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Epilepsy and Behavior Case Reports最新文献

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Auras localized to the temporal lobe disrupt verbal memory and learning — Causal evidence from direct electrical stimulation of the hippocampus 位于颞叶的光环破坏了言语记忆和学习——来自海马体直接电刺激的因果证据
Epilepsy and Behavior Case Reports Pub Date : 2018-01-01 DOI: 10.1016/j.ebcr.2018.07.006
Diana Pizarro , Emilia Toth , Auriana Irannejad , Kristen O. Riley , Zeenat Jaisani , Wolfgang Muhlhofer , Roy Martin , Sandipan Pati
{"title":"Auras localized to the temporal lobe disrupt verbal memory and learning — Causal evidence from direct electrical stimulation of the hippocampus","authors":"Diana Pizarro ,&nbsp;Emilia Toth ,&nbsp;Auriana Irannejad ,&nbsp;Kristen O. Riley ,&nbsp;Zeenat Jaisani ,&nbsp;Wolfgang Muhlhofer ,&nbsp;Roy Martin ,&nbsp;Sandipan Pati","doi":"10.1016/j.ebcr.2018.07.006","DOIUrl":"10.1016/j.ebcr.2018.07.006","url":null,"abstract":"<div><p>Auras (focal aware seizure; FAS) are subjective ictal events with retained consciousness. Epileptiform activities can disrupt cognitive tasks, but studies are limited to seizures with impaired awareness. As a proof of concept, we examined the cognitive effects of direct electrical stimulation to the left hippocampus which induced a habitual FAS in a patient with left mesial temporal lobe epilepsy. During the induced habitual FAS, verbal memory performance declined significantly as compared to pre-stimulation testing. Tasks measuring auditory working memory and psychomotor processing speed were not affected by the stimulation. The study confirms that FAS can impair episodic verbal memory and learning.</p></div>","PeriodicalId":56365,"journal":{"name":"Epilepsy and Behavior Case Reports","volume":"10 ","pages":"Pages 99-101"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ebcr.2018.07.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36459479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Sign and magnitude scaling properties of heart rate fluctuations following vagus nerve stimulation in a patient with drug-resistant epilepsy 耐药癫痫患者迷走神经刺激后心率波动的体征和幅度标度特征
Epilepsy and Behavior Case Reports Pub Date : 2018-01-01 DOI: 10.1016/j.ebcr.2018.05.003
Eduardo Gutiérrez-Maldonado, Claudia Ivette Ledesma-Ramírez, Adriana Cristina Pliego-Carrillo, José Javier Reyes-Lagos
{"title":"Sign and magnitude scaling properties of heart rate fluctuations following vagus nerve stimulation in a patient with drug-resistant epilepsy","authors":"Eduardo Gutiérrez-Maldonado,&nbsp;Claudia Ivette Ledesma-Ramírez,&nbsp;Adriana Cristina Pliego-Carrillo,&nbsp;José Javier Reyes-Lagos","doi":"10.1016/j.ebcr.2018.05.003","DOIUrl":"10.1016/j.ebcr.2018.05.003","url":null,"abstract":"<div><p>Vagus nerve stimulation (VNS) therapy has been recently incorporated in Latin America as a treatment for drug-resistant epilepsy. In particular, it is known that linear analysis and fractal parameters of heart rate variability (HRV) are able to indirectly measure cardiac autonomic activity. This case report presents a 17-year-old female with drug-resistant epilepsy implanted with a VNS device. In order to explore cardiac autonomic changes due to VNS, linear and fractal HRV indices were calculated in the presence and absence of neurostimulation. Novel fractal scaling exponents from HRV analysis were obtained from this patient and from a healthy control subject. Our results indicate that fractal indices of HRV, such as short-term scaling parameters from magnitude and sign analyses seem to be sensitive to the presence or absence of VNS, being confirmed by linear classical methods. This study shows that VNS therapy increases the complexity of cardiac fluctuations in a patient with drug-resistant epilepsy, reflecting an augmented HRV non-linearity and a diminished anticorrelated pattern in heart rate fluctuations. A potential clinical use of these parameters includes the early identification of bradycardia, sudden unexpected death (SUDEP) risk and preoperative VNS approaches. Thus, the scaling and magnitude properties of HRV have potential importance as a non-invasive and easy method for adequate diagnostic/prognostic implications in epilepsy treatment.</p></div>","PeriodicalId":56365,"journal":{"name":"Epilepsy and Behavior Case Reports","volume":"10 ","pages":"Pages 78-81"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ebcr.2018.05.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36386046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Epilepsy in patients with long QT syndrome type 1: A Norwegian family 1型长QT综合征患者的癫痫:一个挪威家庭
Epilepsy and Behavior Case Reports Pub Date : 2018-01-01 DOI: 10.1016/j.ebcr.2018.09.006
Alba González , Dag Aurlien , Kristina H. Haugaa , Erik Taubøll
{"title":"Epilepsy in patients with long QT syndrome type 1: A Norwegian family","authors":"Alba González ,&nbsp;Dag Aurlien ,&nbsp;Kristina H. Haugaa ,&nbsp;Erik Taubøll","doi":"10.1016/j.ebcr.2018.09.006","DOIUrl":"10.1016/j.ebcr.2018.09.006","url":null,"abstract":"<div><p>The congenital long QT syndrome (cLQTS) is an inherited cardiac disorder and is associated with sudden cardiac death. We describe a Norwegian family with mutations within the <em>KCNQ1</em> gene causing cLQTS type 1 (LQT1) and epilepsy. The index patient had Jervell and Lange-Nielsen-syndrome (JLNS) with deafness and recurrent episodes of cardiac arrhythmia. The mother and the brother have Romano-Ward syndrome (RWS) with recurrent arrhythmias. Whereas the father has focal epilepsy and genetically verified LQT1, the sister has both focal epilepsy and RWS.</p><p>Our findings are consistent with the notion that mutations in the <em>KCNQ1</em> gene can cause epilepsy.</p></div>","PeriodicalId":56365,"journal":{"name":"Epilepsy and Behavior Case Reports","volume":"10 ","pages":"Pages 118-121"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ebcr.2018.09.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36656195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Successful use of pure cannabidiol for the treatment of super-refractory status epilepticus 成功使用纯大麻二酚治疗超难治性癫痫持续状态
Epilepsy and Behavior Case Reports Pub Date : 2018-01-01 DOI: 10.1016/j.ebcr.2018.07.004
Rajsekar R. Rajaraman , Raman Sankar , Shaun A. Hussain
{"title":"Successful use of pure cannabidiol for the treatment of super-refractory status epilepticus","authors":"Rajsekar R. Rajaraman ,&nbsp;Raman Sankar ,&nbsp;Shaun A. Hussain","doi":"10.1016/j.ebcr.2018.07.004","DOIUrl":"10.1016/j.ebcr.2018.07.004","url":null,"abstract":"<div><p>We present the case of a child with long-standing, super-refractory status epilepticus (SRSE) who manifested prompt and complete resolution of SRSE upon exposure to pure cannabidiol. SRSE emerged in the context of remote suspected encephalitis with previously well-controlled epilepsy. We discuss the extent to which response may be specifically attributed to cannabidiol, with consideration and discussion of multiple potential drug–drug interactions. Based on this case, we propose that adjunctive cannabidiol be considered in the treatment of SRSE.</p></div>","PeriodicalId":56365,"journal":{"name":"Epilepsy and Behavior Case Reports","volume":"10 ","pages":"Pages 141-144"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ebcr.2018.07.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36866136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Visual hallucinations: A novel complication after hemispherectomy 视幻觉:半脑切除术后的新并发症
Epilepsy and Behavior Case Reports Pub Date : 2018-01-01 DOI: 10.1016/j.ebcr.2017.09.005
Jonas Vanags , Monisha Sachdev , Gerald Grant , Mohamad A. Mikati
{"title":"Visual hallucinations: A novel complication after hemispherectomy","authors":"Jonas Vanags ,&nbsp;Monisha Sachdev ,&nbsp;Gerald Grant ,&nbsp;Mohamad A. Mikati","doi":"10.1016/j.ebcr.2017.09.005","DOIUrl":"10.1016/j.ebcr.2017.09.005","url":null,"abstract":"<div><p>Two patients at our center experienced florid visual hallucinations following hemispherectomy. The first patient had drug-resistant left hemispheric focal seizures at 20<!--> <!-->months of age from a previous stroke. Following functional hemispherectomy at age 3, he experienced frightening hallucinations 1<!--> <!-->month post-operatively lasting 3.5<!--> <!-->months. Our second patient underwent subtotal hemispherectomy at age 6 for drug-resistant focal seizures from right hemispheric cortical dysplasia. Eighteen<!--> <!-->months later he developed scary visual hallucinations during which he would shout and throw things. Hallucinations recurred for 6<!--> <!-->months. In our experience in these patients, even though symptoms were florid, they were transient and subsided 3–6<!--> <!-->months later.</p></div>","PeriodicalId":56365,"journal":{"name":"Epilepsy and Behavior Case Reports","volume":"9 ","pages":"Pages 51-53"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ebcr.2017.09.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36041875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Teratoma-negative anti-NMDA receptor encephalitis presenting with a single generalized tonic–clonic seizure 畸胎瘤阴性抗nmda受体脑炎表现为单一全身性强直-阵挛性发作
Epilepsy and Behavior Case Reports Pub Date : 2018-01-01 DOI: 10.1016/j.ebcr.2018.02.001
Andy Cheuk-Him Ng , Miljan Tripic , Seyed M. Mirsattari
{"title":"Teratoma-negative anti-NMDA receptor encephalitis presenting with a single generalized tonic–clonic seizure","authors":"Andy Cheuk-Him Ng ,&nbsp;Miljan Tripic ,&nbsp;Seyed M. Mirsattari","doi":"10.1016/j.ebcr.2018.02.001","DOIUrl":"10.1016/j.ebcr.2018.02.001","url":null,"abstract":"<div><p>Herein, we describe a case report of anti-NMDA receptor encephalitis characterized by a single generalized tonic–clonic seizure and predominantly psychiatric symptoms, persisting long after EEG abnormalities had resolved. We discuss common presentations of anti-NMDA receptor encephalitis and advocate for the inclusion of this disease entity in the differential diagnosis of patients presenting with one generalized tonic–clonic seizure and prominent psychiatric symptoms.</p></div>","PeriodicalId":56365,"journal":{"name":"Epilepsy and Behavior Case Reports","volume":"10 ","pages":"Pages 29-31"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ebcr.2018.02.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36286340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Neurosurgical treatment of nonconvulsive status epilepticus due to focal cortical dysplasia 局灶性皮质发育不良所致非惊厥性癫痫持续状态的神经外科治疗
Epilepsy and Behavior Case Reports Pub Date : 2018-01-01 DOI: 10.1016/j.ebcr.2018.03.003
Emin Timer , Saeid Charsouei , Nerses Bebek , Betül Baykan , Bilge Bilgiç , Pulat Akın Sabancı , Yavuz Aras , Nail İzgi , Candan Gürses
{"title":"Neurosurgical treatment of nonconvulsive status epilepticus due to focal cortical dysplasia","authors":"Emin Timer ,&nbsp;Saeid Charsouei ,&nbsp;Nerses Bebek ,&nbsp;Betül Baykan ,&nbsp;Bilge Bilgiç ,&nbsp;Pulat Akın Sabancı ,&nbsp;Yavuz Aras ,&nbsp;Nail İzgi ,&nbsp;Candan Gürses","doi":"10.1016/j.ebcr.2018.03.003","DOIUrl":"10.1016/j.ebcr.2018.03.003","url":null,"abstract":"<div><p>We present a rare case of focal cortical dysplasia (FCD) and nonconvulsive status epilepticus (NCSE) treated successfully with early surgical intervention. Our case is a 9-year-old boy whose seizures, characterized by short episodes of loss of consciousness, appeared at the age of 7, and he showed progressive cognitive decline in the following years. NCSE was diagnosed, and his MRI revealed FCD in the left frontal region which was the same side as his EEG abnormality. Following lesionectomy, his NCSE disappeared and cognitive functions improved. Histopathologic analysis of the resected tissue revealed type-IIB FCD. This case illustrates the importance of early surgery to help restore cognitive functions by eliminating the clinical and electrophysiological features of NCSE.</p></div>","PeriodicalId":56365,"journal":{"name":"Epilepsy and Behavior Case Reports","volume":"10 ","pages":"Pages 4-7"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ebcr.2018.03.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36326190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Recurrent seizures from chronic kratom use, an atypical herbal opioid 慢性使用克拉托姆，一种非典型的草药类阿片
Epilepsy and Behavior Case Reports Pub Date : 2018-01-01 DOI: 10.1016/j.ebcr.2018.04.002
William O. Tatum , Tasneem F. Hasan , Erin E. Coonan , Christopher P. Smelick
{"title":"Recurrent seizures from chronic kratom use, an atypical herbal opioid","authors":"William O. Tatum ,&nbsp;Tasneem F. Hasan ,&nbsp;Erin E. Coonan ,&nbsp;Christopher P. Smelick","doi":"10.1016/j.ebcr.2018.04.002","DOIUrl":"10.1016/j.ebcr.2018.04.002","url":null,"abstract":"<div><p>Kratom is an herbal compound that has been used as a recreational drug though is not regulated by the Food and Drug Administration. We report a 19-year-old male with recurrent seizures that developed during daily Kratom abuse as a self-treatment for anxiety. Following recurrent focal impaired awareness seizures in addition to generalized tonic–clonic seizures, he was begun on anti-seizure drugs. Seizures subsided after completing rehabilitation. Brain MRI at 29 months revealed bilaterally symmetric T1-hyperintensity in globus pallidus, subthalamic nuclei, and cerebral peduncles. Our case suggests Kratom abuse may be associated with structural brain lesions on MRI and symptomatic focal epilepsy.</p></div>","PeriodicalId":56365,"journal":{"name":"Epilepsy and Behavior Case Reports","volume":"10 ","pages":"Pages 18-20"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ebcr.2018.04.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36359150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 32
Drug resistant epilepsy with mesial temporal sclerosis as possible late neurological complication in two AML survivors after stem cell transplantation 两例干细胞移植后AML幸存者的耐药癫痫伴内侧颞叶硬化可能的晚期神经系统并发症
Epilepsy and Behavior Case Reports Pub Date : 2018-01-01 DOI: 10.1016/j.ebcr.2018.05.001
Kwan-Ming Karen Yam , Wing-Kwan Alex Leung , Xian-Lun Zhu , Lai-Wah Eva Fung
{"title":"Drug resistant epilepsy with mesial temporal sclerosis as possible late neurological complication in two AML survivors after stem cell transplantation","authors":"Kwan-Ming Karen Yam ,&nbsp;Wing-Kwan Alex Leung ,&nbsp;Xian-Lun Zhu ,&nbsp;Lai-Wah Eva Fung","doi":"10.1016/j.ebcr.2018.05.001","DOIUrl":"10.1016/j.ebcr.2018.05.001","url":null,"abstract":"","PeriodicalId":56365,"journal":{"name":"Epilepsy and Behavior Case Reports","volume":"10 ","pages":"Pages 71-77"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ebcr.2018.05.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36367215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Long-term use of methylphenidate in a boy with hypothalamic tumor, drug-resistant epilepsy and ADHD 长期使用哌甲酯治疗患有下丘脑肿瘤、耐药癫痫和多动症的男孩
Epilepsy and Behavior Case Reports Pub Date : 2018-01-01 DOI: 10.1016/j.ebcr.2018.03.002
Dobrinko Socanski , Nebojsa Jovic , Harald Beneventi , Anita Herigstad
{"title":"Long-term use of methylphenidate in a boy with hypothalamic tumor, drug-resistant epilepsy and ADHD","authors":"Dobrinko Socanski ,&nbsp;Nebojsa Jovic ,&nbsp;Harald Beneventi ,&nbsp;Anita Herigstad","doi":"10.1016/j.ebcr.2018.03.002","DOIUrl":"10.1016/j.ebcr.2018.03.002","url":null,"abstract":"","PeriodicalId":56365,"journal":{"name":"Epilepsy and Behavior Case Reports","volume":"10 ","pages":"Pages 82-85"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ebcr.2018.03.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36382947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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