Journal of the Anus Rectum and Colon最新文献_第8页

A Successful Simultaneous Robotic Resection of Giant Uterine Fibroids and Rectal Cancer. 机器人成功同时切除巨大子宫肌瘤和直肠癌。

IF 1.5

Journal of the Anus Rectum and Colon Pub Date : 2025-07-25 eCollection Date: 2025-01-01 DOI: 10.23922/jarc.2024-097

Yuichiro Furutani, Masanori Kotake, Tetsuro Oda, Kei Sugano, Daisuke Fujimori, Takahiro Yoshimura, Koichiro Sawada, Hironori Hayashi, Kaeko Oyama, Takuo Hara, Noriyuki Inaki

{"title":"A Successful Simultaneous Robotic Resection of Giant Uterine Fibroids and Rectal Cancer.","authors":"Yuichiro Furutani, Masanori Kotake, Tetsuro Oda, Kei Sugano, Daisuke Fujimori, Takahiro Yoshimura, Koichiro Sawada, Hironori Hayashi, Kaeko Oyama, Takuo Hara, Noriyuki Inaki","doi":"10.23922/jarc.2024-097","DOIUrl":"10.23922/jarc.2024-097","url":null,"abstract":"The number of reports of robotic surgery for colorectal cancer, including reports of simultaneous surgery involving multiple organs, has increased in recent years. We report a case of simultaneous robotic surgery for a giant uterine fibroid and rectal cancer. The patient 45-year-old woman was diagnosed with rectal cancer and a giant uterine fibroid measuring 18 cm in maximum diameter. The uterine fibroid was oriented toward the cervix and was approached from both sides, and the broad ligament of the uterus was cut off using a vessel sealer. The cervix was dissected from the side of the abdominal cavity using monopolar curved scissors. The GelPOINT Access Platform™ was attached to the vagina, and the laparoscopic camera was inserted into the vagina to confirm the resection site. The border between the uterus and rectum was confirmed from both the abdominal cavity and vaginal sides, and simple total hysterectomy was safely performed. The rectum was dissected below the peritoneal reflection. The excised uterine specimen measured 18×13×5 cm long. The patient underwent robotic surgery for a giant uterine fibroid and rectal cancer. It is important to plan and simulate the surgery beforehand as well as select the site for trocar placement.","PeriodicalId":56349,"journal":{"name":"Journal of the Anus Rectum and Colon","volume":"9 3","pages":"345-349"},"PeriodicalIF":1.5,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12307017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fibrinogen-Albumin Ratio: An Independent Recurrence Factor for Colorectal Cancer Stages II and III in a Competing Risk Model. 纤维蛋白原-白蛋白比率：在竞争风险模型中结直肠癌II期和III期的独立复发因素。

IF 1.5

Journal of the Anus Rectum and Colon Pub Date : 2025-07-25 eCollection Date: 2025-01-01 DOI: 10.23922/jarc.2024-112

Michiaki Shimada, Takanori Goi, Takayuki Tagai, Katsuzi Sawai, Mitsuhiro Morikawa, Masato Tamaki, Kenji Koneri

{"title":"Fibrinogen-Albumin Ratio: An Independent Recurrence Factor for Colorectal Cancer Stages II and III in a Competing Risk Model.","authors":"Michiaki Shimada, Takanori Goi, Takayuki Tagai, Katsuzi Sawai, Mitsuhiro Morikawa, Masato Tamaki, Kenji Koneri","doi":"10.23922/jarc.2024-112","DOIUrl":"10.23922/jarc.2024-112","url":null,"abstract":"Objectives: Colorectal cancer remains a major global health concern. Identifying high-risk patients is crucial for optimizing treatment strategies. The prognostic value of biomarkers, especially considering competing risks, remains unclear. We used a competing risks model to exclude the influence of non-cancer-related mortality and examined FAR as a predictor of recurrence in colorectal cancer.Methods: This retrospective study analyzed 359 patients with stage II or III colorectal cancer from the cecum to the oral side of the peritoneal inversion, all of whom underwent curative resection at Fukui University Hospital. The primary outcome was cancer recurrence. The fibrinogen-albumin ratio (FAR) was assessed using univariate and multivariate analyses, including competing risk models, with a cutoff value of >0.131.Results: Univariate analysis identified factors significantly associated with poorer outcomes, including T4 stage, gross appearance type 3/4/5 tumors, stage III disease, elevated neutrophil-to-lymphocyte ratio, prognostic nutritional index, carcinoembryonic antigen, and FAR. Multivariate analysis confirmed FAR as an independent prognostic factor. A predictive model combining FAR, stage III disease, and T4 stage demonstrated the best performance based on Akaike information criterion and Bayesian information criterion values.Conclusions: FAR is a robust prognostic biomarker for colorectal cancer. Incorporating FAR into clinical practice may enable healthcare providers to more accurately stratify high-risk patients, facilitating personalized treatment strategies.","PeriodicalId":56349,"journal":{"name":"Journal of the Anus Rectum and Colon","volume":"9 3","pages":"321-329"},"PeriodicalIF":1.5,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12307011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is Injectable Sclerotherapy with Polidocanol Foam Effective for Treating Hemorrhoids in Patients with Severe Anemia? 聚多醇泡沫注射硬化治疗严重贫血患者痔疮有效吗？

IF 1.5

Journal of the Anus Rectum and Colon Pub Date : 2025-07-25 eCollection Date: 2025-01-01 DOI: 10.23922/jarc.2024-072

Yang Liu, Xiaochun Tao, Yingxin Fu, Chen Wang

{"title":"Is Injectable Sclerotherapy with Polidocanol Foam Effective for Treating Hemorrhoids in Patients with Severe Anemia?","authors":"Yang Liu, Xiaochun Tao, Yingxin Fu, Chen Wang","doi":"10.23922/jarc.2024-072","DOIUrl":"10.23922/jarc.2024-072","url":null,"abstract":"Objectives: The aim of this study was to evaluate the effectiveness of injectable sclerotherapy using Polidocanol foam in patients with hemorrhoids and severe anemia during a 1-year follow-up period, while utilizing the Hemorrhoidal Disease Severity Score (HDSS) in conjunction with Short Health Scale (SHS) for assessment.Methods: A retrospective analysis was conducted on patients with severe anemia and hemorrhoids who underwent injectable sclerotherapy using Polidocanol foam between February 2022 and May 2023.Results: The bleeding symptoms in all patients resolved immediately after treatment. Hemoglobin levels increased rapidly within one month after treatment, and statistically significant improvements were observed in HDSS score, and SHS score (P<0.001) during the one-year follow-up. Two patients experienced recurrence of prolapse symptoms during the one-year follow-up period and subsequently underwent hemorrhoidectomy.Conclusions: The use of Polidocanol foam in injectable sclerotherapy demonstrates highly promising effects in patients suffering from severe anemia caused by hemorrhoids.","PeriodicalId":56349,"journal":{"name":"Journal of the Anus Rectum and Colon","volume":"9 3","pages":"339-344"},"PeriodicalIF":1.5,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12307016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary Choriocarcinoma of Colon: Case Report and Literature Review. 结肠原发性绒毛膜癌：病例报告及文献复习。

IF 1.5

Journal of the Anus Rectum and Colon Pub Date : 2025-07-25 eCollection Date: 2025-01-01 DOI: 10.23922/jarc.2024-114

Naoto Okazaki, Akira Tanaka, Masanori Yasuda, Yu Hiraoka, Shintaro Ishikawa, Masatoshi Yoshizawa, Hisashi Hayashi, Yoshio Gunji, Yasumitsu Hirano

{"title":"Primary Choriocarcinoma of Colon: Case Report and Literature Review.","authors":"Naoto Okazaki, Akira Tanaka, Masanori Yasuda, Yu Hiraoka, Shintaro Ishikawa, Masatoshi Yoshizawa, Hisashi Hayashi, Yoshio Gunji, Yasumitsu Hirano","doi":"10.23922/jarc.2024-114","DOIUrl":"10.23922/jarc.2024-114","url":null,"abstract":"Primary colorectal choriocarcinoma is extremely rare with only 35 cases described in the literature during over 40 years. The neoplasm is characterized by biphasic tumor growth composed of adenocarcinomatous and choriocarcinomatous differentiation. Diagnostic elusiveness, aggressive nature and lack of established treatment make the prognosis extremely poor, and most patients die during the first year after diagnosis. We present a 66-year-old man with a primary choriocarcinoma of the transverse colon presenting with peritoneal metastasis and acute colonic obstruction. The patient was treated with systemic three-drug chemotherapy (mFOLFOXIRI: 5-fluorouracil/leucovorin + oxaliplatin + irinotecan) in combination with bevacizumab, a highly active regimen for metastatic colorectal adenocarcinoma. Tumor shrinkage was accompanied by a decrease of mononucleated trophoblast-like carcinoma cells in an endoscopic biopsy during the treatment, and the symptoms of disease were relieved within a quite short period of therapy, though rapid regrowth associated with serum beta human chorionic gonadotropin escalation occurred following discontinuation of therapy. The patient died 8 months after the initial diagnosis. Although our patient survived longer than the median survival period documented in the literature, further cases will need to be examined in the future to establish whether this antitumor treatment is effective to prolong survival.","PeriodicalId":56349,"journal":{"name":"Journal of the Anus Rectum and Colon","volume":"9 3","pages":"356-361"},"PeriodicalIF":1.5,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12307013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Local Resection of Secondary Perianal Paget Disease Appearing during "Watch and Wait" Management of Locally Advanced Rectal Cancer after Preoperative Chemoradiotherapy. 局部晚期直肠癌术前放化疗后“观察等待”治疗中继发肛周Paget病局部切除1例

IF 1.5

Journal of the Anus Rectum and Colon Pub Date : 2025-07-25 eCollection Date: 2025-01-01 DOI: 10.23922/jarc.2025-007

Takahiro Amano, Toshiki Mukai, Masashi Akiya, Tatsuki Noguchi, Takashi Sakamoto, Shimpei Matsui, Senzo Taguchi, Tomohiro Yamaguchi, Akiko Chino, Tomoyuki Yano, Hiroshi Kawachi, Takashi Akiyoshi

{"title":"A Case of Local Resection of Secondary Perianal Paget Disease Appearing during \"Watch and Wait\" Management of Locally Advanced Rectal Cancer after Preoperative Chemoradiotherapy.","authors":"Takahiro Amano, Toshiki Mukai, Masashi Akiya, Tatsuki Noguchi, Takashi Sakamoto, Shimpei Matsui, Senzo Taguchi, Tomohiro Yamaguchi, Akiko Chino, Tomoyuki Yano, Hiroshi Kawachi, Takashi Akiyoshi","doi":"10.23922/jarc.2025-007","DOIUrl":"10.23922/jarc.2025-007","url":null,"abstract":"A 78-year-old woman was diagnosed with lower rectal cancer extending to the dentate line. She underwent preoperative chemoradiotherapy, which resulted in tumor shrinkage and clinical complete response (cCR), leading to the implementation of the \"Watch and Wait\" strategy. At the 21-month surveillance mark, pruritus and erythematous lesions appeared around her anus, which were histologically diagnosed as secondary Paget disease with invasion based on biopsy specimens. Because the primary lesion maintained cCR, local excision of the skin lesion was performed, and negative resection margins were confirmed by pathological examination. At the 4-year postoperative follow-up, neither local recurrence nor distant metastases were observed. This case suggests that although the primary focus disappeared entirely with the use of chemoradiotherapy, microscopic perianal secondary Paget disease hidden outside the radiation field became apparent during surveillance. As total neoadjuvant therapy (TNT) becomes more widespread, the frequency of cCR is expected to increase. During the \"Watch and Wait\" period, vigilant observation of the perianal skin as well as the rectal region should be performed.","PeriodicalId":56349,"journal":{"name":"Journal of the Anus Rectum and Colon","volume":"9 3","pages":"350-355"},"PeriodicalIF":1.5,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12307010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Solitary Fibrous Tumor in the Pelvis Completely Resected Using the Hugo RAS System. Hugo RAS系统完全切除骨盆孤立性纤维性肿瘤1例。

IF 1.5

Journal of the Anus Rectum and Colon Pub Date : 2025-07-25 eCollection Date: 2025-01-01 DOI: 10.23922/jarc.2025-027

Maho Toyota, Masaaki Miyo, Koichi Okuya, Ai Noda, Masayuki Ishii, Ryo Miura, Kohei Okamoto, Tatsuya Ito, Yuji Akiyama, Tadashi Ogawa, Akina Kimura, Ichiro Takemasa

{"title":"A Case of Solitary Fibrous Tumor in the Pelvis Completely Resected Using the Hugo RAS System.","authors":"Maho Toyota, Masaaki Miyo, Koichi Okuya, Ai Noda, Masayuki Ishii, Ryo Miura, Kohei Okamoto, Tatsuya Ito, Yuji Akiyama, Tadashi Ogawa, Akina Kimura, Ichiro Takemasa","doi":"10.23922/jarc.2025-027","DOIUrl":"10.23922/jarc.2025-027","url":null,"abstract":"Solitary fibrous tumors (SFT) are rare mesenchymal neoplasms, and surgical resection with a negative margin is considered to have a good prognosis. It is commonly located in the thoracic cavity but rarely develops in the pelvis. One of the features of the Hugo RAS system is the independent robotic arm carts that enable high flexibility of settings and safe operations with reduced interference, even in a narrow pelvis, which may be particularly useful in surgery for pelvic masses. A 34-year-old woman presented to our hospital with a pelvic mass detected by transvaginal ultrasound during a prenatal check-up. Colonoscopy, computed tomography, and magnetic resonance imaging suggested a gastrointestinal stromal tumor, smooth muscle tumor, schwannoma, and SFT. However, since a definitive diagnosis could not be obtained and continuity with the rectum could not be ruled out, intersphincteric resection (ISR) was performed for diagnostic and therapeutic purposes. The pathological results showed complete resection of the SFT with negative margins, and the patient had a good postoperative course. Herein, we report the first case of safe and complete resection of a massive pelvic SFT using the Hugo RAS system.","PeriodicalId":56349,"journal":{"name":"Journal of the Anus Rectum and Colon","volume":"9 3","pages":"362-367"},"PeriodicalIF":1.5,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12307012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of Hybrid Endoscopic Submucosal Dissection to Ensure Adequate Submucosal Layer for T1b Colorectal Carcinomas of 20-30 mm in Diameter. 混合内镜下粘膜下夹层对直径20- 30mm的T1b型结直肠癌粘膜下层的保护作用

IF 1.5

Journal of the Anus Rectum and Colon Pub Date : 2025-07-25 eCollection Date: 2025-01-01 DOI: 10.23922/jarc.2025-009

Yudai Takehara, Ken Yamashita, Shin Morimoto, Fumiaki Tanino, Noriko Yamamoto, Yuki Kamigaichi, Hidenori Tanaka, Hidehiko Takigawa, Yuji Urabe, Toshio Kuwai, Koji Arihiro, Shiro Oka

{"title":"Efficacy of Hybrid Endoscopic Submucosal Dissection to Ensure Adequate Submucosal Layer for T1b Colorectal Carcinomas of 20-30 mm in Diameter.","authors":"Yudai Takehara, Ken Yamashita, Shin Morimoto, Fumiaki Tanino, Noriko Yamamoto, Yuki Kamigaichi, Hidenori Tanaka, Hidehiko Takigawa, Yuji Urabe, Toshio Kuwai, Koji Arihiro, Shiro Oka","doi":"10.23922/jarc.2025-009","DOIUrl":"10.23922/jarc.2025-009","url":null,"abstract":"Objectives: Although hybrid endoscopic submucosal dissection (ESD) has gained popularity over the years, its usefulness in ensuring an adequate submucosal [SM] layer for T1b (SM invasion depth ≥1,000 μm) colorectal carcinoma (CRC) remains unknown. We retrospectively compared conventional ESD (C-ESD) with planned hybrid ESD (PH-ESD) for cT1b CRCs measuring 20-30 mm.Methods: We analyzed 71 consecutive cases of cT1b CRC (20-30 mm). The patients were classified into C-ESD (n=38), PH-ESD (n=21), or salvage hybrid ESD (n=12) groups. We compared the clinicopathological characteristics, including resected SM and vertical margin (VM) distance, and outcomes between the C-ESD and PH-ESD groups. We also investigated the factors leading to VM positivity (VM1).Results: The PH-ESD group exhibited a significantly shorter procedure time (40.5 vs. 60.5 min) and a significantly higher rate of VM ≥500 μm (81.0% vs. 47.4%) compared to the C-ESD group. Regarding superficial tumors, the PH-ESD group exhibited significantly longer resected SM (1,243 vs. 837 μm) and VM (545 vs. 302 μm) distances and a significantly higher rate of VM ≥500 μm (72.7% vs. 14.3%) than the C-ESD group. All VM1 lesions were resected using C-ESD or salvage hybrid ESD. VM1 lesions exhibited significantly higher rates of poorly differentiated histology at the deepest invasive front (71.9% vs. 14.3%) and perioperative perforation (28.6% vs. 0%) than VM-negative lesions.Conclusions: PH-ESD for 20-30-mm T1b CRCs may be more useful than C-ESD in terms of procedure time, especially for superficial lesions, ensuring a longer resected SM distance and VM ≥500 μm.","PeriodicalId":56349,"journal":{"name":"Journal of the Anus Rectum and Colon","volume":"9 3","pages":"292-301"},"PeriodicalIF":1.5,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12307009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preoperative MRI Assessment of Mesorectal Lymph Node Metastasis in Patients with Rectal Cancer: A Retrospective Study. 直肠癌患者直肠系膜淋巴结转移的术前MRI评估：回顾性研究。

IF 1.5

Journal of the Anus Rectum and Colon Pub Date : 2025-07-25 eCollection Date: 2025-01-01 DOI: 10.23922/jarc.2024-095

Fumi Shigehara, Hirotoshi Kobayashi, Ayaka Koizumi, Junpei Takashima, Kenji Yamazaki, Hitoshi Sugimoto, Daisuke Fujimoto, Fumihiko Miura

{"title":"Preoperative MRI Assessment of Mesorectal Lymph Node Metastasis in Patients with Rectal Cancer: A Retrospective Study.","authors":"Fumi Shigehara, Hirotoshi Kobayashi, Ayaka Koizumi, Junpei Takashima, Kenji Yamazaki, Hitoshi Sugimoto, Daisuke Fujimoto, Fumihiko Miura","doi":"10.23922/jarc.2024-095","DOIUrl":"10.23922/jarc.2024-095","url":null,"abstract":"Objectives: This study aimed to determine the optimal cutoff values for predicting mesorectal lymph node metastasis in rectal cancer using preoperative magnetic resonance imaging (MRI) parameters.Methods: We retrospectively analyzed 67 patients with rectal cancer who underwent resection and preoperative pelvic MRI at our institution between April 2015 and December 2023. The MRI-based long- and short-axis diameters of mesorectal lymph nodes were compared with pathological findings to assess their correlation with lymph node metastasis. Receiver operating characteristic (ROC) curve analysis was used to determine the optimal cutoff values for metastasis prediction.Results: The median age was 70.5 years, and 48 were male. Among the 67 patients, 30 had mesorectal lymph node metastasis. At our institution, lymph nodes with a long-axis diameter of ≥ 8 mm on MRI were considered positive for metastasis. Using this threshold, the sensitivity and specificity for predicting mesorectal lymph node metastasis were 0.63 and 0.54, respectively. ROC curve analysis identified cutoff values of 6.9 mm for the long-axis diameter, 4.8 mm for the short-axis diameter, and 0.83 for the short-to-long axis ratio. The areas under the ROC curve for the long-axis, short-axis, and short-to-long axis ratio were 0.81, 0.86, and 0.60, respectively.Conclusions: A preoperative long-axis diameter of ≥ 7 mm and a short-axis diameter of ≥ 5 mm were found to be reliable predictors of mesorectal lymph node metastasis in rectal cancer. Using a 5-mm short-axis cutoff improved diagnostic specificity. These findings require further validation in clinical settings to optimize treatment strategies.","PeriodicalId":56349,"journal":{"name":"Journal of the Anus Rectum and Colon","volume":"9 3","pages":"285-291"},"PeriodicalIF":1.5,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12307018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk Assessment of Stoma Outlet Obstruction Development when a Temporary Ileostomy is Created during Rectal Cancer Surgery. 直肠癌手术中临时回肠造口时造口出口梗阻的风险评估。

IF 1.4

Journal of the Anus Rectum and Colon Pub Date : 2025-04-25 eCollection Date: 2025-01-01 DOI: 10.23922/jarc.2024-109

Chiharu Yasui, Kyoichi Kihara, Ryo Ishiguro, Takuki Yagyu, Yusuke Kono, Manabu Yamamoto, Tomoyuki Matsunaga, Naruo Tokuyasu, Teruhisa Sakamoto, Yoshiyuki Fujiwara

{"title":"Risk Assessment of Stoma Outlet Obstruction Development when a Temporary Ileostomy is Created during Rectal Cancer Surgery.","authors":"Chiharu Yasui, Kyoichi Kihara, Ryo Ishiguro, Takuki Yagyu, Yusuke Kono, Manabu Yamamoto, Tomoyuki Matsunaga, Naruo Tokuyasu, Teruhisa Sakamoto, Yoshiyuki Fujiwara","doi":"10.23922/jarc.2024-109","DOIUrl":"https://doi.org/10.23922/jarc.2024-109","url":null,"abstract":"Objectives: In surgery for lower rectal cancer, temporary ileostomy can be created to avoid complications, such as anastomotic leakage. However, various complications may occur with the stoma, including stoma outlet obstruction (SOO). The occurrence of SOO can prolong the length of hospital stay and delay the introduction of adjuvant chemotherapy, which can negatively affect the prognosis. We retrospectively reviewed cases of temporary ileostomy at our hospital and evaluated the risk factors for SOO.Methods: We extracted data pertaining to patients with temporary ileostomy created during surgery for rectal cancer from 2013 to 2023, and compared clinicopathologic factors or short-term outcomes, with or without SOO complications. We scored the independent factors obtained and created predictive scoring model for SOO.Results: Total of 107 patients were included. SOO was observed in 21 patients (19.6%), all of whom were male. SOO was most frequently diagnosed on sixth postoperative day. In most cases, feeding resumed 4 days after the diagnosis of SOO. Age (≥67 years; p = 0.002), rectus abdominis muscle thickness (≥13.5 mm; p < 0.001) and the amount of stoma output greater than 1,500 ml/day within 3 days of surgery (p < 0.001) were independent risk factors for SOO. The preoperative and early postoperative predictive scoring model, created by adding one point to each risk factor, predicted SOO with sensitivity of 76.2%, specificity of 89.5%.Conclusions: Age, gender, rectus abdominis muscle thickness, and high early postoperative output are risk factors for SOO. A scoring model may be useful for predicting SOO.","PeriodicalId":56349,"journal":{"name":"Journal of the Anus Rectum and Colon","volume":"9 2","pages":"260-269"},"PeriodicalIF":1.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hereditary Colorectal Cancer: Clinical Implications of Genomic Medicine and Precision Oncology. 遗传性结直肠癌：基因组医学和精确肿瘤学的临床意义。

IF 1.4

Journal of the Anus Rectum and Colon Pub Date : 2025-04-25 eCollection Date: 2025-01-01 DOI: 10.23922/jarc.2025-001

Atsushi Yamada, Tomohiro Kondo

{"title":"Hereditary Colorectal Cancer: Clinical Implications of Genomic Medicine and Precision Oncology.","authors":"Atsushi Yamada, Tomohiro Kondo","doi":"10.23922/jarc.2025-001","DOIUrl":"https://doi.org/10.23922/jarc.2025-001","url":null,"abstract":"Approximately 10% of colorectal cancer (CRC) cases occur in the context of hereditary cancer-predisposing conditions caused by germline pathogenic variants (PVs) in cancer predisposition genes, with Lynch syndrome and familial adenomatous polyposis at the top of the list. Although the identification of hereditary CRC has traditionally relied on clinical characteristics, including familial accumulation, multiple and early onset of CRC and other related cancers, and the presence of gastrointestinal polyposis, more comprehensive approaches, such as universal tumor screening and universal germline testing, have recently been employed. From a technical standpoint, next-generation sequencing has enabled genome-wide analysis of genetic alterations in germline and somatic settings. Taking advantage of this technology, germline multigene panel testing has been utilized in genetic testing, which leads to the identification of PVs, not only in well-known hereditary CRC genes but also in rare causal genes, moderate-risk genes, and high-risk genes previously not linked to CRC predisposition. In addition, comprehensive genomic profiling and companion diagnostics for solid tumors occasionally yield unexpected hereditary CRC diagnoses. Thus, more hereditary CRCs have been identified not based on clinical phenotypes but rather by comprehensive approaches or as secondary findings of treatment drug testing. In this review, we discuss the impact of recent advances in genomic medicine on the clinical aspects of hereditary CRC, which has promoted an understanding of the entire landscape of genetic predisposition to CRC.","PeriodicalId":56349,"journal":{"name":"Journal of the Anus Rectum and Colon","volume":"9 2","pages":"167-178"},"PeriodicalIF":1.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0