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耐辐射奇球菌极端辐射抗性机制和潜在利用 Mechanism and potential utilization of extreme radiation resistance of radiation resistant Staphylococcus aureus
中国科学(生命科学) Pub Date : 2023-08-01 DOI: 10.1360/ssv-2023-0062
Ye Zhao, Qingqiao Cha
{"title":"耐辐射奇球菌极端辐射抗性机制和潜在利用","authors":"Ye Zhao, Qingqiao Cha","doi":"10.1360/ssv-2023-0062","DOIUrl":"https://doi.org/10.1360/ssv-2023-0062","url":null,"abstract":"","PeriodicalId":61900,"journal":{"name":"中国科学(生命科学)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43659424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
经会阴前列腺穿刺诱发迷走神经反射的原因分析与预防措施 经会阴前列腺穿刺诱发迷走神经反射的原因分析与预防措施
中国科学(生命科学) Pub Date : 2023-08-01 DOI: 10.1360/ssv-2023-0148
Haiyan Ma, Xuejing Wang, C. Liang
{"title":"经会阴前列腺穿刺诱发迷走神经反射的原因分析与预防措施","authors":"Haiyan Ma, Xuejing Wang, C. Liang","doi":"10.1360/ssv-2023-0148","DOIUrl":"https://doi.org/10.1360/ssv-2023-0148","url":null,"abstract":"","PeriodicalId":61900,"journal":{"name":"中国科学(生命科学)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48854333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
组蛋白甲基化修饰与早期胚胎发育及相关疾病的研究进展 组蛋白甲基化修饰与早期胚胎发育及相关疾病的研究进展
中国科学(生命科学) Pub Date : 2023-08-01 DOI: 10.1360/ssv-2023-0134
Dan Bo, Zihui Yan, Shanyao Liu, Wenqiang Liu, Shaorong Gao
{"title":"组蛋白甲基化修饰与早期胚胎发育及相关疾病的研究进展","authors":"Dan Bo, Zihui Yan, Shanyao Liu, Wenqiang Liu, Shaorong Gao","doi":"10.1360/ssv-2023-0134","DOIUrl":"https://doi.org/10.1360/ssv-2023-0134","url":null,"abstract":"","PeriodicalId":61900,"journal":{"name":"中国科学(生命科学)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44155902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
脑血管发育与相关疾病研究进展 脑血管发育与相关疾病研究进展
中国科学(生命科学) Pub Date : 2023-08-01 DOI: 10.1360/ssv-2023-0092
J. Ma, Xiao Min, Mei Wu, Jingjing Zhang
{"title":"脑血管发育与相关疾病研究进展","authors":"J. Ma, Xiao Min, Mei Wu, Jingjing Zhang","doi":"10.1360/ssv-2023-0092","DOIUrl":"https://doi.org/10.1360/ssv-2023-0092","url":null,"abstract":"","PeriodicalId":61900,"journal":{"name":"中国科学(生命科学)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47656458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
植物中相分离研究进展 Research progress on phase separation in plants
中国科学(生命科学) Pub Date : 2023-07-01 DOI: 10.1360/ssv-2023-0112
Xiaofen Fang
{"title":"植物中相分离研究进展","authors":"Xiaofen Fang","doi":"10.1360/ssv-2023-0112","DOIUrl":"https://doi.org/10.1360/ssv-2023-0112","url":null,"abstract":"","PeriodicalId":61900,"journal":{"name":"中国科学(生命科学)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45069245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
非编码RNA调控蛋白翻译与疾病发生 非编码RNA调控蛋白翻译与疾病发生
中国科学(生命科学) Pub Date : 2023-07-01 DOI: 10.1360/ssv-2023-0156
Wentao Wang, Yue Chen
{"title":"非编码RNA调控蛋白翻译与疾病发生","authors":"Wentao Wang, Yue Chen","doi":"10.1360/ssv-2023-0156","DOIUrl":"https://doi.org/10.1360/ssv-2023-0156","url":null,"abstract":"","PeriodicalId":61900,"journal":{"name":"中国科学(生命科学)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46275720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RNA修饰与人类疾病研究进展 RNA修饰与人类疾病研究进展
中国科学(生命科学) Pub Date : 2023-07-01 DOI: 10.1360/ssv-2023-0127
Chunchun Gao, Minxin Guan, Xiao He, Hao Jin, Yongfeng Jin, Jun Liu, Hui Luo, Huiru Qu, Shanshan Xie, Yungui Yang, Rui Zhang, Xinning Zhang, Yifan Zhang, Tianhua Zhou
{"title":"RNA修饰与人类疾病研究进展","authors":"Chunchun Gao, Minxin Guan, Xiao He, Hao Jin, Yongfeng Jin, Jun Liu, Hui Luo, Huiru Qu, Shanshan Xie, Yungui Yang, Rui Zhang, Xinning Zhang, Yifan Zhang, Tianhua Zhou","doi":"10.1360/ssv-2023-0127","DOIUrl":"https://doi.org/10.1360/ssv-2023-0127","url":null,"abstract":"","PeriodicalId":61900,"journal":{"name":"中国科学(生命科学)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43893258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
“国之所需、吾志所向”——纪念创新药物开拓者蒋华良院士 “国之所需、吾志所向”——纪念创新药物开拓者蒋华良院士
中国科学(生命科学) Pub Date : 2023-07-01 DOI: 10.1360/ssv-2023-0167
Jiyuan Li
{"title":"“国之所需、吾志所向”——纪念创新药物开拓者蒋华良院士","authors":"Jiyuan Li","doi":"10.1360/ssv-2023-0167","DOIUrl":"https://doi.org/10.1360/ssv-2023-0167","url":null,"abstract":"","PeriodicalId":61900,"journal":{"name":"中国科学(生命科学)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41423832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural and functional studies of PR-DUB: molecular mechanism of its specific H2AK119 deubiquitination activity PR-DUB的结构和功能研究:其特异性H2AK119去泛素化活性的分子机制
中国科学(生命科学) Pub Date : 2023-07-01 DOI: 10.1360/ssv-2023-0057
Ni Wang, Xudong Wu
{"title":"Structural and functional studies of PR-DUB: molecular mechanism of its specific H2AK119 deubiquitination activity","authors":"Ni Wang, Xudong Wu","doi":"10.1360/ssv-2023-0057","DOIUrl":"https://doi.org/10.1360/ssv-2023-0057","url":null,"abstract":"导的转录抑制性染色质状态是一种重要的表观遗传调 控机制, 精细调控发育基因的正确时空表达和细胞的 命运决定, 其失调导致肿瘤等多种疾病. PcG蛋白往 往形成复合物调控组蛋白修饰 , 其中PRC1催化 H2AK119单泛素化(H2AK119ub1), PRC2催化H3K27 甲基化(H3K27me), PR-DUB去除H2AK119ub1. 目 前, PRC1和PRC2的作用机制和结构学基础已经比较 清楚, 而对PR-DUB还知之甚少. H2AK119ub1修饰是发现最早的一类组蛋白修饰, 对于募集PRC2、沉积H3K27me3、增强PRC稳定性以 及抑制性染色质高级结构形成均不可或缺 . PR-DUB 通过拮抗PRC1酶活性, 限制基因组的H2AK119ub1分 布和水平, 从而防止活性基因被沉默, 也确保PRC1 能在多梳染色质域内稳定地发挥抑制作用 . 哺乳动 物PR-DUB复合物通过由BAP1和辅助蛋白如HCFC1 和FOXK1/2组成的多蛋白核心与ASXL1/2或3结合. 其中BAP1是泛素水解酶, 但其酶活性依赖与ASXL蛋 白的DEUBAD结构域结合. 以游离组蛋白和肽为底 物时, PR-DUB可以不加区分地去泛素化, 但其对核小 体底物的催化活性却是H2AK119特异的. 此前, 通过 果蝇PR-DUB的晶体结构解析, Müller团队发现了 ASX增加BAP1果蝇同源物Calypso的泛素亲和力以介 导激活的机制, 其中Calypso ULD-Asx DEU相互作用 而形成一个完整的泛素结合口袋, 但是仍然缺乏对结 合核小体底物的PR-DUB的结构分析, 决定核小体依 赖的H2AK119ub特异去除的因素尚不清楚. 近日, 中国科学院生物物理研究所许瑞明、朱冰","PeriodicalId":61900,"journal":{"name":"中国科学(生命科学)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44815531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
宿主细胞骨架与内膜网络重构调控病毒复制 宿主细胞骨架与内膜网络重构调控病毒复制
中国科学(生命科学) Pub Date : 2023-07-01 DOI: 10.1360/ssv-2023-0107
Yaming Jiu, Yue Zhang, Xuedi Gao
{"title":"宿主细胞骨架与内膜网络重构调控病毒复制","authors":"Yaming Jiu, Yue Zhang, Xuedi Gao","doi":"10.1360/ssv-2023-0107","DOIUrl":"https://doi.org/10.1360/ssv-2023-0107","url":null,"abstract":"","PeriodicalId":61900,"journal":{"name":"中国科学(生命科学)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42837140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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