Journal of Biological Inorganic Chemistry最新文献

{"title":"Effects of the tetravanadate [V4O12]4− anion on the structural, magnetic, and biological properties of copper/phenanthroline complexes","authors":"Eduardo Sánchez-Lara,&nbsp;Roberto Favela,&nbsp;Kitze Tzian,&nbsp;Brian Monroy-Torres,&nbsp;Adriana Romo-Pérez,&nbsp;María Teresa Ramírez-Apan,&nbsp;Marcos Flores-Alamo,&nbsp;Antonio Rodríguez-Diéguez,&nbsp;Javier Cepeda,&nbsp;Ivan Castillo","doi":"10.1007/s00775-023-02035-9","DOIUrl":"10.1007/s00775-023-02035-9","url":null,"abstract":"<div><p>The aim to access linked tetravanadate [V₄O₁₂]⁴⁻ anion with mixed copper(II) complexes, using <i>α</i>-amino acids and phenanthroline-derived ligands, resulted in the formation of four copper(II) complexes [Cu(dmb)(Gly)(OH₂)]₂[Cu(dmb)(Gly)]₂[V₄O₁₂]·9H₂O (<b>1</b>) [Cu(dmb)(Lys)]₂[V₄O₁₂]·8H₂O (<b>2</b>), [Cu(dmp)₂][V₄O₁₂]·C₂H₅OH·11H₂O (<b>3</b>), and [Cu(dmp)(Gly)Cl]·2H₂O (<b>4</b>), where dmb = 4,4′-dimethioxy-2,2′-bipyridine; Gly = glycine; Lys = lysine; and dmp = 2,9-dimethyl-1,10-phenanthroline. The [V₄O₁₂]⁴⁻ anion is functionalized with mixed copper(II) units in <b>1</b> and <b>2</b>; while in <b>3</b>, it acts as a counterion of two [Cu(dmp)]²⁺ units. Compound <b>4</b> crystallized as a unit that did not incorporate the vanadium cluster. All compounds present magnetic couplings arising from Cu⋯O/Cu⋯Cu bridges. Stability studies of water-soluble <b>3</b> and <b>4</b> by UV–Vis spectroscopy in cell culture medium confirmed the robustness of <b>3</b>, while <b>4</b> appears to undergo ligand scrambling over time, resulting partially in the stable species [Cu(dmp)₂]⁺ that was also identified by electrospray ionization mass spectrometry at <i>m</i>/<i>z</i> = 479. The in vitro cytotoxicity activity of <b>3</b> and <b>4</b> was determined in six cancer cell lines; the healthy cell line COS-7 was also included for comparative purposes. MCF-7 cells were more sensitive to compound <b>3</b> with an IC₅₀ value of 12 ± 1.2 nmol. The tested compounds did not show lipid peroxidation in the TBARS assay, ruling out a mechanism of action via reactive oxygen species formation. Both compounds inhibited cell migration at 5 µM in wound-healing assays using MCF-7, PC-3, and SKLU-1 cell lines, opening a new window to study the anti-metastatic effect of mixed vanadium–copper(II) systems.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":603,"journal":{"name":"JBIC Journal of Biological Inorganic Chemistry","volume":"29 1","pages":"139 - 158"},"PeriodicalIF":2.7,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11001746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139085429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The deposition of lanthanum carbonate may activate macrophages to induce gastrointestinal mucosal injury in patients with chronic kidney disease: an in vitro caco-2/THP-1 macrophage coculture model study","authors":"Ya-Ju Song,&nbsp;Hui-Xue Liu,&nbsp;Xiao-Gai Yang","doi":"10.1007/s00775-023-02033-x","DOIUrl":"10.1007/s00775-023-02033-x","url":null,"abstract":"<div><p>The aim of this study was to investigate the effect and possible underlying mechanism of La₂(CO₃)₃ deposition on GI mucosal inflammation. Our results showed that La₂(CO₃)₃ can dissolve in artificial gastric fluids and form lanthanum phosphate (LaPO₄) precipitates with an average size of about 1 μm. To mimic the intestinal mucosa and epithelial barrier, we established a Caco-2/THP-1 macrophage coculture model and a Caco-2 monoculture model, respectively. Our findings demonstrated that the medium of THP-1 macrophages stimulated by LaPO₄ particles can damage the Caco-2 monolayer integrity in the coculture model, while the particles themselves had no direct impact on the Caco-2 monolayer integrity in the monoculture model. We measured values of trans-epithelial electrical resistance and detected images using a laser scanning confocal microscope. These results indicate that continuous stimulation of LaPO₄ particles on macrophages can lead to a disruption of intestinal epithelium integrity. In addition, LaPO₄ particles could stimulate THP-1 macrophages to secrete both IL-1β and IL-8. Although LaPO₄ particles can also promote Caco-2 cells to secrete IL-8, the secretion was much lower than that produced by THP-1 macrophages. In summary, the deposition of La₂(CO₃)₃ has been shown to activate macrophages and induce damage to intestinal epithelial cells, which may exacerbate inflammation in patients with chronic kidney disease. Therefore, patients taking lanthanum carbonate, especially those with gastrointestinal mucosal inflammation, should be mindful of the potential for drug deposition in the GI system.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div><p>A schematic diagram of the effect and possible underlying mechanism of the deposition of La₂(CO₃)₃ on GI mucosal inflammation. </p></div>","PeriodicalId":603,"journal":{"name":"JBIC Journal of Biological Inorganic Chemistry","volume":"29 1","pages":"101 - 112"},"PeriodicalIF":2.7,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139039323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Desulfurization of thiosemicarbazones: the role of metal ions and biological implications","authors":"Alondra Jiménez-Pérez,&nbsp;Sandra Fernández-Fariña,&nbsp;Rosa Pedrido,&nbsp;Javier García-Tojal","doi":"10.1007/s00775-023-02037-7","DOIUrl":"10.1007/s00775-023-02037-7","url":null,"abstract":"<div><p>Thiosemicarbazones are biologically active substances whose structural formula is formed by an azomethine, an hydrazine, and a thioamide fragments, to generate a R₂C=N–NR–C(=S)–NR₂ backbone. These compounds often act as ligands to generate highly stable metal–organic complexes. In certain experimental conditions, however, thiosemicarbazones undergo reactions leading to the cleavage of the chain. Sometimes, the breakage involves desulfurization processes. The present work summarizes the different chemical factors that influence the desulfurization reactions of thiosemicarbazones, such as pH, the presence of oxidant reactants or the establishment of redox processes as those electrochemically induced, the effects of the solvent, the temperature, and the electromagnetic radiation. Many of these reactions require coordination of thiosemicarbazones to metal ions, even those present in the intracellular environment. The nature of the products generated in these reactions, their detection in vivo and in vitro, together with the relevance for the biological activity of these compounds, mainly as antineoplastic agents, is discussed.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":603,"journal":{"name":"JBIC Journal of Biological Inorganic Chemistry","volume":"29 1","pages":"3 - 31"},"PeriodicalIF":2.7,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139039322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, crystal structures, and biological activity of aroylhydrazone di-m-chlorobenzyltin complexes","authors":"Wujiu Jiang,&nbsp;Pengfei Zhou,&nbsp;Le Chen,&nbsp;Weiwei Fu,&nbsp;Yuxing Tan","doi":"10.1007/s00775-023-02038-6","DOIUrl":"10.1007/s00775-023-02038-6","url":null,"abstract":"<div><p>Six aroylhydrazone di-<i>m</i>-chlorobenzyltin complexes {[X-C₆H₄(O)C=N–N=C(Me)COO](MeOH)(<i>m</i>-Cl-C₆H₄CH₂)₂Sn}₂ (X = <i>p</i>-Me- (<b>1</b>), <i>p</i>-MeO- (<b>2</b>), <i>p</i>–<i>t</i>-Bu- (<b>3</b>), <i>p</i>-NO₂- (<b>4</b>), <i>p</i>-OH- (<b>5</b>) or <i>o</i>-OH- (<b>6</b>)) were synthesized and characterized by HRMS (high-resolution mass spectrometry), NMR (nuclear magnetic resonance spectroscopy), IR (Fourier transform infrared spectroscopy), and TGA (thermogravimetric analysis) techniques. The molecular structure of complexes <b>1</b>–<b>6</b> was confirmed by single-crystal X-ray crystallography. The structure of complexes showed a distorted pentagonal bipyramidal configuration around the tin atom center, and the ligands adopted a tridentate chelating mode. Fascinatingly, either one-dimensional infinite chain structures or two-dimensional network structures were observed in the complexes through hydrogen bonds. Complex <b>2</b> has the strongest inhibitory effect on MCF7 and HepG2 cell proliferation, its effect was superior to that of the positive control drug cisplatin. The interaction of ct-DNA (calf-thymus DNA) with complex <b>2</b> was explored using UV absorption (ultraviolet absorption) and fluorescence spectroscopy. Complex <b>2</b> exhibited a moderate affinity for ct-DNA through intercalation modes. The interaction of complex <b>2</b> with ct-DNA has also been supported by molecular docking studies.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":603,"journal":{"name":"JBIC Journal of Biological Inorganic Chemistry","volume":"29 1","pages":"87 - 99"},"PeriodicalIF":2.7,"publicationDate":"2023-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138883845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive apatite–wollastonite glass ceramics coating on metallic titanium for biomedical applications: effect of boron","authors":"Eren Yılmaz,&nbsp;Serbülent Türk,&nbsp;Alican Bahadır Semerci,&nbsp;Mine Kırkbınar,&nbsp;Erhan İbrahimoğlu,&nbsp;Fatih Çalışkan","doi":"10.1007/s00775-023-02032-y","DOIUrl":"10.1007/s00775-023-02032-y","url":null,"abstract":"<div><p>Metallic titanium (Ti) implant surfaces need improvement for bioproperties and antibacterial behavior. For this purpose, a new boron-doped bioactive apatite–wollastonite (AW) coating was successfully developed on the Ti plate surface. The effects of boron addition on the microstructure, mechanical properties, and bioproperties of the AW coating were investigated. With the addition of boron (B), the AW coating morphology became less porous and compact. In terms of bio properties, the rate of apatite formation increased with the addition of B, and the cell viability rate increased from approximately 66–81%. B addition increased the elastic modulus of the AW coating from about 24–46 GPa and increased its hardness about 2.5 times. In addition, while no antibacterial activity was observed in the AW coating, the addition of boron slightly introduced antibacterial properties. The novel AW/B composite coating obtained is promising for Ti implant surfaces.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":603,"journal":{"name":"JBIC Journal of Biological Inorganic Chemistry","volume":"29 1","pages":"75 - 85"},"PeriodicalIF":2.7,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138821612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-toxoplasma activity and DNA-binding of copper(II) and zinc(II) coordination compounds with 5-nitroimidazole-based ligands","authors":"Rubí Navarro-Peñaloza,&nbsp;Jhony Anacleto-Santos,&nbsp;Norma Rivera-Fernández,&nbsp;Francisco Sánchez-Bartez,&nbsp;Isabel Gracia-Mora,&nbsp;Ana B. Caballero,&nbsp;Patrick Gamez,&nbsp;Norah Barba-Behrens","doi":"10.1007/s00775-023-02029-7","DOIUrl":"10.1007/s00775-023-02029-7","url":null,"abstract":"<div><p>Tetrahedral copper(II) and zinc(II) coordination compounds from 5-nitroimidazole derivatives, viz<i>.</i> 1-(2-chloroethyl)-2-methyl-5-nitroimidazole (cenz) and ornidazole 1-(3-chloro-2-hydroxypropyl)-2-methyl-5-nitroimidazole (onz), were synthesized and spectroscopically characterized. Their molecular structures were determined by X-ray diffraction studies. The complexes [Cu(onz)₂X₂], [Zn(onz)₂X₂], [Cu(cenz)₂X₂] and [Zn(cenz)₂X₂] (X⁻ = Cl, Br), are stable in solution and exhibit positive LogD_7.4 values that are in the range for molecules capable of crossing the cell membrane via passive difussion. Their biological activity against <i>Toxoplasma gondi</i> was investigated, and IC₅₀ and lethal dose (LD₅₀) values were determined. The ornidazole copper(II) compounds showed very good antiparasitic activity in its tachyzoite morphology. The interaction of the coordination compounds with DNA was examined by circular dichroism, fluorescence (using intercalating ethidium bromide and minor groove binding Hoechst 33258) and UV–Vis spectroscopy. The copper(II) compounds interact with the minor groove of the biomolecule, whereas weaker electrostatic interactions take place with the zinc(II) compounds. The spectroscopic data achieved for the two series of complexes (namely with copper(II) and zinc(II) as metal center) agree with the respective DNA-damage features observed by gel electrophoresis.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":603,"journal":{"name":"JBIC Journal of Biological Inorganic Chemistry","volume":"29 1","pages":"33 - 49"},"PeriodicalIF":2.7,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00775-023-02029-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138686679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization, modes of interactions with DNA/BSA biomolecules and anti-tumor activity of newly synthesized dinuclear platinum(II) complexes with pyridazine bridging ligand","authors":"Sanja Zornić,&nbsp;Bojana Simović Marković,&nbsp;Andjela A. Franich,&nbsp;Goran V. Janjić,&nbsp;Milka B. Jadranin,&nbsp;Jelena Avdalović,&nbsp;Snežana Rajković,&nbsp;Marija D. Živković,&nbsp;Nebojša N. Arsenijević,&nbsp;Gordana D. Radosavljević,&nbsp;Jelena Pantić","doi":"10.1007/s00775-023-02030-0","DOIUrl":"10.1007/s00775-023-02030-0","url":null,"abstract":"<div><p>Platinum-based drugs are widely recognized efficient anti-tumor agents, but faced with multiple undesirable effects. Here, four dinuclear platinum(II) complexes, [{Pt(1,2-pn)Cl}₂(<i>μ</i>-pydz)]Cl₂ (<b>C1</b>), [{Pt(ibn)Cl}₂(<i>μ</i>-pydz)]Cl₂ (<b>C2</b>), [{Pt(1,3-pn)Cl}₂(<i>μ</i>-pydz)]Cl₂ (<b>C3</b>) and [{Pt(1,3-pnd)Cl}₂(<i>μ</i>-pydz)]Cl₂ (<b>C4</b>), were designed (pydz is pyridazine, 1,2-pn is ( ±)-1,2-propylenediamine, ibn is 1,2-diamino-2-methylpropane, 1,3-pn is 1,3-propylenediamine, and 1,3-pnd is 1,3-pentanediamine). Interactions and binding ability of <b>C1</b>–<b>C4</b> complexes with calf thymus DNA (CT-DNA) has been monitored by viscosity measurements, UV–Vis, fluorescence emission spectroscopy and molecular docking. Binding affinities of <b>C1</b>–<b>C4</b> complexes to the bovine serum albumin (BSA) has been monitored by fluorescence emission spectroscopy. The tested complexes exhibit variable cytotoxicity toward different mouse and human tumor cell lines. <b>C2</b> shows the most potent cytotoxicity, especially against mouse (4T1) and human (MDA-MD468) breast cancer cells in the dose- and time-dependent manner. <b>C2</b> induces 4T1 and MDA-MD468 cells apoptosis, further documented by the accumulation of cells at sub-G1 phase of cell cycle and increase of executive caspase 3 and caspase 9 levels in 4T1 cells. <b>C2</b> exhibits anti-proliferative effect through the reduction of cyclin D3 and cyclin E expression and elevation of inhibitor p27 level. Also, <b>C2</b> downregulates c-Myc and phosphorylated AKT, oncogenes involved in the control of tumor cell proliferation and death. In order to measure the amount of platinum(II) complexes taken up by the cells, the cellular platinum content were quantified. However, <b>C2</b> failed to inhibit mouse breast cancer growth in vivo. Chemical modifications of tested platinum(II) complexes might be a valuable approach for the improvement of their anti-tumor activity, especially effects in vivo.</p><h3>Graphical abstract</h3><p>Dinuclear platinum(II) complex [{Pt(ibn)Cl}₂(<i>μ</i>-pydz)]Cl₂ shows anti-tumor activity, triggers the apoptosis and reduces the proliferation of mouse breast cancer cells in vitro. However, its inhibitory effect on tumor growth in vivo is absent.</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":603,"journal":{"name":"JBIC Journal of Biological Inorganic Chemistry","volume":"29 1","pages":"51 - 73"},"PeriodicalIF":2.7,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138686672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"6-Pyrazolylpurine and its deaza derivatives as nucleobases for silver(I)-mediated base pairing with pyrimidines","authors":"Daniela Escher,&nbsp;Tim Schäfer,&nbsp;Marian Hebenbrock,&nbsp;Jens Müller","doi":"10.1007/s00775-023-02022-0","DOIUrl":"10.1007/s00775-023-02022-0","url":null,"abstract":"","PeriodicalId":603,"journal":{"name":"JBIC Journal of Biological Inorganic Chemistry","volume":"28 8","pages":"791 - 803"},"PeriodicalIF":3.0,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138045906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gadolinium(III) complex formation with a β-cyclodextrin ligand: an XAS study of a potential MRI contrast agent","authors":"Farideh Jalilehvand,&nbsp;Saba Homayonia,&nbsp;Ping Zhang,&nbsp;Chang-Chun Ling","doi":"10.1007/s00775-023-02027-9","DOIUrl":"10.1007/s00775-023-02027-9","url":null,"abstract":"<div><p>In the search for improved and safer gadolinium-based magnetic resonance imaging (MRI) contrast agents, macrocyclic cyclodextrins (CDs) attract great interest. Our group previously synthesized a cyclodextrin-based ligand with 1,2,3-triazolmethyl residues conjugated to β-CD, called β-CD(<b>A</b>), which efficiently chelates Gd(III) ions. To probe the local structure around the Gd(III) ion in the 1:1 Gd(III): β-CD(<b>A</b>) complex in aqueous solution (pH 5.5), we used extended X-ray absorption fine structure (EXAFS) spectroscopy. Least-squares curve fitting of the Gd L₃-edge EXAFS spectrum revealed 5 Gd–O (4 COO⁻ and 1 H₂O) and 4 Gd–N (from two imino and two 1,2,3-triazole groups) bonds around the Gd(III) ion with average distances 2.36 and 2.56 ± 0.02 Å, respectively. A similar EXAFS spectrum was obtained from an aqueous solution of the clinically used MRI contrast agent Na[Gd(DOTA)(H₂O)], also 9-coordinated in its first shell. Careful analysis revealed that the mean Gd–N distance is shorter in the Gd(III): β-CD(<b>A</b>) (1:1) complex, indicating stronger Gd–N bonding and stronger Gd(III) complex formation than with the DOTA⁴⁻ ligand. This is consistent with the lower free Gd³⁺ concentration found previously for the Gd(III): β-CD(<b>A</b>) (1:1) complex than for the [Gd(DOTA)(H₂O)]^<b>−</b> complex, and shows its potential as an MRI probe.</p><h3>Graphical abstract</h3><p>EXAFS spectroscopy revealed a similar Gd(III) 9-coordination although slightly stronger for a modified β-cyclodextrin: Gd(III) 1:1 complex, [Gd(LH₄)]⁷⁻, in aqueous solution than for the clinically used MRI contrast agent Na[Gd(DOTA)(H₂O)].</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":603,"journal":{"name":"JBIC Journal of Biological Inorganic Chemistry","volume":"28 8","pages":"805 - 811"},"PeriodicalIF":3.0,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138045907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multistep synthesis of a novel copper complex with potential for Alzheimer’s disease diagnosis","authors":"Fatma Dellal,&nbsp;Diego Santo Domingo Porqueras,&nbsp;Stacy Narayanin-Richenapin,&nbsp;Marine Thimotee,&nbsp;Vanessa Delahaye,&nbsp;Yacine Diouf,&nbsp;Karolina Piasta,&nbsp;Elżbieta Gumienna-Kontecka,&nbsp;Henryk Kozlowski,&nbsp;Maryline Beyler,&nbsp;Raphael Tripier,&nbsp;Alban Moyeux,&nbsp;Olivier Gager,&nbsp;Valérie Besnard,&nbsp;Milena Salerno","doi":"10.1007/s00775-023-02028-8","DOIUrl":"10.1007/s00775-023-02028-8","url":null,"abstract":"<div><p>Positron emission tomography (PET) imaging of Aβ plaques, is recognized as a tool for the diagnosis of Alzheimer’s disease. As a contribution to the development of new strategies for early diagnosis of the disease, using PET medical imaging technique, a new copper complex, the [Cu(TE1PA-ONO)]⁺ was synthesized in ten steps. The key step of our strategy is the coupling of a monopicolinate-N-alkylated cyclam-based ligand with a moiety capable of recognizing Aβ plaques via a successful and challenging Buchwald-Hartwig coupling reaction. To our knowledge, it is the first time that such a strategy is used to functionalize polyazamacrocyclic derivatives. The thermodynamic stability constants determined in MeOH/H₂O solvent indicate that the attachment of this moiety does not weaken the chelating properties of TE1PA-ONO ligand in relation to parent HTE1PA. The novel complex described here is able to recognize amyloid plaques in brain sections from Alzheimer's disease patients and shows low toxicity to human neuronal cells.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":603,"journal":{"name":"JBIC Journal of Biological Inorganic Chemistry","volume":"28 8","pages":"777 - 790"},"PeriodicalIF":3.0,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136395678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}