现代药物与临床最新文献

{"title":"Using \"compartment model\" dynamics to understand the transmission regularity of coronavirus disease 2019 (COVID-19) during the outbreak period","authors":"Chang Liu","doi":"10.7501/j.issn.1674-5515.2020.04.001","DOIUrl":"https://doi.org/10.7501/j.issn.1674-5515.2020.04.001","url":null,"abstract":"Since the outbreak of coronavirus disease 2019 (COVID-19) on a large scale in late January 2020, the relevant reports of COVID-19 dynamics modeling found that it was very important to establish an appropriate data collection system and scientifically deal with massive information for epidemic control. No matter in theory or in practice, the transmission and treatment of virus infected persons with the kind of nonlinear epidemic diseases are affected by various factors, multiple levels, and different prevention and control measures. After confirming the transmission route of \"human-to-human transmission\", the data change rules of confirmed cases and new cases of infectious population in China and in the early stage of the outbreak I - 40 d after the closure of Wuhan were analyzed. China has quickly adopted measures to control the spread of the virus, such as \"city closure\", \"isolation\", and \"wearing masks\", and has achieved phased success. In order to scientifically determine the degree of harm of infectious diseases, a simplified \"two-compartment\" model of \"transmission phase\" and \"disposition phase\" is proposed and analyzed based on domestic and international epidemic data. It is more practical to study the speed of virus transmission and the dynamics analysis to control the outbreak. Acceding to data from the Global Epidemic l'invonian Consulting Center and WHO. the growth Me 041 and doubling time of the total number of confirmed caws and the number of confirmed cases from the two sources have little change. The study found that the global propagation doubling time is significantly shorter than 6.27 - 7.03 d in China. indicating that the global propagation rate is significantly higher than that in China. K. fir and atonality rate of the total number of confined eases in Italy. Spain. and Iran are obviously different from the global data. The special mortality:ate is significantly higher than the global level, with 9.576s. 6.59%. and 7. Sets respectively. which is alined twice that of the world. Therefore. the study believes that it is the key to deal with the transmission pathway and could of the transmission rate.","PeriodicalId":60587,"journal":{"name":"现代药物与临床","volume":"35 1","pages":"597-606"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71345431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress on diagnosis and treatment technology based on structural protein of SARS-CoV-2","authors":"Tianhan Yang","doi":"10.7501/j.issn.1674-5515202005041","DOIUrl":"https://doi.org/10.7501/j.issn.1674-5515202005041","url":null,"abstract":"A review In recent years, coronavirus infections have occurred frequently, causing huge losses to humans The new coronavirus (SARS-CoV-2) not only spread rapidly, but is also lethal It has now constituted a global pandemic, resulting in the death of hundreds of thousands of people Therefore, the timely diagnosis and treatment of new coronavirus is very important Since coronavirus structural proteins play an important role in the process of viral replication, infection and transmission The research progress on diagnostic, therapeutic and prevention technologies based on this new coronavirus structural proteins S, E, M, and N is reviewed in this paper, in order to better understand the pathogenic mechanism of coronavirus as well as provide strong support for clin detection, drug development, and vaccine preparation","PeriodicalId":60587,"journal":{"name":"现代药物与临床","volume":"35 1","pages":"1015-1023"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71345287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress on potential application of chalcone and its derivatives in prevention and treatment of coronavirus disease 2019 (COVID-2019)","authors":"Qingli Fang","doi":"10.7501/j.issn.1674-5515.2020.04.004","DOIUrl":"https://doi.org/10.7501/j.issn.1674-5515.2020.04.004","url":null,"abstract":"Since the occurrence of coronavirus diseaseZOl9, the epidemic has progressed rapidly and seriously that threatened people's health. At present, there is no specific drug for its treatment in clinic, and most of them are symptomatic treatment, mainly to delay the body damage caused by the new coronavirus, and it is urgent to find a safe and effective drug. Chalcone and its derivatives have a wide range of pharmacological effects, such as antiviral, antibacterial, and anti-inflammatory, antioxidant, anti-fibrosis. The pharmacological action and mechanism of chalcone and its derivatives are mainly summarized, and the feasibility of its application in the prevention and treatment of coronavirus disease 2019 is discussed, which may provide reference for clinical treatment. Key words: chalcone and its derivatives;coronavirus disease 2019 (COVID-2019);antiviral;anti-inflammatory;anti fibrosis.","PeriodicalId":60587,"journal":{"name":"现代药物与临床","volume":"35 1","pages":"620-624"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71345439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress on potential application of gualou xiebai banxia decoction in prevention and treatment of COVID-19","authors":"Lingge He","doi":"10.7501/j.issn.1674-5515.2020.05.042","DOIUrl":"https://doi.org/10.7501/j.issn.1674-5515.2020.05.042","url":null,"abstract":"Since December 2019, COVID-19 cases have appeared in many parts Ofthe world and the number has soared. The epidemic situation is very serious. With the participation ot'traditional Chinese medicine in China, the epidemic prevention and control effect is remarkable, highlighting the unique advantages of traditional Chinese medicine. The symptoms of severe COVID-19 are very consistent with that of chest discomfort in Chinese medicine. Gualou Xiebai Banxia decoction is the first choice for the treatment of chest discomfort. In the diagnosis and treatment programs of COVID-19 in various provinces and cities, it has been recommended to add or subtracted Gualou Xiebai Banxia decoction. In clinical practice, XiangYang Hospital of Traditional Chinese and Western Medicine has added or subtracted Gualou Xiebai Banxia decoction to cure many patients with COVID-19. The modern pharmacological effects in Gualou Xiebai Banxia decoction are reviewed in this paper. to provide theoretical basis for its prevention and treatment of COVID-19, and to provide clinical reference for the later treatment of COVID-19.","PeriodicalId":60587,"journal":{"name":"现代药物与临床","volume":"35 1","pages":"1024-1027"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71345449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}