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From influenza infection to anti-ADAMTS13 autoantibodies via cross-reactivity 通过交叉反应从流感感染到抗adamts13自身抗体
国际感染病学(电子版) Pub Date : 2018-12-30 DOI: 10.2478/ii-2019-0002
D. Kanduc
{"title":"From influenza infection to anti-ADAMTS13 autoantibodies via cross-reactivity","authors":"D. Kanduc","doi":"10.2478/ii-2019-0002","DOIUrl":"https://doi.org/10.2478/ii-2019-0002","url":null,"abstract":"Abstract Autoantibodies (AAbs) against von Willebrand factor (vWF)-cleaving protease ADAMTS13 causally relate to thrombotic thrombocytopenic purpura (TTP). How anti-ADAMTS13 AAbs are generated is unknown. Starting from reports according to which influenza infection can trigger TTP by the production of ADAMTS13 AAbs, this study explores influenza viruses and ADAMTS13 protein for common peptide sequences that might underlie anti-influenza immune responses able to cross-react with ADAMTS13. Results document that numerous peptides are shared between influenza A and B viruses and ADAMTS13, thus supporting the hypothesis of cross-reactivity as a mechanism driving the generation of anti-ADAMTS13 AAbs.","PeriodicalId":69735,"journal":{"name":"国际感染病学(电子版)","volume":"7 1","pages":"113 - 120"},"PeriodicalIF":0.0,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41417680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Influenza and sudden unexpected death: the possible role of peptide cross-reactivity 流感与意外猝死:肽交叉反应性的可能作用
国际感染病学(电子版) Pub Date : 2018-12-30 DOI: 10.2478/ii-2018-0023
D. Kanduc
{"title":"Influenza and sudden unexpected death: the possible role of peptide cross-reactivity","authors":"D. Kanduc","doi":"10.2478/ii-2018-0023","DOIUrl":"https://doi.org/10.2478/ii-2018-0023","url":null,"abstract":"Abstract This study investigates the hypothesis that cross-reactions may occur between human cardiac proteins and influenza antigens, thus possibly representing the molecular mechanism underlying influenzaassociated sudden unexpected death (SUD). Using titin protein as a research model, data were obtained on (1) the occurrence of the titin octapeptide AELLVLLE or its mimic AELLVALE in influenza A virus hemagglutinin (HA) sequences; (2) the immunological potential of AELLVLLE and its mimic AELLVALE; (3) the possible role of the flanking amino acid aa) context of the two octapeptide determinants in eliciting cross-reactivity between the human cardiac titin protein and HA antigens.","PeriodicalId":69735,"journal":{"name":"国际感染病学(电子版)","volume":"7 1","pages":"121 - 131"},"PeriodicalIF":0.0,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41923726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Correlation between the invasive fungal infection among and their blood glucose levels 侵袭性真菌感染与血糖水平的关系
国际感染病学(电子版) Pub Date : 2018-12-30 DOI: 10.2478/ii-2019-0001
Jiangeng Han, Xin Wang, Wei-Ming Chai, Kunbin Liu, Chen Wang
{"title":"Correlation between the invasive fungal infection among and their blood glucose levels","authors":"Jiangeng Han, Xin Wang, Wei-Ming Chai, Kunbin Liu, Chen Wang","doi":"10.2478/ii-2019-0001","DOIUrl":"https://doi.org/10.2478/ii-2019-0001","url":null,"abstract":"Abstract The purpose of this study was to study the association of deep fungal infection with glucose levels in critically ill intensive care unit (ICU) patients. Fasting blood glucose level was measured for 108 critically ill ICU patients in the morning. After analyzed according to the Spearman method found deep fungal infections in patients with the rise in blood glucose levels and the ratio increases, a positive correlation between the two. Deep infection in critically ill ICU patients and their blood glucose levels was closely related, and therefore, there should a focus on controlling blood sugar levels in patients.","PeriodicalId":69735,"journal":{"name":"国际感染病学(电子版)","volume":"7 1","pages":"109 - 112"},"PeriodicalIF":0.0,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48153583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of tuberculosis infection complicated with liver transplant 肺结核感染合并肝移植的治疗
国际感染病学(电子版) Pub Date : 2018-09-30 DOI: 10.2478/ii-2018-0025
J. Qiu, Sibo Liu, Qian Wang
{"title":"Treatment of tuberculosis infection complicated with liver transplant","authors":"J. Qiu, Sibo Liu, Qian Wang","doi":"10.2478/ii-2018-0025","DOIUrl":"https://doi.org/10.2478/ii-2018-0025","url":null,"abstract":"Abstract Liver transplant is considered the best choice for treating various end-stage liver diseases either at home or abroad. Among patients of liver transplant complicated with tuberculosis (TB), the incidence and mortality of postoperative active TB are bound to increase remarkably. Diagnosing and treating TB in patients with end-stage liver diseases who received immunosuppressants after liver transplant are difficult because of the absence of specific clinical manifestations while being complicated with TB, reduced sensitivity to cellular immunoassay, and interaction between anti-TB drugs and immunosuppressants. Therefore, the screening of high-risk groups, improvement in diagnostic accuracy, preoperative treatment, and reduced interaction between anti-TB drugs and immunosuppressants can help optimize diagnosis and treatment regimes and thus further improve the prognosis of patients.","PeriodicalId":69735,"journal":{"name":"国际感染病学(电子版)","volume":"7 1","pages":"81 - 87"},"PeriodicalIF":0.0,"publicationDate":"2018-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47353544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research progress on human microecology and infectious diseases 人体微生态与传染病研究进展
国际感染病学(电子版) Pub Date : 2018-09-30 DOI: 10.2478/ii-2018-0027
L. Bai, Wenlong He
{"title":"Research progress on human microecology and infectious diseases","authors":"L. Bai, Wenlong He","doi":"10.2478/ii-2018-0027","DOIUrl":"https://doi.org/10.2478/ii-2018-0027","url":null,"abstract":"Abstract Human microecology has been extensively investigated. Similar to an important physiologically functioning organ of the human body, the microecological system is one of the leading systems for environmental survival, health, genetics, disease, and aging. It is also an essential carrier for drug metabolism and microbial resistance. The occurrence, development, and deterioration of many infectious diseases are closely related to human microecological systems. This study mainly focuses on the changes in microbial groups associated with various infectious diseases to explore the relevant role of human microecology in the development of infectious diseases and its breakthrough implications in future accurate treatments of infectious diseases.","PeriodicalId":69735,"journal":{"name":"国际感染病学(电子版)","volume":"7 1","pages":"100 - 94"},"PeriodicalIF":0.0,"publicationDate":"2018-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48351508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progress of research on the immune tolerance of chronic HBV infection 慢性HBV感染免疫耐受研究进展
国际感染病学(电子版) Pub Date : 2018-09-30 DOI: 10.2478/ii-2018-0026
Xuemei Li, Xiaoxia Li
{"title":"Progress of research on the immune tolerance of chronic HBV infection","authors":"Xuemei Li, Xiaoxia Li","doi":"10.2478/ii-2018-0026","DOIUrl":"https://doi.org/10.2478/ii-2018-0026","url":null,"abstract":"Abstract Immune tolerance is a specific lack or negative response of T and B lymphocytes to antigen. According to different formation periods, immune tolerance can be divided into central and peripheral tolerances. The immune tolerance of the body to hepatitis B virus (HBV) after infection is the main cause of chronic HBV infection. In this paper, the functional defects of hepatitis B virus e antigen and dendritic cells, hyporesponsiveness of cytotoxic T lymphocyte, variation of helper T lymphocytes and cytokines, HBV genotype and genome, and the role of host gene polymorphism in the formation of immune tolerance in chronic HBV infection and its related research progress are introduced briefly.","PeriodicalId":69735,"journal":{"name":"国际感染病学(电子版)","volume":"7 1","pages":"88 - 93"},"PeriodicalIF":0.0,"publicationDate":"2018-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43839662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progress in clinical research complicated infection with diabetes mellitus 糖尿病并发感染的临床研究进展
国际感染病学(电子版) Pub Date : 2018-09-30 DOI: 10.2478/ii-2018-0028
Jiangeng Han, Xin Wang, Zhengju Chen, Ning Gao, Chen Wang
{"title":"Progress in clinical research complicated infection with diabetes mellitus","authors":"Jiangeng Han, Xin Wang, Zhengju Chen, Ning Gao, Chen Wang","doi":"10.2478/ii-2018-0028","DOIUrl":"https://doi.org/10.2478/ii-2018-0028","url":null,"abstract":"Abstract Patients with diabetes are prone to concurrent infection. The mechanism of concurrent infection is related to factors such as hyperglycemia and weakened defense function. The infections of patients with diabetes include general and special infections. General infection includes infections in the respiratory system, urinary system, hepatobiliary system, and skin mucosa. Meanwhile, special infection includes invasive otitis externa, nasal mucormycosis, necrotizing fasciitis, and emphysema infection. Patients with special infections also have a higher mortality rate than those with general ones. Complicated infection with diabetes is difficult to treat and has poor prognosis. Therefore, a patient requires active treatment once infected with this infection.","PeriodicalId":69735,"journal":{"name":"国际感染病学(电子版)","volume":"7 1","pages":"101 - 108"},"PeriodicalIF":0.0,"publicationDate":"2018-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41662726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Review on the laboratory diagnosis of Mycoplasma pneumoniae infection 肺炎支原体感染实验室诊断研究进展
国际感染病学(电子版) Pub Date : 2018-09-30 DOI: 10.2478/ii-2018-0030
J. Zhang
{"title":"Review on the laboratory diagnosis of Mycoplasma pneumoniae infection","authors":"J. Zhang","doi":"10.2478/ii-2018-0030","DOIUrl":"https://doi.org/10.2478/ii-2018-0030","url":null,"abstract":"Abstract Mycoplasma pneumoniae (MP) is an important pathogen of community-acquired pneumonia in children. As a type of self-limited disease, most MP infections cause mild clinical symptoms, but they can also lead to severe pneumonia or extrapulmonary complications. The resistance rate of MP has increased in recent years. Early and rapid diagnosis of MP infection is important for the treatment and prognosis of the disease. Current methods for diagnosing MP infection include isolation culture, serological diagnosis, and molecular biological diagnosis. This review summarizes the recent research progress in the internal and external laboratory diagnoses of MP infection both at home and abroad and the advantages and disadvantages of various diagnostic methods.","PeriodicalId":69735,"journal":{"name":"国际感染病学(电子版)","volume":"7 1","pages":"67 - 74"},"PeriodicalIF":0.0,"publicationDate":"2018-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47655559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevention of patch infection after abdominal external hernia repair 预防腹外疝修补术后补片感染
国际感染病学(电子版) Pub Date : 2018-09-30 DOI: 10.2478/ii-2018-0024
S. Xiang
{"title":"Prevention of patch infection after abdominal external hernia repair","authors":"S. Xiang","doi":"10.2478/ii-2018-0024","DOIUrl":"https://doi.org/10.2478/ii-2018-0024","url":null,"abstract":"Abstract External abdominal hernia is a common clinical disease. The application of hernia patch is a breakthrough in the treatment of external abdominal hernia. However, complications such as patch infection need to be solved urgently. Patch infection markedly prolongs the hospitalization time and increases the medical expenses of patients. At present, a standard method for the diagnosis, treatment, and prevention of patch infection remains to be developed. This paper summarizes the literature in recent years to explore the research progress in the prevention and treatment of patch infection.","PeriodicalId":69735,"journal":{"name":"国际感染病学(电子版)","volume":"7 1","pages":"75 - 80"},"PeriodicalIF":0.0,"publicationDate":"2018-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42300123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Role of transferrin receptor in hepatitis C viral infection 转铁蛋白受体在丙型肝炎病毒感染中的作用
国际感染病学(电子版) Pub Date : 2018-06-29 DOI: 10.2478/ii-2018-0016
Q. Liang
{"title":"Role of transferrin receptor in hepatitis C viral infection","authors":"Q. Liang","doi":"10.2478/ii-2018-0016","DOIUrl":"https://doi.org/10.2478/ii-2018-0016","url":null,"abstract":"Abstract Hepatitis C virus (HCV) is the main pathogen causing chronic hepatitis and primary liver cancer. Various viral proteins and host cell molecules are involved in the HCV cell entry, but the mechanism of infection has not been completely elucidated. The transferrin receptor can act as a receptor for many viruses during cell entry. The transferrin receptor is not only closely related to HCV-induced iron metabolism disorders but also mediates the fusion of HCV with the host cell membrane as a specific receptor for CD81-dependent viral adhesion.","PeriodicalId":69735,"journal":{"name":"国际感染病学(电子版)","volume":"7 1","pages":"33 - 37"},"PeriodicalIF":0.0,"publicationDate":"2018-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46171615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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