临床个性化医学最新文献

{"title":"Regulatory Effects of miRNA-182-5p Expression on Fibrosis in AC16 Cells","authors":"日格乐 娜","doi":"10.12677/jcpm.2026.52173","DOIUrl":"https://doi.org/10.12677/jcpm.2026.52173","url":null,"abstract":"","PeriodicalId":56773,"journal":{"name":"临床个性化医学","volume":"05 02","pages":"699-707"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147899542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Macrophage-Mediated Immune Regulation in Temporomandibular Joint Osteoarthritis","authors":"嘉琪 胡","doi":"10.12677/jcpm.2026.52129","DOIUrl":"https://doi.org/10.12677/jcpm.2026.52129","url":null,"abstract":"","PeriodicalId":56773,"journal":{"name":"临床个性化医学","volume":"05 02","pages":"302-308"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147890894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress on Regulated Cell Death in Traumatic Brain Injury","authors":"嵩民 沈","doi":"10.12677/jcpm.2026.51038","DOIUrl":"https://doi.org/10.12677/jcpm.2026.51038","url":null,"abstract":"","PeriodicalId":56773,"journal":{"name":"临床个性化医学","volume":"05 01","pages":"258-265"},"PeriodicalIF":0.0,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147920097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress on the Mechanism of Lipid Metabolism Disorders in Diabetic Nephropathy","authors":"瑜 张","doi":"10.12677/jcpm.2025.44451","DOIUrl":"https://doi.org/10.12677/jcpm.2025.44451","url":null,"abstract":"","PeriodicalId":56773,"journal":{"name":"临床个性化医学","volume":"04 04","pages":"325-332"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147905290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Ginsenoside Rg1 in Treating Aplastic Anemia in Mice via MAPK Pathway","authors":"焱 李","doi":"10.12677/jcpm.2025.42254","DOIUrl":"https://doi.org/10.12677/jcpm.2025.42254","url":null,"abstract":"目的：本研究旨在评价人参皂苷Rg1对AA的保护作用，并进一步探讨其机制。方法：本研究通过注射环磷酰胺(CTX)建立骨髓抑制小鼠模型。CTX + Rg1组小鼠Rg1灌胃13 d。HE检测骨髓、胸腺和脾脏的病理变化。取小鼠眼眶血进行血常规检查。然后用流式细胞仪检测骨髓细胞的比例。通过WB检测MAPK通路中p-p38、p38、p-JNK、JNK、p-ERK、ERK的表达。结果：病理检查显示，CTX严重破坏小鼠骨髓、胸腺和脾脏的结构特征，降低骨髓造血细胞的比例。Rg1可通过抑制MAPK信号通路显著减轻小鼠骨髓抑制。结论：本研究提示人参皂苷Rg1通过MAPK信号通路缓解骨髓抑制作用，对AA有一定的治疗作用。Objective: This study was designed to evaluate the protective effects of ginsenoside Rg1 on AA and further investigate the underlying mechanism. Methods: In this study, Cyclophosphamide (CTX) was injected to establish the myelosuppression mouse model. The mice in the CTX + Rg1 group were treated with Rg1 for 13 days. The pathological changes of bone marrow, thymus, and spleen were detected through HE (Hematoxylin-Eosin St). Orbital blood of mice was collected for blood routine examination. Afterwards, the proportions of bone marrow cells were evaluated by flow cytometry assay. MAPK pathway was detected via WB for the expressions of p-p38, p38, p-JNK, JNK, p-ERK, and ERK. Results: Pathological examination revealed that CTX severely damaged the structural features of the bone marrow, thymus, and spleens, and decreased the proportion of hematopoietic cells in the bone marrow of mice. Treatment of Rg1 significantly alleviated myelosuppression in mice by inhibiting MAPK signaling pathway. Conclusion: This study suggested that ginsenoside Rg1 treated AA by alleviating myelosuppression through MAPK signaling pathway.","PeriodicalId":56773,"journal":{"name":"临床个性化医学","volume":"04 02","pages":"860-869"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pdf.hanspub.org/jcpm202542_1173120646.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147893509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism of Inhibition of Apoptosis after Cerebral Hemorrhage by Acupuncture and Its Research Progress","authors":"蕊 汤","doi":"10.12677/jcpm.2025.44410","DOIUrl":"https://doi.org/10.12677/jcpm.2025.44410","url":null,"abstract":"脑出血(Intracerebral Hemorrhage, ICH)后细胞凋亡是受损脑组织迟发性细胞死亡的主要途径，是受凋亡基因控制的，主要存在于血肿周边较大范围的缺血水肿带中。针刺是一种传承百年的中医疗法，近年来针刺作为ICH的辅助治疗手段，其保护机制逐渐成为研究热点。本文以针刺抑制ICH后细胞凋亡的机制研究进展为切入点，通过梳理近20年来国内外关于ICH后细胞凋亡机制及针刺干预效果的研究。归纳发现针刺对于调控细胞凋亡信号通路、调控双通路靶向凋亡关键因子、调节自噬与凋亡的平衡、调节神经干细胞增殖与分化、抑制氧化应激通路、介导PAR-1蛋白表达等多个环节都有干预作用，为相关机制研究提供参考。Apoptosis after Intracerebral hemorrhage (ICH) is the main pathway of delayed cell death in damaged brain tissues, which is controlled by apoptosis genes, and mainly exists in the larger ischemic-edematous zone around the hematoma. Acupuncture is a centuries-old traditional Chinese medicine therapy, and in recent years, as an adjunctive treatment for ICH, its protective mechanism has gradually become a research hotspot. In this paper, we take the research progress on the mechanism of inhibition of apoptosis after ICH by acupuncture as an entry point, by combing the domestic and foreign studies on the mechanism of apoptosis after ICH and the effect of acupuncture intervention in the past 20 years. It was found that acupuncture has an intervention effect on regulating apoptosis signaling pathway, regulating dual pathway targeting apoptosis key factors, regulating the balance between autophagy and apoptosis, regulating the proliferation and differentiation of neural stem cells, inhibiting the oxidative stress pathway, and mediating the expression of PAR-1 protein, which can provide references to the research of related mechanisms.","PeriodicalId":56773,"journal":{"name":"临床个性化医学","volume":"04 04","pages":"13-20"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pdf.hanspub.org/jcpm_3120930.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147901283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulatory Role of Interleukin 4-Inducible Protein 1 in Glioma and Research Progress","authors":"新 齐","doi":"10.12677/jcpm.2025.42246","DOIUrl":"https://doi.org/10.12677/jcpm.2025.42246","url":null,"abstract":"神经胶质瘤是一种常见、具有高度侵袭性的神经系统肿瘤，因生长快速，广泛浸润邻近脑组织，假性坏死和诱导血管生成，且无明显的作用靶点，所以胶质瘤预后较差，复发率高，其发生和发展受到多种细胞因子的调节。其中白细胞介素4诱导蛋白1 (IL-4I1)作为一种重要的神经系统细胞因子，逐渐引起了研究者的关注。IL-4I1不仅参与肿瘤微环境的调节，还可能影响肿瘤细胞的增殖、存活和迁移等过程，在神经胶质瘤的发生与发展中发挥重要作用。目前的研究表明，IL-4I1通过多条信号通路影响神经胶质瘤的生物学特性，但其具体机制还未有明确说明。因此，通过影响IL-4I1的表达为神经胶质瘤的治疗提供了新的思路。本文旨在综述IL-4I1在神经胶质瘤中的作用机制、相关信号通路以及其在临床应用中的前景，为研究人员提供关于IL-4I1在这一领域的最新进展和未来研究方向。Glioma is a common and highly aggressive neurologic tumor with a poor prognosis and high recurrence rate due to its rapid growth, extensive invasion of adjacent brain tissues, pseudonecrosis and induction of angiogenesis, and no obvious target, and its occurrence and progression are regulated by a variety of cytokines. Among them, interleukin 4-inducible protein 1 (IL-4I1), as an important nervous system cytokine, has gradually attracted the attention of researchers. IL-4I1 is not only involved in the regulation of tumor microenvironment, but also may affect the proliferation, survival and migration of tumor cells, and plays an important role in the occurrence and development of glioma. Current studies have shown that IL-4I1 affects the biology of glioma through multiple signaling pathways, but the specific mechanism of IL-4I1 has not been clearly explained. Therefore, by affecting the expression of IL-4I1, it provides a new idea for the treatment of glioma. The purpose of this article is to review the mechanism of IL-4I1 in glioma, related signaling pathways, and its prospects for clinical application, and to provide researchers with the latest progress and future research directions of IL-4I1 in this field.","PeriodicalId":56773,"journal":{"name":"临床个性化医学","volume":"04 02","pages":"808-814"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pdf.hanspub.org/jcpm202542_1093120712.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147881835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Diagnostic Value and Significance of Combined Detection of Coagulation Indicators and CEA for Colon Cancer","authors":"超凡 张","doi":"10.12677/jcpm.2025.43380","DOIUrl":"https://doi.org/10.12677/jcpm.2025.43380","url":null,"abstract":"目的：本研究旨在评估纤维蛋白原/前白蛋白比值(Fibrinogen-Prealbumin Ratio, FPR)联合纤维蛋白原(Fibrinogen, FIB)、D-二聚体(D-dimer, D-D)及癌胚抗原(Carcinoembryonic antigen, CEA)检测对结肠癌的诊断价值。通过多指标联合检测策略，系统分析这些血清标志物在结肠癌筛查和诊断中的临床应用潜力。方法：本研究选取2021年10月至2024年10月期间在北华大学附属医院接受诊治的140例患者作为研究对象。病例组纳入70例经病理学确诊并接受手术治疗的结肠癌患者，对照组纳入70例经结肠镜检查确诊的结肠良性病变患者。对两组患者术前的FPR、FIB、D-D、CEA水平及术后病理资料进行差异性分析，并绘制受试者工作特征曲线(ROC)。结果：1. 在结肠癌组患者中，血清FPR、FIB、D-D、CEA水平均高于对照组，且这种差异在统计学上具有显著性(Z = 7.469, P Objective: This study aims to evaluate the fibrinogen-prealbumin Ratio (FPR) combined with Fibrinogen (FIB) and D-dimer. The diagnostic value of D-D and Carcinoembryonic antigen (CEA) detection for colon cancer. Through the multi-index combined detection strategy, the clinical application potential of these serum markers in the screening and diagnosis of colon cancer was systematically analyzed. Method: In this study, 140 patients who were diagnosed and treated at the Affiliated Hospital of Beihua University from October 2021 to October 2024 were selected as the research subjects. The case group included 70 patients with colon cancer who were pathologically diagnosed and received surgical treatment, while the control group included 70 patients with benign colon lesions diagnosed by colonoscopy. The differences in the levels of FPR, FIB, D-D, CEA before the operation and the postoperative pathological data of the two groups of patients were analyzed, and the receiver operating characteristic curve (ROC) was drawn. Result: 1. The levels of serum FPR, FIB, D-D and CEA in the colon cancer group were higher than those in the control group, and the differences were statistically significant (Z = 7.469, P < 0.001; Z = 8.485, P < 0.001; Z = 8.201, P < 0.001; Z = 8.905, P < 0.001). 2. Analysis of the pathological data of patients with colon cancer revealed that TNM stage and lymph node metastasis were related to FIB (U = 393.00, P = 0.010; U = 438.50, P = 0.041), and the tumor size was related to FPR (U = 416.00, P = 0.024). 3. The areas under the curves of FPR, FIB, D-D, CEA and combined detection were 0.812, 0.780, 0.765, 0.844 and 0.880 respectively. Conclusion: The combined detection of FPR, FIB, D-D and CEA can significantly improve the diagnostic efficacy of colon cancer.","PeriodicalId":56773,"journal":{"name":"临床个性化医学","volume":"04 03","pages":"553-559"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pdf.hanspub.org/jcpm_3120889.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147890101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the Mechanism of Action of Fangji Fuling Decoction in the Treatment of Sepsis-Induced AKI Based on Network Pharmacology and Molecular Docking","authors":"雨荣 骆","doi":"10.12677/jcpm.2025.42304","DOIUrl":"https://doi.org/10.12677/jcpm.2025.42304","url":null,"abstract":"目的：采用网络药理学和分子对接技术，对防己茯苓汤治疗脓毒症AKI的作用机制进行预测性研究。方法：先通过TCMSP数据库收集防己茯苓汤中药物组成的活性成分，SwissTargetPrediction搜索活性成分所作用的靶点蛋白。再通过GeneCards、PharmGKb、数据库、TTD数据库收集脓毒症AKI靶点蛋白，选择药物成分以及对应的靶点蛋白，利用Cytoscape构建药物–成分–靶点–疾病网络，将药物–疾病交集靶点录入STRING分析后导入Cytoscape软件，进一步构建PPI网络图。在DAVID平台获取交集靶点的作图数据，在微生信平台进行GO富集分析和KEGG通路分析。最后使用MOE和Pymol进行分子对接和渲染。结果：筛选出防己茯苓汤活性成分126种及药物靶点993个，疾病靶点3301个，防己茯苓汤治疗脓毒症AKI作用靶点448个，其中联苯双酯、(E)-1-(2,4-二羟基苯基)-3-(2,2-二甲基色烯-6-基)丙-2-烯-1-酮、四脉银胶菊素A、β-谷甾醇、茯苓酸A为治疗疾病的核心成分，AKT1、TNF、TP53、CASP3、MAPK3为治疗疾病的核心靶点。GO富集分析得到1742个结果，主要富集于蛋白质磷酸化、磷酸化作用、炎症反应、ATP结合、蛋白丝氨酸激酶活性等过程，KEGG通路分析得到189条通路，主要通路为癌症通路、脂质和动脉粥样硬化、乙型肝炎等。分子对接验证了药物成分和疾病靶点蛋白有良好的结合能力。其中核心靶点TP53与β-谷甾醇的结合能最小，为−7.95 kg/mol。结论：本研究采用网络药理学和分子对接技术，预测性地研究了防己茯苓汤通过多成分–多靶点–多通路治疗脓毒症AKI的机制，为临床治疗脓毒症AKI提供了证明，并为进一步提高该类病症的临床治疗效果提供了参考。Objective: To predict the mechanism of action of Fangji Fuling Decoction in treating sepsis-induced AKI by using network pharmacology and molecular docking technology. Methods: The active ingredients of Fangji Fuling Decoction were first collected through the TCMSP database, and the target proteins acted by the active ingredients were searched by SwissTargetPrediction. Then, the target proteins of sepsis-induced AKI were collected through GeneCards, PharmGKb, database, and TTD database, and the drug ingredients and corresponding target proteins were selected. The drug-ingredient-target-disease network was constructed using Cytoscape. The drug-disease intersection targets were entered into STRING analysis and then imported into Cytoscape software to further construct the PPI network diagram. The mapping data of the intersection targets were obtained on the DAVID platform, and GO enrichment analysis and KEGG pathway analysis were performed on the Microbiological Information Platform. Finally, MOE and Pymol were used for molecular docking and rendering. Results: A total of 126 active ingredients and 993 drug targets, 3301 disease targets of Fangji Fuling Decoction were screened, and 448 targets of Fangji Fuling Decoction in the treatment of sepsis AKI were found, among which bifendate, (E)-1-(2,4-dihydroxyphenyl)-3-(2,2-dimethylchromen-6-yl)prop-2-en-1-one,guaiacin A, β-sitosterol, and pachymic acid A were the core components for the treatment of diseases, and AKT1, TNF, TP53, CASP3, and MAPK3 were the core targets for the treatment of diseases. GO enrichment analysis obtained 1742 results, which were mainly enriched in protein phosphorylation, phosphorylation, inflammatory response, ATP binding, protein serine kinase activity, etc. KEGG pathway analysis obtained 189 pathways, and the main pathways were cancer pathways, lipids and atherosclerosis, hepatitis B, etc. Molecular docking verified that the drug components and disease target proteins had good binding ability. Among them, the binding energy of the core target TP53 with β-sitosterol was the smallest, which was −7.95 kg/mol. Conclusion: This study used network pharmacology and molecular docking technology to predictively study the mechanism of Fangji","PeriodicalId":56773,"journal":{"name":"临床个性化医学","volume":"04 02","pages":"1313-1326"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pdf.hanspub.org/jcpm202542_1673120783.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147895101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinformatics Analysis of MMP11 Expression and Clinical Significance in Breast Cancer","authors":"政 舒","doi":"10.12677/jcpm.2025.44444","DOIUrl":"https://doi.org/10.12677/jcpm.2025.44444","url":null,"abstract":"","PeriodicalId":56773,"journal":{"name":"临床个性化医学","volume":"04 04","pages":"266-275"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147921562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}