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Unveiling Vaginal Fibrosis: A Novel Murine Model Using Bleomycin and Epithelial Disruption. 揭示阴道纤维化：一种使用博来霉素和上皮破坏的新小鼠模型。
妇产科期刊(英文) Pub Date : 2025-03-01 Epub Date: 2025-03-19 DOI: 10.4236/ojog.2025.153033
Jennifer M McCracken, Gisele A Calderon, Felipe Rivas, Dorothea Erxleben, Taylor Moseley, Lishore A Kumar, Daniel E Kennedy, Swathi Balaji, Adam Hall, Julie C E Hakim
{"title":"Unveiling Vaginal Fibrosis: A Novel Murine Model Using Bleomycin and Epithelial Disruption.","authors":"Jennifer M McCracken, Gisele A Calderon, Felipe Rivas, Dorothea Erxleben, Taylor Moseley, Lishore A Kumar, Daniel E Kennedy, Swathi Balaji, Adam Hall, Julie C E Hakim","doi":"10.4236/ojog.2025.153033","DOIUrl":"10.4236/ojog.2025.153033","url":null,"abstract":"<p><p>Vaginal fibrosis induced by cancer therapy continues to take a physical and psychoemotional burden. To advance the efforts to generate a reproducible and cost-effective animal model, we tested the effect of repeated bleomycin instillations with mucosal layer disruption on induction of vaginal fibrosis. Tissue samples collected at various time points were analyzed for fibrosis-related gene expression changes and collagen content. Low (1.5 U/kg) and high-dose (2.5 U/kg) bleomycin instillations alone did not induce fibrosis, but when high-dose bleomycin was combined with epithelial disruption, increased profibrotic gene expression and trichrome staining were observed. To evaluate spatial and temporal changes in the ECM structure and gene expression, tissue samples were collected at 1 day, 3 weeks, and 6 weeks after bleomycin and epithelial disruption. Data analyses revealed a significant decrease in matrix metabolizing genes and an increase in pro-fibrotic genes and inhibitors of matrix metabolizing genes in the bleomycin plus epithelial disruption group at 3 weeks. Elevated levels of the profibrotic genes <i>Acta2</i>, <i>Col1a1</i>, and <i>Col3a</i> were exclusively detected in this group at 3 weeks, and trichrome staining confirmed increased collagen content after 3 weeks. Both average hyaluronan (HA) size and mass distribution were increased 3 weeks after bleomycin plus epithelial disruption with return to baseline by 6 weeks. Epithelial disruption combined with bleomycin induces murine vaginal fibrosis within three weeks, characterized by increased collagen synthesis. The vaginal tissue fully recovers within six weeks, elucidating the regenerative capacity of the vagina.</p>","PeriodicalId":67381,"journal":{"name":"妇产科期刊(英文)","volume":"15 3","pages":"371-386"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12392699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144980482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Digital Twin of the Female Pelvic Floor. 女性盆底的数字双胞胎
妇产科期刊(英文) Pub Date : 2024-11-01 Epub Date: 2024-11-06 DOI: 10.4236/ojog.2024.1411138
Vladimir Egorov
{"title":"Digital Twin of the Female Pelvic Floor.","authors":"Vladimir Egorov","doi":"10.4236/ojog.2024.1411138","DOIUrl":"10.4236/ojog.2024.1411138","url":null,"abstract":"<p><p>Digital twin technology, originally developed for intricate physical systems, holds great potential in women's healthcare, particularly in the management of pelvic floor disorders. This paper delves into the development of a digital twin specifically for the female pelvic floor, which can amalgamate various data sources such as imaging, biomechanical assessments, and patient-reported outcomes to offer personalized diagnostic and therapeutic insights. Through the utilization of 3D modeling and machine learning, the digital twin may facilitate precise visualization, prediction, and individualized treatment planning. Nevertheless, it is crucial to address the ethical and practical challenges related to data privacy and ensuring fair access. As this technology progresses, it has the potential to revolutionize gynecological and obstetric care by enhancing diagnostics, customizing treatments, and increasing patient involvement.</p>","PeriodicalId":67381,"journal":{"name":"妇产科期刊(英文)","volume":"14 11","pages":"1687-1694"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating the Efficacy of Cervical Tactile Ultrasound Technique as a Predictive Tool for Spontaneous Preterm Birth. 评估宫颈触觉超声技术作为自然早产预测工具的有效性
妇产科期刊(英文) Pub Date : 2024-05-01 Epub Date: 2024-05-24 DOI: 10.4236/ojog.2024.145067
Vladimir Egorov, Todd Rosen, Jennifer Hill, Meena Khandelwal, Victors Kurtenoks, Brendan Francy, Noune Sarvazyan
{"title":"Evaluating the Efficacy of Cervical Tactile Ultrasound Technique as a Predictive Tool for Spontaneous Preterm Birth.","authors":"Vladimir Egorov, Todd Rosen, Jennifer Hill, Meena Khandelwal, Victors Kurtenoks, Brendan Francy, Noune Sarvazyan","doi":"10.4236/ojog.2024.145067","DOIUrl":"10.4236/ojog.2024.145067","url":null,"abstract":"<p><strong>Background: </strong>Premature cervical softening and shortening may be considered an early mechanical failure that predispose to preterm birth.</p><p><strong>Purpose: </strong>This study aims to explore the applicability of an innovative cervical tactile ultrasound approach for predicting spontaneous preterm birth (sPTB).</p><p><strong>Materials and methods: </strong>Eligible participants were women with low-risk singleton pregnancies in their second trimester, enrolled in this prospective observational study. A Cervix Monitor (CM) device was designed with a vaginal probe comprising four tactile sensors and a single ultrasound transducer operating at 5 MHz. The probe enabled the application of controllable pressure to the external cervical surface, facilitating the acquisition of stress-strain data from both anterior and posterior cervical sectors. Gestational age at delivery was recorded and compared against cervical elasticity.</p><p><strong>Results: </strong>CM examination data were analyzed for 127 women at 24<sup>0/7</sup> - 28<sup>6/7</sup> gestational weeks. sPTB was observed in 6.3% of the cases. The preterm group exhibited a lower average cervical stress-to-strain ratio (elasticity) of 0.70 ± 0.26 kPa/mm compared to the term group's 1.63 ± 0.65 kPa/mm with a p-value of 1.1 × 10<sup>-4</sup>. Diagnostic accuracy for predicting spontaneous preterm birth based solely on cervical elasticity data was found to be 95.0% (95% CI, 88.5 - 100.0).</p><p><strong>Conclusion: </strong>These findings suggest that measuring cervical elasticity with the designed tactile ultrasound probe has the potential to predict spontaneous preterm birth in a cost-effective manner.</p>","PeriodicalId":67381,"journal":{"name":"妇产科期刊(英文)","volume":"14 5","pages":"832-846"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11155442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors Predicting Transformation of Non-Severe Pre-Eclampsia into Pre-Eclampsia with Severe Features 非重度子痫前期转化为重度子痫前期的预测因素
妇产科期刊(英文) Pub Date : 2023-01-01 DOI: 10.4236/ojog.2023.132017
M. Samy, Ahmed Nagy Abdul-Rahman Younis, Karim Mohammed Labib
{"title":"Factors Predicting Transformation of Non-Severe Pre-Eclampsia into Pre-Eclampsia with Severe Features","authors":"M. Samy, Ahmed Nagy Abdul-Rahman Younis, Karim Mohammed Labib","doi":"10.4236/ojog.2023.132017","DOIUrl":"https://doi.org/10.4236/ojog.2023.132017","url":null,"abstract":"","PeriodicalId":67381,"journal":{"name":"妇产科期刊(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70469820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prediction of Success Rates of Vaginal Birth after Cesarean Delivery According to the Previous Indication for Cesarean Delivery 根据既往剖宫产适应证预测剖宫产后阴道分娩成功率
妇产科期刊(英文) Pub Date : 2023-01-01 DOI: 10.4236/ojog.2023.131004
Hytham Atia, Amani Khider, N. M. Metwally
{"title":"Prediction of Success Rates of Vaginal Birth after Cesarean Delivery According to the Previous Indication for Cesarean Delivery","authors":"Hytham Atia, Amani Khider, N. M. Metwally","doi":"10.4236/ojog.2023.131004","DOIUrl":"https://doi.org/10.4236/ojog.2023.131004","url":null,"abstract":"","PeriodicalId":67381,"journal":{"name":"妇产科期刊(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70469199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gingival Hyperplasia during Pregnancy: Frequency and Clinical Presentation in a Tertiary Level Hospital in Yaoundé-Cameroon 怀孕期间牙龈增生:在喀麦隆雅温德萨的一家三级医院的频率和临床表现
妇产科期刊(英文) Pub Date : 2023-01-01 DOI: 10.4236/ojog.2023.132016
C. Nsahlai, V. M. Batoum, Azemafac Njifac Vianny, Nokam Abena Marie Elvire, Foumane Pascal
{"title":"Gingival Hyperplasia during Pregnancy: Frequency and Clinical Presentation in a Tertiary Level Hospital in Yaoundé-Cameroon","authors":"C. Nsahlai, V. M. Batoum, Azemafac Njifac Vianny, Nokam Abena Marie Elvire, Foumane Pascal","doi":"10.4236/ojog.2023.132016","DOIUrl":"https://doi.org/10.4236/ojog.2023.132016","url":null,"abstract":"","PeriodicalId":67381,"journal":{"name":"妇产科期刊(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70469799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mothers’ Level of Schooling, Monitoring of Their Pregnancy and Perinatal Prognosis at the Reference Health Centre of Commune V of the District of Bamako 巴马科区第五公社参考保健中心的母亲受教育程度、妊娠监测和围产期预后
妇产科期刊(英文) Pub Date : 2023-01-01 DOI: 10.4236/ojog.2023.132037
Albachar Hamidou, S. Dembélé, C. Sylla, Sissoko Hamady, S. Dao, A. Samaké, S. Doumbia, Cissao Chiaka, Sanogo Siaka Amara, Séma Kéita
{"title":"Mothers’ Level of Schooling, Monitoring of Their Pregnancy and Perinatal Prognosis at the Reference Health Centre of Commune V of the District of Bamako","authors":"Albachar Hamidou, S. Dembélé, C. Sylla, Sissoko Hamady, S. Dao, A. Samaké, S. Doumbia, Cissao Chiaka, Sanogo Siaka Amara, Séma Kéita","doi":"10.4236/ojog.2023.132037","DOIUrl":"https://doi.org/10.4236/ojog.2023.132037","url":null,"abstract":"","PeriodicalId":67381,"journal":{"name":"妇产科期刊(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70470603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determinants of Breastfeeding Practices among Working Mothers in Solwezi District of Zambia 赞比亚Solwezi地区职业母亲母乳喂养行为的决定因素
妇产科期刊(英文) Pub Date : 2023-01-01 DOI: 10.4236/ojog.2023.133043
Twaambo Mwiza, Dorothy Chanda, E. Musenge
{"title":"Determinants of Breastfeeding Practices among Working Mothers in Solwezi District of Zambia","authors":"Twaambo Mwiza, Dorothy Chanda, E. Musenge","doi":"10.4236/ojog.2023.133043","DOIUrl":"https://doi.org/10.4236/ojog.2023.133043","url":null,"abstract":"","PeriodicalId":67381,"journal":{"name":"妇产科期刊(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70470623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and Adverse Pregnancy Outcomes Associated with Maternal Obesity in the Bamenda Regional Hospital 巴门达地区医院孕产妇肥胖的患病率及不良妊娠结局
妇产科期刊(英文) Pub Date : 2023-01-01 DOI: 10.4236/ojog.2023.134060
Dobgima Walter Pisoh, Ngek Edwin Foinsok, L. Niba, Tameh Theodore, Achuo Ascensius Mforteh, B. Merlin, Takang William Ako, D. Julius
{"title":"Prevalence and Adverse Pregnancy Outcomes Associated with Maternal Obesity in the Bamenda Regional Hospital","authors":"Dobgima Walter Pisoh, Ngek Edwin Foinsok, L. Niba, Tameh Theodore, Achuo Ascensius Mforteh, B. Merlin, Takang William Ako, D. Julius","doi":"10.4236/ojog.2023.134060","DOIUrl":"https://doi.org/10.4236/ojog.2023.134060","url":null,"abstract":"","PeriodicalId":67381,"journal":{"name":"妇产科期刊(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70470836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum Vitamin E Reference Intervals in a Black Congolese Population of Kinshasa 金沙萨刚果黑人人群血清维生素E参考区间
妇产科期刊(英文) Pub Date : 2023-01-01 DOI: 10.4236/ojog.2023.134062
Monzango Sibo, Mboloko Esimo, Mputu Lobota, Mbemba Fundu, N. Mireille, Itewa Monka, Mayoka Mamoi, Ntanga Kabuya, Amba Naomie, Lezaka Ensemeya, Bola Jonita, M. Fastrez, Lebwaze Bienvenu, Balthazar Phoba, D. Mbongi, T. Léon, Kahindo P. Muyalalo, Mbanzulu Pita, E. Darai
{"title":"Serum Vitamin E Reference Intervals in a Black Congolese Population of Kinshasa","authors":"Monzango Sibo, Mboloko Esimo, Mputu Lobota, Mbemba Fundu, N. Mireille, Itewa Monka, Mayoka Mamoi, Ntanga Kabuya, Amba Naomie, Lezaka Ensemeya, Bola Jonita, M. Fastrez, Lebwaze Bienvenu, Balthazar Phoba, D. Mbongi, T. Léon, Kahindo P. Muyalalo, Mbanzulu Pita, E. Darai","doi":"10.4236/ojog.2023.134062","DOIUrl":"https://doi.org/10.4236/ojog.2023.134062","url":null,"abstract":"","PeriodicalId":67381,"journal":{"name":"妇产科期刊(英文)","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70471008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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