药剂与药理学:英文版最新文献_第4页

Acacia mangium Willd (Acácia) Extract Antioxidant and Antiproliferative Activities Acacia mangium Willd（Acácia）提取物抗氧化和抗增殖活性

药剂与药理学:英文版 Pub Date : 2022-10-28 DOI: 10.17265/2328-2150/2022.10.004

Paula Roberta Costalonga Pereira, Jean Carlos Vencioneck Dutra, Schirley Costalonga, Vanessa Silva Santos, Lucas Evangelista dos Santos, Maria Gabriela Pissinati Trindade, Maria do Carmo Pimentel Batitucci

引用次数: 0

In Vitro Antioxidant, Anticancer and Anti-cytotoxic Activity of Lippia alba 白脂的体外抗氧化、抗癌和抗细胞毒活性

药剂与药理学:英文版 Pub Date : 2022-10-28 DOI: 10.17265/2328-2150/2022.10.003

In Vitro Antioxidant, Jean Carlos, Vencioneck Dutra, Victor Nogueira da Gama Kohls, Paula Roberta Costalonga Pereira, Jean Moisés Ferreira, Lucas Evangelista, Santos, M. Gabriela, Pissinati Trindade, M. D. Carmo, Pimentel Batitucci, David Publishing

{"title":"In Vitro Antioxidant, Anticancer and Anti-cytotoxic Activity of Lippia alba","authors":"In Vitro Antioxidant, Jean Carlos, Vencioneck Dutra, Victor Nogueira da Gama Kohls, Paula Roberta Costalonga Pereira, Jean Moisés Ferreira, Lucas Evangelista, Santos, M. Gabriela, Pissinati Trindade, M. D. Carmo, Pimentel Batitucci, David Publishing","doi":"10.17265/2328-2150/2022.10.003","DOIUrl":"https://doi.org/10.17265/2328-2150/2022.10.003","url":null,"abstract":": Lippia alba is a herb widely distributed in Latin America used in the traditional medicine. Considering that medicinal plants present anticancer action, the aim of the work was to verify the in vitro antioxidant, cytotoxic, anti-cytotoxic and anticancer effects of L. alba extract, correlating the results with phytochemical content. Phytochemicals were evaluated by spectrophotometry; antioxidant activity was evaluated by DPPH, ABTS and Fe 2+ chelating activity. In vitro cytotoxicity and anti-cytotoxicity were evaluated in human lymphocytes and anticancer action was evaluated in sarcoma-180 cells. L. alba extract presents good antioxidant, antiproliferative and anti-cytotoxic effects. Total flavonoid content was correlated to the antiproliferative effect; total tannin content was correlated to ABTS antioxidant activity and to health cells maintenance. Tannins were also correlated to the prevention of cisplatin-induced damage. Our finds support the use of L. alba as a source of natural antioxidants and as a potent anticancer and anti-cytotoxic agent, reinforcing the use of natural products for health promotion.","PeriodicalId":59706,"journal":{"name":"药剂与药理学:英文版","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48898583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HELLP Syndrome and Preeclampsia in Patient with Neurofibromatosis Type 1 - Case Report 1型神经纤维瘤病患者HELLP综合征和先兆子痫1例报告

药剂与药理学:英文版 Pub Date : 2022-10-28 DOI: 10.17265/2328-2150/2022.10.002

Maja Kłopecka, Dorota Agata Bomba Opoń

引用次数: 0

Rare 3q28 Deletion in Patient with Autism Spectrum Disorder in Manaus, Brazil: A Case Report 巴西马瑙斯自闭症谱系障碍患者罕见的3q28缺失:一例报告

药剂与药理学:英文版 Pub Date : 2022-09-28 DOI: 10.17265/2328-2150/2022.09.001

Cleiton Fantin, Isabella Cristina Amaral Dantas, Daniella Yleane Gadelha Viana, Vânia Mesquita Gadelha Prazeres, Natalia Dayane Moura Carvalho

引用次数: 0

Small Marker Chromosome in a Pediatric Patient with Hypertelorism, Micropenis, Cryptorchidism and Congenital Heart Defects: A Case Report 一例患有高血压、微阴茎、隐睾和先天性心脏缺陷的儿童患者的小标记染色体

药剂与药理学:英文版 Pub Date : 2022-09-28 DOI: 10.17265/2328-2150/2022.09.002

Paloma de Sousa Passos, Suely Regina da Silva Teles, Natalia Dayane Moura Carvalho, Cleiton Fantin

引用次数: 0

Identification and Therapeutic Development of Spinal Muscular Atrophy 脊髓性肌萎缩症的鉴别与治疗进展

药剂与药理学:英文版 Pub Date : 2022-08-28 DOI: 10.17265/2328-2150/2022.08.002

Payal Makwana, Jaydeep Parmar, Priya Patel

引用次数: 0

Assessment of Knowledge and Attitude in Adverse Drug Reaction (ADR) Reporting of Final Year Undergraduate Pharmacy Students 药学本科毕业班学生药物不良反应(ADR)报告知识与态度的评估

药剂与药理学:英文版 Pub Date : 2022-08-28 DOI: 10.17265/2328-2150/2022.08.001

Gopal Pokhrel, Gulshan Jahan Ansari, Rojina Napit, Santosh Kafle, Dipesh Kumar Yadav

引用次数: 1

Inhibition of human ether-à-go-go-related gene K+ currents expressed in HEK293 cells by three gingerol components from ginger. 生姜中的三种姜酚成分对 HEK293 细胞中表达的人类醚-à-go-go 相关基因 K+ 电流的抑制作用。

药剂与药理学:英文版 Pub Date : 2022-08-19 DOI: 10.1093/jpp/rgac029

Miaomaio Liu, Yakun Yang, Muqing Zhang, Yucong Xue, Bin Zheng, Yuanyuan Zhang, Yu Liu, Xi Chu, Zhenqing Sun, Xue Han

引用次数: 1

Application of Different Analytical Methods for Characterization of Pharmaceutical Materials 不同分析方法在药用材料表征中的应用

药剂与药理学:英文版 Pub Date : 2022-07-28 DOI: 10.17265/2328-2150/2022.07.001

Kasylda Milczewska, Joanna Maziarczyk, Aleksandra Borkowska

引用次数: 0

Clonidine ameliorates cisplatin-induced nephrotoxicity: impact on OCT2 and p38 MAPK pathway. 可乐定改善顺铂诱导的肾毒性:对OCT2和p38 MAPK通路的影响。

药剂与药理学:英文版 Pub Date : 2022-06-15 DOI: 10.1093/jpp/rgac039

Mariam H Fawzy, Dina M. Khodeer, N. Elsayed, Y. M. Ahmed, Noha M Saeed

{"title":"Clonidine ameliorates cisplatin-induced nephrotoxicity: impact on OCT2 and p38 MAPK pathway.","authors":"Mariam H Fawzy, Dina M. Khodeer, N. Elsayed, Y. M. Ahmed, Noha M Saeed","doi":"10.1093/jpp/rgac039","DOIUrl":"https://doi.org/10.1093/jpp/rgac039","url":null,"abstract":"OBJECTIVES\u0000To explore clonidine (Clon) nephroprotective effects as an inhibitor of organic cationic transporter 2 (OCT2) and p38 mitogen-activated protein kinase (p38 MAPK) against cisplatin (CP)-induced nephrotoxicity. OCT2 is mainly responsible for renal accumulation of CP. Clon has been recently recognized as an OCT2 inhibitor and exerts beneficial effects on renal function and p38 MAPK. This study further investigates its underlying anti-inflammatory, antioxidative and antiapoptotic effects.\u0000\u0000\u0000METHODS\u0000Rats were randomly assigned into five groups: (I) CON, (II) CP, (III) CP + Clon 0.125, (IV) CP + Clon 0.25, (V) CP + Clon 0.5, and (VI) Clon 0.5 alone. Clon was administered orally at 0.125, 0.25 and 0.5 mg/kg/day dosages for 10 days. On day 7, rats in groups from (II) to (V) received a single intraperitoneal injection of CP (10 mg/kg).\u0000\u0000\u0000KEY FINDINGS\u0000Clon 0.25 mg/kg displayed the best nephroprotective outcomes, justified by the significant amelioration of parameters like renal function, oxidative stress, and inflammatory status, as well as modulated the OCT2 expression, phosphorylation of p38 and p53, compared with Clon 0.125 and 0.5 mg/kg.\u0000\u0000\u0000CONCLUSION\u0000This study suggests the promising nephroprotective impact of Clon as an OCT2 inhibitor against CP nephrotoxicity and its proficient role in attenuating oxidative stress, inflammatory status and apoptotic status.","PeriodicalId":59706,"journal":{"name":"药剂与药理学:英文版","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61686035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1