"Radiation and Risk" Bulletin of the National Radiation and Epidemiological Registry最新文献

{"title":"Radioecological problems in the site of the former Lermontov Production Association \"Almaz\" for mining and processing of uranium ore. Review","authors":"A. Panov","doi":"10.21870/0131-3878-2023-32-1-131-153","DOIUrl":"https://doi.org/10.21870/0131-3878-2023-32-1-131-153","url":null,"abstract":"This paper presents the comprehensive analysis of long-term study of radioecological situation at the site of the former Lermontov Production Association “Almaz” (LPA “Almaz”). The history of LPA and \"uranium heritage\" objects creation has been considered: the association consisted of two mines with adits and rock dumps, the hydrometallurgical plant and a dump. Emissions and discharges of natural radionuclides during the LPA “Almaz” operation (1950-1991) and the impact of radiation on human health and the environment after its shutdown were assessed. Though a lot of remediation work was made, in the near future radiation safety in the territory of the former LPA “Almaz” location is not guaranteed. The important radioecological problems in the territory of the enterprise location have been specified. Areas of terrestrial ecosystems, industrial and residential buildings in which the content of radon isotopes in the atmosphere exceeded the standards have been identified. Heavy natural radionuclides with high specific activity have been found in dumps, and the increased content of the radionuclides have been found in the soil of adjacent agricultural fields. Risks of exceeding the established national radiation safety standards NRB-99/2009 for natural radionuclides in underground waters of mines and in some foodstuffs produced near the tunnels have been assessed. Gaps in radioecological data for a number of radionuclides, ecosystems and food groups have been identified. The necessity of further monitoring of the radiation situation at the objects of LPA ”Almaz” and in the territory of the enterprise location is substantiated. The program for radioecological monitoring of the lowest atmospheric layer, terrestrial (natural, agricultural, anthropogenic) and aquatic (groundwater and surface water) ecosystems. Monitoring objects, parameters to be measured, list of radionuclides, as well as periodicity of taking samples and making measurements in objects of the LPA ”Almaz” and adjacent territory have ben specified. Monitoring will provide data for a correct assessment of human and biota radiation doses, with account for all dose-generating radionuclides and exposure pathways.","PeriodicalId":6315,"journal":{"name":"\"Radiation and Risk\" Bulletin of the National Radiation and Epidemiological Registry","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78262987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospects of the multiangle scanning method for determining the transverse profile of a medical electron beam","authors":"A. A. Bulavskaya, A. Batranin, E. A. Bushmina, Y. Cherepennikov, A. Grigorieva, I. Miloichikova, S. Stuchebrov","doi":"10.21870/0131-3878-2023-32-2-66-77","DOIUrl":"https://doi.org/10.21870/0131-3878-2023-32-2-66-77","url":null,"abstract":"This study is aimed at assessing the applicability of the proposed method of multiangle beam scanning for determining the transverse profile of an electron beam. The application area of the proposed approach will be control of the therapeutic beams spatial and dose characteristics in order to increase the irradiation accuracy and, as a result, reduce the side effects of radiation therapy. One of the main applied problems to be solved by the proposed approach is to determine the beam characteristics during electron beam therapy. For carrying out of electron beam therapy procedures it is necessary to form electron beams with the complex shape of transverse profile. The need to precisely control beam shapes throughout all irradiation stages determines the relevance of this study. The integral transform method was used in this study to obtain distributions of medical electron beam intensity. For the study, we used electron beam transverse pro-files calculated on the basis of a radiation therapy planning system for real clinical cases. The method was applied both theoretical beam profiles with sharp edge and to ones experimentally obtained with real medical electron beams. Integral transforms were performed for a different number of scan projections. Due to this, the optimal number of projections was calculated for each considered profile. The results of the study demonstrate that the multiangle beam scanning method needs 12 scan projections which corresponds to an angular displacement of 15° to control the medical electron beam profile.","PeriodicalId":6315,"journal":{"name":"\"Radiation and Risk\" Bulletin of the National Radiation and Epidemiological Registry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78502655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalized dosimetry of internal exposure to foci and organs at risk of patients: development and implementation of a methodological basis for dosimetric support of clinical trials of therapeutic radiopharmaceuticals","authors":"V. Stepanenko, V. Petriev, A. Kaprin, S. A. Ivanov, P. Shegay, V. Bogacheva, T. Kolyzhenkov, A. Petukhov, V. Krylov, V. Kucherov, M. A. Sigov, O. Vlasova, A. Petrosyan, K. Petrosyan, O. N. Spichenkova, A. Ivannikov, A. Khailov, V. A. Korotkov, E. Zharova, M.R. Eremeev","doi":"10.21870/0131-3878-2023-32-1-156-167","DOIUrl":"https://doi.org/10.21870/0131-3878-2023-32-1-156-167","url":null,"abstract":"The cluster of calculational and instrumental methods for estimation of personalized internal radiation doses to foci and organs at risk among patients undergoing to therapy by radiopharmaceuticals has been developed. The developed set of methods was used for dosimetrical support of clinical trials of therapeutic radiopharmaceuticals: a) Lu-177-DOTA-PSMA (or \"Lutaprost\") targeted for radioligand therapy of metastatic castrate-resistant prostate cancer; b) Re-188 albumin microspheres 5-10 μm (or \"Artroren\") targeted for radiosynovectomy in the local treatment of chronic inflammatory diseases of the joints and c) 188Re albumin microspheres 20-40 μm (or \"Gepatoren\") targeted for intra-arterial radionuclide embolization in the treatment of inoperable liver cancer. The results of estimations absolute activities of radiopharmaceuticals and their dynamics during SPECT/CT scanning of radiopharmaceuticals in the body of patients were verified by measurements using physical phantoms of humans with different body weights and various standard activities of radionuclides distributed inside the phantoms. The developed cluster of programs (for calculating the absorbed fraction of energy in biostructures), relevant databases and instrumental methods were used as the basis for estimations personalized internal radiation doses in foci and organs at risk among patients included in clinical trials of the studied radiopharmaceuticals. Individual internal radiation doses in foci among 39 patients, included in the first phase of clinical trials of the three studied radiopharmaceuticals, were estimated. The analysis of the distribution of estimated doses shows that absorbed doses in foci are very differing not only in different patients, but also in different foci in the same patient. Irradiation doses in foci increase with an increasing in the administered activities of radiopharmaceuticals and, depending on the volume of foci, are within the following ranges: 1) in a case of “Lutaprost” – from 1.4 to 32 Gy (planned administered activity – 5 GBq), from 5.1 to 59 Gy (planned activity – 7.5 GBq), from 13 to 94 Gy (planned activity – 10 GBq); 2) in a case of \"Arthroren\" – from 17.5 to 74 Gy (planned administered activities – from 0.37 to 0.925 GBq); 3) in a case of “Gepatoren” – from 10.7 to 43 Gy (planned administered activities – from 1 to 3 GBq). Individual absorbed doses in organs at risk were estimated as well. Dose values in organs at risk also vary greatly between different patients and between different critical organs. These doses ranged from 0.01 to 7.4 Gy (39 patients), which is many times less than “commonly applied dose constraints” in radiotherapy.","PeriodicalId":6315,"journal":{"name":"\"Radiation and Risk\" Bulletin of the National Radiation and Epidemiological Registry","volume":"86 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83691700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photodynamic therapy for thin endometrium in patients with infertility","authors":"N. A. Arutyunyan, S. N. Katsalap, A.S. Akatieva, V.F. Khmelevskaya, A. I. Alekhin","doi":"10.21870/0131-3878-2023-32-2-56-65","DOIUrl":"https://doi.org/10.21870/0131-3878-2023-32-2-56-65","url":null,"abstract":"There is now evidence of certain structural and functional changes in the endometrium that may be etiological factors affecting the reproductive system health. Endometrial hypoplasia and alter-ations in uterine hemodynamics may cause implantation failure. Because thin endometrium is associated with infertility, early miscarriage and difficulty of treating, further search and use of new therapeutic methods designed on the basis of domestic state-of-the-art technologies is relevant. Effectiveness of intracavitary photodynamic therapy (PDT) for patients with thin endometrium was investigated. Fifty patients at the age of 35.4+/-3.3 years with established diagnoses of thin endometrium and infertility were included in the study. All patients were given PDT. Before the treatment the photosensitiser “Photoditazine” was injected intracavitary in the II phase of the menstrual cycle. For irradiation of the uterine cavity the medical apparatus “LAMI” providing laser radiation with wavelength of 660 nm, was used. To distribute evenly the light in the uterine cavity, intrauterine cylinder optical fiber diffuser (OFD «KOVB-660») was used. The average laser power density was 0.05+/-0.02 W/cm2, energy density 36.7+/-5.9 J/cm2, laser exposure time 11.7+/-2.25 min. We found that the use of intracavitary PDT for thin endometrium allows to correct the menstrual cycle, to achieve long-lasting clinical effect, to regenerate the thickness and 3-layer structure of the endometrium, to increase the percentage of recognised pregnancies and to reduce the risk of pregnancy complications.","PeriodicalId":6315,"journal":{"name":"\"Radiation and Risk\" Bulletin of the National Radiation and Epidemiological Registry","volume":"142 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78042212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calculation of pharmacokinetic and dosimetric characteristics of Lu-177-EDTMP – a potential drug for radionuclide therapy of bone metastases","authors":"A. V. Matveev, V. Petriev, V. Tishchenko, N. G. Minaeva","doi":"10.21870/0131-3878-2023-32-2-96-109","DOIUrl":"https://doi.org/10.21870/0131-3878-2023-32-2-96-109","url":null,"abstract":"Phosphonic acids labeled with beta-emitting radionuclides are promising radiopharmaceutical drugs for palliative therapy of bone metastases. Currently, the possibility of using a new osteotropic compound N,N,N’,N’-ethylenediaminetetrakis (methylene phosphonic acid) with lutetium-177 (177Lu-EDTMP) is being studied. The aim of the work is to develop a compartment mathematical model of the kinetics of 177Lu labeled osteotropic radiopharmaceutical drugs in the body of laboratory animals and calculate their pharmacokinetic and dosimetric characteristics based on it. To assess the stability of 177Lu-EDTMP in vivo, the characteristics of the distribution of free lutetium in the form of 177LuCl3 were also studied. To identify the model parameters and calculate the characteristics of radiopharmaceutical drugs, quantitative data on the bio-distribution of 177Lu-EDTMP and 177LuCl3 in the body of intact Wistar rats were used. A compartment model of kinetics has been developed and two approaches to the identification of its transport constants have been proposed – through the residual functional and using approximation by monoexponential functions. According to pharmacokinetic modeling, it was found that 177Lu-EDTMP is deposited in bone tissues (up to 55% of the administered dose). The calculated value of the apparent volume of distribution of 177Lu-EDTMP is approximately 200 times greater than the volume of blood plasma, the values of biological half-lives from bone tissues are 10-20 times higher than from internal organs. The excretion of 177Lu-EDTMP from the body occurs mainly through renal clearance. Comparative modeling with 177LuCl3 revealed high resistance of 177Lu-EDTMP in vivo. The highest values of absorbed doses are formed in the skeleton and kidneys with minimal radiation load on other internal organs and blood. The results obtained indicate the prospects for further studies of 177Lu-EDTMP and the possibility of its clinical application for the treatment of skeletal metastases.","PeriodicalId":6315,"journal":{"name":"\"Radiation and Risk\" Bulletin of the National Radiation and Epidemiological Registry","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88582979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The study of practical experience in the purification and protection of api-products from radioactive contamination in the period from 1986-1989 for use in modern food production","authors":"I. Prokhoda, E. Myasnikova, R. V. Sinitsyn, V. Feshchenko","doi":"10.21870/0131-3878-2022-31-4-161-171","DOIUrl":"https://doi.org/10.21870/0131-3878-2022-31-4-161-171","url":null,"abstract":"A large area of the Bryansk region was contaminated with radionuclides as a result of the Chernobyl accident. The article shows the boundaries and levels of radioactive contamination of bee products during this period. During the four years after the accident, from 1986 to 1989, samples of bee products were taking in full accordance with generally accepted methods of beekeeping and radiometry. The task was to determine the degree of influence of contamination on food products such as honey, pollen, wax and propolis for further safe use in the food industry. The article analyzes the previously known ways of cleaning beekeeping products from radioactive contamination and presents the result of developing a method for neutralizing radionuclides contained in propolis and wax. It became possible to reduce the content of radionuclides in honey to the recommended level by changing the location of the apiary in such a way that there would be no contaminated soils and light forests within a radius of 2-3 km from it. The developed measures made it possible to significantly reduce the radioactive contamination of agricultural products, and in some cases completely avoid it.","PeriodicalId":6315,"journal":{"name":"\"Radiation and Risk\" Bulletin of the National Radiation and Epidemiological Registry","volume":"87 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74613442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of chronic radiation exposure on phytohormonal status of pine trees in the Chernobyl exclusion zone","authors":"S. Bitarishvili, S. Geras'kin, E. Shesterikova, A. Prazyan","doi":"10.21870/0131-3878-2022-31-4-64-72","DOIUrl":"https://doi.org/10.21870/0131-3878-2022-31-4-64-72","url":null,"abstract":"The paper presents results of the study of impacts of chronic radiation exposure on the hormonal system of the Scots pine in the Chernobyl exclusion zone. Pine needles taken from three experimental plots with a contrasting level of radioactive contamination: the Polesie State Radioecological Reserve, the Kozeluzh’ye forestry and the Khoiniki forestry in June 2021 were used in the study. Artificial stands of the Scots pine were planted in the experimental plots in 1982, few years before the Chernobyl accident. When radiation impact on pine trees was assessed the content of Cs-137, Sr-90, Am-241, Pu-238 и Pu-239+240 in soil and pine needles was taken into account. The absorbed dose rates in the needles taken from contaminated sites varied in the range of 1.5-24.6 µGy/h, the control dose rate was 0.58-0.6 µGy/h. The content of main classes of phytohormones: indol-3-acetic acid, indolyl-3-butyric acid, zeatin and abscisic acid in needles was estimated with the use of high-performance liquid chromatography. No significant changes in the phytohormonal status of pines from the contaminated plots of the Chernobyl exclusion zone were found. No relationship between statistically significant difference in phytohormones content in the pine needles and irradiation exposure is found. The difference may be caused by great biological variability in natural populations or other nonradiation factors.","PeriodicalId":6315,"journal":{"name":"\"Radiation and Risk\" Bulletin of the National Radiation and Epidemiological Registry","volume":"136 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78605499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcription factors as potential markers of carcinogenic effects of chronic exposure. Review","authors":"E. A. Kodintseva","doi":"10.21870/0131-3878-2022-31-4-132-147","DOIUrl":"https://doi.org/10.21870/0131-3878-2022-31-4-132-147","url":null,"abstract":"Chronic human exposure to ionizing radiation causes mainly damage to red bone marrow cells, that primarily affects T-cell part of the immunity. Increased incidence of cancer and cardiovascular diseases in the affected people has been registered during long time. Mechanisms of the late radiation-induced immunity changes have not been sufficiently studied. Pathophysiological mechanisms of late effects of chronic exposure are unknown. The paper reviews the latest information on some transcription factors, among them NF-κB, JNK, Р38 and other, involved in cellular response to ionizing radiation. The main transcription factors, such as STAT3, GATA3, T-BOX, FOXР3, RORС and other, control T-lymphocytes differentiation. Location of some transcription factors and short description of their functions are given in the paper. The latest methods of the transcription factors research have been summarized, their advantages and disadvantages have been analyzed. Radiation effects on cells are mainly realized through stress-adaptive mechanism, this makes difficult to study cells response to ionizing radiation and mechanisms of the effects realization, especially delayed effects. Complex research of intracellular signal pathway in relation to genetic and receptor cells apparatus (Т-lymphocytes, performing regulatory functions, and cells effectors of antitumor immunity) will allow the future researches to find out mechanisms of late effects of ionizing radiation chronic exposure to a human, primarily carcinogenic effects","PeriodicalId":6315,"journal":{"name":"\"Radiation and Risk\" Bulletin of the National Radiation and Epidemiological Registry","volume":"93 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84165686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiobiological model for calculating the probability of death of mammalian cells exposed to ionizing radiation with different linear energy transfer","authors":"A. P. Dolgikh, T. Pavlik","doi":"10.21870/0131-3878-2022-31-2-97-110","DOIUrl":"https://doi.org/10.21870/0131-3878-2022-31-2-97-110","url":null,"abstract":"One of the fundamental problems of radiobiology is to predict a quantitative relationship between the onset of a specified radiation-induced effect on a biological object and the dose of exposure to ionizing radiation under different conditions (for ionizing radiation of different quality and different time of exposure). The purpose of this article is to solve a particular part of the general problem: the development of a mathematical model for the probability of death of mammalian cells depending on the radiation dose with arbitrarily specified linear energy transfer (LET), with a single irradiation of these cells in vitro. To solve this problem, microdosimetric approaches based on the theory of the dual action of radiation were used. When developing the model, the following assumptions were used: 1) there are sensitive volumes (SVs) in the cell, damage to the volumes can lead to cell death; 2) the probability of cell death depends on the number of damaged SVs; 3) the probability of damage to the SVs depends on the energy absorbed in it; 4) to calculate the energy absorbed in the SVs, a simple model for the interaction of ionizing particles with matter was used: the particles move in a straight line, the LET of the particles coincide with the linear energy absorbed in the matter. The developed mathematical model for estimating relationship of the probability of cell death on the dose explicitly contains LET. Thus, the use of the proposed model makes possible separation of biological parameters responsible for the onset of radiation-induced effect from radiation characteristics of the irradiation conditions., Classical radiobiological data, underlying the IAEA ionizing radiation recommendations for determining the relative biological effectiveness (RBE) of different types present an argument for the model validation. Experimental data on irradiation of human kidney T1 cells present an example. The article demonstrates that the developed model makes it possible to calculate the probability of cell death depending on the dose of ionizing radiation with an arbitrarily set LET for photons, electrons, and -particles with a LET from 0.4 to 200 keV/ µm. It follows from the proposed model that a linear-quadratic dependence can occur not only in DNA damage, but also in other biologically important molecules. The use of this model can be extended to predict other radiation-induced effects, as well as the probability of occurrence of radiation-induced effects under various time exposure regimes.","PeriodicalId":6315,"journal":{"name":"\"Radiation and Risk\" Bulletin of the National Radiation and Epidemiological Registry","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74578253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Binding capacity of plasma corticosteroid-binding globulin as a mechanism for increasing the free fraction of the hormone in the pathogenesis of acute radiation sickness","authors":"N. N. Omelchuk","doi":"10.21870/0131-3878-2022-31-3-139-146","DOIUrl":"https://doi.org/10.21870/0131-3878-2022-31-3-139-146","url":null,"abstract":"The research of the hormonal level of the body in the pathogenesis of acute radiation sickness does not lose its relevance due to the expansion of the list of radiation hazard sources. The study results are necessary for clarification of a number of radiobiology concepts on the role of the binding capacity of plasma corticosteroid-binding globulin to blood plasma proteins for increasing the free fraction of the hormone in the dynamics of acute radiation sickness. Determination of the role of free corticoids in the hormonal effect in acute radiation sickness in animals with mono- and biphasic curves of adrenocortical response to radiation was the aim of the work. The experiments were carried out on male rabbits and outbred rats. Animals received a dose of gamma-irradiation, that caused acute radiation sickness of the stage IV. The total content of 11-OX, mcg% was determined by the fluorimetric method Guillemin et al. in the author's modification. To determine the free 11-OX and the binding capacity of CSG, the gel filtration method was used by De Moor et al. in the author's modification. Rabbits were tested 2 hours after irradiation, on days 4 and 8 of radiation sickness. Rats were tested one hour after irradiation, on days 1, 3, 8, and 10 of radiation sickness. The results of the study showed that acute radiation syndrome occurs against the background of an increase in free corticosteroids, which is essential in the pathogenesis of acute radiation sickness. The increase in free corticosteroids in the midst of radiation sickness is primarily due to a decrease in the binding capacity of corticosteroid-binding globulin (CSG or transcortin) and does not depend on the total concentration of the hormone in the blood plasma, which is a general radiobiological pattern. The magnitude of the binding capacity of transcortin is an indicator of protein-steroid interaction.","PeriodicalId":6315,"journal":{"name":"\"Radiation and Risk\" Bulletin of the National Radiation and Epidemiological Registry","volume":"104 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87601195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}