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Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry最新文献

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Two pools of microsomal phosphatidylethanolamine detected by the use of fluorescamine. 荧光胺检测两池微粒体磷脂酰乙醇胺。
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1985-01-01 DOI: 10.3891/acta.chem.scand.39b-0411
C Valtersson, L Filipsson
{"title":"Two pools of microsomal phosphatidylethanolamine detected by the use of fluorescamine.","authors":"C Valtersson, L Filipsson","doi":"10.3891/acta.chem.scand.39b-0411","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.39b-0411","url":null,"abstract":"","PeriodicalId":6886,"journal":{"name":"Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry","volume":"39 5","pages":"411-3"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15148675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Synthesis, antidiuretic and pressor activities of [arginine4]arginine-vasopressin and two related analogues. [精氨酸]精氨酸-加压素及两种相关类似物的合成、抗利尿和加压活性。
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1985-01-01 DOI: 10.3891/acta.chem.scand.39b-0453
P Rekowski, B Lammek, P Melin, U Ragnarsson, G Kupryszewski
{"title":"Synthesis, antidiuretic and pressor activities of [arginine4]arginine-vasopressin and two related analogues.","authors":"P Rekowski,&nbsp;B Lammek,&nbsp;P Melin,&nbsp;U Ragnarsson,&nbsp;G Kupryszewski","doi":"10.3891/acta.chem.scand.39b-0453","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.39b-0453","url":null,"abstract":"<p><p>Using well-established solid-phase techniques, three new analogues of arginine-vasopressin (AVP) were synthesized. In these the glutamine residue in position 4 was replaced with an additional arginine. The new analogues were: [Arginine4]arginine-vasopressin ([Arg4]AVP), [2-thiopropionic acid1,arginine4]arginine-vasopressin (d[Arg4]AVP) and [1-thiocyclohexaneacetic acid1,arginine4]arginine-vasopressin (d(CH2)5[Arg4]AVP). [Arg4]AVP showed about the same antidiuretic activity as AVP but had only about 40% of its pressor activity. Unexpectedly, deamination caused a drop in the antidiuretic activity to about 50%. d(CH2)5[Arg4]AVP had practically negligible antidiuretic and low pressor effects.</p>","PeriodicalId":6886,"journal":{"name":"Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry","volume":"39 6","pages":"453-7"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15173321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Fructosylvaline. A simple model of the N-terminal residue of human haemoglobin A1c. Fructosylvaline。人血红蛋白A1c n端残基的简单模型。
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1985-01-01 DOI: 10.3891/acta.chem.scand.39b-0191
P Keil, H B Mortensen, C Christophersen
{"title":"Fructosylvaline. A simple model of the N-terminal residue of human haemoglobin A1c.","authors":"P Keil,&nbsp;H B Mortensen,&nbsp;C Christophersen","doi":"10.3891/acta.chem.scand.39b-0191","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.39b-0191","url":null,"abstract":"<p><p>The phenylhydrazone of N-[D-fructosyl-(1)]-L-valine (1-deoxy-L-valine-D-fructose) was synthesized. The hydrazone was shown to exist in open form in basic solution and in closed form in acidic solution. The findings have bearings upon the discussion of the reaction of human haemoglobin A1c with phenylhydrazine.</p>","PeriodicalId":6886,"journal":{"name":"Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry","volume":"39 3","pages":"191-3"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15108655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 32
Effect of prolonged phthalate ester administration on rat liver. 邻苯二甲酸酯长期给药对大鼠肝脏的影响。
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1985-01-01 DOI: 10.3891/acta.chem.scand.39b-0319
A E Ganning, A Elhammer, U Brunk, G Dallner
{"title":"Effect of prolonged phthalate ester administration on rat liver.","authors":"A E Ganning,&nbsp;A Elhammer,&nbsp;U Brunk,&nbsp;G Dallner","doi":"10.3891/acta.chem.scand.39b-0319","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.39b-0319","url":null,"abstract":"","PeriodicalId":6886,"journal":{"name":"Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry","volume":"39 4","pages":"319-22"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15116645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
On the self-affinity of heparan sulfates from quiescent or proliferating normal 3T3 cells and from SV40-transformed cells. 静止或增殖的正常3T3细胞和sv40转化细胞对硫酸肝素的自亲和力。
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1985-01-01 DOI: 10.3891/acta.chem.scand.39b-0163
L A Fransson, M Del Rosso
{"title":"On the self-affinity of heparan sulfates from quiescent or proliferating normal 3T3 cells and from SV40-transformed cells.","authors":"L A Fransson,&nbsp;M Del Rosso","doi":"10.3891/acta.chem.scand.39b-0163","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.39b-0163","url":null,"abstract":"<p><p>35S-Labelled heparan sulfates derived from the culture medium (extracellular), a trypsinate of the cells (pericellular) and the cell residue (intracellular) of quiescent normal, proliferating normal or SV40-transformed 3T3 cells were analyzed for charge heterogeneity, by ion exchange chromatography and for self-affinity, by chromatography on heparan sulfate-agarose gels. Quiescent normal cells retained most of their heparan sulphate intra- or pericellularly. The surface-exposed material was charge heterogeneous and had a strong affinity for heparan sulfate. In cultures of growing cells and transformed cells most of the heparan sulfate was found in the medium. The heparan sulfate retained on the surface or growing cells had a lower self-affinity than did the corresponding material from normal and transformed cells. Although cell surface heparan sulfates from transformed cells showed affinity for a matrix substituted with the total heparan sulfate pool, the affinity for one particular subtype was much less pronounced or non-existent.</p>","PeriodicalId":6886,"journal":{"name":"Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry","volume":"39 3","pages":"163-70"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14120331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
5-Ethyl-2'-deoxyuridine. Cytotoxicity and DNA incorporation demonstrated with human leukemic cells and PHA-stimulated lymphocytes in vitro. 5-Ethyl-2脱氧尿苷。细胞毒性和DNA结合与人白血病细胞和pha刺激淋巴细胞在体外证明。
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1985-01-01 DOI: 10.3891/acta.chem.scand.39b-0735
H Tuominen, D Bergstrom, J A Vilpo
{"title":"5-Ethyl-2'-deoxyuridine. Cytotoxicity and DNA incorporation demonstrated with human leukemic cells and PHA-stimulated lymphocytes in vitro.","authors":"H Tuominen,&nbsp;D Bergstrom,&nbsp;J A Vilpo","doi":"10.3891/acta.chem.scand.39b-0735","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.39b-0735","url":null,"abstract":"<p><p>5-Ethyl-2'-deoxyuridine (5EtdUrd) is a biologically active thymidine analogue. The cytotoxicity of 5EtdUrd was investigated with seven established human leukemia cell lines as well as with human peripheral blood PHA-stimulated lymphocytes. All types of leukemia cells were susceptible to the toxicity of 5EtdUrd as assayed with a [U-14C]-L-leucine incorporation system developed for this study. A 50% inhibition of leucine incorporation in 3-day cultures was induced by 1.3-3.8 microM 5EtdUrd with leukemic cells, but the concentration required to induce similar inhibition with PHA-stimulated lymphocytes was approximately was approximately 100-fold. The toxicity of 5EtdUrd seemed to require active DNA synthesis, since the inhibition of leucine incorporation became obvious only after the first 24 hours of culture. The DNA incorporation studies were based on a new isotopically labeled 5EtdUrd derivative, [2-14C]5EtdUrd, synthesized for this study in our laboratory. It was demonstrated for the first time that most of the radioactivity derived from [2-14C]5EtdUrd in DNA was in 5-ethyluracil. 5EtdUrd has a powerful antileukemic potency in vitro. Its effects against human leukemia in vivo remain to be tested.</p>","PeriodicalId":6886,"journal":{"name":"Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry","volume":"39 9","pages":"735-43"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14996730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
An improved synthesis of 3,8-dimethyl-3H-imidazo[4,5-f]quinoxalin-2-amine ("MeIQx") and its 2-14C-labelled analogue. 3,8-二甲基- 3h -咪唑[4,5-f]喹诺沙林-2-胺(“MeIQx”)及其2- 14c标记类似物的改进合成。
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1985-01-01 DOI: 10.3891/acta.chem.scand.39b-0031
S Grivas, K Olsson
{"title":"An improved synthesis of 3,8-dimethyl-3H-imidazo[4,5-f]quinoxalin-2-amine (\"MeIQx\") and its 2-14C-labelled analogue.","authors":"S Grivas,&nbsp;K Olsson","doi":"10.3891/acta.chem.scand.39b-0031","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.39b-0031","url":null,"abstract":"<p><p>The highly mutagenic title compound (MeIQx) was prepared in 21% overall yield from 4-fluoro-o-phenylenediamine. The 3,7-dimethyl isomer may be obtained as a minor by-product. The 14C-label was introduced in the last step through cyclization with [14C]cyanogen bromide. An alternative synthesis of MeIQx from p-fluoroaniline avoided the separation of isomers but gave poorer yield.</p>","PeriodicalId":6886,"journal":{"name":"Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry","volume":"39 1","pages":"31-4"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15099545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 25
5-Hydroxymethyl-2'-deoxyuridine. Cytotoxicity and DNA incorporation studied by using a novel [2-14C]-derivative with normal and leukemic human hematopoietic cells. 5-Hydroxymethyl-2脱氧尿苷。用一种新的[2-14C]衍生物研究了正常和白血病人造血细胞的细胞毒性和DNA掺入。
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1985-01-01 DOI: 10.3891/acta.chem.scand.39b-0477
L I Kahilainen, D E Bergstrom, J A Vilpo
{"title":"5-Hydroxymethyl-2'-deoxyuridine. Cytotoxicity and DNA incorporation studied by using a novel [2-14C]-derivative with normal and leukemic human hematopoietic cells.","authors":"L I Kahilainen,&nbsp;D E Bergstrom,&nbsp;J A Vilpo","doi":"10.3891/acta.chem.scand.39b-0477","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.39b-0477","url":null,"abstract":"<p><p>5-Hydroxymethyl-2'-deoxyuridine is a biologically active thymidine analogue. This investigation was aimed at characterizing the cytotoxicity of 5-hydroxymethyl-2'-deoxyuridine and its incorporation into DNA. Fifty percent inhibition of cellular proliferation, assessed by incorporation of [U-14C]-L-leucine in vitro, was caused by 1.7-5.8 X 10(-5) incorporation of [U-14C]-L-leucine in vitro, was caused by 1.7-5.8 X 10(-5) M 5-hydroxymethyl-2'-deoxyuridine in seven human leukemia cell lines. Higher concentrations of 5-hydroxymethyl-2'-deoxyuridine, i.e. 6-8 X 10(-5) M, were required for a comparable inhibition in human PHA-stimulated peripheral blood lymphocytes. A new synthesis procedure for [2-14C]5-hydroxymethyl-2'-deoxyuridine was developed. The net incorporation of [2-14C]5-hydroxymethyl-2'-deoxyuridine into DNA of hematopoietic cells was low. The possibility of a repair mechanism for 5-hydroxymethyluracil bound to DNA is discussed.</p>","PeriodicalId":6886,"journal":{"name":"Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry","volume":"39 6","pages":"477-84"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15173269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 27
Secondary metabolites from marine bryozoans. A review. 海洋苔藓虫次生代谢物。复习一下。
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1985-01-01 DOI: 10.3891/acta.chem.scand.39b-0517
C Christophersen
{"title":"Secondary metabolites from marine bryozoans. A review.","authors":"C Christophersen","doi":"10.3891/acta.chem.scand.39b-0517","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.39b-0517","url":null,"abstract":"<p><p>Secondary metabolites from marine bryozoans are reviewed. Two ctenosome bryozoans are dealt with, one, Alcyonidium gelatinosum containing a sulfoxonium ion acting as hapten in an allergic contact dermatitis and the other, Zoobotryon verticillatum yielding bromogramines. Five cheilostome bryozoans have given rise to the isolation of unique secondary natural products. Bugula neritina is the source of the antineoplastic bryostatins and Bugula purple while Flustra foliacea have yielded an array of bromoindole alkaloids and a brominated quinoline. Chartella papyracea also have bromoindole alkaloids while Sessibugula translucens have ecological active bipyrroles. A biological active xanthine derivative has been reported from Phidolopora pacifica. The structure and chemistry of these compounds are discussed as are their origin, function and biological activity.</p>","PeriodicalId":6886,"journal":{"name":"Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry","volume":"39 7","pages":"517-29"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15023794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 74
Polyprenol content in primary human liver carcinoma. 聚戊二醇在原发性人肝癌中的含量。
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1985-01-01 DOI: 10.3891/acta.chem.scand.39b-0326
I Eggens, G Elmberger
{"title":"Polyprenol content in primary human liver carcinoma.","authors":"I Eggens,&nbsp;G Elmberger","doi":"10.3891/acta.chem.scand.39b-0326","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.39b-0326","url":null,"abstract":"","PeriodicalId":6886,"journal":{"name":"Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry","volume":"39 4","pages":"326-8"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14122986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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