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国际感染病学(电子版)最新文献

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Research progress of siRNA in anti-influenza viral infection siRNA在抗流感病毒感染中的研究进展
国际感染病学(电子版) Pub Date : 2018-06-29 DOI: 10.2478/ii-2018-0019
Lixiu Han
{"title":"Research progress of siRNA in anti-influenza viral infection","authors":"Lixiu Han","doi":"10.2478/ii-2018-0019","DOIUrl":"https://doi.org/10.2478/ii-2018-0019","url":null,"abstract":"Abstract The harms of seasonal flu and global pandemic influenza have generally attracted attention. However, the currently administered influenza drugs and flu vaccines have certain limitations. Since the discovery of the small interfering RNA (siRNA) and its mediated RNA interference process, this molecule has been widely used in the study of anti-influenza viral infections because of its high specificity and strong selectivity. The results provided new concepts for the prevention and treatment of influenza virus. However, the siRNA still faces an enormous challenge despite extensive studies on this molecule. The research progress of siRNA in anti-influenza viral infection was reviewed in this study.","PeriodicalId":69735,"journal":{"name":"国际感染病学(电子版)","volume":"7 1","pages":"50 - 55"},"PeriodicalIF":0.0,"publicationDate":"2018-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/ii-2018-0019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45517063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Basic and clinical research progress in acute lung injury/acute respiratory distress syndrome 急性肺损伤/急性呼吸窘迫综合征的基础与临床研究进展
国际感染病学(电子版) Pub Date : 2018-06-29 DOI: 10.2478/ii-2018-0017
Tongxin Wang
{"title":"Basic and clinical research progress in acute lung injury/acute respiratory distress syndrome","authors":"Tongxin Wang","doi":"10.2478/ii-2018-0017","DOIUrl":"https://doi.org/10.2478/ii-2018-0017","url":null,"abstract":"Abstract Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is an acute progressive respiratory failure caused by severe infection, trauma, shock, poisoning, inhaled harmful gas, acute pancreatitis, and pathological obstetrics. ALI and ARDS demonstrate similar pathophysiological changes. The severe stage of ALI is defined as ARDS. At present, a significant progress has been achieved in the study of the pathogenesis and pathophysiology of ALI/ARDS. Whether or not ALI/ARDS patients can recover depends on the degree of lung injury, extra-pulmonary organ damage, original primary disease of a patient, and adequacy in supportive care. Conservative infusion strategies and protective lung ventilation reduce ARDS disability and mortality. In this study, the pathogenesis of ALI/ARDS, lung injury, molecular mechanisms of lung repair, and conservative infusion strategies and pulmonary protective ventilation are reviewed comprehensively.","PeriodicalId":69735,"journal":{"name":"国际感染病学(电子版)","volume":"7 1","pages":"38 - 43"},"PeriodicalIF":0.0,"publicationDate":"2018-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/ii-2018-0017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43468557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Research progress on anti-infection therapy for sepsis in children 儿童败血症抗感染治疗的研究进展
国际感染病学(电子版) Pub Date : 2018-06-29 DOI: 10.2478/ii-2018-0018
Guoxiu Lu
{"title":"Research progress on anti-infection therapy for sepsis in children","authors":"Guoxiu Lu","doi":"10.2478/ii-2018-0018","DOIUrl":"https://doi.org/10.2478/ii-2018-0018","url":null,"abstract":"Abstract Sepsis is a systemic inflammatory response caused by infection and a critical illness in pediatrics. This disease is the leading cause of death in infants and children worldwide. An early, appropriate, and adequate anti-infective treatment can effectively prevent disease progression and improve the survival rate of children. However, antimicrobial drug abuse, increased drug-resistant bacteria, and lack of epidemiological data have hampered the effective and rational anti-infective treatment of patients with sepsis and enhancement of the success rate of rescue, especially for children. This article briefly reviews the recent advances in anti-infective treatment for sepsis in children at home and abroad based on sepsis definition, pathogen distribution and drug resistance, infection source control, and rational anti-infection. The results provide a foundation for clinical treatment of sepsis.","PeriodicalId":69735,"journal":{"name":"国际感染病学(电子版)","volume":"7 1","pages":"44 - 49"},"PeriodicalIF":0.0,"publicationDate":"2018-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42509396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research progress in the correlation between oral and stomach Hpinfections 口腔与胃幽门螺杆菌感染相关性研究进展
国际感染病学(电子版) Pub Date : 2018-06-29 DOI: 10.2478/ii-2018-0021
H. Feng
{"title":"Research progress in the correlation between oral and stomach Hpinfections","authors":"H. Feng","doi":"10.2478/ii-2018-0021","DOIUrl":"https://doi.org/10.2478/ii-2018-0021","url":null,"abstract":"Abstract Helicobacter pylori (Hp) is one of the most common human pathogens. The infection caused by this bacterium is closely related to various clinical diseases. However, the eradication rate of conventional quadruple therapy has decreased, but the recurrence rate of infections has increased. The oral cavity is another major storage of Hp in addition to the stomach, and a certain homology exists between Hp in the oral cavity and Hp in the stomach. Periodontal treatment has a certain role in the killing of oral Hp, which can increase the eradication rate and reduce the recurrence rate of Hp in the stomach. This article summarizes the influence of oral Hp on the eradication rate and recurrence rate of gastric Hp.","PeriodicalId":69735,"journal":{"name":"国际感染病学(电子版)","volume":"7 1","pages":"62 - 66"},"PeriodicalIF":0.0,"publicationDate":"2018-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/ii-2018-0021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46414082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Research progress in urinary tract infection and its therapeutic drugs 尿路感染及其治疗药物的研究进展
国际感染病学(电子版) Pub Date : 2018-06-29 DOI: 10.2478/ii-2018-0020
Xiaoming Gu
{"title":"Research progress in urinary tract infection and its therapeutic drugs","authors":"Xiaoming Gu","doi":"10.2478/ii-2018-0020","DOIUrl":"https://doi.org/10.2478/ii-2018-0020","url":null,"abstract":"Abstract Objective The objective of this study was to understand the pathological mechanism and therapeutic progress in the study of urinary tract infections to provide references for clinical diagnosis and identification and development of therapeutic drugs. Methods We summarized the types, pathological mechanisms, and therapeutic drugs for urinary tract infections on the basis of recent publications on these infections, both domestic and abroad. Results and conclusions Urinary tract infection is mainly caused by pathogenic bacterial infection and treated by targeting bacterial adhesion, bacterial toxin, protease, urease, and siderophores, as well as using pili as vaccines and small-molecule drugs. Vaccines that target bacterial adhesion can block well the interaction between pathogens and the body, thereby reducing the incidence of urinary tract infections. The clinical efficacy of vaccines targeting bacterial toxins and proteases needs further evaluation. Vaccines targeting iron carriers retard disease progression and attenuate bacterial colonization. Urease-targeted small-molecule drugs exhibit certain curative effects and serious side effects. Small pili-targeted drugs can prevent and treat urinary tract infections by blocking the colonization and invasion of pathogens in animal models of urinary tract infections on the bladder. Adhesive FimH antibodies have entered Phase I clinical trials. However, pilicides, mannosides, and vaccines that target pili, iron carriers, and other virulence factors are still in the experimental or preclinical stages of research.","PeriodicalId":69735,"journal":{"name":"国际感染病学(电子版)","volume":"7 1","pages":"56 - 61"},"PeriodicalIF":0.0,"publicationDate":"2018-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42282641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of Helicobacter pylori-associated gastritis using traditional Chinese medicine 中医药治疗幽门螺杆菌相关性胃炎
国际感染病学(电子版) Pub Date : 2018-05-09 DOI: 10.2478/ii-2018-0009
Mengjiao Hu, Zhenfei Wang
{"title":"Treatment of Helicobacter pylori-associated gastritis using traditional Chinese medicine","authors":"Mengjiao Hu, Zhenfei Wang","doi":"10.2478/ii-2018-0009","DOIUrl":"https://doi.org/10.2478/ii-2018-0009","url":null,"abstract":"Abstract Helicobacter pylori is a pathogenic bacterium with strong pathogenicity, which can induce chronic gastritis and peptic ulcer in addition to causing gastric mucosal atrophy and intestinal metaplasia after longterm infection. It is even associated closely with the occurrence of gastric cancer and mucosa-associated lymphoid tissue lymphoma. Recently, the incidence of H.pylori-associated gastritis has increased rapidly worldwide, especially in China. The prevention and treatment of H. pylori infection has become an urgent issue to be resolved by the medical community. Traditional Chinese medicine and the combination of traditional Chinese medicine and Western medicine have recently shown unique advantages in the treatment of H.pylori–associated gastritis. The progress in this area is summarized in this review.","PeriodicalId":69735,"journal":{"name":"国际感染病学(电子版)","volume":"7 1","pages":"1 - 5"},"PeriodicalIF":0.0,"publicationDate":"2018-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2478/ii-2018-0009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46603272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
The mechanism of HBx protein to promote the initiation and progression of hepatocellular carcinoma HBx蛋白促进肝细胞癌发生和发展的机制
国际感染病学(电子版) Pub Date : 2018-05-09 DOI: 10.2478/ii-2018-0010
Mu-Zi-he Zhang, Xing-Hui Wei, Zhenfei Wang
{"title":"The mechanism of HBx protein to promote the initiation and progression of hepatocellular carcinoma","authors":"Mu-Zi-he Zhang, Xing-Hui Wei, Zhenfei Wang","doi":"10.2478/ii-2018-0010","DOIUrl":"https://doi.org/10.2478/ii-2018-0010","url":null,"abstract":"Abstract Hepatocellular carcinoma (HCC) is the sixth most common malignancy worldwide and the third most common cause of death from cancer, after lung and stomach cancer. Hepatitis B virus (HBV) infection is closely related to HCC and is a major cause of HCC. HBV is a lysogenic virus of the hepadnavirus family. Its genome presents a slack, ring-like, double-chain structure, containing four open reading frames. The X region encodes the product HBV X protein (HBx), which is a multifunctional regulatory protein that plays an important role in intracellular signal transduction, viral genome replication and transcription, cell proliferation and apoptosis, cell cycle progression, protein degradation, and genetic stability of hepatocytes. This article summarizes the recent research on the mechanism of promotion of initiation and progression of HCC by HBx protein.","PeriodicalId":69735,"journal":{"name":"国际感染病学(电子版)","volume":"7 1","pages":"18 - 22"},"PeriodicalIF":0.0,"publicationDate":"2018-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48899487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Research progress on the role of immune cells in Brucella infection 免疫细胞在布鲁氏菌感染中作用的研究进展
国际感染病学(电子版) Pub Date : 2018-05-09 DOI: 10.2478/ii-2018-0014
J. Zhang
{"title":"Research progress on the role of immune cells in Brucella infection","authors":"J. Zhang","doi":"10.2478/ii-2018-0014","DOIUrl":"https://doi.org/10.2478/ii-2018-0014","url":null,"abstract":"Abstract Brucellosis is one of the most prevalent zoonoses in the world. Incidence of the disease has increased significantly in recent years and has seriously affected the health of human beings and the development of animal husbandry. The pathogenesis of brucellosis remains unclear. Current studies suggest that this disease may be related to changes in natural killer cells, dendritic cells, and macrophages in immune cell subsets. Brucellosis may be also related to T helper (Th) 1 cell/Th2 cell imbalance in the CD4+ T cell subset, immunoregulation of regulatory T cells and Th17 cells, and the mechanism of action of CD8+ T cell. This paper aims to review the research progress on these inherent immune cells, the CD4+ T cell subset, and CD8+ T cells in Brucella infection.","PeriodicalId":69735,"journal":{"name":"国际感染病学(电子版)","volume":"7 1","pages":"23 - 27"},"PeriodicalIF":0.0,"publicationDate":"2018-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43844083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
A New Technique for The Therapy of Complicated Deep Tissue Infection (with 4 Cases) 治疗复杂深部组织感染的新技术(附4例)
国际感染病学(电子版) Pub Date : 2018-05-09 DOI: 10.2478/ii-2018-0015
Feng Li, Hao Qin, Xing Zhi, Wang Zhenfei, W. Ziwei
{"title":"A New Technique for The Therapy of Complicated Deep Tissue Infection (with 4 Cases)","authors":"Feng Li, Hao Qin, Xing Zhi, Wang Zhenfei, W. Ziwei","doi":"10.2478/ii-2018-0015","DOIUrl":"https://doi.org/10.2478/ii-2018-0015","url":null,"abstract":"Abstract Objective The objective of this study was to discuss the effect of double perfusion cannula accompanied with low negative pressure drainage in the treatment of complexity of abdominopelvic and perineal infections. Methods The technology of the double perfusion cannula accompanied with low negative pressure drainage was used to treat complexity of abdominopelvic and perineal infections. Results Double perfusion cannula accompanied with low negative pressure drainage can be applied to the treatment of complexity of abdominopelvic and perineal infections. It has an obvious effect on infection control and reduces recovery time. Conclusion Double perfusion cannula accompanied with low negative pressure drainage has a good effect on complexity of abdominopelvic and perineal infections; it can be used in wider surgical fields to prevent infections.","PeriodicalId":69735,"journal":{"name":"国际感染病学(电子版)","volume":"7 1","pages":"28 - 32"},"PeriodicalIF":0.0,"publicationDate":"2018-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48577188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Common types of infection with multitypes of HPV on uterine cervix 子宫颈常见的多种类型HPV感染
国际感染病学(电子版) Pub Date : 2018-05-09 DOI: 10.2478/ii-2018-0013
Ting Miao
{"title":"Common types of infection with multitypes of HPV on uterine cervix","authors":"Ting Miao","doi":"10.2478/ii-2018-0013","DOIUrl":"https://doi.org/10.2478/ii-2018-0013","url":null,"abstract":"Abstract Persistent infection by human papillomavirus (HPV) is an important factor causing cervical cancer. In recent years, infection with multiple HPV types has been confirmed in various studies. High-risk HPV 16 and 18 and low-risk HPV 6 are the most common causes of multitype HPV infection. Infection with multiple types of HPV, which results from individual susceptibility, is crucial in tumor susceptibility. This paper summarizes the common types of multiple HPV infection to enable further research on the relationship between HPV and tumor susceptibility.","PeriodicalId":69735,"journal":{"name":"国际感染病学(电子版)","volume":"7 1","pages":"12 - 17"},"PeriodicalIF":0.0,"publicationDate":"2018-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45786061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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