美国分析化学(英文)最新文献_第5页

Spectrophotometric Method for Determination of Chromium Ion in Aqueous Solution Using Ninhydrin 茚三酮分光光度法测定水溶液中铬离子

美国分析化学(英文) Pub Date : 2022-01-01 DOI: 10.4236/ajac.2022.1310026

H. Baker, Tiba Dheyaa Rahoomi, H. Abdel-Halim

引用次数: 0

Microwave-Assisted Inactivation of Fomite-Microorganism Systems: Energy Phase-Space Projection 微波辅助微生物系统的失活:能量相空间投影

美国分析化学(英文) Pub Date : 2022-01-01 DOI: 10.4236/ajac.2022.137018

V. Law, D. Dowling

引用次数: 3

Trace Metal Leaching from Cookware Locally Fabricated from Scrap Metal: A Case Study of Ntungamo District, Uganda 从当地废金属制造的炊具中提取微量金属:乌干达恩通加莫地区的案例研究

美国分析化学(英文) Pub Date : 2022-01-01 DOI: 10.4236/ajac.2022.139022

Samuel Habimaana, Hannington Gumisiriza, Grace Birungi

引用次数: 0

Nucleation and Growth of Thallium on Thin Film Mercury Electrode: Voltammetric, Scanning Electron Microscopy, Chronoamperometric and Electrochemical Impedance Studies 铊在薄膜汞电极上的成核和生长:伏安法、扫描电镜、时安培法和电化学阻抗研究

美国分析化学(英文) Pub Date : 2022-01-01 DOI: 10.4236/ajac.2022.1311028

Abdoulkadri Ayouba Mahamane, B. Guel, P. Fabre

引用次数: 0

Simultaneous Determination by HPLC-UV Vis of Tartrazine and Sunset Yellow in Soft Drinks Sold in Benin HPLC-UV - Vis同时测定贝宁市售软饮料中的酒黄石和日落黄

美国分析化学(英文) Pub Date : 2022-01-01 DOI: 10.4236/ajac.2022.138019

Janvier Engelbert Agbokponto, A. P. S. Kpaibé, L. Yemoa, A. G. Assanhou, H. Ganfon, G. Gbassi, M. Ake, N’cho Christoph Amin

引用次数: 4

LC-MS/MS Analysis of Lycorine and Galantamine in Human Serum Using Pentafluorophenyl Column 五氟苯基柱LC-MS/MS分析人血清中石蒜碱和加兰他明

美国分析化学(英文) Pub Date : 2022-01-01 DOI: 10.4236/ajac.2022.139021

C. Sasaki, T. Shinozuka, K. Yoshimura, Takaaki Maruhashi, Y. Asari, Fumiko Satoh

引用次数: 1

Validated Chiral Ultra Fast Liquid Chromatographic Method for Quantitative Analysis of Enantiomeric Vildagliptin 手性超快速液相色谱法定量分析维格列汀对映体

美国分析化学(英文) Pub Date : 2021-11-11 DOI: 10.4236/AJAC.2021.1211026

C. Srinivas, Husna Kanwal Qureshi, C. Veeresham

{"title":"Validated Chiral Ultra Fast Liquid Chromatographic Method for Quantitative Analysis of Enantiomeric Vildagliptin","authors":"C. Srinivas, Husna Kanwal Qureshi, C. Veeresham","doi":"10.4236/AJAC.2021.1211026","DOIUrl":"https://doi.org/10.4236/AJAC.2021.1211026","url":null,"abstract":"A rapid, accurate, and precise chiral Ultra fast liquid chromatography (UFLC) method was developed and validated for enantiomeric separation of racemic vildagliptin and S-vildagliptin according to the guidelines of the International Conference on Harmonization (ICH). The chiral chromatographic separation was achieved with a mobile phase consisting of 20 mM borax buffer (pH 9.0 ± 0.05), ACN, and 0.1% Triethylamine (50:50:0.1, v/v/v) at a flow rate of 1 ml/min using a chiralcel OD-RH column, tris(3,5-dimethyl phenyl carbamate) (250 mm × 4.6 mm, 5 μm) column. The UFLC analysis was monitored at 210 nm. The method showed good linearity with a regression coefficient (r2) of 0.999 in the range of 1 - 12 μg/ml for S-vilda. The detection limit (LOD), quantitation limit (LOQ), and the average percentage recovery for S-vilda were found to be 0.024, 0.075 μg/mL, and 99.19% to 100.4%, respectively. The percentages of relative standard deviation (% RSD) for intra- and inter-day precision were found to be 0.346% and 0.364%, respectively. The developed method proved to be reproducible as % RSD was S-vilda was found to be 99.19 w/w. The proposed chiral method can be put in application for the enantiomeric purity determination of S-vilda formulations.","PeriodicalId":63216,"journal":{"name":"美国分析化学(英文)","volume":"12 1","pages":"429-439"},"PeriodicalIF":0.0,"publicationDate":"2021-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43097665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Analytical Method Development and Validation of Filgrastim by UV and RP-UFLC Methods 非格司汀的紫外和RP-UFLC分析方法的建立及验证

美国分析化学(英文) Pub Date : 2021-10-22 DOI: 10.4236/AJAC.2021.1210021

Husna Kanwal Qureshi, C. Veeresham, C. Srinivas

{"title":"Analytical Method Development and Validation of Filgrastim by UV and RP-UFLC Methods","authors":"Husna Kanwal Qureshi, C. Veeresham, C. Srinivas","doi":"10.4236/AJAC.2021.1210021","DOIUrl":"https://doi.org/10.4236/AJAC.2021.1210021","url":null,"abstract":"The research work was carried out for establishing a new Ultra Violet (UV)— Visible spectroscopy and Reverse phase-Ultra Fast Liquid Chromatography (RP-UFLC) method for the analysis and quantification of a biosimilar drug, Filgrastim. Filgrastim or recombinant methionyl granulocyte colony stimulating factor (rGCSF) is a glycoprotein. It has a biological action essential for proliferation and differentiation of hematopoetic and progenitor cells. The UV and RP-UFLC work was carried on a Shimadzu UV1800 Spectrophotometer and Shimadzu Prominence LC-20AD UFLC systems, respectively. The λmax of filgrastim was found to be 215 nm. The correlation coefficient by UV spectroscopy was found to be 0.9994 for the concentration range of 1 to 3 μg/ml in double distilled water. The Reverse phase UFLC was done by using Phenomenex C4 (25 cm × 0.46 cm internal diameter) 15 μ, 300 A° analytical column. The optimized mobile phase for binary elution was Acetonitrile and double distilled water (80:20) with a flow rate of 1 ml/min. The retention time of drug was at 3.2 min. It was observed that the response of the detector was linear in the range of 5 - 15 μg/ml with correlation coefficient value of 0.999. After developing the methods, it was assured for the intended use by validation of the analytical parameters like linearity, accuracy, precision, limit of detection, limit of quantitation, ruggedness and robustness. The results of all the parameters for both the methods were found to be within the acceptance criteria as per the International Council for Harmonisation (ICH) guidelines.","PeriodicalId":63216,"journal":{"name":"美国分析化学(英文)","volume":"12 1","pages":"333-346"},"PeriodicalIF":0.0,"publicationDate":"2021-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47596199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neonatal Cord Tox Panel and Maternal Perinatal Fentanyl Exposure: A Retrospective Chart Review 新生儿脐带毒素小组和产妇围产期芬太尼暴露:回顾性图表回顾

美国分析化学(英文) Pub Date : 2021-09-18 DOI: 10.4236/ajac.2021.129020

Joseph T Jones, D. Coy, Ryan Mitacek, Stephanie Thompson, Stefan Maxwell

引用次数: 3

Extraction Methods of Cyanotoxins Aqueous Media and Sediments 水体和沉积物中氰毒素的提取方法

美国分析化学(英文) Pub Date : 2021-09-18 DOI: 10.4236/ajac.2021.129019

H. El-Nahhal, M. Yassin, Mazan Alzaharna, Ibrahim Y. El-Nahhal, Y. El-Nahhal

{"title":"Extraction Methods of Cyanotoxins Aqueous Media and Sediments","authors":"H. El-Nahhal, M. Yassin, Mazan Alzaharna, Ibrahim Y. El-Nahhal, Y. El-Nahhal","doi":"10.4236/ajac.2021.129019","DOIUrl":"https://doi.org/10.4236/ajac.2021.129019","url":null,"abstract":"Cyanotoxins are chemical compounds produced by cyanobacterial mats grown in aquatic ecosystems. These may threaten human health and aquatic organisms. Extraction of these toxins is usually associated with many difficulties due to their concentration in aquatic ecosystems. This study is designed to provide suitable and effective extraction procedures that can effectively extract low concentration cyanotoxin from water and bacterial cells. The methodology is based on collecting raw material of cyanobacterial mats from naturally growing sites such as Wadi Gaza along with 16 liters of aquatic surrounding media. The materials were left in the Lab for 24 - 48 h for stabilization of the mats. The floating mats were collected using special funnel and allowed to air drying. The aqueous phase was extracted by liquid/liquid extraction using solvent mixture (hexane + ethylacetate 10% w:w), and by liquid solid extraction using several types of organoclays complexes. The solid phase was extracted by acetone and ultrasonic device. Results showed some difficulties were associated with liquid/liquid extraction whereas effective and easy extraction procedures were obtained by liquid solid extraction using either organoclay complex or activated charcoal. In contrast combination of both solid materials did not show improvement in the extracted cyanotoxin. Thus we recommend the use of organoclays or activated charcoal separately for extracting cyanotoxin. Further improvement of extraction can be tailored by using a specific organoclay complex that has some similarity in the chemical structure between the pre-adsorbed organic cation to the clay mineral and the chemical structure of cyanotoxin.","PeriodicalId":63216,"journal":{"name":"美国分析化学(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48412288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1