临床个性化医学最新文献

{"title":"The Role of miRNAs in the Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells","authors":"振然 夏","doi":"10.12677/jcpm.2025.41051","DOIUrl":"https://doi.org/10.12677/jcpm.2025.41051","url":null,"abstract":"","PeriodicalId":56773,"journal":{"name":"临床个性化医学","volume":"04 01","pages":"334-340"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147884035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress on Natural Products Overcoming EGFR-TKIs Resistance in Non-Small Cell Lung Cancer","authors":"起凤 宋","doi":"10.12677/jcpm.2025.46478","DOIUrl":"https://doi.org/10.12677/jcpm.2025.46478","url":null,"abstract":"","PeriodicalId":56773,"journal":{"name":"临床个性化医学","volume":"04 06","pages":"65-71"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147918380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Immunosuppressive Cells in TME during the Progression of Bladder Cancer","authors":"浩彤 周","doi":"10.12677/jcpm.2025.41034","DOIUrl":"https://doi.org/10.12677/jcpm.2025.41034","url":null,"abstract":"","PeriodicalId":56773,"journal":{"name":"临床个性化医学","volume":"04 01","pages":"217-224"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147880490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinformatics Studies of Genes Related to the Extracellular Matrix of Pancreatic Cancer","authors":"兵 齐","doi":"10.12677/jcpm.2025.42261","DOIUrl":"https://doi.org/10.12677/jcpm.2025.42261","url":null,"abstract":"通过生物信息学方法挖掘胰腺癌组织中差异基因，明确差异基因的功能与信号通路，筛选出与细胞外基质有关的信号通路，确定细胞外基质通路研究与胰腺癌之间的关系，找寻胰腺癌中外基质的潜在生物标志物。从Gene Expression Omnibus (GEO)数据库中下载胰腺癌样本数据，基于GSE91035芯片数据，运用R语言筛选数据中的差异表达基因(differentially expressed genes, DGEs)，对胰腺癌DGEs进行基因本体功能注释(GO)和京都基因与基因组百科全书通路分析(KEGG)。利用GSEA数据库构建细胞外基质通路可视化，并确定关键基因，用GEPIA2数据库验证关键基因的表达与预后的关系。结果确定有3023个差异基因，上调1803个，下调1220个。其中和细胞外基质相关的基因为COL1A1，LAMB3，COMP，FN1，THBS2，LAMC2，ITGA11，ITGB6，COL4A5，HMMR并对其进行验证确定LAMB3，ITGB6，HMMR三个基因与胰腺癌的发生发展相关。该数据集的差异基因主要通过参与抗原加工和呈递，ECM受体相互作用，细胞粘附分子，细胞黏附等生物学过程从而影响胰腺癌的发生发展，并确定细胞外基质有关基因对胰腺癌至关重要。本研究通过对胰腺癌差异基因的分析，确定细胞外基质有关基因可以作为关键影响靶点。This paper aims to identify differentially expressed genes (DGEs) in pancreatic cancer tissues using bioinformatics methods, elucidate the functions and signaling pathways of these DGEs, screen out signaling pathways related to the extracellular matrix (ECM), determine the relationship between ECM pathway research and pancreatic cancer, and identify potential biomarkers of the ECM in pancreatic cancer. Sample data of pancreatic cancer were downloaded from the Gene Expression Omnibus (GEO) database. Based on the chip data from GSE91035, R language was used to screen DGEs in the data. Gene Ontology (GO) functional annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed on the DGEs related to pancreatic cancer. The GSEA database was utilized to visualize the ECM pathway and identify key genes. The GEPIA2 database was employed to verify the relationship between the expression of these key genes and prognosis. A total of 3023 DGEs were identified, with 1803 upregulated and 1220 downregulated genes. Among them, genes related to the ECM included COL1A1, LAMB3, COMP, FN1, THBS2, LAMC2, ITGA11, ITGB6, COL4A5, and HMMR. Verification was conducted to confirm that LAMB3, ITGB6, and HMMR are associated with the occurrence and development of pancreatic cancer. The DGEs in this dataset primarily affect the occurrence and development of pancreatic cancer by participating in biological processes such as antigen processing and presentation, ECM receptor interaction, cell adhesion molecules, and cell adhesion. It was determined that genes related to the ECM are crucial in pancreatic cancer. Through the analysis of DGEs in pancreatic cancer, this study identified genes related to the ECM as key targets of influence.","PeriodicalId":56773,"journal":{"name":"临床个性化医学","volume":"04 02","pages":"925-935"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pdf.hanspub.org/jcpm202542_1243120744.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147901088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis, Treatment and Research Progress of Head-Up Tilt Test and Physical Back Pressure Action in Children with Vasovagal Syncope","authors":"星雨 付","doi":"10.12677/jcpm.2025.43355","DOIUrl":"https://doi.org/10.12677/jcpm.2025.43355","url":null,"abstract":"血管迷走性晕厥(vasovagal syncope, VVS)是自主神经介导性晕厥中最常见，也是儿童晕厥类型最普遍的一种疾病，其发病机制复杂不清，目前尚无定论。随着愈来愈多儿童罹患VVS，其诊疗仍是一研究热点。直立倾斜试验(head-up tilt test，HUTT)为VVS辅诊的首要方式，对患儿VVS分型及诊断起到了至关重要的作用。一般预后好，但近年研究发现部分患儿会出现猝死、有危及生命的风险，严重影响学习和生活质量。一线治疗即非药物治疗，其中健康教育和物理反压动作(PCMs)被推崇，简单方便，升压速度快。PCMs通过调节自主神经活性、释放神经递质改善晕厥，降低复发率，是急救的首要方式。HUTT通过降低交感神经和/增高迷走神经活性复刻晕厥场景，监测心率、血压等关键指标，有助于评估及预测VVS的复发。本文将结合国内外大量文献就自主神经功能在VVS中发挥的作用及HUTT、PCMs对VVS患儿的诊疗进行详细阐述。Vasovagal syncope (VVS) is the most common type of autonomic nerve-mediated syncope and the most common type of syncope in children. Its pathogenesis remains complex and not fully understood. With more and more children suffering from VVS, its diagnosis and treatment is still a research hotspot. The head-up tilt test (HUTT) is the primary method for auxiliary diagnosis of VVS, and it plays a crucial role in classifying and diagnosing VVS in children. Research indicates that the diagnostic accuracy of HUTT can vary among physicians, with those having a moderate level of experience being more likely to report a positive result. For instance, a study conducted at the Fuwai Hospital suggests that physicians with a moderate cumulative workload in performing HUTT tests tend to report a higher rate of suspicious positive cases. Generally, the prognosis is good, but in recent years, studies have found that some children may face sudden death and life-threatening risks, thereby severely impacting their education and overall well-being. The first-line treatment is non-drug treatment. Among these, health education and physical countermeasures (PCMs) are currently recognized as effective. They present no contraindications, are simple and convenient, and provide rapid efficacy. The PCMs treatment method is equally suitable for immediate first aid and serves as the primary approach for emergency response. PCMs improve syncope and reduce the recurrence rate by regulating autonomic nerve activity and releasing neurotransmitters. HUTT reproduces syncope scenes by modulating autonomic nervous system activity, and monitoring heart rate, blood pressure, and other vital signs to evaluate and analyze the patient’s condition. This article will integrate a comprehensive review of international and domestic literature to detail the significance of cardiac autonomic function in the diagnosis and treatment of vasovagal syncope (VVS) in children, with a focus on the use of head-up tilt testing (HUTT) and PCMs.","PeriodicalId":56773,"journal":{"name":"临床个性化医学","volume":"04 03","pages":"370-376"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pdf.hanspub.org/jcpm_3120861.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147902850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the Study of Estrogen and Estrogen Receptors in the Inflammatory Process of SPID-CPP","authors":"金花 关","doi":"10.12677/jcpm.2025.41102","DOIUrl":"https://doi.org/10.12677/jcpm.2025.41102","url":null,"abstract":"","PeriodicalId":56773,"journal":{"name":"临床个性化医学","volume":"04 01","pages":"720-726"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147909205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Clinical Significance of miR-34a-5p Level in Diabetic Retinopathy","authors":"晓云 蒋","doi":"10.12677/jcpm.2024.34357","DOIUrl":"https://doi.org/10.12677/jcpm.2024.34357","url":null,"abstract":"","PeriodicalId":56773,"journal":{"name":"临床个性化医学","volume":"03 04","pages":"2505-2511"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147886090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress on the Protective Effect of Apelin’s Antioxidant Activity on Aminoglycoside Induced Hearing Loss","authors":"鹏昊 牛","doi":"10.12677/jcpm.2024.34330","DOIUrl":"https://doi.org/10.12677/jcpm.2024.34330","url":null,"abstract":"","PeriodicalId":56773,"journal":{"name":"临床个性化医学","volume":"03 04","pages":"2315-2320"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147906553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress on Pharmacological Treatment for Cholestatic Liver Disease","authors":"浩源 金","doi":"10.12677/jcpm.2024.34320","DOIUrl":"https://doi.org/10.12677/jcpm.2024.34320","url":null,"abstract":"","PeriodicalId":56773,"journal":{"name":"临床个性化医学","volume":"03 04","pages":"2248-2255"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147914915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between Peripheral Blood T Lymphocyte Subsets, Cytokine Levels and PASI Score in Patients with Psoriasis Vulgaris","authors":"奥奇 马","doi":"10.12677/jcpm.2024.34313","DOIUrl":"https://doi.org/10.12677/jcpm.2024.34313","url":null,"abstract":"","PeriodicalId":56773,"journal":{"name":"临床个性化医学","volume":"03 04","pages":"2207-2212"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147886309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}