{"title":"Spatial-Temporal Source Reconstruction of MEG via Variational EM Algorithm","authors":"J. Kan, Richard C. Wilson","doi":"10.1109/ICBBE.2010.5517755","DOIUrl":"https://doi.org/10.1109/ICBBE.2010.5517755","url":null,"abstract":"Magnetoencephalography(MEG) is a new noninvasive brain imaging technique reconstructed electronic activities of brain by measured the magnetic field surrounding scalp. The aim of this paper is to explore a new method of MEG source spatio-temporal reconstruction based on optimizing the reconstructed MEG source model. We make the assumption that the stimulated electronic activities of the brain are located on a particular part of cortex where we partition it with multiple even voxels. In terms of Biot-Savart Law of electromagnetism, the spatial source model is built with multiple unknown parameters which reflect the information of the source location. Then, we try to solve this parameters optimization as a Maximum-likelihood estimation (MLE) using variational EM algorithm. According to the application of this approach, this paper also addresses that the solution of MEG signal reconstruction should be considered to avoid overlapping the calculation complexity, which may result in too expensive calculation to practice. Whereas, this approach also provides a new possibility and the new angle to solve MEG source reconstruction.","PeriodicalId":6396,"journal":{"name":"2010 4th International Conference on Bioinformatics and Biomedical Engineering","volume":"69 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2010-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79754043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Min Li, Hongyan Luo, Renbin He, Wenwu Zhu, L. Tan, Yi Wu
{"title":"Segmentation of White Matter Based on Region Growing and Threshold Theory","authors":"Min Li, Hongyan Luo, Renbin He, Wenwu Zhu, L. Tan, Yi Wu","doi":"10.1109/ICBBE.2010.5516524","DOIUrl":"https://doi.org/10.1109/ICBBE.2010.5516524","url":null,"abstract":"In order to reduce the massive manual intervention involved in the existing segmentation methods for human cross-section slice images, a segmentation algorithm based on the theory of region growing and threshold in normal gray histogram was proposed in this paper, according to the features of slice images of human brain. More exactly, these slice images were initially segmented coarsely by means of the region growing. Then the method of threshold in normal gray histogram was adopted to refine the segmentation. The experimental results indicate that the proposed algorithm can segment white matter accurately and effectively.","PeriodicalId":6396,"journal":{"name":"2010 4th International Conference on Bioinformatics and Biomedical Engineering","volume":"24 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2010-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80176588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Textural Feature Analysis for Ultrasound Breast Tumor Images","authors":"Qiuxia Chen, Qi Liu","doi":"10.1109/ICBBE.2010.5516918","DOIUrl":"https://doi.org/10.1109/ICBBE.2010.5516918","url":null,"abstract":"Texture is one of the important characteristics used in identifying objects or regions of interest in an image. This paper describes some textural features based on integrated spatial gray level co-occurrence matrix, and illustrates the effectiveness of four textural features in categorizing ultrasound breast tumor images by means of Fuzzy C-means and K-medoid clustering algorithms respectively. The experimental identification accuracy is 72.6415 percent. These results indicate that textural features probably have a general applicability for classification of breast tumors.","PeriodicalId":6396,"journal":{"name":"2010 4th International Conference on Bioinformatics and Biomedical Engineering","volume":"24 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2010-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80204755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Gui, Jing Liu, Deng-qing Li, Hua Tang, Zhenqian Feng, X. Nie
{"title":"NOR1 Enhanced CB1954 Induced Cell Cytotoxicity in HepG2 Is Dependent on Grb2 Mediated MAPK Pathway","authors":"R. Gui, Jing Liu, Deng-qing Li, Hua Tang, Zhenqian Feng, X. Nie","doi":"10.1109/ICBBE.2010.5516376","DOIUrl":"https://doi.org/10.1109/ICBBE.2010.5516376","url":null,"abstract":"Nitroreductase gene NOR1 is possibly involved in the chemical carcinogenesis of hepatic cancer and nasopharyngeal carcinoma. We have demonstrted that NOR1 overexpression could convert monofunction alalkylating agent, CB1954 ([5-aziridin-1-yl]-2,4-dinitrobenzamide) into a toxic form by reduction of the 4-nitro group of CB1954 and enhancing cell killing in nasopharyngeal carcinoma(NPC) cell line CNE1. However, the mechanisms are not known.Using cDNA microarrys and quantitative Real-time PCR, we previously found that NOR1 increased the expression of Grb2 mRNA by 4.8 fold in hepatic cancer cell HepG2. In the present study, we found that NOR1 increased the Grb2 protein expression by 3 fold and enhanced the CB1954 induced cell killing in HepG2 cells ,and the cell cytotoxicity could be inhibited by adding tyrosine kinase inhibitor genestein or by stable transfection of Grb2 shRNA (pU6+27-shGrb2) to silence the expression of Grb2. Western blot analysis showed that Grb2 downexpression could reduce the activity of MAPK. Moreover, inhibiting the activatiton of MAPK by MEK inhibtor PD98059 suppressed CB1954 induced cell killing. These results suggested that NOR1 gene enhanced CB1954 cell cytotoxicity through upregulating expression of Grb2 and activiation of MAPK signal transduction in HepG2 cells.","PeriodicalId":6396,"journal":{"name":"2010 4th International Conference on Bioinformatics and Biomedical Engineering","volume":"9 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2010-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80513429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Preparation of a Composite Plate Using Nonmetallic Materials Powder from the Waste Printed Circuit Boards","authors":"Yin Jin, Guangming Li, Wenzhi He","doi":"10.1109/ICBBE.2010.5516729","DOIUrl":"https://doi.org/10.1109/ICBBE.2010.5516729","url":null,"abstract":"With the production of electrical and electronic equipment (EEE) being one of the fastest growing markets in the world, the steep increasing amount of waste electrical and electronic equipment (WEEE) has triggered off a serious environmental crisis. A composite plate produced by using nonmetallic materials of pulverized waste printed circuit boards(PCBs) obtained after air classification as filler was prepared. The main mechanical properties of composite plate such as tensile strength, bending and impact strength were compared according to different filler particle size, dosage, and modifier and the inner structure of the composite plate was investigated by fractography study. The results indicated that using polypropylene S700 as the base resin and maleic anhydride grafted polypropylene (MAH-g-PP) as a modifier, the mechanical properties of composite plate were excellent when non-metallic materials with particle size from 0.125 to 0.3mm adding amount was 20 wt%. This technique of recycling waste PCBs offers a new way for the improvement of recovery and treatment system of WEEE and possesses wide application prospects.","PeriodicalId":6396,"journal":{"name":"2010 4th International Conference on Bioinformatics and Biomedical Engineering","volume":"92 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2010-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79014282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"On the Integration of Different Physiological Model Systems","authors":"J. Kretschmer, A. Wahl, K. Moller","doi":"10.1109/ICBBE.2010.5516509","DOIUrl":"https://doi.org/10.1109/ICBBE.2010.5516509","url":null,"abstract":"A versatile software for dynamic generation of physiological model systems is proposed. Via a graphical user interface the user can choose and combine models of varying abstraction level and complexity from the following three model families: respiratory mechanics, gas exchange and cardiovascular dynamics. Tests of different simulation runs showed results and model delay times consistent with human physiology.","PeriodicalId":6396,"journal":{"name":"2010 4th International Conference on Bioinformatics and Biomedical Engineering","volume":"50 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2010-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78996184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ting Liu, Zhulei Chen, Qianwen Fu, B. Shi, Lie Yang
{"title":"Acute Toxicity Test of Landfill Leachates Using Protozoan Communities","authors":"Ting Liu, Zhulei Chen, Qianwen Fu, B. Shi, Lie Yang","doi":"10.1109/ICBBE.2010.5515286","DOIUrl":"https://doi.org/10.1109/ICBBE.2010.5515286","url":null,"abstract":"Leachate contains high concentrations of organic matter, ammonia, metals, and other toxic compounds, which may pose serious risks to ecosystems and human health. In order to set up the appropriate toxicological criteria for the leachate, leachate toxicity tests with various organisms need to be conducted. The objective of this investigation was to evaluate the toxicity of leachate using the protozoan community, and the toxic effects of varies seasonal leachates were also compared. Leachates from two municipal solid waste landfills in Wuhan, China were used to develop short-term acute toxicity testing. Bioassays were conducted recording toxicity against various seasonal protozoan communities as median effective concentrations (EC50 values) of species after 24 h exposure. Various seasonal protozoan communities were all sensitive to the leachate samples and the species of the communities decreased with an increase in the leachates concentrations. The EC50 values of Landfill A oscillated between 1.03% and 2.24%, and the EC50 values of Landfill B were between 2.79% and 6.60%. Fluctuation of physicochemical parameters and EC50s of leachates depended rather on landfill age than season of the year (seasonal variations). The results from the bivariate correlation analyses between EC50s and physicochemical parameters implied that the toxicity of leachate might reliably depend on the chemical oxygen demand (COD) and ammonia nitrogen (NH4+-N).","PeriodicalId":6396,"journal":{"name":"2010 4th International Conference on Bioinformatics and Biomedical Engineering","volume":"45 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2010-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79048808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shengjiong Yang, Chuanping Feng, L. Hou, Chun-bo Hao
{"title":"Pollutants Removal from Municipal Wastewater Using Vertical Multilevel Soil Infiltration System","authors":"Shengjiong Yang, Chuanping Feng, L. Hou, Chun-bo Hao","doi":"10.1109/ICBBE.2010.5517425","DOIUrl":"https://doi.org/10.1109/ICBBE.2010.5517425","url":null,"abstract":"In this study, we have investigated the effect of pollutants removal of a vertical multilevel soil infiltration (VMSI) system on municipal wastewater treatment. The VMSI was of 30cm*20cm*50cm column, in which combined stuffing consisted of soil, quartz sand, active carbon and scrap irons were packed. As a result, VMSI system exhibited excellent removal efficiency with 91.7% of COD, 98.4% of NH4+-N, 81.0% of TN and 97.3% of TP. Moreover, the proportion of biological and abiological effects in pollutants removal was also investigated through different reactor, and abiological effect against organic removal was 53-62%. In a long-term performance, the VMSI system exhibited excellent ability and stability in pollutants removal.","PeriodicalId":6396,"journal":{"name":"2010 4th International Conference on Bioinformatics and Biomedical Engineering","volume":"70 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2010-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81517894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zili Zhang, H. Yu, Zunying Hu, Bin Zhou, Mingchun Han
{"title":"Agricultural Burning Detection Using Remote Sensing: A Case Study in Zhejiang Province, China","authors":"Zili Zhang, H. Yu, Zunying Hu, Bin Zhou, Mingchun Han","doi":"10.1109/ICBBE.2010.5516543","DOIUrl":"https://doi.org/10.1109/ICBBE.2010.5516543","url":null,"abstract":"Random agricultural burning such as crop straw fire, especial during the harvest seasons of summer and autumn, is a very common phenomenon in rural or suburban cities in China. However, several pollutions may caused by this kind of biomass burning including climate-destructive aerosols and carbon fluxes which decrease seriously regional air quality and may have an negative impact on public human health leading to respiratory illness. Using remote sensing is an available method to detect and monitor agricultural burning arbitrarily with its better time and spatial effectiveness. As a part of EOS mission, MODIS was suitable for fire detection as some high-temperature-sensitive bands of the sensor had been improved. A hybrid algorithm presented by the paper had archived two major advancements on adjusting the potential thresholds to suit lower temperature of crop straw burning than forest fires and introducing latest land cover data to exclude fake agriculture burning fire points which not located in croplands. The results had been validated by FIRMS's active fire production suggesting that the modified algorithm works well for agriculture burning under complex land characteristic of eastern China, especially in Zhejiang province. A very large potential for satellite data as an efficient method to detect agriculture burning was also demonstrated in the study.","PeriodicalId":6396,"journal":{"name":"2010 4th International Conference on Bioinformatics and Biomedical Engineering","volume":"38 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2010-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81566441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Disinfection for Removal of Zooplankton with Chlorine Dioxide","authors":"Tao Lin, S. Fan, Wei Chen","doi":"10.1109/ICBBE.2010.5516154","DOIUrl":"https://doi.org/10.1109/ICBBE.2010.5516154","url":null,"abstract":"The disinfection effect of Copepod of zooplankton with chlorine dioxide was compared with that of chlorine. The experimental results showed that chlorine dioxide was more effective to kill Copepod. Copepod was completely killed by 1.0mg/L of chlorine dioxide for contacting 30 min but the required dosage were about 2.0mg/L of liquid chlorine. The body structure variety of Copepod indicated that the direct oxidation on structure surface was the main reason for chlorine dioxide causing the death of Copepod. As for chlorine, disinfection of Copepod mainly depended on hypochlorous acid (HOCl) permeation to destroy inner cellular protein. The exterior factors of organic precursors and temperature had a negative influence on disinfection rate of Copepod. There was high oxidizability and prone selectivity to kill Copepod during chlorine dioxide. Therefore, the disinfection effect of chlorine dioxide may be less influenced by extraneous factors than that of chlorine. The GC-MS examination showed that the sort and amount of organic substances in treated water by chlorine dioxide were less than that by chlorination.","PeriodicalId":6396,"journal":{"name":"2010 4th International Conference on Bioinformatics and Biomedical Engineering","volume":"28 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2010-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81573667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}