[Hokkaido igaku zasshi] The Hokkaido journal of medical science最新文献_第7页

Adrenomedullin ameliorates ischemia reperfusion injury in rat livers. 肾上腺髓质素改善大鼠肝脏缺血再灌注损伤。

[Hokkaido igaku zasshi] The Hokkaido journal of medical science Pub Date : 2009-07-01

Tsunenori Sakurai

{"title":"Adrenomedullin ameliorates ischemia reperfusion injury in rat livers.","authors":"Tsunenori Sakurai","doi":"","DOIUrl":"","url":null,"abstract":"Adrenomedullin (ADM) is a novel potent vasodilatory peptide that was isolated from human pheochromocytoma cells in 1993. It consists of 52 amino acids with 1 intramolecular disulfide bond and a C-terminal amide structure. The vasodilatory effect of ADM is mediated by the activation of secondary messengers, including cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) that are induced by nitric oxide (NO). The objective of the present study was to ascertain the protective effect of ADM against ischemia/reperfusion (I/R) injury on isolated perfused rat liver (IPRL) model after 60 min of warm ischemic preservation and identify the pathways involved. Administration of ADM in the perfusate during initial perfusion and in the preserving fluid during reperfusion after preservation augmented portal flow by 1.3-fold (p < 0.01), increased bile production by 2.3-fold (p < 0.01), reduced the release of lactate dehydrogenase (LDH) to 0.73-fold (p < 0.05), increased oxygen consumption by 1.28-fold (p < 0.01), and augmented tissue cAMP by 1.8-fold (p < 0.05) those observed in the absence of ADM. However, ADM administration did not increase tissue cGMP and the uptake of hyaluronio acid, which are the functions of endothelial cells. Histological examination revealed that ADM administration resulted in an improvement in the structural changes induced by the I/R insult; however, it could not prevent the destruction of the sinusoidal endothelial cells. These results indicated that the ADM-mediated increased portal flow in the liver under an I/R insult is not induced by the NO-cGMP pathway but by the activation of cAMP.","PeriodicalId":6338,"journal":{"name":"[Hokkaido igaku zasshi] The Hokkaido journal of medical science","volume":"84 4","pages":"239-49"},"PeriodicalIF":0.0,"publicationDate":"2009-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40018993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The educational impact of home care in community medicine training in a Japanese medical residency program. 日本住院医师计划中家庭护理对社区医学培训的教育影响。

[Hokkaido igaku zasshi] The Hokkaido journal of medical science Pub Date : 2009-07-01

Hidenobu Kawabata, Megumi Kawabata, Manabu Murakami, Masaji Maezawa

{"title":"The educational impact of home care in community medicine training in a Japanese medical residency program.","authors":"Hidenobu Kawabata, Megumi Kawabata, Manabu Murakami, Masaji Maezawa","doi":"","DOIUrl":"","url":null,"abstract":"In light of Japan's aging society, the number of homebound people is expected to increase, and health care services for such patients will need to expand. The authors implemented a one-month pilot program in a rural hospital, which uses home care as an educational tool to further resident interns' understanding in community medicine. The program was conducted for nine medical residents. Each resident was involved in a series of eight home visits, accompanied by an experienced nurse. Upon completion, to investigate the effect of the training program, the residents were interviewed about their experiences. Responses were analyzed by using qualitative methodology. Six categories for residents' learning emerged from the analysis. They included: fostering good doctor-patient relationships while recognizing psychosocial aspects, decision-making in view of ethics and patients' preferences, the value of teamwork, medical knowledge in geriatric care, consideration of the notion of home care itself, and the significance of local characteristics. It was found that home care experience with a geriatric team can not only help deepen the residents' knowledge and skills regarding geriatric care at home, but also foster the residents' attitude toward consideration of psychosocial aspects. It was concluded that initiating a home care program is both a valuable and useful educational tool for residents in managing chronic elderly patients. Residents achieved a new viewpoint which integrated both patients' and physicians' perspectives while witnessing patients' daily lives in the community.","PeriodicalId":6338,"journal":{"name":"[Hokkaido igaku zasshi] The Hokkaido journal of medical science","volume":"84 4","pages":"251-6"},"PeriodicalIF":0.0,"publicationDate":"2009-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40018875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Pathological mechanisms and potential new therapies for autoimmune disease]. [自身免疫性疾病的病理机制和潜在新疗法]。