Igor O Shmarakov, Iuliia P Mukha, Volodymyr V Karavan, Olexander Yu Chunikhin, Mykhailo M Marchenko, Natalia P Smirnova, Anna M Eremenko
{"title":"Tryptophan-Assisted Synthesis Reduces Bimetallic Gold/Silver Nanoparticle Cytotoxicity and Improves Biological Activity.","authors":"Igor O Shmarakov, Iuliia P Mukha, Volodymyr V Karavan, Olexander Yu Chunikhin, Mykhailo M Marchenko, Natalia P Smirnova, Anna M Eremenko","doi":"10.5772/59684","DOIUrl":"https://doi.org/10.5772/59684","url":null,"abstract":"<p><p>Aiming to reduce the potential in vivo hepato-and nephrotoxicity of Ag/Au bimetallic nanoparticles (NPs) stabilized by sodium dodecyl sulphate (SDS), an approach involving a simultaneous reduction of silver nitrate and tetrachlorauratic acid using tryptophan (Trp) as a reducing/stabilizing agent was applied during NP synthesis. The obtained Ag/Au/Trp NPs (5-15 nm sized) were able to form stable aggregates with an average size of 370-450 nm and were potentially less toxic than Ag/Au/SDS in relation to a mouse model system based on clinical biochemical parameters and oxidative damage product estimation. Ag/Au/Trp NPs were shown to exhibit anticancer activity in relation to a Lewis lung carcinoma model. The data generated from the present study support the fact that the use of tryptophan in NP synthesis is effective in attenuating the potential hepatotoxicity and nephrotoxicity of NPs during their in vivo application.</p>","PeriodicalId":56366,"journal":{"name":"Nanobiomedicine","volume":"1 ","pages":"6"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5772/59684","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36326140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhenghong Gao, Chunyi Zhi, Yoshio Bando, Dmitri Golberg, Takeshi Serizawa
{"title":"Noncovalent Functionalization of Boron Nitride Nanotubes in Aqueous Media Opens Application Roads in Nanobiomedicine.","authors":"Zhenghong Gao, Chunyi Zhi, Yoshio Bando, Dmitri Golberg, Takeshi Serizawa","doi":"10.5772/60000","DOIUrl":"10.5772/60000","url":null,"abstract":"<p><p>Boron nitride nanotubes (BNNTs) are of intense scientific interest due to their unique physiochemical properties and prospective applications in various nanotechnologies, particularly nanobiomedicine. A critical problem hampering the application processing of BNNTs is the outer sidewall functionalization, which is primarily acquired to lead BNNTs dispersible in various solvents. Furthermore, the surface of BNNTs should be intelligently designed and precisely controlled to satisfy the specific demands of different applications. For these purposes, covalent and noncovalent approaches have been factually developed to help to extend the full potential of applications. Importantly, wrapping the outermost sidewall of BNNTs with either water-soluble polymers or biomolecules through weak noncovalent interactions has been proved to be efficient for giving BNNTs considerable dispersity in aqueous media, and endowing novel chemical functions to BNNTs with almost no change in their pristine physiochemical properties. This article summarizes recent progress in this field and addresses future perspectives on the noncovalent functionalization of BNNTs for promoting their application processing in various bio-related nanotechnologies.</p>","PeriodicalId":56366,"journal":{"name":"Nanobiomedicine","volume":"1 ","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5772/60000","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36326141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aitziber L Cortajarena, Daniel Ortega, Sandra M Ocampo, Alberto Gonzalez-García, Pierre Couleaud, Rodolfo Miranda, Cristobal Belda-Iniesta, Angel Ayuso-Sacido
{"title":"Engineering Iron Oxide Nanoparticles for Clinical Settings.","authors":"Aitziber L Cortajarena, Daniel Ortega, Sandra M Ocampo, Alberto Gonzalez-García, Pierre Couleaud, Rodolfo Miranda, Cristobal Belda-Iniesta, Angel Ayuso-Sacido","doi":"10.5772/58841","DOIUrl":"https://doi.org/10.5772/58841","url":null,"abstract":"<p><p>Iron oxide nanoparticles (IONPs) occupy a privileged position among magnetic nanomaterials with potential applications in medicine and biology. They have been widely used in preclinical experiments for imaging contrast enhancement, magnetic resonance, immunoassays, cell tracking, tissue repair, magnetic hyperthermia and drug delivery. Despite these promising results, their successful translation into a clinical setting is strongly dependent upon their physicochemical properties, toxicity and functionalization possibilities. Currently, IONPs-based medical applications are limited to the use of non-functionalized IONPs smaller than 100 nm, with overall narrow particle size distribution, so that the particles have uniform physical and chemical properties. However, the main entry of IONPs into the scene of medical application will surely arise from their functionalization possibilities that will provide them with the capacity to target specific cells within the body, and hence to play a role in the development of specific therapies. In this review, we offer an overview of their basic physicochemical design parameters, giving an account of the progress made in their functionalization and current clinical applications. We place special emphasis on past and present clinical trials.</p>","PeriodicalId":56366,"journal":{"name":"Nanobiomedicine","volume":"1 ","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5772/58841","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36326138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mustafa Unal, Yunus Alapan, Hao Jia, Adrienn G Varga, Keith Angelino, Mahmut Aslan, Ismail Sayin, Chanjuan Han, Yanxia Jiang, Zhehao Zhang, Umut A Gurkan
{"title":"Micro and Nano-Scale Technologies for Cell Mechanics.","authors":"Mustafa Unal, Yunus Alapan, Hao Jia, Adrienn G Varga, Keith Angelino, Mahmut Aslan, Ismail Sayin, Chanjuan Han, Yanxia Jiang, Zhehao Zhang, Umut A Gurkan","doi":"10.5772/59379","DOIUrl":"10.5772/59379","url":null,"abstract":"<p><p>Cell mechanics is a multidisciplinary field that bridges cell biology, fundamental mechanics, and micro and nanotechnology, which synergize to help us better understand the intricacies and the complex nature of cells in their native environment. With recent advances in nanotechnology, microfabrication methods and micro-electro-mechanical-systems (MEMS), we are now well situated to tap into the complex micro world of cells. The field that brings biology and MEMS together is known as Biological MEMS (BioMEMS). BioMEMS take advantage of systematic design and fabrication methods to create platforms that allow us to study cells like never before. These new technologies have been rapidly advancing the study of cell mechanics. This review article provides a succinct overview of cell mechanics and comprehensively surveys micro and nano-scale technologies that have been specifically developed for and are relevant to the mechanics of cells. Here we focus on micro and nano-scale technologies, and their applications in biology and medicine, including imaging, single cell analysis, cancer cell mechanics, organ-on-a-chip systems, pathogen detection, implantable devices, neuroscience and neurophysiology. We also provide a perspective on the future directions and challenges of technologies that relate to the mechanics of cells.</p>","PeriodicalId":56366,"journal":{"name":"Nanobiomedicine","volume":"1 ","pages":"5"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5772/59379","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36326142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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