医学微生物学(英文)最新文献

{"title":"Clinical Isolate of <i>Candida tropicalis</i> from a Patient in North Carolina: Identification, Whole-Genome Sequence Analysis, and Anticandidal Activity of <i>Ganoderma lucidum</i>.","authors":"Akamu Ewunkem, Lydia Merrills, Zahirah Williams, Lisa Maness, Jeffery Meixner, Brittany Justice, Uchenna Iloghalu, Vera Williams, Larisa Kiki, Dinesh Singh","doi":"10.4236/ojmm.2025.151002","DOIUrl":"10.4236/ojmm.2025.151002","url":null,"abstract":"<p><p>In North Carolina, candida infections are on the rise and pose a significant threat to human health in clinical settings. In addition, the rise of resistance to antifungal drugs has only heightened this concern. Importantly, misidentification of <i>Candida</i> spp. may result in underdiagnosis, patients getting the wrong treatment and incomplete infection prevention measures. The correct and rapid etiological identification of <i>Candida</i> infections is of paramount importance because it provides adequate therapy, reduces mortality, and controls outbreaks. Hence, this study aimed to identify <i>Candida</i> sp. up to species level of a clinical isolate from an infected patient treated in North Carolina using biochemical and molecular techniques. Due to the emergence of resistance, we explored whole genomic analysis to highlight polymorphisms that can impact candida resistance. Exploration for the effectiveness of bioactive compounds in natural products to treat <i>Candida</i> spp. resistant to present-day drugs could provide promising new treatment options for managing infected patients. Thus, this study also investigated anticandida activity of three solvent extracts of <i>Ganoderma lucidum</i> against the clinical isolate of <i>Candida</i> sp. The findings of this study provided evidence that <i>Candida tropicalis</i> MYA-3404 was the only strain present in the clinical isolate. The whole genome sequencing of <i>C. tropicalis</i> identified mutations in genes that most likely underscore drug resistance. All extracts from <i>G. lucidum</i> significantly (P < 0.05) inhibited the growth of <i>C. tropicalis</i>. Together, this work highlights the enormous potential of biochemical and molecular techniques in identifying clinical isolates of candida to species level and the use of bioactive compounds from extracts of <i>G. lucidum</i> as promising anticandidal agents. Further testing is needed to confirm the phenotypic expression of resistance.</p>","PeriodicalId":58937,"journal":{"name":"医学微生物学(英文)","volume":"15 1","pages":"11-35"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic Profile and Molecular Characterization of Typhoidal Salmonellosis among Abattoir Workers in the Southern Region of Nigeria","authors":"Idongesit Ata Udom, Effiong Effiong Owowo, L. E. Udofia","doi":"10.4236/ojmm.2023.131001","DOIUrl":"https://doi.org/10.4236/ojmm.2023.131001","url":null,"abstract":"","PeriodicalId":58937,"journal":{"name":"医学微生物学(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70329021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic Resistance in the Uropathogenic Enterobacteria Isolated from Patients Attending General Reference Hospital (GRH) of Niamey, Niger","authors":"Alassane Halawen Mohamed, R. Dembélé, Chaibou Salaou, Alix Bénédicte Kagambèga, Hiliassa Coulibaly, Frédéric François Bado, Alio Mahamadou Fody, L. Boubou, A. Ibrahim, E. A. Omar, Mauricio Arcos Holzinger, N. Barro","doi":"10.4236/ojmm.2023.131007","DOIUrl":"https://doi.org/10.4236/ojmm.2023.131007","url":null,"abstract":"","PeriodicalId":58937,"journal":{"name":"医学微生物学(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70329501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors and Prevalence of Mother to New-Born Transmission of Carbapenemase Producing Enterobacteriaceae in Two Hospitals in Yaounde, Cameroon","authors":"Cecile Ingrid Djuikoué, N. Chounna, Paule Dana Djouela Djoulako, Farid Wega, J. Nzenya, Cedric Dylan Seugnou Nana, Dorine Ngatcheu Ekeu, Blondelle Kitio Messeu, Laurene Nzangem Doumene, Joviale Magne Talla, Mireille Fock, B. Pokam","doi":"10.4236/ojmm.2023.131010","DOIUrl":"https://doi.org/10.4236/ojmm.2023.131010","url":null,"abstract":"","PeriodicalId":58937,"journal":{"name":"医学微生物学(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70329928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variation in Progesterone Levels and Urinary Tract Infections in Pregnant Women Attending Moi Teaching and Referral Hospital, Eldoret, Kenya","authors":"Anne Wanjiku, L. Mwamburi, M. Ngeiywa, A. Obala","doi":"10.4236/ojmm.2023.131011","DOIUrl":"https://doi.org/10.4236/ojmm.2023.131011","url":null,"abstract":"","PeriodicalId":58937,"journal":{"name":"医学微生物学(英文)","volume":"77 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70329972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotypic Characterization of Carbapenemase-Producing Enterobacteriaceae Strains in a Referral Teaching Hospital in Yaoundé, Cameroon","authors":"Cecile Ingrid Djuikoué, Paule Dana Djouela Djoulako, Kamga Wouambo Rodrigue, C. Tomi, Christiane Possi Kiyang, Murielle Chantale Tchitchoua, Vynnie Manuella Nyatchoutou, Blondelle Kitio Messeu, Herman Koyouo Tagne, Cedric Dylan Seugnou Nana, N. Benhamed, H. Kamga, B. Pokam","doi":"10.4236/ojmm.2023.131005","DOIUrl":"https://doi.org/10.4236/ojmm.2023.131005","url":null,"abstract":"","PeriodicalId":58937,"journal":{"name":"医学微生物学(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70329277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Resistance Profile of Muenchen Cefotaximase (CTX-M) Group 1 Extended Spectrum Beta-Lactamase (ESBL)-Producing Uropathogenic <i>Escherichia coli</i> Strains in Dakar, Senegal","authors":"A. Seck, B. Ndiaye, A. Diop, Malick Ndao, C. Fall, A. Dieng, T. Diallo, C. Mahou, P. Dubrous","doi":"10.4236/ojmm.2023.132012","DOIUrl":"https://doi.org/10.4236/ojmm.2023.132012","url":null,"abstract":"","PeriodicalId":58937,"journal":{"name":"医学微生物学(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70329532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection, Biochemical and Molecular Characterization of <i>Clostridium sporogens</i> in <i>Nono</i>: A Nigerian Traditionally Fermented Yoghurt Drink","authors":"N. Oyedokun, G. Olukotun, Uchenna Iman Igwegbe, B. Adamu, Roseline Rumi Ideh, Olaitan Comfort Shekoni, A. O. Igwegbe","doi":"10.4236/ojmm.2023.131008","DOIUrl":"https://doi.org/10.4236/ojmm.2023.131008","url":null,"abstract":"","PeriodicalId":58937,"journal":{"name":"医学微生物学(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70329544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Antimicrobial Resistance of <i>ESKAPE</i> Pathogens before and during Pandemic COVID-19 Pandemic in a University Affiliated Hospital in Tangerang, Indonesia","authors":"N. Lugito, C. Cucunawangsih, V. Wiwing, N. Suryadinata","doi":"10.4236/ojmm.2023.132013","DOIUrl":"https://doi.org/10.4236/ojmm.2023.132013","url":null,"abstract":"Introduction: Antimicrobial resistance is the most important health problems currently. Antibiotic prophylaxis to prevent bacterial co-infections in hospitalized COVID-19 patients, and lack of surveillance were associated with antimicrobial resistance. ESKAPE pathogens consisting of E. faecium, S. aureus, K. pneumoniae, A. baumanii, P. aeruginosa and Enterobacter spp. are associated with healthcare-associated infections. Patients and Methods: This descriptive, retrospective, longitudinal study aims to describe the resistance rates of bloodstream infection due to ESKAPE pathogens from patients admitted in Siloam Hospital Karawaci, before and during COVID-19 pandemic (January 1 st , 2019 until December 31 st , 2022). Out of 296 ESKAPE pathogens collected from blood samples, S. aureus was the most frequent species, followed by K. pneumoniae, A. baumannii, P. aeruginosa, Enterobacter spp., and E. faecium. Results: Resistance rates of E. faecium were alarmingly high from 2019 until 2021, but in 2022 no sample was found. Resistance rates of S.","PeriodicalId":58937,"journal":{"name":"医学微生物学(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70329626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in Bacterial Blood Culture Isolates and Resistance in Children in Two Microbiologic Eras from a Tertiary Health Facility in North East Nigeria","authors":"E. Isaac, I. Jalo, M. Manga, A. J. Difa, Mercy Raymond Poksireni, Oyeniyi Christianah, I. Mohammed, Muhammad Saminu Charanci","doi":"10.4236/ojmm.2023.132014","DOIUrl":"https://doi.org/10.4236/ojmm.2023.132014","url":null,"abstract":"","PeriodicalId":58937,"journal":{"name":"医学微生物学(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70329729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}