生物物理学期刊(英文)最新文献_第8页

A Comparison of Gamma Irradiation Response Models of Bovine Blood, Liver and Kidney Tissues at Radiofrequency 牛血液、肝脏和肾脏组织射频辐射响应模型的比较

生物物理学期刊(英文) Pub Date : 2018-05-29 DOI: 10.4236/ojbiphy.2018.83013

T. Sombo, E. Agba, T. Ige, T. Igbawua, T. S. Azande, E. R. Nyatso, I. S. Aondoakaa, T. J. Shivil

{"title":"A Comparison of Gamma Irradiation Response Models of Bovine Blood, Liver and Kidney Tissues at Radiofrequency","authors":"T. Sombo, E. Agba, T. Ige, T. Igbawua, T. S. Azande, E. R. Nyatso, I. S. Aondoakaa, T. J. Shivil","doi":"10.4236/ojbiphy.2018.83013","DOIUrl":"https://doi.org/10.4236/ojbiphy.2018.83013","url":null,"abstract":"This study is aimed at identifying gamma irradiated response of bovine blood, liver and kidney tissues at radiofrequency. For this purpose, impedence meter (Booton 7200) working in conjunction with signal generators (Loadster, SG416013 and Harris G857993) and improvised parallel plate dielectric cells constructed in line with the method of Laogun et al., (2005) were used to obtain the dielectric spread parameter gamma radiation α, of blood, liver and kidney tissues exposed to gamma irradiation dose range of 1.0 - 85.0 Gy. The dielectric spread parameter α gives the extent of damage induced in an irradiated tissue. Results of this work revealed that at 0 - 50 MHz frequency range, Kidney tissues displayed higher sensitive, followed Liver tissues and lasted the bovine blood between 0 - 60 Gy but reversed for blood and liver at 85 Gy. At 0 - 100 kHz frequency range liver tissue is more venerable to radiation injuries between gamma irradiation dose range of 0 - 20 Gy while between 43 - 85 Gy the Kidney’s sensitivity is the highest followed by blood and liver tissues. This implies that the liver tissues are less liable to radiation injuries at radiofrequency. A comparison of the linear, exponential and polynomial models using Akaike Information Criteria (AIC) revealed that linear models were the most suitable models for describing the effect of gamma radiation on the dielectric dispersion properties of bovine tissues at low and high radiofrequencies. This implies that the response of the investigated tissues increases linearly with gamma irradiation dose.","PeriodicalId":59528,"journal":{"name":"生物物理学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43940684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Quantum-Mechanical Sensitivity of Cell Hydration in Mammals 哺乳动物细胞水合作用的量子力学敏感性

生物物理学期刊(英文) Pub Date : 2018-05-29 DOI: 10.4236/OJBIPHY.2018.83009

A. Nikoghosyan, Lilia Narinyan, Armenuhi Heqimyan, S. Ayrapetyan

{"title":"The Quantum-Mechanical Sensitivity of Cell Hydration in Mammals","authors":"A. Nikoghosyan, Lilia Narinyan, Armenuhi Heqimyan, S. Ayrapetyan","doi":"10.4236/OJBIPHY.2018.83009","DOIUrl":"https://doi.org/10.4236/OJBIPHY.2018.83009","url":null,"abstract":"The elucidation of the mechanism on the biological effects of weak chemical and physical factors on cells and organism is one of the modern problems in life sciences. According to the Receptor Theory of Prof. Bernard Katz the impact of the biological substances on cells is realized through the activation of ligand-gated ion channels in the membrane. However, this theory doesn’t provide a satisfactory explanation on the similar biological effects of extremely low concentrations of different chemical substances, which are unable to activate the ionic channels in the membrane and have non-linear dose-dependent effect on cells. Previously we have suggested that the metabolic control of cell hydration serves as a universal quantum-mechanical sensor for different weak physical and chemical signals. For supporting this hypothesis, in this article the comparative study of the effects of low concentrations of both cold (non-radioactive) and [3H]-ouabain (specific inhibitor for Na+/K+-ATPase) on the hydration in different tissues of rats has been performed. The obtained data have shown that cold and [3H]-ouabain have different effects on cell hydration and such a difference depends on the initial metabolic state of tissues. On the basis of our previous and present results it is suggested that such a quantum-mechanical sensitivity of cell hydration is realized through the cyclic-nucleotides-dependent Na+/Ca2+ exchange, having a crucial role in the metabolic regulation of cell hydration.","PeriodicalId":59528,"journal":{"name":"生物物理学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48444786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Similarities of Modulation by Temperature and by Electric Field 温度和电场调制的相似性

生物物理学期刊(英文) Pub Date : 2018-05-29 DOI: 10.4236/OJBIPHY.2018.83008

G. Vincze, A. Szász

引用次数: 8

Role of Electrical Forces in Angiogenesis 电力在血管生成中的作用

生物物理学期刊(英文) Pub Date : 2018-03-30 DOI: 10.4236/ojbiphy.2018.82005

O. Szász, G. Szigeti, A. Szász, Z. Benyó

引用次数: 6

HPV Genotypes of Senegalese Women Attending Radiotherapy 接受放射治疗的塞内加尔妇女的HPV基因型

生物物理学期刊(英文) Pub Date : 2018-03-30 DOI: 10.4236/ojbiphy.2018.82007

M. Soumboundou, I. Thiam, K. Doh, M. Dieng, C. Dial, C. Malésys, P. M. Guaye, A. Thioune, A. Dem, M. Diarra, C. R. Lafrasse

{"title":"HPV Genotypes of Senegalese Women Attending Radiotherapy","authors":"M. Soumboundou, I. Thiam, K. Doh, M. Dieng, C. Dial, C. Malésys, P. M. Guaye, A. Thioune, A. Dem, M. Diarra, C. R. Lafrasse","doi":"10.4236/ojbiphy.2018.82007","DOIUrl":"https://doi.org/10.4236/ojbiphy.2018.82007","url":null,"abstract":"Objectives: This work was carried out in order to determine the profile of different HPV genotypes in a population of women attending radiotherapy (RT). Material and Methods: This is a retrospective study. Sixty paraffin blocks were chosen by simple random method upon 1015 blocks of cervix cancer diagnosed in Senegal’s public hospitals laboratories of anatomopathology. The strains of HPV genotyping were done with polymerase chain reaction (PCR) multiplex using primers MY09-MY11, GP5+ and GP6+. Results: Among the sixty examined blocks, DNA extraction was unsatisfactory in three cases. All women were infected with HPV high risk (HR). The different HPV genotypes isolated were HPV 16 (49/96%), 18 (8/16%), 35 (7/14%), 45 (4/8%), and 58 (2/4%). It was a single infection in 36 cases (70, 60%), co-infection in 11 cases (21, 60%) and a multi-infection in 4 cases (7, 80%). Conclusion: The prevalence of HPV found in our series is comparable to that found in the world. To complete this study, a large population of Senegalese patients with uterine cervix cancer (CC) and HPV genotype, is needed to determine if HPV genotypes could be considered as a prognostic marker in patients with uterine CC after RT.","PeriodicalId":59528,"journal":{"name":"生物物理学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42778525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Water/Oil Pickering Emulsion Stabilized by Magnesium Oxide Particles: A Potential System with Two Active Substances (Paracetamol and Griseofulvin) 氧化镁颗粒稳定的水/油酸洗乳剂:含有两种活性物质(扑热息痛和灰黄霉素)的潜在体系

生物物理学期刊(英文) Pub Date : 2018-03-30 DOI: 10.4236/ojbiphy.2018.82006

P. M. Sy, A. Djiboune, L. Diouf, M. Soumboundou, B. Ndong, A. Ndiaye, S. Dieng, O. Diop, E. Bathily, G. Mbaye, Mack Faye, M. Mbodj, M. Diarra

{"title":"Water/Oil Pickering Emulsion Stabilized by Magnesium Oxide Particles: A Potential System with Two Active Substances (Paracetamol and Griseofulvin)","authors":"P. M. Sy, A. Djiboune, L. Diouf, M. Soumboundou, B. Ndong, A. Ndiaye, S. Dieng, O. Diop, E. Bathily, G. Mbaye, Mack Faye, M. Mbodj, M. Diarra","doi":"10.4236/ojbiphy.2018.82006","DOIUrl":"https://doi.org/10.4236/ojbiphy.2018.82006","url":null,"abstract":"Pickering emulsions are systems without surfactants, stabilized by solid particles. These emulsions are experiencing a renewed interest, on the one hand, because it is preferable to limit the use of synthetic surfactants for toxicological and environmental reasons and, on the other hand, the need to make new formulations in order to control the drug release patterns by encapsulation or controlled release. Thus, we were interested in the formulation and evaluation of W/O Pickering emulsions stabilized by particles of magnesium oxide with paracetamol in the internal phase and griseofulvin in the external phase. The Bancroft rule served as a model for the formulation. The emulsification was carried out by progressively adding an aqueous phase dispersed in an oil-dispersing phase using a turbo rotor stator mixer. The stability of these emulsions was studied using several parameters (droplet size, pH, viscosity, conductivity ...) and the qualitative and quantitative analysis of the active ingredients by UV-visible spectrophotometry. The results obtained showed that the dye test and the conductivity measurement confirmed the W/O nature of these emulsions. Some parameters such as droplet size, pH and viscosity were strongly influenced by the amounts of magnesium oxide particles and the two active ingredients used. The qualitative and quantitative analysis of the active ingredients confirmed the presence of griseofulvin in the oil phase and paracetamol in the aqueous phase. Thus, we have succeeded in developing a stable W/O Pickering emulsion with magnesium oxide particles. In addition, we were able to incorporate paracetamol into the dispersed phase and griseofulvin into the dispersing phase of the emulsion.","PeriodicalId":59528,"journal":{"name":"生物物理学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49248419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Hyperthermia Dosing and Depth of Effect 热疗剂量和作用深度

生物物理学期刊(英文) Pub Date : 2018-01-23 DOI: 10.4236/OJBIPHY.2018.81004

S. Oliver, Szigeti Gyula Peter, V. Tamas, Szasz Andras

引用次数: 11

On the Feynman Ratchet and the Brownian Motor 关于费曼棘轮和布朗马达

生物物理学期刊(英文) Pub Date : 2018-01-10 DOI: 10.4236/OJBIPHY.2018.81003

G. Vincze, G. Szigeti, A. Szász

引用次数: 0

Knowledge of Togolese Doctors on Biological Effects of Ultrasound and Their Attitudes towards the Ultrasonographic Explorations Performed in Lome (Togo) 多哥医生对超声生物学效应的认识及对多哥洛美超声检查的态度

生物物理学期刊(英文) Pub Date : 2018-01-01 DOI: 10.4236/OJBIPHY.2018.81001

K. Adambounou, E. Bathily, Amégninou Mawuko Yao Adigo, P. Gbande, Kpalma Duga Bakpatina-Batako, L. Sonhaye, Tapsoba Tl, K. Adjénou

{"title":"Knowledge of Togolese Doctors on Biological Effects of Ultrasound and Their Attitudes towards the Ultrasonographic Explorations Performed in Lome (Togo)","authors":"K. Adambounou, E. Bathily, Amégninou Mawuko Yao Adigo, P. Gbande, Kpalma Duga Bakpatina-Batako, L. Sonhaye, Tapsoba Tl, K. Adjénou","doi":"10.4236/OJBIPHY.2018.81001","DOIUrl":"https://doi.org/10.4236/OJBIPHY.2018.81001","url":null,"abstract":"We evaluate the level of knowledge of clinician doctors asking for echographies on the biological effects of ultrasounds and their attitudes towards ultrasounds examinations performed in Lome. Transverse study based on a survey led from August 16th till November 30th, 2013 including 105 doctors applicant of ultrasound in Lome (Togo). The middle age of the applicant doctors was of 34 years with a sex-ratio of 4/1 and more than half practiced in public facilities. Approximately ten percent applicants thought that the ultrasound is an irradiant exam and those practicing for less than 5 years were the ones who had a good level of knowledge on the not irradiant character of the ultrasounds. The existence of the thermal and mechanical effects of the ultrasounds was known only by 4.8% of the applicants and only 1.9% of the doctors had information on the thermal index (TI) and the mechanical index (MI). More than half (66.7%) analyzed the ultrasound images joined to the report but none verified the conformity with the standards of the values of the TI and at MI shown on the images. They were 43.5% to read only the conclusion. The level of knowledge of the doctors on the biological effects of the ultrasounds is unsatisfactory. The ultrasounds although not irradiant, have biological effects imposing precautionary measures which have to guide the attitude of the applicants towards the ultrasonographic explorations.","PeriodicalId":59528,"journal":{"name":"生物物理学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70617729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Emergent Mitotic Chromosome Motions from a Changing Intracellular pH 细胞内pH值变化引起的有丝分裂染色体运动

生物物理学期刊(英文) Pub Date : 2018-01-01 DOI: 10.4236/OJBIPHY.2018.81002

L. J. Gagliardi, D. Shain

引用次数: 1