人体生理学杂志(英文)Pub Date : 2020-03-24DOI: 10.31829/2691-5391/jhp2020-3(1)-104
{"title":"Are Plasma ST2 and Galectin-3 Predictors for Clinical Outcomes After Myectomy in Patients With Obstructive Hypertrophic Cardiomyopathy?","authors":"","doi":"10.31829/2691-5391/jhp2020-3(1)-104","DOIUrl":"https://doi.org/10.31829/2691-5391/jhp2020-3(1)-104","url":null,"abstract":"ST2 is a member of the interleukin-1 receptor family, which is expressed in a trans membrane form (ST2L) as well as in a soluble secreted form [1]. Recently, soluble ST2(sST2) was found to be elevated in patients with chronic heart failure with reduced ejection fraction (HFrEF) and regarded as a promising novel biomarkers that can improve risk stratification [2, 3]. In 2012, Broch K et al. showed that baseline sST2 was associated with death due to worsening heart failure (HF), hospitalization due to worsening HF, and all cardiovascular hospitalization in older patients with ischemic HF[4]. In a multicenter study enrolled 447 patients with acutely decompensated heart failure, sST2 was an independent predictor of mortality for 1 year follow-up, regardless of the left ventricular ejection fraction[5]. As a β-galactoside-binding lectin secreted by activated macrophages, galectin-3 (Gal-3) exists in the cytoplasm and in a secreted form, and is involved in several physiological and pathological processes that contribute to HF, including myocardial fibrosis, inflammation and cardiac remodeling [6-8]. Sub study of RELAX trial suggested that Gal-3 levels were associated with severity of renal dysfunction. De Boer et al. found that Gal-3 is an independent marker for composite end of all-cause mortality and HF hospitalization in HF and appears to be more powerful in patients with heart failure with preserved ejection fraction (HFpEF)[9]. According to results from the Aldo-DHF trial, plasma Gal-3 in HFpEF was associated with adverse outcome, independent of treatment or NT-proBNP [10].","PeriodicalId":69096,"journal":{"name":"人体生理学杂志(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47112958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
人体生理学杂志(英文)Pub Date : 2020-01-13DOI: 10.31829/2691-5391/jhp2020-3(1)-101
{"title":"Neonatal Size and Birth Canal Dimensions","authors":"","doi":"10.31829/2691-5391/jhp2020-3(1)-101","DOIUrl":"https://doi.org/10.31829/2691-5391/jhp2020-3(1)-101","url":null,"abstract":"The limitation of the fetal growth process during pregnancy is supposed to be an\u0000adaptative response to a physical or a physiological constraint: the pelvic size or the maternal resources and metabolism. In this study 131 mother-infant dyads were recruited. We investigate correlation between maternal traits (height, BMI) pelvic variables (conjugate diameter, inter-spinous diameter, sub-pubic angle) and neonatal traits (gestational age, birthweight, head, suboccipito-brematic and abdominal girth). We found that the three neonatal variables are significantly inter-correlated. Among maternal traits, height is highly correlated with conjugate and inter-spinous diameters. Subpubic angle is correlated with inter-spinous diameter. Among neonatal and pelvimetry correlations, conjugate diameter is highly correlated with suboccipito-bregmatic girth. The pelvic size seems to be the primary constraint to the fetal growth process. This adjustement of fetus size to the birth canal dimensions limits the risk of dystocia. But the way this adjustement occurs at the end of pregnancy is unclear. We assume that the uterus expansion limitation may be an intermediate mechanism explaining the high correlation between pelvic and neonatal traits.","PeriodicalId":69096,"journal":{"name":"人体生理学杂志(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43905485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
人体生理学杂志(英文)Pub Date : 2019-01-01DOI: 10.31829/2691-5391/jhp2019-2(1)-102
Miroshnikov Alexander Borisovich
{"title":"Blood Pressure and Geometry of the Left Ventricle in Power Sports Athletes of Heavy Weight Categories","authors":"Miroshnikov Alexander Borisovich","doi":"10.31829/2691-5391/jhp2019-2(1)-102","DOIUrl":"https://doi.org/10.31829/2691-5391/jhp2019-2(1)-102","url":null,"abstract":"To research blood pressure and heart geometry in power sports athletes of heavy weight categories. Material and methods 645 representatives of the power sports (weightlifting, powerlifting, bodybuilding) having sports qualification of CMS, MS, IMS with the average body weight of 102.7 ± 6.4kg were examined. Everything to the examined athletes along with survey carried out the standard electrocardiogram of rest, double measurement of the ABP, a transthoracic echocardiography. Results A survey of 645 athletes of power sports of heavy weight categories showed that 238 (37%) athletes have high blood pressure (systolic blood pressure-157.4 ± 5.6, diastolic blood pressure-91.2 ± 5.3) and violation of left ventricular geometry. Reliably in hypertensive athletes, compared with normotensive athletes, the following heart parameters were increased: TIS by 0.1mm (p<0.01), TPWLV by 0.2mm <0.01), DRV by 4.2mm (p<0.01), LVMM by 32.2g (p<0.01), LVMI by 17.8g/m2 (p<0.01), RWTLV by 0.08mm (p<0.01). And also in the group of hypertensive athletes there was a significantly lower EDD by 0.2mm (p<0.05). Conclusion Thus, the patterns obtained in relation to associations of blood pressure and disorders of heart geometry of athletes of power sports, heavy weight categories, it may be implemented in prevention programs in future with priority focus on the \"risk-bearing\" groups of men.","PeriodicalId":69096,"journal":{"name":"人体生理学杂志(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69521199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
人体生理学杂志(英文)Pub Date : 2018-08-30DOI: 10.31829/2691-5391/jhp2018-1(1)-101
mdash Case Reportmdash, N. Aoki
{"title":"Sunken Brain Syndrome","authors":"mdash Case Reportmdash, N. Aoki","doi":"10.31829/2691-5391/jhp2018-1(1)-101","DOIUrl":"https://doi.org/10.31829/2691-5391/jhp2018-1(1)-101","url":null,"abstract":"A 34-year old Chinese lady presented to the hospital in 2013 with acute left sided weakness and was found to have a right middle cerebral artery territory infarct requiring thrombolysis using intravenous alteplase. Her condition deterioriated post thrombolysis as it was complicated by right subdural hematoma, left parieto-occipital hematoma with mass effect and midline shift, for which she required urgent decompressive craniectomy and insertion of ventriculo-peritoneal (VP) shunt for hydrocephalus.\u0000\u0000Post-operatively she had severe physical and cognitive impairments. She was discharged home with a caregiver after an extensive period of inpatient rehabilitation. Repeated computed tomography (CT) brain between 2014 to 2016 revealed interval resolution of hematoma and stable hydrocephalus. (Figure 1). In late 2017 she was noted to have right gaze preference. Her Glasgow Coma Scale was 15 with no changes to her cognition or behavior.\u0000\u0000Blood pressure was 110/60 mmHg and pulse rate was 72/minute. Physical examination revealed concavity on the left temporalparietal region of the head. A repeat CT brain showed a concavity of the left craniectomy site suggestive of sunken brain syndrome (SBS) and progressive hydrocephalus from partial shunt blockage without trans-tentorial herniation (Figure 2). Prompt neurosurgical consult was sought and this was quickly followed with an acrylic cranioplasty and revision of VP shunt. She was reviewed post-operatively with resolution of right gaze preference.","PeriodicalId":69096,"journal":{"name":"人体生理学杂志(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42063501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
