David C. Koomen, Katrina L. Leaptrot, Jody C. May, Bailey S. Rose, Kyle E. Lira, Julia A. Raziel, Andrew D. Pumford, Gustavo de A. Cavalcanti, Monica C. Padilha, Henrique M. G. Pereira and John A. McLean*,
{"title":"","authors":"David C. Koomen, Katrina L. Leaptrot, Jody C. May, Bailey S. Rose, Kyle E. Lira, Julia A. Raziel, Andrew D. Pumford, Gustavo de A. Cavalcanti, Monica C. Padilha, Henrique M. G. Pereira and John A. McLean*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":672,"journal":{"name":"Journal of the American Society for Mass Spectrometry","volume":"36 8","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":2.7,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/jasms.5c00129","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144779246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xuesen Hu, Tianrun Xu, Shengkai Xia, Yang Xu, Yao Chen, Liliang Wen, Wangshu Qin, Xianzhe Shi, Xinyu Liu, Qi Wang*, Chunxiu Hu* and Guowang Xu*,
{"title":"Metabolic Adaptation Study of Tumor Cells during Lung Cancer Bone Metastasis in Mice Based on Single-Cell Metabolome Analysis","authors":"Xuesen Hu, Tianrun Xu, Shengkai Xia, Yang Xu, Yao Chen, Liliang Wen, Wangshu Qin, Xianzhe Shi, Xinyu Liu, Qi Wang*, Chunxiu Hu* and Guowang Xu*, ","doi":"10.1021/jasms.5c00177","DOIUrl":"10.1021/jasms.5c00177","url":null,"abstract":"<p >Lung cancer metastasis, the leading cause of patient mortality, is driven by circulating tumor cells (CTCs), which act as direct mediators of metastatic spread. To elucidate the metabolic heterogeneity across lung cancer metastatic stages, a panoramic single-cell metabolomics study in a mouse lung cancer bone metastasis model was performed using a concentric hybrid nanoelectrospray ionization-atmospheric pressure chemical ionization source. This platform enables high-coverage detection of polar and nonpolar metabolites, overcoming limitations in sensitivity and metabolite diversity. Unsupervised clustering and dimensionality reduction (t-SNE) of single-cell metabolic profiles distinguished primary tumor cells, CTCs, and bone metastatic cells, revealing stage-specific metabolic reprogramming. Machine learning identified key metabolites (e.g., aminobenzoic acid, 2-methyl-3-ketovaleric acid, pantothenic acid) that robustly discriminated metastatic stages with high accuracy (AUC > 0.96). CTCs exhibited dynamic metabolic adaptions at different stages: during blood circulation, amino acid and glutamine metabolism dominated to counteract nutrient deprivation, while during bone colonization, the tricarboxylic acid cycle and one-carbon metabolism were upregulated to support proliferation. This study provides important data to shed light on the metabolic heterogeneity of tumor cells and the metastasis mechanism of lung cancer.</p>","PeriodicalId":672,"journal":{"name":"Journal of the American Society for Mass Spectrometry","volume":"36 9","pages":"1959–1969"},"PeriodicalIF":2.7,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zifan Li*, Xiaoqing Kong, Xiao Zhou, Li Xiao, Rasika Phansalkar, Tai Nguyen, Thomas C. Pickel, David Cho, Xuan Zhou and George M. Bou-Assaf*,
{"title":"","authors":"Zifan Li*, Xiaoqing Kong, Xiao Zhou, Li Xiao, Rasika Phansalkar, Tai Nguyen, Thomas C. Pickel, David Cho, Xuan Zhou and George M. Bou-Assaf*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":672,"journal":{"name":"Journal of the American Society for Mass Spectrometry","volume":"36 8","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":2.7,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/jasms.5c00157","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144779231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jonathan M. Bell, Gargey Yagnik, Leonardo G. Dettori, Philip Carvalho, Zhi Wan, Kenneth J. Rothschild* and Mark J. Lim*,
{"title":"","authors":"Jonathan M. Bell, Gargey Yagnik, Leonardo G. Dettori, Philip Carvalho, Zhi Wan, Kenneth J. Rothschild* and Mark J. Lim*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":672,"journal":{"name":"Journal of the American Society for Mass Spectrometry","volume":"36 8","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":2.7,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/jasms.5c00057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144779236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"","authors":"Axel Pramann*, and , Olaf Rienitz, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":672,"journal":{"name":"Journal of the American Society for Mass Spectrometry","volume":"36 8","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":2.7,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/jasms.5c00137","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144779239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Theodore S. Dibble*, Kwonmuang T. Thanthima and Elliot M. O’Connell,
{"title":"","authors":"Theodore S. Dibble*, Kwonmuang T. Thanthima and Elliot M. O’Connell, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":672,"journal":{"name":"Journal of the American Society for Mass Spectrometry","volume":"36 8","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":2.7,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/jasms.5c00173","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144779225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Théo Voellinger, Sébastien Schramm*, Pierre Pacholski, Nathan Traullé and Frédéric Aubriet*,
{"title":"","authors":"Théo Voellinger, Sébastien Schramm*, Pierre Pacholski, Nathan Traullé and Frédéric Aubriet*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":672,"journal":{"name":"Journal of the American Society for Mass Spectrometry","volume":"36 8","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":2.7,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/jasms.5c00151","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144779224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"","authors":"Kevin D. McCarty, and , F. Peter Guengerich*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":672,"journal":{"name":"Journal of the American Society for Mass Spectrometry","volume":"36 8","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":2.7,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/jasms.5c00099","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144779238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marielle van der Peet, Pascal Maas, Agnieszka Wegrzyn, Lieke Lamont, Ronan Fleming, Constance Bordes, Stéphanie Debette, Amy Harms, Thomas Hankemeier and Alida Kindt*,
{"title":"","authors":"Marielle van der Peet, Pascal Maas, Agnieszka Wegrzyn, Lieke Lamont, Ronan Fleming, Constance Bordes, Stéphanie Debette, Amy Harms, Thomas Hankemeier and Alida Kindt*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":672,"journal":{"name":"Journal of the American Society for Mass Spectrometry","volume":"36 8","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":2.7,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/jasms.5c00073","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144779220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Margot Bligh*, Sebastian Silva-Solar, Linda Biehler, Christopher C. J. Fitzgerald, Conor J. Crawford, Mikkel Schultz-Johansen, Sofie Niggemeier, Peter H. Seeberger, Manuel Liebeke and Jan-Hendrik Hehemann,
{"title":"","authors":"Margot Bligh*, Sebastian Silva-Solar, Linda Biehler, Christopher C. J. Fitzgerald, Conor J. Crawford, Mikkel Schultz-Johansen, Sofie Niggemeier, Peter H. Seeberger, Manuel Liebeke and Jan-Hendrik Hehemann, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":672,"journal":{"name":"Journal of the American Society for Mass Spectrometry","volume":"36 8","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":2.7,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/jasms.5c00093","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144779227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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