动物疾病(英文)最新文献_第5页

Antigen epitopes of animal coronaviruses: a mini-review. 动物冠状病毒的抗原表位：一个小型综述。

动物疾病(英文) Pub Date : 2023-01-01 Epub Date: 2023-05-17 DOI: 10.1186/s44149-023-00080-0

Mingjun Su, Guanghui Zheng, Xiangwen Xu, Houhui Song

引用次数: 0

Roles of host proteases in the entry of SARS-CoV-2. 宿主蛋白酶在SARS-CoV-2进入中的作用

动物疾病(英文) Pub Date : 2023-01-01 DOI: 10.1186/s44149-023-00075-x

Alexandria Zabiegala, Yunjeong Kim, Kyeong-Ok Chang

{"title":"Roles of host proteases in the entry of SARS-CoV-2.","authors":"Alexandria Zabiegala, Yunjeong Kim, Kyeong-Ok Chang","doi":"10.1186/s44149-023-00075-x","DOIUrl":"https://doi.org/10.1186/s44149-023-00075-x","url":null,"abstract":"The spike protein (S) of SARS-CoV-2 is responsible for viral attachment and entry, thus a major factor for host susceptibility, tissue tropism, virulence and pathogenicity. The S is divided with S1 and S2 region, and the S1 contains the receptor-binding domain (RBD), while the S2 contains the hydrophobic fusion domain for the entry into the host cell. Numerous host proteases have been implicated in the activation of SARS-CoV-2 S through various cleavage sites. In this article, we review host proteases including furin, trypsin, transmembrane protease serine 2 (TMPRSS2) and cathepsins in the activation of SARS-CoV-2 S. Many betacoronaviruses including SARS-CoV-2 have polybasic residues at the S1/S2 site which is subjected to the cleavage by furin. The S1/S2 cleavage facilitates more assessable RBD to the receptor ACE2, and the binding triggers further conformational changes and exposure of the S2' site to proteases such as type II transmembrane serine proteases (TTPRs) including TMPRSS2. In the presence of TMPRSS2 on the target cells, SARS-CoV-2 can utilize a direct entry route by fusion of the viral envelope to the cellular membrane. In the absence of TMPRSS2, SARS-CoV-2 enter target cells via endosomes where multiple cathepsins cleave the S for the successful entry. Additional host proteases involved in the cleavage of the S were discussed. This article also includes roles of 3C-like protease inhibitors which have inhibitory activity against cathepsin L in the entry of SARS-CoV-2, and discussed the dual roles of such inhibitors in virus replication.","PeriodicalId":69105,"journal":{"name":"动物疾病(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10125864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10118413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Case report: Diagnosis and treatment of a chinchilla's old radius and ulna fracture. 病例报告:一只栗鼠老年性桡骨、尺骨骨折的诊断与治疗。

动物疾病(英文) Pub Date : 2023-01-01 DOI: 10.1186/s44149-023-00072-0

Siyu Long, YuJing Qiao, Hua Cao, Tiantian Qiu, Yuji Chen, Yaoqin Shen

{"title":"Case report: Diagnosis and treatment of a chinchilla's old radius and ulna fracture.","authors":"Siyu Long, YuJing Qiao, Hua Cao, Tiantian Qiu, Yuji Chen, Yaoqin Shen","doi":"10.1186/s44149-023-00072-0","DOIUrl":"https://doi.org/10.1186/s44149-023-00072-0","url":null,"abstract":"The cortex of the limb bones of chinchillas is very thin and brittle, so it is prone to fractures of the limb bones, among which fractures of the tibia, radius and ulna are the most frequent types. When a chinchilla has a closed fracture, it can be immobilized with a splint, cast, or bandage. If the broken end of the fracture pierces the skin, it is best to choose internal fixation or external fixation brackets for treatment. In this report, a 0.661 kg, 2-year-old male uncastrated chinchilla was presented to the Veterinary Teaching Hospital of Huazhong Agricultural University due to an old fracture of the right forearm. With the consent of the owner, we decided to use a 25-gauge needle as an IM pin to fix the fracture. Ten days after surgery, the wound had healed well, and the limb could support body weight, but the palm did not show a grasping position. Twenty four days after the operation, the affected limb had not regained the ability to grasp. The X-ray showed a slight rotation of the IM pin and good callus growth in the ulna, but not in the radius. One month after the operation, it was found that the function of the affected limb of the chinchilla was normal and the grasping ability was restored through follow-up consultation and the return visit.","PeriodicalId":69105,"journal":{"name":"动物疾病(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10033294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9204617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation and identification of four pathogenic bacterial strains from edible snake (Elaphe carinata and Ptyas mucosus) farms with pneumonia in China 中国食用蛇养殖场4株肺炎病原菌的分离鉴定

动物疾病(英文) Pub Date : 2022-12-12 DOI: 10.1186/s44149-022-00062-8

Ying Xia, Siyu Long, Yuxuan Peng, S. Qin, Yaoqin Shen