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ANMCO position paper 'Appropriateness of prescribing direct oral anticoagulants in stroke and systemic thromboembolism prevention in adult patients with non-valvular atrial fibrillation'. ANMCO 立场文件《在预防非瓣膜性心房颤动成年患者中风和全身血栓栓塞症时处方直接口服抗凝剂的适当性》。
IF 1.7
ACTA Pharmaceutica Sciencia Pub Date : 2022-05-18 eCollection Date: 2022-05-01 DOI: 10.1093/eurheartj/suac015
David Mocini, Stefania Angela Di Fusco, Leonardo De Luca, Pasquale Caldarola, Manlio Cipriani, Marco Corda, Andrea Di Lenarda, Alfredo De Nardo, Giuseppina Maura Francese, Cosimo Napoletano, Alessandro Navazio, Carmine Riccio, Loris Roncon, Emanuele Tizzani, Federico Nardi, Stefano Urbinati, Serafina Valente, Michele Massimo Gulizia, Domenico Gabrielli, Fabrizio Oliva, Furio Colivicchi
{"title":"ANMCO position paper 'Appropriateness of prescribing direct oral anticoagulants in stroke and systemic thromboembolism prevention in adult patients with non-valvular atrial fibrillation'.","authors":"David Mocini, Stefania Angela Di Fusco, Leonardo De Luca, Pasquale Caldarola, Manlio Cipriani, Marco Corda, Andrea Di Lenarda, Alfredo De Nardo, Giuseppina Maura Francese, Cosimo Napoletano, Alessandro Navazio, Carmine Riccio, Loris Roncon, Emanuele Tizzani, Federico Nardi, Stefano Urbinati, Serafina Valente, Michele Massimo Gulizia, Domenico Gabrielli, Fabrizio Oliva, Furio Colivicchi","doi":"10.1093/eurheartj/suac015","DOIUrl":"10.1093/eurheartj/suac015","url":null,"abstract":"<p><p>The appropriateness of prescribing direct oral anticoagulants [dabigatran, rivaroxaban, apixaban, and edoxaban (DOACs)] is regulated on the criteria established in Phase III trials. These criteria are reported in the summary of the product characteristics of the four DOACs. In clinical practice, prescriptions are not always in compliance with established indications. In particular, the use of lower doses than those recommended in drug data sheets is not uncommon. Literature data show that the inappropriate prescription of reduced doses causes drug underexposure and up to a three-fold increase in the risk of stroke/ischaemic transient attack, systemic thromboembolism, and hospitalization. Possible causes of the deviation between the dose that should be prescribed and that prescribed in the real world include erroneous prescription, an overstated haemorrhagic risk perception, and the presence of frail and complex patients in clinical practice who were not included in pivotal trials, which makes it difficult to apply study results to the real world. For these reasons, we summarize DOAC indications and contraindications. We also suggest the appropriate use of DOACs in common clinical scenarios, in accordance with what international guidelines and national and international health regulatory bodies recommend.</p>","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":"C278-C288"},"PeriodicalIF":1.7,"publicationDate":"2022-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90918413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artemisia campestris and artemisia herbaalba: lc-hresi-ms profile alongside their antioxidant and antimicrobial evaluation 葡萄蒿和草蒿:lc- hesi -ms谱及其抗氧化和抗菌评价
ACTA Pharmaceutica Sciencia Pub Date : 2022-01-01 DOI: 10.23893/1307-2080.aps.6010
B. Bakchiche, A. Gören, Z. Aydoğmuş, Emel Mataracikara, M. Ghareeb
{"title":"Artemisia campestris and artemisia herbaalba: lc-hresi-ms profile alongside their antioxidant and antimicrobial evaluation","authors":"B. Bakchiche, A. Gören, Z. Aydoğmuş, Emel Mataracikara, M. Ghareeb","doi":"10.23893/1307-2080.aps.6010","DOIUrl":"https://doi.org/10.23893/1307-2080.aps.6010","url":null,"abstract":"<jats:p xml:lang=\"tr\" />","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68931876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does eugenol have potential as an anti-campylobacter and antioxidant compound in the food industry and clinical settings? 丁香酚是否有潜力在食品工业和临床环境中作为抗弯曲杆菌和抗氧化化合物?
ACTA Pharmaceutica Sciencia Pub Date : 2022-01-01 DOI: 10.23893/1307-2080.aps6027
Murat Gürbüz, Burcu İrem Omurtag Korkmaz, S. Korkmaz
{"title":"Does eugenol have potential as an anti-campylobacter and antioxidant compound in the food industry and clinical settings?","authors":"Murat Gürbüz, Burcu İrem Omurtag Korkmaz, S. Korkmaz","doi":"10.23893/1307-2080.aps6027","DOIUrl":"https://doi.org/10.23893/1307-2080.aps6027","url":null,"abstract":"<jats:p xml:lang=\"tr\" />","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68932099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potent colon cancer cell line toxicity of the fruit extracts of heptaptera triquetra (vent.) tutin 七翅草果实提取物对结肠癌细胞系的强毒性研究
ACTA Pharmaceutica Sciencia Pub Date : 2022-01-01 DOI: 10.23893/1307-2080.aps.6019
F. Tosun, M. Miski
{"title":"Potent colon cancer cell line toxicity of the fruit extracts of heptaptera triquetra (vent.) tutin","authors":"F. Tosun, M. Miski","doi":"10.23893/1307-2080.aps.6019","DOIUrl":"https://doi.org/10.23893/1307-2080.aps.6019","url":null,"abstract":"<jats:p xml:lang=\"tr\" />","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68932228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Formulation development of oral disintegrating film of fexofenadine hydrochloride 盐酸非索非那定口腔崩解膜的研制
ACTA Pharmaceutica Sciencia Pub Date : 2022-01-01 DOI: 10.23893/1307-2080.aps6023
S. Bhattacharyya, Biradar Gopal Rangarao
{"title":"Formulation development of oral disintegrating film of fexofenadine hydrochloride","authors":"S. Bhattacharyya, Biradar Gopal Rangarao","doi":"10.23893/1307-2080.aps6023","DOIUrl":"https://doi.org/10.23893/1307-2080.aps6023","url":null,"abstract":"<jats:p xml:lang=\"tr\" />","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68932310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Grewia asiatica linn. root extract loaded suspension, microparticulate and nanosuspension dosage form: fabrication, characterization and anthelmintic evaluation 亚洲植物。根提取物负载悬浮液、微颗粒和纳米悬浮液剂型:制备、表征和驱虫剂评价
ACTA Pharmaceutica Sciencia Pub Date : 2022-01-01 DOI: 10.23893/1307-2080.aps6024
T. Kumar, Rimpy Pahwa, M. Ahuja
{"title":"Grewia asiatica linn. root extract loaded suspension, microparticulate and nanosuspension dosage form: fabrication, characterization and anthelmintic evaluation","authors":"T. Kumar, Rimpy Pahwa, M. Ahuja","doi":"10.23893/1307-2080.aps6024","DOIUrl":"https://doi.org/10.23893/1307-2080.aps6024","url":null,"abstract":"<jats:p xml:lang=\"tr\" />","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68932435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Formulation and evaluation of sugar spheres containing antiemetic drug 含止吐药糖球的研制及评价
ACTA Pharmaceutica Sciencia Pub Date : 2022-01-01 DOI: 10.23893/1307-2080.aps.6011
Umme Hanee, V. Gowda
{"title":"Formulation and evaluation of sugar spheres containing antiemetic drug","authors":"Umme Hanee, V. Gowda","doi":"10.23893/1307-2080.aps.6011","DOIUrl":"https://doi.org/10.23893/1307-2080.aps.6011","url":null,"abstract":"<jats:p xml:lang=\"tr\" />","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68932051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vitro ace2 enzyme inhibitory activity evaluation of different salvia essential oils 不同鼠尾草精油体外ace2酶抑制活性评价
ACTA Pharmaceutica Sciencia Pub Date : 2022-01-01 DOI: 10.23893/1307-2080.APS.6008
A. Karadaǧ, S. N. Biltekin, B. Demirci, Fatih Demirci
{"title":"In vitro ace2 enzyme inhibitory activity evaluation of different salvia essential oils","authors":"A. Karadaǧ, S. N. Biltekin, B. Demirci, Fatih Demirci","doi":"10.23893/1307-2080.APS.6008","DOIUrl":"https://doi.org/10.23893/1307-2080.APS.6008","url":null,"abstract":"<jats:p xml:lang=\"tr\" />","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68931482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of putrescine, spermidine and spermine on growth and serum lipid levels in sprague-dawley rat offspring 腐胺、亚精胺和精胺对sd -dawley大鼠子代生长和血脂水平的影响
ACTA Pharmaceutica Sciencia Pub Date : 2022-01-01 DOI: 10.23893/1307-2080.aps.6007
Fatma Mert-Biberoğlu, N. Büyükuslu
{"title":"Effects of putrescine, spermidine and spermine on growth and serum lipid levels in sprague-dawley rat offspring","authors":"Fatma Mert-Biberoğlu, N. Büyükuslu","doi":"10.23893/1307-2080.aps.6007","DOIUrl":"https://doi.org/10.23893/1307-2080.aps.6007","url":null,"abstract":"<jats:p xml:lang=\"tr\" />","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68931452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histological effect of traditional rose ointment application in the excisional wound model 传统玫瑰膏应用于切除创面模型的组织学影响
ACTA Pharmaceutica Sciencia Pub Date : 2022-01-01 DOI: 10.23893/1307-2080.aps.6003
Seda Karabulut, Sümeyye Özyaman, A. Altıntaş, I. Keskin
{"title":"Histological effect of traditional rose ointment application in the excisional wound model","authors":"Seda Karabulut, Sümeyye Özyaman, A. Altıntaş, I. Keskin","doi":"10.23893/1307-2080.aps.6003","DOIUrl":"https://doi.org/10.23893/1307-2080.aps.6003","url":null,"abstract":"<jats:p xml:lang=\"tr\" />","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68931900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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