Research progress on potential application of chalcone and its derivatives in prevention and treatment of coronavirus disease 2019 (COVID-2019)

Since the occurrence of coronavirus diseaseZOl9, the epidemic has progressed rapidly and seriously that threatened people's health. At present, there is no specific drug for its treatment in clinic, and most of them are symptomatic treatment, mainly to delay the body damage caused by the new coronavirus, and it is urgent to find a safe and effective drug. Chalcone and its derivatives have a wide range of pharmacological effects, such as antiviral, antibacterial, and anti-inflammatory, antioxidant, anti-fibrosis. The pharmacological action and mechanism of chalcone and its derivatives are mainly summarized, and the feasibility of its application in the prevention and treatment of coronavirus disease 2019 is discussed, which may provide reference for clinical treatment. Key words: chalcone and its derivatives;coronavirus disease 2019 (COVID-2019);antiviral;anti-inflammatory;anti fibrosis.