生物物理学期刊(英文)最新文献_第4页

A Bioelectromagnetic Proposal Approaching the Complex Challenges of COVID-19 应对COVID-19复杂挑战的生物电磁方案

生物物理学期刊(英文) Pub Date : 2021-01-01 DOI: 10.4236/ojbiphy.2021.111001

A. Szász

{"title":"A Bioelectromagnetic Proposal Approaching the Complex Challenges of COVID-19","authors":"A. Szász","doi":"10.4236/ojbiphy.2021.111001","DOIUrl":"https://doi.org/10.4236/ojbiphy.2021.111001","url":null,"abstract":"The COVID-19 pandemic has experienced unprecedented limitations and extraordinary scientific efforts to address this exceptional situation. Despite blanket closures that have resulted in significant financial constraints and losses around the world, research has an “unlimited” budget, with an exceptional concentration of medical and scientific care on a single topic: understanding the mechanisms for overcoming the disease. A large number of clinical trials have been launched with different drugs that have been behind different concepts and solutions. I would like to focus on the complexity aspect of COVID-19. Living systems are organized in a complex way, which implies dynamic stochastic phenomena, and deterministic reductionism can mislead research. When research focuses on individual molecules or pathways as products, it is distracted from the processes in which these products operate, thus neglecting the complex interactions between regulations and feedback controls. Common problems in product-oriented research are articulated as “double-edged swords”, “Janus behavior”, “two-sided action”, with a simple question: “friend or foe?” I focus on the missing complexity. I propose a bioelectromagnetic process that can maintain a complex approach, affecting processes rather than products. This hypothetical proposal is not a comprehensive solution. Complexity itself limits the overall effects of causing “miracles”. Well-designed electromagnetic effects can support current efforts and, in combination with intensively developed pharmaceuticals, bring us closer to a pharmaceutical solution against COVID-19.","PeriodicalId":59528,"journal":{"name":"生物物理学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70618464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Bio-Electromagnetics without Fields: The Effect of the Vector Potential 无场生物电磁学:矢量电位的影响

生物物理学期刊(英文) Pub Date : 2021-01-01 DOI: 10.4236/OJBIPHY.2021.112007

A. Szász

引用次数: 0

The Mystery on the Physical Conditions for Life 生命的物理条件之谜

生物物理学期刊(英文) Pub Date : 2021-01-01 DOI: 10.4236/ojbiphy.2021.114015

K. Wong, W. Chow

引用次数: 0

Cancer Uses the Common Morphogenesis Source of the Host 癌症利用宿主的共同形态发生源

生物物理学期刊(英文) Pub Date : 2020-09-29 DOI: 10.4236/OJBIPHY.2020.104013

A. N. Shoutko

引用次数: 0

The Growth of Healthy and Cancerous Tissues 健康和癌变组织的生长

生物物理学期刊(英文) Pub Date : 2020-06-09 DOI: 10.4236/ojbiphy.2020.103010

G. Szigeti, A. M. Szász, A. Szász

{"title":"The Growth of Healthy and Cancerous Tissues","authors":"G. Szigeti, A. M. Szász, A. Szász","doi":"10.4236/ojbiphy.2020.103010","DOIUrl":"https://doi.org/10.4236/ojbiphy.2020.103010","url":null,"abstract":"The structure of the tissues is formed in a self-similar manner, forming fractal structures in their transport networks. The structure exhibits allometric forming and so-called scaling behavior. This is a basic growth model fine-tuned by various connections of the cells (junctions and adherent connections), intended to direct material and energy transports between them. This secondary control of cell metabolism decreases primary metabolic transport through the free surfaces of the cells. The cellular network is formed by triggering the endogenous electric fields, which are dominantly governed by cell membrane potential. Proliferation exhibits a different electric pattern due to the low cell-membrane potential and resulting negativity relative to its environment. This potential change characterizes cells in normal proliferation and a cluster of cells (a tumor) in the case of cancerous development. This latter has certain similarities to the leakage transport of liquid in porous media, substituting the pressure with endogenous tumor potential. The average survival of a tumor depends on the kind of available metabolic transport and the fractal dimensions of the newly built angiogenic network.","PeriodicalId":59528,"journal":{"name":"生物物理学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47403709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Mechanics of Twisted DNA Molecule Adsorbed on a Biological Membrane 扭曲DNA分子在生物膜上的吸附力学

生物物理学期刊(英文) Pub Date : 2020-06-09 DOI: 10.4236/ojbiphy.2020.103011

R. E. Kinani, H. Kaidi, Noureddine Barka

{"title":"Mechanics of Twisted DNA Molecule Adsorbed on a Biological Membrane","authors":"R. E. Kinani, H. Kaidi, Noureddine Barka","doi":"10.4236/ojbiphy.2020.103011","DOIUrl":"https://doi.org/10.4236/ojbiphy.2020.103011","url":null,"abstract":"DNA is the carrier of all cellular genetic information and increasingly used in nanotechnology. The study of DNA molecule achieved in vitro while submitting the DNA to all chemicals agent capabilities to destabilize links hydrogen, such as pH, temperature. In fact, the DNA enveloped in the membrane cellular, so it is legitimate to study the influence of membrane undulations. In this work, we try to show that the fluctuations of the membrane can be considerate as a physics agent is also capable to destabilize links hydrogen. In this investigation, we assume that each pair base formed an angle an with the membrane’s surface. We have proposed a theoretical model, and we have established a relationship between the angle formed by the pair base θeq and an angle formed by the membrane and each pair base. We assume that DNA and biomembrane interact via a realistic potential of Morse type. To this end, use is made of a generalized model that extends that introduced by M. Peyrard and A. R. Bishop in the past modified by M. Zoli. This generalized model is based on the resolution of a Schrodinger-like equation. The exact resolution gives the expression of the ground state, and the associated eigenvalue (energy) that equals the free energy, in the thermodynamic limit. First, we compute the denaturation temperature of DNA strands critical temperature. Second, we deduce all critical properties that mainly depend on the parameters of the model, and we quantify the effects of the membrane undulations. These undulations renormalize all physical quantities, such as harmonic stacking, melting temperature, eigenfunctions, eigenvalues and regular part of specific heat.","PeriodicalId":59528,"journal":{"name":"生物物理学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43811472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biological Stress as a Principle of Nature: A Review of Literature 生物应激作为自然规律:文献综述

生物物理学期刊(英文) Pub Date : 2020-06-09 DOI: 10.4236/ojbiphy.2020.103012

C. Cortez, Dílson Silva

{"title":"Biological Stress as a Principle of Nature: A Review of Literature","authors":"C. Cortez, Dílson Silva","doi":"10.4236/ojbiphy.2020.103012","DOIUrl":"https://doi.org/10.4236/ojbiphy.2020.103012","url":null,"abstract":"This review paper attempts to approximate the concept of biological stress to the stress concept in Physics using the phenomenological view of physics to discuss the source of generator forces of biological stress state. Based on the literature, parallels are drawn between the two concepts and a discussion on the steady state in open systems and homeostatic state in biological systems is developed. Using the concepts of thermodynamic entropy and informational entropy, and comparing stress in living systems and nonliving, we attempt to build a basis for a view of stress as a principle of nature linked to the adaptability property of matter, opposing entropy. It is known that the increasing number of microstates possible in a complex system increases the entropy. In that way, entropy is related to the amount of additional information needed to specify the exact physical state of a system, given its macroscopic specification. By controlling the metabolic processes (catabolism-anabolism) to decrease the entropy, stress reduces the number of possible states for which the living system could evolve, avoiding the loss of “life information”, preserving its characteristics and preventing its extinction. The loss of function of a species within an ecosystem or of cells within an organ can be showing that the limits of the stress principle were “transgressed”. That is, the intensity and/or duration of stress exceeded the capacity of living organism to process of information extracted from stressor and reprogram its physiological mechanisms, activating its adaptability process, while its internal balance is preserved.","PeriodicalId":59528,"journal":{"name":"生物物理学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44687881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DNA Sequencing Modified Method through Effective Regulation of Its Translocation Speed in Aqueous Solution 通过有效调节DNA在水溶液中的易位速度来改进DNA测序方法

生物物理学期刊(英文) Pub Date : 2020-04-26 DOI: 10.4236/ojbiphy.2020.102009

L. Gasparyan, I. Mazo, F. Gasparyan, V. Simonyan

{"title":"DNA Sequencing Modified Method through Effective Regulation of Its Translocation Speed in Aqueous Solution","authors":"L. Gasparyan, I. Mazo, F. Gasparyan, V. Simonyan","doi":"10.4236/ojbiphy.2020.102009","DOIUrl":"https://doi.org/10.4236/ojbiphy.2020.102009","url":null,"abstract":"Solid-state nanopore DNA sequencing modified method is developed. Method is based on the tunnel current investigation through the nanogap made on lateral gold electrodes in the form of nanowires or nanoribbons. The movement of DNA in aqueous solution is regulated by the potential applied to reference electrode. The potential applied to the lateral metal electrodes helps to the creation of the molecular junctions. They consist of the nucleosides passing through the pores. Taking into account that DNA moves under gravity, electrophoretic and drag forces, the analytic expression for the DNA translocation speed is calculated and analyzed. The conditions for decreasing the DNA translocation speed or increasing the nucleosides reading time are received. It is shown that one can control value of the DNA molecules bases reading time and the frequency of the bases passes by the choice of magnitude of the potential applied to reference electrode. Our results, therefore potentially suggest a realistic, inherently design-specific, high-throughput nanopore DNA sequencing device/cell as a de-novo alternative to the existing methods.","PeriodicalId":59528,"journal":{"name":"生物物理学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41951575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Exposure of Weak Time-Invariant Electromagnetic Fields to B16-BL6 Cell Cultures Alter Biophoton Emission Profile as a Function of Distance 弱时不变电磁场暴露于B16-BL6细胞培养物中改变生物光子发射曲线作为距离的函数

生物物理学期刊(英文) Pub Date : 2020-02-21 DOI: 10.4236/ojbiphy.2020.102004

Billy C. S. Yearington, Victoria L. Hossack, B. Dotta

引用次数: 0

Solar Radiation, Perelman Entropy Mapping, DNA, Viruses etc. 太阳辐射，佩雷尔曼熵图，DNA，病毒等。

生物物理学期刊(英文) Pub Date : 2020-02-21 DOI: 10.4236/ojbiphy.2020.102005

K. W. Wong, P. Fung, W. Chow

引用次数: 1