TMR药理学研究最新文献

{"title":"A network pharmacology-based investigation of the mechanism of action of chrysanthemum in treating dry eye","authors":"Li Cao, Q. Long, Pengfei Jiang, Jun Peng, Q. Peng","doi":"10.53388/pr202303008","DOIUrl":"https://doi.org/10.53388/pr202303008","url":null,"abstract":"","PeriodicalId":69244,"journal":{"name":"TMR药理学研究","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CGD-1, a defensin-related peptide derived from marine Chinese medicine Ostreae concha, inhibits the Gram-negative bacteria by membrane attack","authors":"Wei-Tao Wang, Qingguo Meng, Long-Fen Li, Weizheng Meng, Xin Yin, Peisong Zhao, Mengmeng Wang, Jing-li Ren, Xuemei Xia, Chun-Lei Li","doi":"10.53388/pr202303010","DOIUrl":"https://doi.org/10.53388/pr202303010","url":null,"abstract":"There is an increasing interest in discovering new antibacterial agents derived from nature to enhance the treatment of various bacterial infections. Defensins and their derived peptide fragments exhibit significant antibacterial activity without any cytotoxic effects, making them attractive features for potential novel antibacterial therapeutics. Crassostrea gigas , a traditional seafood that has been used worldwide for centuries, has its shells applied in Chinese medicine as Ostreae concha . In this study, bioinformatics analysis was used to obtain a novel antibacterial peptide, CGD-1, derived from marine Chinese medicine Ostreae concha . The physicochemical characterization and circular dichroism analysis results demonstrated that CGD-1 assembled into an α -helical structure in a simulated membrane environment, and it displayed antibacterial action against Gram-negative bacteria. The minimal inhibitory concentrations against both Pseudomonas aeruginosa ATCC27853 and Escherichia coli ATCC25922 were 25 μ M. CGD-1 was able to efficiently permeate the cell membrane. Changes in bacterial cell morphology were evaluated using a field emission scanning electron microscope. The results suggested that CGD-1 exerted its antibacterial activity through permeabilizing and disrupting the bacterial cell membrane. Therefore, CGD-1 may have potential applications in fighting against pathogenic bacteria such as P. aeruginosa and E. coli .","PeriodicalId":69244,"journal":{"name":"TMR药理学研究","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress on the application of the main components of Cuscuta sinensis in the urogenital system","authors":"Yue Che, Jingning Guo, D. Wang, K. Song, S. Ding","doi":"10.53388/pr202303012","DOIUrl":"https://doi.org/10.53388/pr202303012","url":null,"abstract":"Cuscuta sinensis is a traditional Chinese medicine commonly used in traditional medicine, known for its liver and kidney tonifying effects, sperm fixing and urine reduction properties, fetus calming abilities, eye brightening qualities, and diarrhea stopping capabilities. Modern pharmacological studies have focused on its chemical components such as flavonoids, polysaccharides, alkaloids, steroids, and other bioactive compounds. These studies have revealed its various pharmacological effects, including hormone secretion regulation, ovulation promotion, sperm protection, testicular development promotion, and sperm formation. It is extensively utilized in the treatment of urological and reproductive system diseases, such as male sexual dysfunction, polycystic ovary syndrome, premature ovarian failure, weak spermatozoa, and infertility. This article provides a review of recent advancements in the application of Cuscuta sinensis in the genitourinary system, aiming to enhance the clinical application of Cuscuta sinensis preparations.","PeriodicalId":69244,"journal":{"name":"TMR药理学研究","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress on the source, function and application of AMPs","authors":"Ruo-Nan Zhou, Chun-Ming Dong, Yan-yan Sun","doi":"10.53388/pr202303013","DOIUrl":"https://doi.org/10.53388/pr202303013","url":null,"abstract":"Antibacterial peptide, also known as a host defense peptide, is a small molecular peptide that exhibits antibacterial activity. It disrupts the cell membrane structure of bacteria, leading to the release of internal contents and subsequent cell death, all without promoting the development of drug resistance in bacteria. It serves as a crucial component of the body’s innate immunity, forming the initial defense against the invasion of pathogenic microorganisms. However, the functionality of this small molecule peptide extends beyond this role. It also demonstrates positive effects in promoting organism growth, maintaining the balance of beneficial bacteria within organisms, combating cancer, enhancing immune function, and combating viruses, among other benefits. Additionally, it finds applications in biomaterials, food preservation, animal husbandry, and aquaculture. In summary, this small molecular peptide plays a significant role in various domains.","PeriodicalId":69244,"journal":{"name":"TMR药理学研究","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the mechanism of action of DHI on myeloproliferative neoplasms based on network pharmacology","authors":"Ming-Jie Liu, Yuan Li, Qianyu Zhou, Shu-jing Zhang, Tao Shen, Chun-Hua Lu, Rui-Fen Dong, Pu Wang, Zhi-Da Shi, Baobing Zhao","doi":"10.53388/pr202303007","DOIUrl":"https://doi.org/10.53388/pr202303007","url":null,"abstract":"","PeriodicalId":69244,"journal":{"name":"TMR药理学研究","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The active mechanism of the Sheng Yang San Huo decoction on diabetic peripheral neuropathy on network pharmacology","authors":"Ying Wang, Lei Hua, Guoqiang Chen, Zhen-Han Li, Zhong-Pei Chen","doi":"10.53388/pr202303014","DOIUrl":"https://doi.org/10.53388/pr202303014","url":null,"abstract":"Objectives: To discuss the mechanism of Sheng Yang San Huo decoction on diabetic peripheral neuropathy using the network pharmacology method. Methods: The BATMAN-TCM database, TCM-ID database, Chinese Natural Product Chemical Composition Database, and TCMIP database were employed to screen the chemical active ingredients of each herb in Sheng Yang San Huo decoction based on the “Libinsky Drug Rules”. SwissTargetPrediction was used to screen effective action targets for each herb in the prescription. Additionally, Cytoscape 3.7.0 was utilized to construct a “drug-target” network. GeneCards, OMIM, and MaLaCards databases were utilized to gather targets related to diabetic peripheral neuropathy. VENNY 2.1 online platform was employed to match drug and disease targets, draw a Venn diagram, and construct a “drug-active compounds-common target” network using Cytoscape 3.7.0. gene ontology biological process analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis for the targets were conducted using the DAVID 6.8 database. Enrichment analysis results were visualized using the OmicShareTool online platform. Molecular docking was performed using CB-Dock2. Results: Following screening, a total of 217 active compounds and 132 potential targets were identified in Sheng Yang San Huo decoction. The effects are primarily enriched in pathways such as Lipid and Atherosclerosis, AGE-RAGE signaling pathway in diabetic complications, and the IL-17 signaling pathway. The binding energy of the key active ingredients to the core protein targets of DPN was favorable. Conclusion: The study reveals the characteristics of multiple targets and pathways of Sheng Yang San Huo decoction, providing new insights for the clinical application of this prescription.","PeriodicalId":69244,"journal":{"name":"TMR药理学研究","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70819169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization and pharmacodynamic evaluation of stir-frying with bran for Tangshen processing","authors":"Xiaojuan Qi, Xiaoqing Liu, Xiang-long Meng, Xiaoyan Zhang, Xiaojuan Su, Chenxu Ning, Shuo-sheng Zhang","doi":"10.53388/pr202303009","DOIUrl":"https://doi.org/10.53388/pr202303009","url":null,"abstract":"Background: Traditional Chinese medicine requires special processing before it can be effectively used for clinical treatment of diseases. In particular, Tangshen stir-fried with wheat bran smoke has been found to enhance the function of the stomach and spleen. However, there is limited research on the technology and pharmacodynamic effects of Tangshen fried with bran. Therefore, the objective of this article is to optimize the method of stir-frying with bran for Tangshen processing and to compare the anti-fatigue and hypoxia-resistance effects of Tangshen before and after bran-frying. Methods: The response surface methodology was utilized to optimize the frying temperature, frying time, and the bran-to-Tangshen ratio, using lobetyolin as the indicator. The swimming time of mice and the levels of blood urea nitrogen, lactate dehydrogenase, and blood glucose in fatigued mice were compared before and after Tangshen was fried with bran. Additionally, the hypoxic resistance ability of Tangshen before and after bran-frying was determined through normobaric hypoxia test and sodium nitrite poisoning test. Results: The optimal bran-frying conditions for Tangshen processing were determined as: frying temperature of 167 °C, frying time of 2.67 min, and the bran-to-Tangshen ratio of 50:100. Pharmacodynamic analysis results indicated that Tangshen significantly increased the GLU content ( P < 0.01) and significantly reduced the LDH content ( P < 0.01) both before and after bran-frying. While both traditional and new bran-frying methods significantly increased the content of muscle glycogen ( P < 0.05), the optimized method in this study also significantly elevated the content of liver glycogen ( P < 0.05). The traditional method significantly prolonged the survival time of mice from sodium nitrite poisoning ( P < 0.05). Conclusion: The response surface model proved to be highly effective in optimizing the stir-frying process with bran for Tangshen processing. The results of this study indicate that Tangshen possesses anti-fatigue and hypoxia-resistance effects both before and after bran-frying, with bran-fried Tangshen exhibiting significantly stronger effects.","PeriodicalId":69244,"journal":{"name":"TMR药理学研究","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Important aspects of checkpoint inhibitors’ pharmacokinetics","authors":"Domina Petric","doi":"10.53388/pr202303001","DOIUrl":"https://doi.org/10.53388/pr202303001","url":null,"abstract":"","PeriodicalId":69244,"journal":{"name":"TMR药理学研究","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coagulation and analgesic effects of aqueous extract of peanut shells on mice","authors":"Jin-Hong Wei, Jin-Shuang Wei, Suo-yi Huang","doi":"10.53388/pr202303003","DOIUrl":"https://doi.org/10.53388/pr202303003","url":null,"abstract":"","PeriodicalId":69244,"journal":{"name":"TMR药理学研究","volume":"58 29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of pharmacological activity and application potential in food of tea polyphenols","authors":"Zhang Li, Wang Li, Zhi-Yong Liang, Xian-jun Liu, Hao Li, Zhang Li","doi":"10.53388/pr202303002","DOIUrl":"https://doi.org/10.53388/pr202303002","url":null,"abstract":"","PeriodicalId":69244,"journal":{"name":"TMR药理学研究","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70818626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}