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Organoids-on-a-chip Organoids-on-a-chip
中国科学：生命科学 Pub Date : 2022-11-01 DOI: 10.1360/ssv-2022-0027
Yaqing Wang, Tingting Tao, J. Qin
{"title":"Organoids-on-a-chip","authors":"Yaqing Wang, Tingting Tao, J. Qin","doi":"10.1360/ssv-2022-0027","DOIUrl":"https://doi.org/10.1360/ssv-2022-0027","url":null,"abstract":"Organoids-on-a-chip is a newly emerging and frontier field with a marriage of organoids and microfluidic organ-on-a-chip technology. The synergistic engineering strategies can be adopted to build organ model systems in high fidelity, and to hold great potential in studies of organ development, disease modeling, drug discovery and regenerative medicine. In this review, we introduce the origin, key features and recent progress of organoids-on-chips. The future opportunities and major challenges to advance organoids-on-a-chip systems are also discussed.","PeriodicalId":61900,"journal":{"name":"中国科学：生命科学","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41687024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
靶向铁死亡防治脏器损伤及衰老相关疾病的转化医学研究 靶向铁死亡防治脏器损伤及衰老相关疾病的转化医学研究
中国科学(生命科学) Pub Date : 2022-10-01 DOI: 10.1360/ssv-2022-0241
Xinyi Shen, Yingying Yu, Junyi Chen, Jie Shen, Jinming Zhang, Fu Lee Wang, J. Min
{"title":"靶向铁死亡防治脏器损伤及衰老相关疾病的转化医学研究","authors":"Xinyi Shen, Yingying Yu, Junyi Chen, Jie Shen, Jinming Zhang, Fu Lee Wang, J. Min","doi":"10.1360/ssv-2022-0241","DOIUrl":"https://doi.org/10.1360/ssv-2022-0241","url":null,"abstract":"","PeriodicalId":61900,"journal":{"name":"中国科学(生命科学)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42879688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
蚊虫微生物群系及其在蚊媒疾病防控中的研究进展 蚊虫微生物群系及其在蚊媒疾病防控中的研究进展
中国科学(生命科学) Pub Date : 2022-10-01 DOI: 10.1360/ssv-2022-0093
Yongmao Jiang, Lihua Wang, Wenqi Hu, Han Gao, Siwei Wang
{"title":"蚊虫微生物群系及其在蚊媒疾病防控中的研究进展","authors":"Yongmao Jiang, Lihua Wang, Wenqi Hu, Han Gao, Siwei Wang","doi":"10.1360/ssv-2022-0093","DOIUrl":"https://doi.org/10.1360/ssv-2022-0093","url":null,"abstract":"","PeriodicalId":61900,"journal":{"name":"中国科学(生命科学)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66968609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
小胶质细胞调控自主神经功能参与神经源性高血压的综述进展 Progress in the regulation of autonomic nervous function by microglia in neurogenic hypertension: a review
中国科学：生命科学 Pub Date : 2022-10-01 DOI: 10.1360/ssv-2022-0082
Ningting Chen, Guo Cheng, Bo Wei, Qianqian Bi, Cheng Lu, Shanshan Wang, Peng Shi
{"title":"小胶质细胞调控自主神经功能参与神经源性高血压的综述进展","authors":"Ningting Chen, Guo Cheng, Bo Wei, Qianqian Bi, Cheng Lu, Shanshan Wang, Peng Shi","doi":"10.1360/ssv-2022-0082","DOIUrl":"https://doi.org/10.1360/ssv-2022-0082","url":null,"abstract":"","PeriodicalId":61900,"journal":{"name":"中国科学：生命科学","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42738730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
中国康复医学发展现状与展望 中国康复医学发展现状与展望
中国科学(生命科学) Pub Date : 2022-09-01 DOI: 10.1360/ssv-2022-0235
Q. Wei, Yonghong Yang, Q. Gao, Shaxin Liu, Liqiong Wang, Chengqi He
{"title":"中国康复医学发展现状与展望","authors":"Q. Wei, Yonghong Yang, Q. Gao, Shaxin Liu, Liqiong Wang, Chengqi He","doi":"10.1360/ssv-2022-0235","DOIUrl":"https://doi.org/10.1360/ssv-2022-0235","url":null,"abstract":"","PeriodicalId":61900,"journal":{"name":"中国科学(生命科学)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49192436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
O-GlcNAc 糖基化修饰在神经发育和神经系统疾病中的作用 O-GlcNAc 糖基化修饰在神经发育和神经系统疾病中的作用
中国科学(生命科学) Pub Date : 2022-09-01 DOI: 10.1360/ssv-2022-0069
Jinyu Zhang, Xiaoxue Dong, Xuekun Li
{"title":"O-GlcNAc 糖基化修饰在神经发育和神经系统疾病中的作用","authors":"Jinyu Zhang, Xiaoxue Dong, Xuekun Li","doi":"10.1360/ssv-2022-0069","DOIUrl":"https://doi.org/10.1360/ssv-2022-0069","url":null,"abstract":"","PeriodicalId":61900,"journal":{"name":"中国科学(生命科学)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44353092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent progresses on R-loop biology: from detection methods to biological functions R-loop生物学研究进展:从检测方法到生物学功能
中国科学(生命科学) Pub Date : 2022-09-01 DOI: 10.1360/ssv-2021-0422
Jincong Zhou, Wenjie Wang, Qianwen Sun
{"title":"Recent progresses on R-loop biology: from detection methods to biological functions","authors":"Jincong Zhou, Wenjie Wang, Qianwen Sun","doi":"10.1360/ssv-2021-0422","DOIUrl":"https://doi.org/10.1360/ssv-2021-0422","url":null,"abstract":"R-loops are three-stranded chromatin structures composed of a single-stranded DNA and an RNA:DNA hybrid with important biological functions in numerous organisms. Numbers of R-loop regulators have been found to affect genomic events, such as transcription, replication, DNA damage, and repair, through modulating R-loop homeostasis. Over the last few years, with the development of R-loop detection methods, an increasing number of R-loop biological functions are being discovered. In this review, we provide an overview of R-loop detection methods and focus on the research progresses of R-loop functions in plants.","PeriodicalId":61900,"journal":{"name":"中国科学(生命科学)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47352734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
基于功能磁共振的脑网络连接在癫痫及其共病中的应用与研究进展 Application and research progress of brain network connectivity based on functional magnetic resonance imaging in epilepsy and its comorbidities
中国科学：生命科学 Pub Date : 2022-09-01 DOI: 10.1360/ssv-2022-0194
Wenyu Liu, Chenyang Zhao, F. Xiao, Yingying Zhang, Wei Li, Hesheng Zhang, Xintong Wu, Jingmei Li, Dong Zhou
{"title":"基于功能磁共振的脑网络连接在癫痫及其共病中的应用与研究进展","authors":"Wenyu Liu, Chenyang Zhao, F. Xiao, Yingying Zhang, Wei Li, Hesheng Zhang, Xintong Wu, Jingmei Li, Dong Zhou","doi":"10.1360/ssv-2022-0194","DOIUrl":"https://doi.org/10.1360/ssv-2022-0194","url":null,"abstract":"","PeriodicalId":61900,"journal":{"name":"中国科学：生命科学","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44434075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
细胞表面工程的策略及应用 细胞表面工程的策略及应用
中国科学：生命科学 Pub Date : 2022-09-01 DOI: 10.1360/ssv-2022-0067
Benya Wang, Yuqiao Huang
{"title":"细胞表面工程的策略及应用","authors":"Benya Wang, Yuqiao Huang","doi":"10.1360/ssv-2022-0067","DOIUrl":"https://doi.org/10.1360/ssv-2022-0067","url":null,"abstract":"","PeriodicalId":61900,"journal":{"name":"中国科学：生命科学","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42343093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
生物样本库建设中的低温生物学 Low temperature biology in the construction of biological sample banks
中国科学(生命科学) Pub Date : 2022-09-01 DOI: 10.1360/ssv-2022-0171
Yi Xu, Ningruzongshu Guo, Guoliangxiao Yang, Taijie Zhan, Hengxin Han, Yue Cheng, Gang Zhao, Qiang Wei, Xuexun Zhou, Baolin Liu
{"title":"生物样本库建设中的低温生物学","authors":"Yi Xu, Ningruzongshu Guo, Guoliangxiao Yang, Taijie Zhan, Hengxin Han, Yue Cheng, Gang Zhao, Qiang Wei, Xuexun Zhou, Baolin Liu","doi":"10.1360/ssv-2022-0171","DOIUrl":"https://doi.org/10.1360/ssv-2022-0171","url":null,"abstract":"","PeriodicalId":61900,"journal":{"name":"中国科学(生命科学)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44048546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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