药剂与药理学:英文版最新文献_第8页

Artemisia annua in the Treatment of Malaria, and as Prophylaxis in Case of Travelling to an Endemic Zone; Concerning a Clinical Case 黄花蒿治疗和预防疟疾流行的研究关于一例临床病例

药剂与药理学:英文版 Pub Date : 2022-03-28 DOI: 10.17265/2328-2150/2022.03.001

Kamto Fotso C. S., Doumani Metsim L. F., Muluh Sandra Menyin

引用次数: 0

Takotsubo Syndrome in Octogenarians and Nonagenarians. 八旬老人和非耄耋老人的塔克次氏综合征。

药剂与药理学:英文版 Pub Date : 2022-03-17 eCollection Date: 2022-04-08 DOI: 10.1253/circrep.CR-21-0158

Masahiro Ito, Tsuneo Nagai, Takayuki Inomata

引用次数: 0

Near-infrared spectroscopy and HPLC combined with chemometrics for comprehensive evaluation of six organic acids in Ginkgo biloba leaf extract. 近红外光谱、高效液相色谱结合化学计量学对银杏叶提取物中6种有机酸进行综合评价。

药剂与药理学:英文版 Pub Date : 2022-03-16 DOI: 10.1093/jpp/rgab177

Sijie Zhang, Xingchu Gong, Hai-bin Qu

{"title":"Near-infrared spectroscopy and HPLC combined with chemometrics for comprehensive evaluation of six organic acids in Ginkgo biloba leaf extract.","authors":"Sijie Zhang, Xingchu Gong, Hai-bin Qu","doi":"10.1093/jpp/rgab177","DOIUrl":"https://doi.org/10.1093/jpp/rgab177","url":null,"abstract":"OBJECTIVES\u0000To investigate the feasibility of using near-infrared spectroscopy for rapid determination of main organic acids in Ginkgo biloba leaf extract (EGBL).\u0000\u0000\u0000METHODS\u0000Main organic acids in EGBL were assayed using the HPLC method. Critical factors of the chromatographic separation were optimized by a novel analytical quality by design approach. Partial least squares-discriminant analysis (PLS-DA) was performed to screen the marker components, and principal component analysis (PCA) was utilized to distinguish the different samples. Then, spectral quantification potential was investigated using PLS and support vector machine (SVM) approaches. For modelling, different spectral preprocessing and wavelength selection methods were systematically compared.\u0000\u0000\u0000KEY FINDINGS\u0000It was found that quinic acid, protocatechuic acid and 6-hydroxykynurenic acid were identified as possible index components. PLS-DA based on contents and PCA based on near-infrared spectra can both effectively distinguish the different EGBL samples. The calibration models with wonderful prediction performance can be both developed by the PLS and SVM algorithms.\u0000\u0000\u0000CONCLUSIONS\u0000NIR spectroscopy combined with chemometrics can realize the rapid and non-destructive qualitative and quantitative analysis of EGBL. The proposed method may be applied to quality control of EGBL and other natural products in commercial use.","PeriodicalId":59706,"journal":{"name":"药剂与药理学:英文版","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61684300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A review on the ethnopharmacology, phytochemistry and pharmacology of Polygonum hydropiper Linn. 红蓼民族药理学、植物化学及药理研究进展。

药剂与药理学:英文版 Pub Date : 2022-03-08 DOI: 10.1093/jpp/rgab175

Juli Bairagi, P. Saikia, Freeman Boro, A. Hazarika

{"title":"A review on the ethnopharmacology, phytochemistry and pharmacology of Polygonum hydropiper Linn.","authors":"Juli Bairagi, P. Saikia, Freeman Boro, A. Hazarika","doi":"10.1093/jpp/rgab175","DOIUrl":"https://doi.org/10.1093/jpp/rgab175","url":null,"abstract":"OBJECTIVES\u0000Polygonum hydropiper is a herb with worldwide distribution, having tremendous value as traditional medicine among different communities. It is used to cure many kinds of ailments such as gynaecological disorders, ulcer, anxiety, pain, cancer, etc. The present review gives emphasis on a thorough and updated study of the botanical description and taxonomy, distribution, habitat, ethnopharmacology, phytochemical constituents, pharmacological activities and toxicological aspects of P. hydropiper.\u0000\u0000\u0000METHODS\u0000The information included in this review was collected from different scientific databases like PubMed, ScienceDirect, Google Scholar, etc. In addition to the botanical description and taxonomy, lots of ethnomedicinal use of the water-pepper plant could be found.\u0000\u0000\u0000RESULT\u0000A good number of compounds belonging to the categories like alkaloids, carbohydrates, flavonoids, etc. were confirmed to be present in the plant. Moreover, in different studies, this plant was found to possess activities like anti-Alzheimer, antibacterial, antidementia, antifertility, neuropharmacological, sedative, anxiolytic, thrombolytic and membrane-stabilizing activity, etc. with minimal toxicity.\u0000\u0000\u0000CONCLUSION\u0000These properties may be directly related to its possession of a large number of bioactive molecules of different categories. Based on these properties, isolation of responsible compound(s), evaluation of molecular mechanisms of their action and clinical trials are recommended.","PeriodicalId":59706,"journal":{"name":"药剂与药理学:英文版","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61684620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The development and optimisation of gastro-retentive floating tablets using fused deposition modelling 3D printing. 利用熔融沉积建模3D打印技术开发和优化胃保留漂浮片剂。

药剂与药理学:英文版 Pub Date : 2022-03-07 DOI: 10.1093/jpp/rgab176

Sinmisola A Oladeji, Suha M Dadou, Min Zhao, Shu Li, David S. Jones, G. Andrews

{"title":"The development and optimisation of gastro-retentive floating tablets using fused deposition modelling 3D printing.","authors":"Sinmisola A Oladeji, Suha M Dadou, Min Zhao, Shu Li, David S. Jones, G. Andrews","doi":"10.1093/jpp/rgab176","DOIUrl":"https://doi.org/10.1093/jpp/rgab176","url":null,"abstract":"OBJECTIVES\u0000To develop a robust tablet design for the manufacture of gastro-retentive tablets using fused deposition modelling three-dimensional printing (FDM-3DP) that can provide prolonged gastric residence time with instant floating and minimum influence of process and/or formulation variables.\u0000\u0000\u0000METHODS\u0000Three different polymers, such as polyvinyl alcohol (PVA), hydroxypropyl cellulose (HPC) and Soluplus were used, separately, for the manufacture of tablets using FDM-3DP. Tablets were designed in a sandwich model that included voids in the internal structure to support buoyancy.\u0000\u0000\u0000KEY FINDINGS\u0000Fabricated tablets from all polymers were instantly buoyant with no floating lag time. Floating duration was in the order: HPC > Soluplus > PVA which can be explained by the density of the tablets. PVA tablets exhibited significantly (P < 0.05) higher density values (0.86 ± 0.02 mg/mm3) than HPC and Soluplus (0.69 ± 0.03 and 0.72 ± 0.02 mg/mm3, respectively). HPC and Soluplus showed similar zero-order drug release profiles (f2 > 50) and were able to sustain the release of theophylline for 12 h, whereas complete drug release was achieved from PVA tablets after 3 h.\u0000\u0000\u0000CONCLUSIONS\u0000Robust gastro-retentive tablets that show instant buoyancy regardless of the polymeric carrier type and composition were successfully manufactured utilising FDM-3DP. This allows for overcoming the restrictions posed by process/formulation parameters on the floatability of gastro-retentive tablets.","PeriodicalId":59706,"journal":{"name":"药剂与药理学:英文版","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61684733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

In vitro and in vivo antihyperglycemic activity of the ethanol extract of Heritiera fomes bark and characterization of pharmacologically active phytomolecules. 福马树皮乙醇提取物的体外和体内降血糖活性以及药理活性植物大分子的特征。

药剂与药理学:英文版 Pub Date : 2022-03-01 DOI: 10.1093/jpp/rgac010

Prawej Ansari, Shofiul Azam, Veronique Seidel, Yasser H A Abdel-Wahab

{"title":"In vitro and in vivo antihyperglycemic activity of the ethanol extract of Heritiera fomes bark and characterization of pharmacologically active phytomolecules.","authors":"Prawej Ansari, Shofiul Azam, Veronique Seidel, Yasser H A Abdel-Wahab","doi":"10.1093/jpp/rgac010","DOIUrl":"10.1093/jpp/rgac010","url":null,"abstract":"Objective: This study aimed to demonstrate the mechanistic basis of Heritiera fomes, which has traditionally been used to treat diabetes.Methods: Clonal pancreatic β-cells and primary islets were used to measure insulin release. 3T3-L1 cells were used to analyse insulin action, and in vitro systems were used to measure further glucose-lowering activity. In vivo assessment was performed on streptozotocin (STZ)-induced type-2 diabetic rats and reversed-phase-HPLC followed by liquid chromatography mass spectrometry (LC-MS) to detect bioactive molecules.Key findings: Ethanol extract of Heritiera fomes (EEHF) significantly increased insulin release with stimulatory effects comparable to 1 µM glucagon-like peptide 1, which were somewhat reduced by diazoxide, verapamil and calcium-free conditions. Insulin release was stimulated by tolbutamide, isobutyl methylxanthine and KCl. EEHF induced membrane depolarization and increased intracellular Ca2+ levels. EEHF enhanced glucose uptake in 3T3L1 cells and decreased protein glycation. EEHF significantly inhibited postprandial hyperglycaemia following sucrose loading and inversely elevated unabsorbed sucrose concentration in the gut. It suppressed glucose absorption during in situ gut perfusion. Furthermore, EEHF improved glucose tolerance, plasma insulin and gut motility, and decreased plasma dipeptidyl peptidase IV activity. Procyanidins, epicatechin and proanthocyanidins were some of the identified bioactive constituents that may involve in β-cell actions.Conclusions: This study provides some evidence to support the use of H. fomes as an antidiabetic traditional remedy.","PeriodicalId":59706,"journal":{"name":"药剂与药理学:英文版","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61685667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tubastatin A suppresses the proliferation of fibroblasts in epidural fibrosis through phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signalling pathway. 管司他丁 A 通过磷脂酰肌醇-3-激酶/蛋白激酶 B/哺乳动物雷帕霉素靶标（PI3K/AKT/mTOR）信号通路抑制硬膜外纤维化中成纤维细胞的增殖。

药剂与药理学:英文版 Pub Date : 2022-03-01 DOI: 10.1093/jpp/rgab106

Yang Liu, Ruihong Wang, Huimin Han, Li Li

{"title":"Tubastatin A suppresses the proliferation of fibroblasts in epidural fibrosis through phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signalling pathway.","authors":"Yang Liu, Ruihong Wang, Huimin Han, Li Li","doi":"10.1093/jpp/rgab106","DOIUrl":"10.1093/jpp/rgab106","url":null,"abstract":"Objectives: This study was designed to explore the effect of tubastatin A (Tub A) on epidural fibrosis and the underlying mechanism.Methods: Histone deacetylase 6 (HDAC6)-overexpressed fibroblasts were constructed, and the effect of Tub A on the proliferation of activated fibroblasts was detected by Cell Counting Kit-8, 5-ethynyl-2'-deoxyuridine (EdU) and cell cycle assay. Besides, 20 Sprague-Dawley rats were subjected to animal laminectomy model construction and then randomly treated with 4% dimethyl sulfoxide (DMSO) (diluted in 0.9% saline) or Tub A (10 mg/kg/day), separately. The expression of HDAC6 and phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway-related proteins was measured in epidural fibrosis tissues.Key findings: HDAC6 was overexpressed in activated fibroblasts and epidural scar tissues of rat models. Cell proliferation was remarkably elevated in HDAC6-overexpressed fibroblasts, which was reflected by cell viability, EdU and flow cytometry-based cell cycle assay, and paralleled with the increased expression of phosphorylated PI3K, AKT and mTOR, which was remarkably reversed following Tub A treatment. 740Y-P activator addition significantly reversed the declined fibroblast proliferation induced by Tub A. The expressions of PI3K/AKT/mTOR pathway-related proteins were also reduced in epidural tissues in rat models with Tub A treatment.Conclusion: Tub A could prevent epidural fibrosis formation by inhibiting fibroblast proliferation through mediating PI3K/AKT/mTOR pathway.","PeriodicalId":59706,"journal":{"name":"药剂与药理学:英文版","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61684551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of Chemostimulation of Different Nuclei of the Amygdala on the Implementation of the Drinking Conditioned Reflex 不同杏仁核的化学刺激对饮酒条件反射的影响

药剂与药理学:英文版 Pub Date : 2022-02-28 DOI: 10.17265/2328-2150/2022.02.003

Rafiga Mazahir Baghirova

引用次数: 0

Glucose-6-Phosphate Dehydrogenase Deficiency and Malaria Infections in Brazil 葡萄糖-6-磷酸脱氢酶缺乏与巴西疟疾感染

药剂与药理学:英文版 Pub Date : 2022-02-28 DOI: 10.17265/2328-2150/2022.02.002

Marielle Machado Macêdo, Luciana dos Santos Viana, Cleiton Fantin

引用次数: 0

Integrative Clinical Treatment of Grade II Soft Tissue Sarcoma with Homeopathic Mistletoe and Associations: Case Report 顺势疗法槲寄生综合治疗Ⅱ级软组织肉瘤1例

药剂与药理学:英文版 Pub Date : 2022-02-28 DOI: 10.17265/2328-2150/2022.02.004

Daniela Franco Lopes, Ana Claudia de Benedictis Andreta, Rafael Franchi Traldi

引用次数: 0