TMR生命研究最新文献

{"title":"Current status and future challenges with Coronavirus (COVID-19): an update on vaccines","authors":"K. Rakesh, Shriya Gupta, Anant Gupta","doi":"10.53388/lr20230001","DOIUrl":"https://doi.org/10.53388/lr20230001","url":null,"abstract":"","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70813800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIV-associated neurocognitive disorder (HAND): a review study","authors":"Pedram Bolbolizade, Fatemeh Zahra Seyed-Kolbadi, Nasrin Davari-Dolatabadi, F. Zamani, Faezeh Mirshahi","doi":"10.53388/lr20230002","DOIUrl":"https://doi.org/10.53388/lr20230002","url":null,"abstract":"","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70813879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influencing factors of fatigue in young and middle-aged patients with coronary heart disease: a cross-sectional study","authors":"","doi":"10.53388/lr20230009","DOIUrl":"https://doi.org/10.53388/lr20230009","url":null,"abstract":"","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70814371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacognostic characters of Albizia lebbeck (L.) Benth. leaves: macroscopy, microscopy, and phytochemical analysis","authors":"Ogochukwu Immaculate Obika, I. E. Obika","doi":"10.53388/lr20230012","DOIUrl":"https://doi.org/10.53388/lr20230012","url":null,"abstract":"Background: Albizia lebbeck (L.) Benth, a medium to large tree belonging to the family Fabaceae, is commonly used as a medicinal plant for various disease conditions. Aim: The aim of this study was to establish a pharmacognostical profile for the leaves of Albizia lebbeck (L.) Benth in order to aid its identification and authentication. Method: Standard macroscopic methods were employed to analyze the physical parameters of the Albizia lebbeck (L.) Benth leaves. Fresh leaf samples and dried leaf powder were studied under a microscope to reveal the plant’s microscopic features. Preliminary phytochemical investigation of the plant material was also conducted using standard methods. Result: The results showed the presence of fibers, epidermal cells, stomata, sclereids, prismatic crystals, vascular bundles, and parenchyma cells. Preliminary phytochemical analysis revealed the presence of phenols, flavonoids, glycocides, terpenes, tannins, saponins, carbohydrates, and quinones. Conclusion: These pharmacognostical and preliminary phytochemical observations can be considered as standard for future studies.","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70814712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on feeding habits and stomach fungi in Eothenomys miletus from Hengduan mountain regions","authors":"Bo Yan, Wan-long Zhu","doi":"10.53388/lr20230011","DOIUrl":"https://doi.org/10.53388/lr20230011","url":null,"abstract":"Eothenomys miletus ( E. miletus ) is one of the rodent species found in Yunnan, and it has caused significant harm to local agricultural production. In this study, we aimed to investigate the differences in feeding habits and stomach fungi of E. miletus across different areas in the Hengduan mountain regions. By exploring the main factors affecting the feeding habits and fungi of E. miletus , this study provides a theoretical basis for the prevention and control of this species. We collected E. miletus specimens from five regions, namely Deqin, Xianggelila, Lijiang, Jianchuan, and Ailaoshan. We measured their feeding habits and the types of fungi in their stomachs using high-throughput sequencing technology. The results showed that E. miletus primarily fed on Poaceae, Oxalidaceae, Asteraceae, and Fabaceae. Food diversity of E. miletus in Ailaoshan and Jianchuan was significantly lower than in the other three regions. As for stomach fungi, Ascomycota and Basidiomycota were the absolute dominant sectors. Changes in the diversity of fungi in different regions were consistent with changes in food diversity. The diversity of fungi in Ailaoshan and Jianchuan regions was lower than in the other three regions. These findings suggest that the feeding habits of E. miletus in different regions were affected by plant species, which, in turn, affects the diversity of fungi in their stomachs.","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70814481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bai Hu Ren Shen Soup promotes autophagy in the pancreas tissue of diabetic rats by increasing the level of autophagy protein LC3 and decreasing the level of autophagy protein p62","authors":"Shu-Quan Lv, Baochao Pan, Bin Yao, T. Tian, Xiu-hai Su, Shu-fang Zhang, Hanzhou Li, Wen-juan Sun, Tian-Yu Zhang, Hui Zhang","doi":"10.53388/lr20230003","DOIUrl":"https://doi.org/10.53388/lr20230003","url":null,"abstract":"","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70813941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal Microbiome and related metabolites in Depression and Antidepressants - a comprehensive review","authors":"Yanyan Lu, Tao Jiang, Jia-jia Duan","doi":"10.53388/lr20230016","DOIUrl":"https://doi.org/10.53388/lr20230016","url":null,"abstract":"Depression, a prevalent mood disorder, has emerged as a significant health concern in society. While the exact cause of depression remains incompletely understood, there is substantial evidence linking the gastrointestinal microbiome and its metabolites to this condition. Through combined multi-omics analysis, it has been observed that the composition of the gastrointestinal microbiome, including Firmicutes , Bacteroidetes , and Actinobacteria , undergoes significant alterations in depressed individuals. Moreover, the production of short-chain fatty acids, tryptophan, and bile acids by these gut microbes is also found to be modified in depression. Furthermore, studies have demonstrated that antidepressant medications exert their therapeutic effects by interacting with the gastrointestinal microbiome and their metabolites. This review provides an overview of the association between the gastrointestinal microbiome, related metabolites, and depression. It highlights the potential of these factors to serve as mechanisms of action for antidepressant medications. Additionally, the review summarizes the commonly used technical tools in depression research.","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70814464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk behaviours associated with HIV and AIDS among couples in Rwamiko Sector, Gicumbi District, Rwanda","authors":"Jean Marie Vianney Tuyisenge, E. Rutayisire","doi":"10.53388/lr20230017","DOIUrl":"https://doi.org/10.53388/lr20230017","url":null,"abstract":"Background: Risk behaviours have been linked to the spread of the Human Immunodeficiency Virus (HIV) epidemic in both urban and rural areas. Despite the progress made in the fight against HIV, it remains a public health concern worldwide. Risk behaviours such as not using condoms, having multiple sexual partners, and engaging in early sexual activity increase the risk of HIV infection. Therefore, it is important to assess these risk behaviours and understand the relationship between different factors and HIV, specifically among couples, in order to better understand the dynamics of the epidemic. The main objective of this study was to assess risk behaviours for HIV and AIDS among couples in Rwamiko sector, Gicumbi District, and suggest appropriate interventions for this group. Methods: This cross-sectional survey aimed to assess associated HIV and AIDS risk behaviours among couples in Rwamiko Sector, Gicumbi District, in order to determine the dynamics of the epidemic in this group and suggest appropriate interventions. Data was collected using a self-administered questionnaire and a multistage cluster random sampling technique. The collected data was then computed, analyzed, and presented in the form of tables and figures. Descriptive statistics were used to analyze all variables. Multivariate logistic regression was used to calculate odds ratios and 95% confidence intervals (CI) to investigate the relationship between the assessed factors, such as independent and dependent variables. The association between the studied factors was described using odds ratios with 95% CIs. Results: The majority of respondents were in the age group of 30–39 years. All respondents were married, and approximately 45% had completed primary education. The majority of respondents were unemployed. Respondents reported receiving HIV information from multiple sources, including radio, TV, films, school, church, health workers, parents, and friends. The findings of this study showed that some participants had knowledge about HIV transmission and prevention, while others did not. The proportion of respondents with a high level of HIV and AIDS knowledge was 30.61% (n = 60), while moderate knowledge accounted for 53.57% (n = 105). Furthermore, the proportion of respondents with a low level of knowledge on HIV and AIDS was 15.81% (n = 31). The attitude towards HIV and AIDS was positive for 58.16% (n = 114) of respondents, while 41.83% (n = 82) had a negative attitude. None of the respondents reported using injection drugs. Significant associations were found between age ( P -value = 0.002, odds ratio (OR) = 3.4, 95% CI = 1.59–7.67), gender (p=0.001, OR=2.6, 95% CI=1.44–4.68), and alcohol consumption. There was also an association between age ( P = 0.001, OR = 5.13, 95% CI = 2.04–12.91) and having multiple sexual partners. Conclusion: The majority of couples in Rwamiko Sector, Gicumbi District have a moderate level of knowledge and a positive attitude towards HIV and AIDS. How","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70814517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiological signal processing in heart rate variability measurement: A focus on spectral analysis","authors":"Amin Gasmi","doi":"10.53388/lr20220030","DOIUrl":"https://doi.org/10.53388/lr20220030","url":null,"abstract":"Feelings and emotions are significant determinants of the behavior of an individual. Human emotions can be established and recognized through several approaches, such as facial images, gesture, neuroimaging methods, and psychological signals [1]. The human body produces many physiological signals. These physiological signals can be categorized into eight major groups; the flow of body fluids, pressure, dimensions (e.g., imaging), biopotential, temperature, impendence, and chemical concentration and composition. Due to the importance of these signals in the human body, it is of great significance that these signals be accessible for monitoring [2].","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45083313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperhomocysteinemia dysregulates plasma levels of polyunsaturated fatty acids-derived eicosanoids.","authors":"Mohamed Al-Shabrawey, Ahmed Elmarakby, Yara Samra, Mohamed Moustafa, Stephen W Looney, Krishna Rao Maddipati, Amany Tawfik","doi":"10.53388/2022-0106-103","DOIUrl":"10.53388/2022-0106-103","url":null,"abstract":"<p><p>Hyperhomocysteinemia (HHcy) contributes to the incidence of many cardiovascular diseases (CVD). Our group have previously established crucial roles of eicosanoids and homocysteine in the incidence of vascular injury in diabetic retinopathy and renal injury. Using cystathionine-β-synthase heterozygous mice (cβs^+/-) as a model of HHcy, the current study was designed to determine the impact of homocysteine on circulating levels of lipid mediators derived from polyunsaturated fatty acids (PUFA). Plasma samples were isolated from wild-type (WT) and cβs^+/- mice for the assessment of eicosanoids levels using LC/MS. Plasma 12/15-lipoxygenase (12/15-LOX) activity significantly decreased in cβs^+/- vs. WT control mice. LOX-derived metabolites from both omega-3 and omega-6 PUFA were also reduced in cβs^+/- mice compared to WT control (<i>P</i> < 0.05). Contrary to LOX metabolites, cytochrome P450 (CYP) metabolites from omega-3 and omega-6 PUFA were significantly elevated in cβs^+/- mice compared to WT control. Epoxyeicosatrienoic acids (EETs) are epoxides derived from arachidonic acid (AA) metabolism by CYP with anti-inflammatory properties and are known to limit vascular injury, however their physiological role is limited by their rapid degradation by soluble epoxide hydrolase (sEH) to their corresponding diols (DiHETrEs). In cβs^+/- mice, a significant decrease in the plasma EETs bioavailability was obvious as evident by the decrease in EETs/ DiHETrEs ratio relative to WT control mice. Cyclooxygenase (COX) metabolites were also significantly decreased in cβs^+/- vs. WT control mice. These data suggest that HHcy impacts eicosanoids metabolism through decreasing LOX and COX metabolic activities while increasing CYP metabolic activity. The increase in AA metabolism by CYP was also associated with increase in sEH activity and decrease in EETs bioavailability. Dysregulation of eicosanoids metabolism could be a contributing factor to the incidence and progression of HHcy-induced CVD.</p>","PeriodicalId":61869,"journal":{"name":"TMR生命研究","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40685688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}