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Role of Kappa>Lambda Light-Chain Constant-Domain Switch in the Structure and Functionality of A17 Reactibody Kappa>Lambda轻链常数域开关在A17反应体结构和功能中的作用
IF 2.2 4区 生物学
Acta Crystallographica Section D: Biological Crystallography Pub Date : 2014-02-05 DOI: 10.2210/PDB3ZL4/PDB
N. Ponomarenko, S. Chatziefthimiou, I. Kurkova, Y. Mokrushina, A. Stepanova, I. Smirnov, E. M. Avakyan, T. Bobik, A. Mamedov, V. Mitkevich, A. Belogurov, O. Fedorova, M. Dubina, A. Golovin, V. Lamzin, A. Friboulet, A. Makarov, M. Wilmanns, A. Gabibov
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引用次数: 7
Structure-based drug design 基于结构的药物设计
IF 2.2 4区 生物学
Acta Crystallographica Section D: Biological Crystallography Pub Date : 2013-06-14 DOI: 10.4172/2329-6887.1000E111
M. Rarey, B. Kramer, Thomas Lengauer
{"title":"Structure-based drug design","authors":"M. Rarey, B. Kramer, Thomas Lengauer","doi":"10.4172/2329-6887.1000E111","DOIUrl":"https://doi.org/10.4172/2329-6887.1000E111","url":null,"abstract":"Volume 1 • Issue 4 • 1000e111 J Pharmacovigilance ISSN: 2329-6887 JP, an open access journal In today’s world where life is fast-paced, public health is a big concern. With the tremendous ongoing development in the field of pharmaceutical drugs, people can find cure for a vast variety of diseases. These modern-day medicines have been proven to be more effective in treating, managing, controlling and preventing the diseases and their reoccurrence. For example, cancer patients, who had a very low rate of survival in 1970’s, can now be treated more efficiently by chemotherapy. At present, the cancer death rate has declined by 20% in comparison to 1990 [1]. However, along with rapid progress in the efficacy of these pharmaceutical medicines, have come long-term undesirable side effects, poor absorption and clearance, multi-drug resistance, excessive toxicities, and adverse reactions of these medicines. Hence, there is a stringent need to get a closer insight into these drugs in terms of their structure and function, their molecular interactions with large biomolecules (protein, nucleic acids) within the cell, so as to design and/or modify the drugs to have improved potency, fewer side effects and selective binding to their biomolecular target.","PeriodicalId":6895,"journal":{"name":"Acta Crystallographica Section D: Biological Crystallography","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2013-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88758578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 205
Visualizing the Invisible: Imaging Techniques for the Structural Biologist. By Peter B. Moore. Pp. 368. Oxford University Press, 2012. Price £45. ISBN 978-0-19-976709-0. 可视化不可见:结构生物学家的成像技术。彼得·b·摩尔著。368页。牛津大学出版社，2012。价格£45。ISBN 978-0-19-976709-0。
IF 2.2 4区 生物学
Acta Crystallographica Section D: Biological Crystallography Pub Date : 2013-05-01 DOI: 10.1107/S0907444913001856
P. Paufler
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引用次数: 0
Guy Dodson FRS (1937–2012)
IF 2.2 4区 生物学
Acta Crystallographica Section D: Biological Crystallography Pub Date : 2013-03-01 DOI: 10.1107/S0907444913004186
E. Baker
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引用次数: 1
Structure of fully liganded Hb zeta 2 beta 2(s) trapped in a tense conformation 完全配位的Hb zeta 2 β 2(s)的结构被困在一个紧张的构象
IF 2.2 4区 生物学
Acta Crystallographica Section D: Biological Crystallography Pub Date : 2013-02-06 DOI: 10.2210/PDB3W4U/PDB
M. Safo, T. Ko, O. Abdulmalik, Zhenning He, A. H. Wang, E. Schreiter, J. E. Russell
{"title":"Structure of fully liganded Hb zeta 2 beta 2(s) trapped in a tense conformation","authors":"M. Safo, T. Ko, O. Abdulmalik, Zhenning He, A. H. Wang, E. Schreiter, J. E. Russell","doi":"10.2210/PDB3W4U/PDB","DOIUrl":"https://doi.org/10.2210/PDB3W4U/PDB","url":null,"abstract":"","PeriodicalId":6895,"journal":{"name":"Acta Crystallographica Section D: Biological Crystallography","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2013-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74311891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Celebrating biological crystallography: Acta D twenty years on 庆祝生物晶体学:学报D二十年
IF 2.2 4区 生物学
Acta Crystallographica Section D: Biological Crystallography Pub Date : 2013-01-01 DOI: 10.1107/S0907444912051190
E. Baker, Z. Dauter
{"title":"Celebrating biological crystallography: Acta D twenty years on","authors":"E. Baker, Z. Dauter","doi":"10.1107/S0907444912051190","DOIUrl":"https://doi.org/10.1107/S0907444912051190","url":null,"abstract":"","PeriodicalId":6895,"journal":{"name":"Acta Crystallographica Section D: Biological Crystallography","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82264809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Macromolecular Crystallization and Crystal Perfection. By Naomi E. Chayen, John R. Helliwell and Edward H. Snell. Pp. xi + 221. Oxford University Press, 2010. International Union of Crystallography Book Series, Monographs in Crystallography 24. Price (hardback) £65. ISBN: 978‐0‐19‐921325‐2. 大分子结晶和完美晶体。作者:Naomi E. Chayen, John R. Helliwell和Edward H. Snell。第xi + 221页。牛津大学出版社，2010。国际晶体学联合丛书，晶体学专著24。精装本售价:65英镑。ISBN: 978量0还是19 921325量2。
IF 2.2 4区 生物学
Acta Crystallographica Section D: Biological Crystallography Pub Date : 2012-07-01 DOI: 10.1107/S0907444912022342
J. Glusker
{"title":"Macromolecular Crystallization and Crystal Perfection. By Naomi E. Chayen, John R. Helliwell and Edward H. Snell. Pp. xi + 221. Oxford University Press, 2010. International Union of Crystallography Book Series, Monographs in Crystallography 24. Price (hardback) £65. ISBN: 978‐0‐19‐921325‐2.","authors":"J. Glusker","doi":"10.1107/S0907444912022342","DOIUrl":"https://doi.org/10.1107/S0907444912022342","url":null,"abstract":"","PeriodicalId":6895,"journal":{"name":"Acta Crystallographica Section D: Biological Crystallography","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2012-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77502101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structure of a thermophilic cyanobacterial b(6)f-type Rieske protein 一种嗜热蓝藻b(6)f型Rieske蛋白的结构
IF 2.2 4区 生物学
Acta Crystallographica Section D: Biological Crystallography Pub Date : 2012-05-23 DOI: 10.2210/PDB3AZC/PDB
S. Veit, K. Takeda, Y. Tsunoyama, Dorothea Rexroth, M. Rögner, K. Miki
{"title":"Structure of a thermophilic cyanobacterial b(6)f-type Rieske protein","authors":"S. Veit, K. Takeda, Y. Tsunoyama, Dorothea Rexroth, M. Rögner, K. Miki","doi":"10.2210/PDB3AZC/PDB","DOIUrl":"https://doi.org/10.2210/PDB3AZC/PDB","url":null,"abstract":"","PeriodicalId":6895,"journal":{"name":"Acta Crystallographica Section D: Biological Crystallography","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2012-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75742563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Novel beta-structure of YLR301w from Saccharomyces cerevisiae. 酿酒酵母YLR301w的新β结构。
IF 2.2 4区 生物学
Acta Crystallographica Section D: Biological Crystallography Pub Date : 2012-03-21 DOI: 10.2210/PDB3RBY/PDB
Kook-Han Kim, H. Ahn, Won-Kyu Lee, Cheolju Lee, Myeong-Hee Yu, E. Kim
{"title":"Novel beta-structure of YLR301w from Saccharomyces cerevisiae.","authors":"Kook-Han Kim, H. Ahn, Won-Kyu Lee, Cheolju Lee, Myeong-Hee Yu, E. Kim","doi":"10.2210/PDB3RBY/PDB","DOIUrl":"https://doi.org/10.2210/PDB3RBY/PDB","url":null,"abstract":"","PeriodicalId":6895,"journal":{"name":"Acta Crystallographica Section D: Biological Crystallography","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2012-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85076702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Crystals, X-rays and Proteins: Comprehensive Protein Crystallography. By Dennis Sherwood and Jon Cooper. Oxford University Press, 2010. Pp. 626. Price USD 98.50. ISBN 978-01995-5904-6. 晶体，x射线和蛋白质:综合蛋白质晶体学。丹尼斯·舍伍德和乔恩·库珀著。牛津大学出版社，2010。626页。价格为98.50美元。ISBN 978-01995-5904-6。
IF 2.2 4区 生物学
Acta Crystallographica Section D: Biological Crystallography Pub Date : 2012-01-01 DOI: 10.1107/S0907444911051456
M. Weiss
{"title":"Crystals, X-rays and Proteins: Comprehensive Protein Crystallography. By Dennis Sherwood and Jon Cooper. Oxford University Press, 2010. Pp. 626. Price USD 98.50. ISBN 978-01995-5904-6.","authors":"M. Weiss","doi":"10.1107/S0907444911051456","DOIUrl":"https://doi.org/10.1107/S0907444911051456","url":null,"abstract":"","PeriodicalId":6895,"journal":{"name":"Acta Crystallographica Section D: Biological Crystallography","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76829399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
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