生物物理化学(英文)最新文献_第2页

A Qualitative Model of the Interaction of Sexual Behavior and Hormone Gene Transcription in Male Blue Gourami during Reproduction 雄性蓝葫芦生殖过程中性行为与激素基因转录相互作用的定性模型

生物物理化学(英文) Pub Date : 2020-10-10 DOI: 10.4236/jbpc.2020.114004

G. Degani

{"title":"A Qualitative Model of the Interaction of Sexual Behavior and Hormone Gene Transcription in Male Blue Gourami during Reproduction","authors":"G. Degani","doi":"10.4236/jbpc.2020.114004","DOIUrl":"https://doi.org/10.4236/jbpc.2020.114004","url":null,"abstract":"In the present study, a \u0000model is suggested to describe hormone control in male blue gourami (Trichogaster \u0000trichopterus) along the gonadotropic brain-pituitary- gonad axis (BPG axis) and the hypothalamic-pituitary-somatotropic \u0000axis (HPS axis). This model is based on the cloning and transcription of \u0000genes encoding hormones of the two axes involved in spermatogenesis during blue \u0000gourami reproduction. Gene transcription is affected by environmental, \u0000biological, and behavioral factors. Mature \u0000males were examined in two different stages—nonreproductive in high-density \u0000habitats and reproductive in low-density habitats. Based on gene \u0000transcription, gonadotropin-releasing hormone 1 (GnRH1) was involved in \u0000controlling spermatogenesis (spermatogonia to spermatids) via the BPG axis in \u0000nonreproductive and reproductive stages by controlling follicle-stimulating \u0000hormone (FSH), 11-ketotestosterone (11KT) and 17β-estradiol (E2). However, GnRH3 had a larger effect \u0000during the reproductive stage via the BPG axis (spermatids to sperm) on \u0000luteinizing hormone (LH), 11KT, and 17α-hydroxyprogesterone (17P). At the same time, the HPS axis was involved in \u0000spermatogenesis via pituitary adenylate cyclase-activating polypeptide (PACAP) \u0000and its related peptide PRP (formerly known as GHRH-like peptide) in the brain, \u0000and growth hormone (GH) in the pituitary affected synthesis of insulin-like \u0000growth factor 1 (IGF1) in the liver.","PeriodicalId":62927,"journal":{"name":"生物物理化学(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42722397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

X-Ray Powder Diffraction Data—Identification and Structure Elucidation of Unknown Stone—Rietveld Refinement Approach x射线粉末衍射数据识别和未知石的结构解析

生物物理化学(英文) Pub Date : 2020-10-10 DOI: 10.4236/jbpc.2020.114005

M. Baskar, Anju Patania

引用次数: 3

Phosphate-Methylated Oligonucleotides Past, Present and Future 磷酸盐甲基化寡核苷酸的过去、现在和未来

生物物理化学(英文) Pub Date : 2020-08-06 DOI: 10.4236/jbpc.2020.113003

Hm Henk Buck

引用次数: 2

Water Molecules in Carbon 70, (H2O)3@C70 碳中的水分子70，(H2O)3@C70

生物物理化学(英文) Pub Date : 2020-05-22 DOI: 10.4236/JBPC.2020.112002

M. Baskar, N. Sathyan

引用次数: 0

Taking into Account the Complex Nature and the Intrinsic Parameters of Agro-Food 考虑农业食品的复杂性和内在参数

生物物理化学(英文) Pub Date : 2020-02-26 DOI: 10.4236/jbpc.2020.111001

Ganame Abdou-Salam, O. Honoré, Zougmoré François

引用次数: 2

Structural Change in Dimyristoyl Phosphatidyl Choline (DMPC) Molecule Alkyl Chains on the Addition of Cholesterol to DMPC Monolayer: Specific Addition Effect of Cholesterol 二肉豆醇酰磷脂酰胆碱(DMPC)分子烷基链对胆固醇向DMPC单层加成的结构变化:胆固醇的特异性加成效应

生物物理化学(英文) Pub Date : 2019-05-28 DOI: 10.4236/jbpc.2019.102002

D. Ito, Takanari Ikeda, K. Taga, Yasushi Yamamoto, Z. Shervani, Masato Yamamoto

引用次数: 1

In Silico and in Vitro Approach for the Understanding of the Xanthine Oxidase Inhibitory Activity of Uruguayan Tannat Grape Pomace and Propolis Poliphenols 乌拉圭单宁、葡萄渣和蜂胶酚类黄嘌呤氧化酶抑制活性的硅法和体外研究

生物物理化学(英文) Pub Date : 2019-03-28 DOI: 10.4236/JBPC.2019.101001

E. Alvareda, F. Iribarne, V. Espinosa, P. Miranda, D. Santi, S. Aguilera, S. Bustos, M. P. Zunini

{"title":"In Silico and in Vitro Approach for the Understanding of the Xanthine Oxidase Inhibitory Activity of Uruguayan Tannat Grape Pomace and Propolis Poliphenols","authors":"E. Alvareda, F. Iribarne, V. Espinosa, P. Miranda, D. Santi, S. Aguilera, S. Bustos, M. P. Zunini","doi":"10.4236/JBPC.2019.101001","DOIUrl":"https://doi.org/10.4236/JBPC.2019.101001","url":null,"abstract":"The use of food additives with xanthine oxidase (XO) inhibitory activity offers an alternative approach to hyperuricemic and gout disease treatment, and provides an example of antioxidant nutraceutics. The in vitro and in silico XO inhibitory activity of polyphenols from Uruguayan Tannat grape pomaces and propolis extracts was evaluated as well as the scavenging capacity of said compounds. When comparing propolis and grape pomace samples, the in vitro studies demonstrated that polyphenols extracted from propolis are more active as free radical scavengers than those from Tannat grape pomace. Both natural products effectively inhibited XO but the capacity of phenols present in GP is higher than the one present in P. The high content of anthocyanins in GP, absent in P, could account for this observation. In silico assays allowed us to determine relevant ligand-receptor interactions between polyphenols, from a database built with previously reported polyphenols from both natural products, and the active site of XO. The in silico results showed that compound (E)-isoprenylcaffeate from propolis was the best potential XO inhibitor displaying hydrophobic aromatic interaction between the conjugated ring of the caffeate moiety and polar interactions between hydroxyl groups from caffeate with the active site polar residues. Among grape pomaces, the Cyanidin-3-O-(6-(E)-p-coumaroyl)-glucoside was the best XO inhibitor; its moiety oxychromenyl being relevant to the docking stabilization. All these results lead us to propose Uruguayan propolis and Tannat grape pomace extracts as food additives as well as phytopharmaceuticals to decrease the uric acid levels in gout disease and to act against oxidative stress.","PeriodicalId":62927,"journal":{"name":"生物物理化学(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47552026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

DNA-Like Duplex Structures Derived from Chemistry Based on 2’-Deoxy-Cytidine: A New Model for Base-Specific Inhibition of G and C on DNA and RNA Level 基于2'-脱氧胞苷的化学衍生DNA样双链结构：G和C在DNA和RNA水平上的碱基特异性抑制新模型

生物物理化学(英文) Pub Date : 2018-12-29 DOI: 10.4236/jbpc.2018.93003

H. Buck

引用次数: 0

Water Molecules in the Carbon C60 Confined Space 碳60密闭空间中的水分子

生物物理化学(英文) Pub Date : 2018-05-31 DOI: 10.4236/jbpc.2018.92002

M. Baskar, N. Sathyan, T. D. R. Nair

引用次数: 3

Gradient Temperature Raman Spectroscopy of Fatty Acids with One to Six Double Bonds Identifies Specific Carbons and Provides Systematic Three Dimensional Structures 具有一到六个双键的脂肪酸的梯度温度拉曼光谱识别特定的碳并提供系统的三维结构

生物物理化学(英文) Pub Date : 2018-01-18 DOI: 10.4236/JBPC.2018.91001

C. Broadhurst, W. Schmidt, Julie K. Nguyen, J. Qin, K. Chao, M. Kim

{"title":"Gradient Temperature Raman Spectroscopy of Fatty Acids with One to Six Double Bonds Identifies Specific Carbons and Provides Systematic Three Dimensional Structures","authors":"C. Broadhurst, W. Schmidt, Julie K. Nguyen, J. Qin, K. Chao, M. Kim","doi":"10.4236/JBPC.2018.91001","DOIUrl":"https://doi.org/10.4236/JBPC.2018.91001","url":null,"abstract":"Specialized pro-resolving mediators provide promising targets for new drugs and natural products. Much work has been accomplished on the structure/ function of the lipoxygenase and cyclooxygenase enzymes but not on the substrates. A better visualization of three-dimensional lipid structures will allow increased refinement of the interactions that produce the pro-resolving mediators, and lead to improvements in synthetic pathways. We present systematic analysis of oleic (18:1n-9), linoleic (18:2n-6), alpha-linolenic (18:3n-3), arachidonic (20:4n-6), docosapentaenoic (22:5n-3), and docosahexaenoic (22:6n-3) acids. Continuous gradient temperature Raman spectroscopy (GTRS) applies the temperature gradients utilized in differential scanning calorimetry to Raman spectroscopy. GTRS can identify and differentiate specific carbon chain sites, finally allowing Raman analysis to explain why the long-chain polyunsaturated fatty acids (LC-PUFA) exhibit such extreme functional differences despite minimal changes in chemical structure. Detailed vibrational analysis of the important frequency ranges 1450 - 1200 cm-1 (includes CH2 bending and twisting) and 1750 - 1425 cm-1 (includes C=C stretching and C-C stretching plus H-C in-plane rocking) shows for the first time that each molecule has its own characteristic set of modes with only some redundancy/commonality. The number and frequency of modes correlates with three-dimensional molecular structure, not the degree of unsaturation. The high degree of specificity of lipoxygenase and cyclooxygenase enzymes should be reconsidered in light of the fact that individual sites on the polyunsaturated fatty acid chain are nonequivalent, and each LC-PUFA molecule has an individual, specific three dimensional structure incorporating torsion.","PeriodicalId":62927,"journal":{"name":"生物物理化学(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49530060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6