Journal of Pharmaceutical Innovation最新文献

{"title":"Artificial Intelligence: Preface, Applications and Future Perspective in Relation to Pharmaceutical Sector","authors":"Supriya Singh,&nbsp;Sanket Kumar,&nbsp;Sheikh Shahnawaz Quadir,&nbsp;Saloni Bhandari,&nbsp;Bhuvanesh Baniya,&nbsp;Garima Joshi,&nbsp;C. P. Jain,&nbsp;Deepak Choudhary","doi":"10.1007/s12247-025-09940-3","DOIUrl":"10.1007/s12247-025-09940-3","url":null,"abstract":"<div><h3>Purpose</h3><p>Artificial intelligence (AI) platforms are among the most prominent digital innovations in the contemporary time. The colossal growth and success of AI has garnered the attention of the scientific community and it is also being accepted in the public domain. The current review aims to provide in depth information about the utilization of AI in the pharmaceutical sector along with the limitations, ethical-legal aspects and future perspective of this technology in uplifting the growth of this sector. </p><h3>Methods</h3><p>The accredited web pages of PubMed, Google Scholar, Scopus and Web of Science were accessed using the terms “artificial intelligence” and “pharmaceutical”. Cross-referencing important articles yielded additional references which were evaluated and utilized for inclusion in writing this review.</p><h3>Result</h3><p>The dexterity of AI tools was explored in numerous domains of pharmaceutical sector like drug discovery, pharmaceutical product development, manufacturing, product management, clinical &amp; diagnostic field, 3D printing technology and community pharmacy. It was found that the augmentation of AI with pharmaceutical sector will lift the growth of this sector by heaps and bounds for the reason that every facet will be reshaped in terms of finances and time.</p><h3>Conclusion</h3><p>Significant developments in AI offers a revolutionary chance for drug discovery, formulation, clinical and diagnostic applications, 3D printing and plentiful applications in the pharmaceutical industry. However, AI presents risk factors and ethical concerns that must be handled before society, health systems, and individuals can fully benefit from it. Pharmaceutical developers should ensure that the AI tools and procedures comply with all ethical and regulatory standards enforced by the regulatory agencies.</p></div>","PeriodicalId":656,"journal":{"name":"Journal of Pharmaceutical Innovation","volume":"20 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143564489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and Development of Resveratrol-Loaded Sulfobutylether β-Cyclodextrin and PVP K90-Based Nanofiber Mat Via Electrospinning for the Breast Cancer Therapy","authors":"Priyanka Shinde,&nbsp;Amol Shete,&nbsp;Vishwajeet Ghorpade,&nbsp;Namdev Harale,&nbsp;Swapnali Patil,&nbsp;Namrata Desai,&nbsp;Snehal Patil","doi":"10.1007/s12247-025-09956-9","DOIUrl":"10.1007/s12247-025-09956-9","url":null,"abstract":"<div><h3>Purpose</h3><p>Breast cancer (BC) remains the leading cause of cancer-related mortality among women. This study aimed to improve the solubility, stability, and therapeutic efficacy of Resveratrol (RES) by developing an electrospun nanofiber mat for targeted drug delivery to breast tissue.</p><h3>Methods</h3><p>RES was incorporated into an inclusion complex with sulfobutylether β-cyclodextrin (SBE-β-Cyd) and polyvinylpyrrolidone (PVP K90). Polymer selection was guided by molecular docking and solution-state stability studies. The nanofibers were characterized using FTIR, DSC, XRD, and SEM, and evaluated for entrapment efficiency, moisture content, contact angle, and tensile strength. In vitro and ex vivo studies assessed drug release in phosphate buffer (pH 7.4) and biocompatibility using the HET-CAM assay. Antioxidant activity was analyzed via the DPPH assay, while anticancer potential was tested against MCF-7 breast cancer cells.</p><h3>Results</h3><p>The nanofibers demonstrated sustained RES release, enhanced solubility, and improved skin permeation. Biocompatibility studies confirmed their non-irritant nature and antioxidant assays showed maintained activity. Cytotoxicity assays indicated that RES-loaded nanofibers exhibited significant anticancer effects against MCF-7 cells, surpassing pure RES.</p><h3>Conclusion</h3><p>The developed RES-loaded nanofiber mat presents a promising localized treatment for breast cancer by overcoming RES’s solubility and stability limitations. The formulation enables sustained drug release and enhanced therapeutic efficacy, warranting further in vivo investigations to validate its clinical potential.</p></div>","PeriodicalId":656,"journal":{"name":"Journal of Pharmaceutical Innovation","volume":"20 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143564490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colloidal Copper Nanoparticles Loaded with Vanillic Acid as Liquid Dressings: Development, Characterisation and Evaluation","authors":"Mohini Yadav,&nbsp;Neelam Datt,&nbsp;Priyanka Maurya,&nbsp;Vishwambhar Mishra,&nbsp;Shailendra K. Saraf","doi":"10.1007/s12247-025-09948-9","DOIUrl":"10.1007/s12247-025-09948-9","url":null,"abstract":"<div><h3>Purpose</h3><p>The study aimed to develop liquid dressings containing copper nanoparticles infused with vanillic acid to enhance their antibacterial properties.</p><h3>Method</h3><p>PEG 6000 served as a stabilising agent in the chemical reduction process. The Box-Behnken design was employed to optimise the synthesised nanoparticles. Vanillic acid, obtained from Vanilla planifolia, possesses medicinal qualities, promoting wound healing and antioxidant properties. The nanoparticles were integrated into an optimised batch of in-situ film (liquid dressing) and assessed using DSC, FESEM, cytotoxicity analysis, and in-vivo testing.</p><h3>Result</h3><p>The optimised batch exhibited an entrapment effectiveness of 90.9%, an in-vitro drug release of 89.6%, a particle size of 97.9 nm, a zeta potential of -31 mV, and a polydispersity index of 0.316.</p><h3>Conclusion</h3><p>The liquid dressing exhibited superior wound healing capabilities compared to the pure Vanillic acid solution.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":656,"journal":{"name":"Journal of Pharmaceutical Innovation","volume":"20 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143564488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Rheum turkestanicum Janisch in the Treatment of Bacterial Vaginosis Recurrence: A triple-Blinded Randomized Clinical Trial","authors":"Sedigheh Mousaei,&nbsp;Zahra Esmaeili,&nbsp;Leila Mohtashami,&nbsp;Shokouh Sadat Hamedi,&nbsp;Fatemeh Mahjoub,&nbsp;Lida Jarahi,&nbsp;Kiarash Ghazvini,&nbsp;Malihe Afiat,&nbsp;Mahnaz Boroumand Rezazadeh,&nbsp;Seyed Kazem Farahmand,&nbsp;Siamak Mokhtari,&nbsp;Maliheh Motavasselian","doi":"10.1007/s12247-025-09945-y","DOIUrl":"10.1007/s12247-025-09945-y","url":null,"abstract":"<div><h3>Objectives</h3><p>Bacterial vaginosis (BV) is a common condition among women of reproductive age. Short-term antibiotic treatments are often clinically effective, but recurrence after treatment is frequent. The high recurrence rate and increasing antibiotic resistance highlight the need for new treatment methods. This study aimed to evaluate the effectiveness of a vaginal gel containing <i>Rheum turkestanicum Janisch</i> in comparison to metronidazole for the treatment and prevention of BV recurrence.</p><h3>Study Design</h3><p>This study was a randomized, triple-blinded, controlled trial involving 30 women. Married women aged 18 to 50 years who had been diagnosed with BV and did not meet any exclusion criteria were randomly allocated to the intervention or control groups. The intervention group received <i>R. turkestanicum</i> vaginal gel and <i>R. turkestanicum</i> capsules, while the control group received metronidazole vaginal gel and placebo capsules. Both groups underwent treatment for 7 days.</p><h3>Main Outcome Measures</h3><p>Variables such as demographic data, bacterial vaginosis patients’ signs and symptoms, Amsel’s criteria, and Nugent score were compared and examined before and after treatment with rhubarb and metronidazole in the patients.</p><h3>Results</h3><p>The initial assessment, conducted 10 days after treatment, showed significant improvement in each control and treatment group, but there was no significant difference between the two groups. However, the evaluation of recurrence status 30 days later indicated that the intervention group (using <i>R. turkestanicum</i> vaginal gel and <i>R. turkestanicum</i> capsules) was significant to metronidazole in treating recurrence.</p><h3>Conclusion</h3><p><i>Rheum turkestanicum</i> has the potential to be offered as a novel treatment for BV.</p></div>","PeriodicalId":656,"journal":{"name":"Journal of Pharmaceutical Innovation","volume":"20 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143553814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of Colon-Targeted Naringin-Loaded Microbeads in Acetic Acid-Induced Colitis Model in Rats for the Management of Inflammatory Bowel Disease","authors":"Sonia Chauhan,&nbsp;Ranjit K. Harwansh,&nbsp;Rupa Mazumder","doi":"10.1007/s12247-025-09947-w","DOIUrl":"10.1007/s12247-025-09947-w","url":null,"abstract":"<div><h3>Purpose</h3><p>The study aimed to develop naringin (NAR)-loaded microbeads coated with Eudragit-S100 polymer for colon-targeted drug delivery, focusing on effectively treating inflammatory bowel disease (IBD).</p><h3>Methods</h3><p>NAR-loaded microbeads were formulated by ionic gelation technique. The formulation variables (concentration of chitosan, sodium alginate and sodium tripolyphosphate) were optimized by using Box-Behnken's Design (BBB). Morphological and characterization of the microbeads were performed. Additionally, the therapeutic potential of the microbeads was evaluated in the acetic-acid-induced colitis model by assessing colitis severity, inflammatory markers and histological examination of colonic tissue.</p><h3>Results</h3><p>The optimized formulation exhibited a particle size (PS) (258.42 ± 2.98 µm), drug entrapment efficacy (DEE) (87.04 ± 1.67%), % yield (88.45 ± 2.87%), swelling index (SI) (1.21 ± 0.08) in pH 7.4, and zeta potential (-26.24 ± 0.21 mV). Maximum drug release (93.07 ± 3.67%) was achieved in simulated colonic fluid at pH 7.4 over 24 h, following a <i>non-Fickian mechanism</i> involving diffusion, matrix erosion, and bacterial degradation. The results demonstrated that optimized formulation significantly alleviated colitis symptoms by reducing oxidative stress and inflammatory cytokines in colon tissue.</p><h3>Conclusion</h3><p>NAR-loaded microbeads, optimized by Box–Behnken design, showed strong therapeutic potential in an acetic acid (AA)-induced colitis model. They reduced tissue necrosis factor-α and myeloperoxidase while improving antioxidant levels such as catalase and superoxide dismutase, offering a promising targeted therapy for IBD.</p></div>","PeriodicalId":656,"journal":{"name":"Journal of Pharmaceutical Innovation","volume":"20 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143553768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Anxiolytic and Antidepressant-Like Effects of Citrus Maxima Oil and its Inclusion Complex: A Focus on GABAergic and Serotonergic Pathways","authors":"Srabona Dutta,&nbsp;Shilpa Chatterjee,&nbsp;Sourav Ghosh,&nbsp;Biswajit Basu,&nbsp;Bhupendra Prajapati,&nbsp;Nemat Ali","doi":"10.1007/s12247-025-09936-z","DOIUrl":"10.1007/s12247-025-09936-z","url":null,"abstract":"<div><h3>Objective</h3><p>The purpose of this research was to investigate the effects of <i>Citrus maxima</i> and its inclusion complex on neuropharmacological diseases, such as depression and anxiety, and its potential mechanisms.</p><h3>Materials and methods</h3><p>The essential oil (EO) was extracted and collected using a Clevenger apparatus. A gas Chromatography-Mass Spectroscopy (GCMS) study was performed to analyze the chemical constituents of EO. The Inclusion complex was prepared using the paste complexation technique and its characterization was done by Karl Fisher Titration (KFT), X-ray diffraction (XRD), and scanning electron microscopy (SEM). Swiss albino mice about 3 months old, were purchased from the establishment of Environment Controlled Facilities. Behavioral tests conducted were the Open Field Test (OFT), Elevated Plus Maze (EPM), Tail Suspension Test (TST), and Forced Swimming Test (FST).</p><h3>Results</h3><p>The SEM, XRD, and KFT analysis shows that the inclusion complex formed by using the essential oil and β-CD shows significant results in forming complexation, that helps in proper entrapment of the essential oil thus protecting it from various environmental factors. After conducting the toxicity study, behavioral studies as well as the neurochemical examinations it is concluded that the <i>Citrus maxima</i> essential oil used in a concentration of 100 mg/kg along with its inclusion complex used in the concentration of 50, 100 mg/kg shows significant results.Mechanism of action shows the involvement of GABA and serotonin to be the neurotransmitters associated with the study.</p><h3>Conclusion</h3><p>EO extracted from the peel of <i>Citrus maxima</i> and its inclusion complex demonstrates strong neuropharmacological effects on anxiety and depression models in mice, indicating the involvement of GABAergic and serotonergic pathways.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":656,"journal":{"name":"Journal of Pharmaceutical Innovation","volume":"20 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143521636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Optimization of Curcumin-Loaded Citric Acid Functionalized Multi-Walled Carbon Nanotubes for Enhanced Breast Cancer Treatment Using Design of Experiment","authors":"Saurabh Morparia,&nbsp;Vasanti Suvarna","doi":"10.1007/s12247-025-09944-z","DOIUrl":"10.1007/s12247-025-09944-z","url":null,"abstract":"<div><p>Curcumin, a natural polyphenol derived from turmeric, holds significant promise for breast cancer treatment due to its diverse pharmacological properties, which include antioxidant, neuroprotective, anti-inflammatory, and anti-amyloid effects. However, its clinical application is limited by its poor solubility and low bioavailability. The objective of this study is to develop a novel drug delivery system using citric acid (CA)-functionalized carboxylated (COOH) Multi-Walled Carbon Nanotubes (MWCNTs) to enhance the solubility and bioavailability of curcumin for effective breast cancer treatment. The formulation of curcumin-loaded MWCNT-COOH-CA was optimized using a Box-Behnken design. The characterization of curcumin-loaded MWCNT-COOH-CA incorporated evaluations of particle size, zeta potential, and % entrapment efficiency. Furthermore, the formulation underwent in vitro release and cytotoxicity assessments. The optimal formulation exhibited a particle size of 371 nm, a zeta potential of -25.2 mV, and an entrapment efficiency of 77.86%. In vitro release study demonstrated a pH-dependent release pattern, with enhanced release under acidic conditions simulating the tumor microenvironment, which showed a cumulative release of 93.48% at pH 5.5 as compared to 91.24% at pH 7.4 at the 24-hour time point. The formulated product exhibited significant cytotoxic activity against MCF7 breast cancer cells, with an IC₅₀ value of 30.82 µg/mL, and demonstrated efficient cellular uptake. The novel curcumin-loaded MWCNT-COOH-CA demonstrated potential as an efficacious and targeted approach for the treatment of breast cancer.</p></div>","PeriodicalId":656,"journal":{"name":"Journal of Pharmaceutical Innovation","volume":"20 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143521635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the Influence of Various Degrees of Conicity in Pharmaceutical Reactors on Mixing and Homogenization Processes, Heat Transfer, and Emptying","authors":"Emiliano Frenquelli,&nbsp;Juan P. Real,&nbsp;Juan M. Llabot,&nbsp;Liliana Pierella,&nbsp;Santiago D. Palma,&nbsp;Daniel A. Real","doi":"10.1007/s12247-025-09923-4","DOIUrl":"10.1007/s12247-025-09923-4","url":null,"abstract":"<div><h3>Purpose</h3><p>The purpose of this research is to assess the impact of conical geometry in pharmaceutical reactors. The study aims to evaluate how different degrees of bottom conicity in reactors influence critical aspects such as component mixing and homogenization, heat transfer, and the emptying/dosing of the internal fluid.</p><h3>Methods</h3><p>Reactors with varying degrees of bottom conicity were designed, and computational fluid dynamics (CFD) simulations were conducted alongside a central composite design (CCD) to assess the interactions between design factors and variables in the mixing and homogenization process. Additionally, CFD simulations were performed to analyze the heat transfer within the internal fluid, generated by an external electric heater, as well as the emptying of the fluid over time, driven by a conical helical screw paddle.</p><h3>Results</h3><p>The results indicate that reactor conicity significantly influences mixing efficiency, homogenization, and heat transfer. Reactors with intermediate/high conicity (25º, 40º, and 60º) demonstrated more effective homogenization over time, whereas those with low conicity (5º and 10º) achieved faster initial thermal distribution. The reactor with intermediate conicity (25º) stood out for its balance between operational efficiency and ergonomics, making it an optimal choice for pharmaceutical applications.</p><h3>Conclusions</h3><p>This study highlights the importance of reactor geometry in process optimization, emphasizing that conicity plays a crucial role in operational efficiency and overall reactor performance. The findings underscore the need for further research to refine these systems and enhance efficiency in pharmaceutical applications. Future validation efforts will focus on experimental comparisons based on the optimized system identified in this study.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":656,"journal":{"name":"Journal of Pharmaceutical Innovation","volume":"20 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143521637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective Effects of Supercritical CO2-Extracted Mulberry Leaf Extract against Non-Alcoholic Fatty Liver Disease in Mice","authors":"Yu Mao,&nbsp;Yanyu Hu,&nbsp;Qiujin Jia,&nbsp;Mengmeng Chang,&nbsp;Min Zhao,&nbsp;Dongdong Sun","doi":"10.1007/s12247-025-09942-1","DOIUrl":"10.1007/s12247-025-09942-1","url":null,"abstract":"<div><h3>Purpose</h3><p>Alcohol or other known liver toxins are not the cause of non-alcoholic fatty liver disease (NAFLD), which is defined by the buildup of fat in the liver cells. Numerous studies have indicated that compounds found in mulberry leaves exhibit hepatoprotective effects. This study aims to optimize the extraction process of mulberry leaves and demonstrate the hepatoprotective properties of the extract. The Further objective is to explore the potential biological advantages of mulberry leaf extracts in the treatment of NAFLD.</p><h3>Methods</h3><p>In this research, we optimized the extraction process of mulberry leaves using response surface methodology. The advantages of supercritical carbon dioxide extraction were investigated through LC-MS analysis. Following the establishment of a NAFLD mouse model, the mice were treated with mulberry leaf extract(108, 162, 217 mg/kg/d) for 12 weeks. Post-treatment analyses included histopathological examination, lipid profile assessment and immunofluorescence staining to confirm the antioxidant capacity and therapeutic efficacy of the mulberry leaf extract against NAFLD.</p><h3>Results</h3><p>We identified the optimal extraction conditions for both supercritical carbon dioxide extraction and ethanol reflux methods in obtaining mulberry leaf extract. Ultimately, the extraction rates of the two methods reached 13.76% and 12.60% respectively. Research shows that the mulberry leaf extracts obtained by the two methods contain 54 active components, and the extract obtained by the supercritical carbon dioxide extraction method has a higher content of active components. Furthermore, studies have shown that mulberry leaf extracts can improve cellular morphology, decrease the quantity of lipid droplets and the degree of hepatic steatosis, improve mice’s immunity, and decrease weight gain and liver weight in mice. They can also lower serum levels of TC, TG, ALT, and AST in diseased mice. In addition, we found that the treatment effect of medium and high concentrations of mulberry leaf extracts is better.</p><h3>Conclusion</h3><p>Our investigation enhanced the process of extracting mulberry leaves. We determined that the extract is safe to use, has potent antioxidant qualities, and shields the liver. Additionally, compared to the ethanol reflux approach, the supercritical CO2 extraction method extracted greater types and quantities of chemicals from the leaves.</p></div>","PeriodicalId":656,"journal":{"name":"Journal of Pharmaceutical Innovation","volume":"20 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143496845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"(Bio)Hybrid System of Layered Double Hydroxides and Dapsone: One-Pot Synthesis, Structural Characterization and Cell Viability","authors":"Felipe de Albuquerque Marinho,&nbsp;Amanda Damasceno Leão,&nbsp;Antônia Carla de Jesus Oliveira,&nbsp;Luise Lopes Chaves,&nbsp;Jessica Cavalcante Martins,&nbsp;Izabel Maria de Melo Amaral,&nbsp;Mylena Karolina Oliveira Do Amaral,&nbsp;Lucas José de Alencar Danda,&nbsp;Raiza Raianne Luz Rodrigues,&nbsp;Rafael Alexandre Raimundo,&nbsp;Klinger Antonio da Franca Rodrigues,&nbsp;Mônica Felts de La Rocca Soares,&nbsp;José Lamartine Soares-Sobrinho","doi":"10.1007/s12247-025-09938-x","DOIUrl":"10.1007/s12247-025-09938-x","url":null,"abstract":"<p>Dapsone (DAP) is a bacteriostatic antibiotic classically used in the therapeutic regimen for leprosy (HANS). Its low solubility reduces the absorption rate, directly affecting bioavailability, requiring its association with matrices, such as layered double hydroxides (LDH).</p><p>The synthesis of LDH, molar ratio of 2:1 (M²⁺/M³⁺), was carried out associated with DAP by the one-pot coprecipitation method. The characterizations and performance were evaluated by XRD, FTIR, zeta potential, thermogravimetry, SEM, dissolution and MTT assay.</p><p>XRD showed DAP adsorbed on the lamellae, with a reduction in the intensity of the crystallographic plane (003) and the Bragg and Scherrer equations were used to determine the crystallographic parameters d, t and c. In addition, cif files were indexed to the experimental data to evaluate the relationship between theoretical and experimental data. Scanning Electron Microscopy showed a less defined shape for LDH-DAP. Furthermore, FT-IR spectra suggested electrostatic interactions between the sulfonyl groups of DAP and the lamellae of LDH, confirmed by the change in zeta potential, drug loading (29.2%) and thermogravimetry (TGA-DTA). In simulated intestinal medium, a change in the DAP dissolution profile was observed, with the Baskar model being the most adjusted to explain the release of LDH-DAP over 8 h of experiments. Furthermore, biocompatibility was proven in the MTT assay in epithelial macrophages, making them therapeutically promising.</p><p>Thus, LDH-DAP was able to modify the crystal structure and dissolution rate of DAP and can be considered a promising hybrid system for future applications in the pharmaceutical field.</p>","PeriodicalId":656,"journal":{"name":"Journal of Pharmaceutical Innovation","volume":"20 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143496824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}