the daily diet, can have effects on ADHD and its symptoms. In the literature, it is stated that omega-3 fatty acids are low in children with ADHD, and supplementation studies may be effective in improving symptoms. In addition, high omega-6/omega-3 fatty acids ratio in the diet and diets rich in saturated and trans fatty acids are associated with ADHD. In this review, the relationship between ADHD and dietary fatty acids will be evaluated.","PeriodicalId":7003,"journal":{"name":"Acta Medica Alanya","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82081290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ELE GELMEYEN TESTİSTE LAPAROSKOPİ DENEYİMİMİZ","authors":"Osman Hakan Kocaman, Tansel Günendi","doi":"10.30565/medalanya.1061628","DOIUrl":"https://doi.org/10.30565/medalanya.1061628","url":null,"abstract":"AIM: To demonstrate the superiority of laparoscopic undescended testicular surgery for nonpalpable testicles in children in diagnosis and treatment. \u0000METHODS: The files of patients between the age of 6 months-18 years who underwent laparoscopic undescended testis investigation due to nonpalpable testis in our clinic between January 2010 and September 2021 were reviewed retrospectively. Patients with palpable testicles and patients with disorders of sex development in the examination performed under general anesthesia were excluded from the study. \u0000RESULTS: 53 patients were included in the study. The mean age of the patients is 3.2 years (min: 8 months-max 17 years). Laparoscopic intervention was performed for a total of 59 nonpalpable testicles which were left-sided in 54.7% (n=29) of the patients, right-sided in 34% (n=18), and bilateral in 11.3% (n=6). Throughout these 59 testicles, cords and vessels of 31 testicles were visualized entering the inguinal canal, atrophic testes in the abdomen were detected in 7 patients, the cord and vessels had an intraabdominal blind ending (vanishing testis) in 7 patients, and 14 testicles were in the abdomen with normal aspect. \u0000CONCLUSION: Simultaneous laparoscopic orchiectomy is performed in case of atrophic testis in laparoscopic exploration for nonpalpable testicles. It allows the ligation of vessels of testes farther than 2 cm away from the inguinal canal, and for testes that are closer than 2 cm it grants the vessels to be released under a more precise vision thereby protecting from the complications of conventional surgery.","PeriodicalId":7003,"journal":{"name":"Acta Medica Alanya","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91532749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}