Breast Journal最新文献

{"title":"Recurrence Rate Following Breast Conservation Surgery: A Retrospective Cohort Study","authors":"Liyang Wang,&nbsp;Yuchen Yuan,&nbsp;Urvashi Jain,&nbsp;Eleftheria Kleidi","doi":"10.1155/tbj/5063047","DOIUrl":"10.1155/tbj/5063047","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Breast-conserving surgery (BCS) has become the standard treatment for early-stage breast cancer, offering oncological safety, better breast aesthetics, and enhanced health-related quality of life. The optimal margins for BCS have been debated. However, evidence on the impact of margin widths greater than 0 mm for invasive breast cancer remains limited. Cambridge Breast Unit (CBU) has adopted a policy where a single margin of &lt; 1 mm (not at ink) for invasive disease would be acceptable, provided the other three radial margins are ≥ 1 mm.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>Retrospective cohort study analyzed 372 women who underwent BCS for invasive breast cancer at CBU between 2015 and 2016. Patients with pure ductal carcinoma in situ (DCIS), prior breast cancer treatment, or neoadjuvant chemotherapy were excluded. Clinical data, including patient demographics, tumor characteristics, margin status, and recurrence and survival outcomes, were extracted from electronic records.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>At a median follow-up of 5.2 years, the ipsilateral breast tumor recurrence (IBTR) rate was 1.6% (6/372) with an overall recurrence rate of 5.6% (21/372). No significant association was found between final resection margins and local or overall recurrence rates, nor was margin status correlated with breast cancer recurrence-free survival. A total of 53 patients (14.2%) required additional surgeries due to margin status. By accepting a single radial margin &lt; 1 mm, our margin policy reduced reoperations by 33%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Margin assessment in breast surgery is multifaceted, requiring a personalized approach that considers tumor biology, systemic treatments, and pathological variability. Our findings support accepting a margin width of &lt; 1 mm (no tumor on ink) for a single radial margin in invasive breast cancer, provided the other three radial margins are ≥ 1 mm. It reduces reoperations without compromising oncological outcomes. Integrating advanced intraoperative techniques and multidisciplinary decision-making will further optimize patient care and long-term outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2026 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/tbj/5063047","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147445680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding Disparities in Breast Reconstruction Rates in Regional Populations Following Oncologic Resection of Breast Cancer: A 10-Year Retrospective Observational Cohort Study.","authors":"Samuel M Jansson, Calyb J Austin, Mingchun Liu, Steven J Craig","doi":"10.1155/tbj/1281318","DOIUrl":"10.1155/tbj/1281318","url":null,"abstract":"<p><strong>Introduction: </strong>Breast cancer is the most common cancer among women globally, with 2.3 million new cases in 2020. Globally, incidence rates of breast cancer are highest in Australia, yet only 29% of Australian women opt for breast reconstruction (BR). The decision-making process for BR is complex, involving various surgical and nonsurgical considerations. Approximately 50% of women would choose BR if adequately informed and given the option. This study evaluates the factors contributing to reduced BR rates in regional and rural New South Wales over a 10-year period.</p><p><strong>Methods: </strong>A multicentre, retrospective observational cohort study analysed 2052 women who were diagnosed with breast cancer in the Illawarra Shoalhaven Local Health District between 2012 and 2022, focussing on primary resection outcomes and other objective factors that contributed to BR rates. Descriptive statistics, chi-squared tests and logistic regression were used to assess relationships between age, comorbidities, language and rurality, with reconstruction rates.</p><p><strong>Results: </strong>Among the 2052 women diagnosed with breast cancer who required oncologic resection, the mean age was 65 years. Only 127 (6.2%) underwent BR across the total cohort of 2052 patients, and just 65 of the 724 (9%) patients in the post-mastectomy subgroup underwent BR, significantly lower than state averages. Significant relationships were found between age and reconstruction rates (<i>p</i> < 0.001), with younger patients (< 55 years old) more likely to opt for BR. Logistic regression confirmed that increased age and rurality both significantly affected the likelihood of undergoing reconstruction.</p><p><strong>Conclusion: </strong>Women aged < 55 years old and those residing in metropolitan areas showed a higher likelihood of opting for BR, highlighting the influence of age and rural residency on access to reconstruction services. These findings emphasise the need for targeted interventions to enhance BR access, particularly for older and rural patients.</p>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2026 ","pages":"1281318"},"PeriodicalIF":2.0,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12968317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147437991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Shoulder Mobility After Breast Reconstruction With a Lipofilled Latissimus Dorsi Mini-Flap: A Prospective Cohort Study","authors":"Bruno Carvalho Carelli,&nbsp;Fabio Bagnoli,&nbsp;Eduardo de Melo Carvalho Rocha,&nbsp;José Francisco Rinaldi,&nbsp;Vilmar Marques de Oliveira","doi":"10.1155/tbj/5107548","DOIUrl":"10.1155/tbj/5107548","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The lipofilled latissimus dorsi mini-flap (LDMF-L) broadens autologous breast-reconstruction options, yet its functional impact on the shoulder remains uncertain.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate shoulder strength, range of motion (ROM) and patient-reported upper-limb function QuickDash 90 days after breast reconstruction with the LDMF-L.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Prospective cohort of 20 patients operated on between November 2022 and November 2024. Inclusion: Breast cancer requiring immediate or delayed reconstruction with LDMF-L; exclusion: Implant use or major pre-existing limitation. Strength (Oxford scale), ROM (goniometry) and QuickDASH score were assessed preoperatively and at 90 days. Wilcoxon, Student′s <i>t</i>-test, Mann–Whitney and McNemar tests were used appropriately (<i>α</i> = 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Mean age 54 ± 11.8 years; immediate/delayed reconstruction = 50/50%. Strength remained unchanged in 85% (<i>p</i> = 1.000). Active flexion and abduction showed significant reductions (<i>p</i> = 0.016 and 0.045), with no difference in rotations. QuickDASH increased from 8 ± 16 to 19 ± 24 (<i>p</i> = 0.008); nevertheless, 80% stayed within minimal/mild disability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The LDMF-L preserves strength and produces only mild early ROM decreases with limited functional impact, supporting its functional safety as an implant-free autologous option.</p>\u0000 </section>\u0000 </div>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2026 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12968331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147438018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding Disparities in Breast Reconstruction Rates in Regional Populations Following Oncologic Resection of Breast Cancer: A 10-Year Retrospective Observational Cohort Study","authors":"Samuel M. Jansson,&nbsp;Calyb J. Austin,&nbsp;Mingchun Liu,&nbsp;Steven J. Craig","doi":"10.1155/tbj/1281318","DOIUrl":"10.1155/tbj/1281318","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Breast cancer is the most common cancer among women globally, with 2.3 million new cases in 2020. Globally, incidence rates of breast cancer are highest in Australia, yet only 29% of Australian women opt for breast reconstruction (BR). The decision-making process for BR is complex, involving various surgical and nonsurgical considerations. Approximately 50% of women would choose BR if adequately informed and given the option. This study evaluates the factors contributing to reduced BR rates in regional and rural New South Wales over a 10-year period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A multicentre, retrospective observational cohort study analysed 2052 women who were diagnosed with breast cancer in the Illawarra Shoalhaven Local Health District between 2012 and 2022, focussing on primary resection outcomes and other objective factors that contributed to BR rates. Descriptive statistics, chi-squared tests and logistic regression were used to assess relationships between age, comorbidities, language and rurality, with reconstruction rates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the 2052 women diagnosed with breast cancer who required oncologic resection, the mean age was 65 years. Only 127 (6.2%) underwent BR across the total cohort of 2052 patients, and just 65 of the 724 (9%) patients in the post-mastectomy subgroup underwent BR, significantly lower than state averages. Significant relationships were found between age and reconstruction rates (<i>p</i> &lt; 0.001), with younger patients (&lt; 55 years old) more likely to opt for BR. Logistic regression confirmed that increased age and rurality both significantly affected the likelihood of undergoing reconstruction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Women aged &lt; 55 years old and those residing in metropolitan areas showed a higher likelihood of opting for BR, highlighting the influence of age and rural residency on access to reconstruction services. These findings emphasise the need for targeted interventions to enhance BR access, particularly for older and rural patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2026 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/tbj/1281318","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptom Clusters in Brazilian Women With Stage I and Stage III Nonmetastatic Breast Cancer: A Cross-Sectional Study","authors":"Luís Carlos Lopes-Júnior,&nbsp;Etreo Junior Carneiro da Silva Minarini,&nbsp;Raphael Manhães Pessanha,&nbsp;Luiz Cláudio Barreto Silva Neto,&nbsp;Naira Santos D’Agostini,&nbsp;Jonathan Grassi,&nbsp;Karla Anacleto Vasconcellos,&nbsp;Roberto Júnio Gomes Silva,&nbsp;Leticia Batista de Azevedo,&nbsp;Livia Machado Giacomin,&nbsp;Oscar Geovanny Enriquez-Martinez,&nbsp;Wesley Rocha Grippa","doi":"10.1155/tbj/5427340","DOIUrl":"10.1155/tbj/5427340","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Breast cancer is the most commonly diagnosed malignancy among women worldwide and a leading cause of cancer-related morbidity. As treatment advances have improved survival rates, symptom management has become a key component of comprehensive cancer care. Cancer-related symptoms often present in clusters rather than in isolation, potentially amplifying patient discomfort and negatively impacting quality of life. Identifying stage-specific symptom cluster patterns may provide critical insights for developing personalized supportive care strategies. This study aimed to identify and compare the prevalence, intensity, and discomfort of symptom clusters in women with Stage I and Stage III nonmetastatic breast cancer.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Method&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This cross-sectional study included 87 women aged &gt; 18 years with histopathological diagnoses of Stages I–III breast cancer, undergoing any phase of antineoplastic treatment at an oncology hospital in Brazil. Symptoms were assessed using the Memorial Symptom Assessment Scale (MSAS). The bootstrap resampling method was used to estimate 95% confidence intervals (CIs) for prevalence ratios (PRs) of MSAS symptoms, stratified by cancer stage. Symptom clusters were identified using hierarchical and k-means clustering analyses.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Among Stage I patients, the most prevalent symptoms were pain (68.6%), worrying (62.8%), difficulty sleeping (62.8%), and fatigue (60.8%). In Stage III patients, the most frequent symptoms were pain (72.0%), fatigue (66.7%), worrying (63.9%), and dry mouth (50.0%). Stage I patients had a higher prevalence of difficulty concentrating (PR = 1.50; &lt;i&gt;p&lt;/i&gt; = 0.015), shortness of breath (PR = 1.51; &lt;i&gt;p&lt;/i&gt; &lt; 0.001), feeling sad (PR = 1.41; &lt;i&gt;p&lt;/i&gt; = 0.002), and hair loss (PR = 1.60; &lt;i&gt;p&lt;/i&gt; = 0.037) compared to those with Stage III disease. Four clusters were identified for Stage I patients—neuropsychological, gastrointestinal, neurocognitive, and psychological—and for Stage III patients—psychoneurocognitive, gastrointestinal, chemotherapy-related, and neurocognitive.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;These findings highlight the heterogeneity of symptom experiences in women with nonmetastatic breast cancer, with distinct cluster profiles emerging at different disease stages. Understanding stage-specific symptom patterns may inform more personalized and targeted supportive care strategies to improve quality of life and clinical outcomes in this population.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 ","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2026 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12951005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OGT-Mediated O-GlcNAcylation Stabilizes c-Myc Activity and Promotes Chemoresistance in Triple-Negative Breast Cancer","authors":"Jie Li,&nbsp;Jing Zhang","doi":"10.1155/tbj/2120017","DOIUrl":"10.1155/tbj/2120017","url":null,"abstract":"<p>The transcription factor c-Myc is often overexpressed in chemotherapy-resistant triple-negative breast cancer (TNBC). c-Myc function and stability are considered key factors regulating chemoresistance. Recent studies have revealed a potential link between the O-linked β-N-acetylglucosamine modification (O-GlcNAcylation) of c-Myc and its function and stability; however, the underlying mechanisms remain unexplored. This study aimed to investigate the role of O-GlcNAcylation in promoting chemoresistance and to explore the underlying mechanisms. A cisplatin (DDP)-resistant MDA-MB-231 cell line was established using a dose escalation. CCK-8, flow cytometry, and colony formation assays were used to evaluate cell resistance under different treatments. Western blotting and coimmunoprecipitation analyses were performed to evaluate the expression of c-Myc and its O-GlcNAcylation under different conditions. The possible O-GlcNAcylation sites were predicted using DictyOGlyc 1.1. Inhibition of O-linked N-acetylglucosamine transferase (OGT) significantly suppressed colony formation and promoted apoptosis of DDP-resistant cells. c-Myc expression was downregulated when OGT-mediated O-GlcNAcylation was inhibited. Additionally, OGT interacted with c-Myc, promoting its stability at the Thr58 residue. Mutation of Thr58 not only resulted in lower c-Myc stability, reduced colony formation ability, and increased apoptosis but also resulted in a decrease in both the total expression and O-GlcNAcylation of c-Myc. Therefore, O-GlcNAcylation at Thr-58 regulates c-Myc activity to promote chemoresistance of TNBC cells.</p>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2026 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12947114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147328259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Axillary Recurrence After a Negative Sentinel Lymph Node Biopsy (SLNB) for Initial Positive Node Breast Cancer Postneoadjuvant Therapy: Insights From a Systematic Review and Meta-Analysis","authors":"Maha A. Alghamdi,&nbsp;Hemali Deshpande,&nbsp;Walid M. Abd El Maksoud,&nbsp;Fahad S. Al Amri,&nbsp;Mohammed A. Bawahab,&nbsp;Khaled S. Abbas,&nbsp;Abdullah Dalboh,&nbsp;Hassan A. Alzahrani,&nbsp;Marei H. Alshandeer,&nbsp;Ahmad Jebril M. Bosaily,&nbsp;Haytham M. Fayed,&nbsp;Ibrahim A. Alghamdi","doi":"10.1155/tbj/8396104","DOIUrl":"https://doi.org/10.1155/tbj/8396104","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Despite the use of sentinel lymph node biopsy (SLNB) to stage the axilla in clinically node-negative breast cancer patients’ postneoadjuvant therapy, the incidence and clinical significance of axillary recurrence (AR) after a negative SLNB remain under-explored in the literature. Understanding these factors is essential to improving patient outcomes and guiding future treatment strategies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a systematic review and meta-analysis using PubMed, Scopus, ScienceDirect, and Google Scholar. A random effects model was used to calculate pooled incidence of AR, while heterogeneity was assessed using the I² and Q-statistics. Publication bias was evaluated with a funnel plot and Egger’s test. We performed all analyses using the R meta and metafor packages.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 37 studies were included in the qualitative synthesis and meta-analysis. The pooled analysis of these studies highlights a remarkably low incidence of AR, with an overall proportion of 1% (95% CI: [0.0%, 1.0%]) under a random-effects model and no significant heterogeneity (<i>I</i>² = 0%, <i>p</i> = 0.95). Egger’s test for publication bias was conducted to assess the presence of funnel plot asymmetry in the meta-analysis, indicating no significant evidence of publication bias (<i>z</i>-value = 0.6074, <i>p</i>-value = 0.5436).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The meta-analysis demonstrated a remarkably low incidence of AR after a negative SLNB in initially node-positive breast cancer patients postneoadjuvant therapy. These findings suggest that such recurrences are rare, supporting the reliability of SLNB in accurately staging the axilla. This highlights its importance in clinical decision-making for treatment strategies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2026 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/tbj/8396104","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147288509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rising Breast Cancer Incidence and Poor Outcomes in Young Women: A Retrospective Study","authors":"Jennifer Den,&nbsp;Nicole Nelson,&nbsp;Raj Vaghjiani,&nbsp;Douglas Tyler,&nbsp;V. Suzanne Klimberg","doi":"10.1155/tbj/5584726","DOIUrl":"https://doi.org/10.1155/tbj/5584726","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>Recent studies suggest a rise in breast cancer (BC) among young women. We analyzed BC incidence patterns among women aged 18–40 in the TriNetX network from 2014 to 2023, stratifying by age, race, and ethnicity. We also examined mortality and local recurrence (LR) in women aged 18–40 diagnosed with primary BC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study used data from the TriNetX network. Female patients aged 18–40 were identified, and the incidence proportion of primary BC from 2014 to 2023 was assessed using the TriNetX Incidence and Prevalence Analytics function, with stratification by age, ethnicity, and race. A second cohort of women aged 18–40 with a primary BC diagnosis was created to evaluate mortality and LR over the same period. All analyses were descriptive.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the 18,250,987 women aged 18–40 years in the TriNetX network, the incidence proportion of BC increased from 635 cases in 2014 to 4475 in 2023. White women accounted for the greatest number of BC cases; however, increasing incidence proportions were also observed among American Indian/Alaskan Native (AI/AN), Asian, and Native Hawaiian/Pacific Islanders (NHPIs) women over the last four years. Non-Hispanic women initially had higher incidence proportions but were surpassed by Hispanic women in 2022. Among 38,683 women aged 18–40 with primary BC, both mortality (0.09%–0.851%) and LR (0.3%–2.9%) increased over the study period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Within the TriNetX network, BC incidence proportion among women aged 18–40 demonstrated an upward trend from 2014 to 2023, particularly among non-Hispanic White women 30–39 years old. An uptrend was also seen in young AI/AN, Asian, NHPI, and Hispanic women. In addition, increased documented mortality and LR were also observed. These findings underscore the importance of further research to understand these trends and develop diagnostic and therapeutic approaches tailored to younger patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2026 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/tbj/5584726","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147288508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mastitis and Mammary Abscess Management Audit (MAMMA): A Survey of Patients’ Perspective on the Management of Mammary Abscesses in the UK","authors":"Ronak Patel,&nbsp;Alona Courtney,&nbsp;Natasha Elysha Jiwa,&nbsp;Nur Amalina Che Bakri,&nbsp;Sophie Paterson,&nbsp;Daniel Richard Leff","doi":"10.1155/tbj/5901980","DOIUrl":"10.1155/tbj/5901980","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The recent Mastitis and Mammary Abscess Management Audit demonstrated widespread variation in the management of breast abscesses across the United Kingdom (UK), with up to one-fifth undergoing surgical drainage rather than image-guided needle aspiration. The impact of these practices on patient’s perspective and quality of life is unclear. This study aimed to assess patients’ experiences following breast abscess treatment, focusing on treatment modality, cosmesis, breastfeeding and quality of life.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional online survey was conducted between February and August 2024, aimed at UK-wide adult women with a history of breast abscess. Descriptive and thematic analyses were performed using SPSS and NVivo software, with multiple imputation for missing data.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 172 participants, half underwent needle aspiration (50.58%), while 23.84% received surgical incision and drainage. Among those undergoing surgery, 68.29% reported prolonged wound healing, 85.37% experienced permanent scarring and a significant negative impact on their breast appearance (<i>p</i> = 0.029). Breastfeeding was disrupted in 58.12%, and 40.17% were unable to resume breastfeeding following treatment. Amongst participants who underwent surgery, 36.5% reported negative impacts on sexual well-being, 31.7% on mental health, and 24.4% on self-confidence. Thematic analysis revealed two major themes: repercussions of the treatment and issues with provision of care, highlighting delays in diagnosis, inadequate breastfeeding support, and negative cosmetic outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>This study is the first to investigate patients’ experiences of breast abscess management, highlighting significant variability in practice and the association of worse cosmetic and breastfeeding outcomes with surgical treatment. Standardisation of care and improved patient counselling may improve patient experience and outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2026 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12910386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146222205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Tolerability of Methotrexate for Idiopathic Granulomatous Mastitis: A Systematic Review and Meta-Analysis","authors":"Ying Han,&nbsp;LiHui Shi,&nbsp;YanRan Zhang","doi":"10.1155/tbj/6710172","DOIUrl":"10.1155/tbj/6710172","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Idiopathic granulomatous mastitis (IGM) is a challenging inflammatory breast disease with limited standardized treatment guidelines.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This meta-analysis systematically evaluated the efficacy and safety of methotrexate (MTX) in IGM, pooling data from observational studies. We assessed complete remission rates, recurrence rates, and severe side effects leading to MTX discontinuation using both common and random effects models, accounting for heterogeneity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Nine studies were included. In analyses without control groups, the pooled complete response rate for MTX was 61.6% (95% CI: 40.4–79.2%), with significant heterogeneity (<i>I</i>² = 81.4%). Combination therapy showed a higher complete response rate in the common effect model (78.0%, 95% CI: 71.4–83.3%) compared to monotherapy (46.6%, 95% CI: 34.2–59.3%), though this difference was not significant in the random effects model. The overall pooled proportion of severe side effects leading to MTX discontinuation was low at 1.23% (95% CI: 0.40–3.74%) in the common effect model and 0.51% (95% CI: 0.03–9.37%) in the random effects model, with no significant heterogeneity. In controlled studies, MTX showed no significant difference in complete remission compared to steroid-containing controls.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Based on a pooled complete response rate of 61.6%, MTX appears to be an effective and well-tolerated treatment for IGM, though substantial heterogeneity exists in uncontrolled studies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2026 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12905005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}