Annals of Physical and Rehabilitation Medicine最新文献

{"title":"Role of exercise on pain, functional capacity, and inflammatory biomarkers in osteoarthritis: A systematic review and meta-analysis","authors":"C. Mauri,&nbsp;C. Cerulli,&nbsp;E. Grazioli,&nbsp;C. Minganti,&nbsp;E. Tranchita,&nbsp;A. Scotto di Palumbo,&nbsp;A. Parisi","doi":"10.1016/j.rehab.2024.101909","DOIUrl":"10.1016/j.rehab.2024.101909","url":null,"abstract":"<div><h3>Background</h3><div>Osteoarthritis (OA) is a complex disease that causes pain, stiffness and swelling, limiting function and mobility, thus interfering with daily life and affecting personal, social, and psychological aspects of life.</div></div><div><h3>Objective</h3><div>To evidence the role of exercise on pain reduction and the effectiveness of one type of training over another in terms of pain, functional capacity, and inflammatory biomarkers in OA.</div></div><div><h3>Methods</h3><div>Studies retrieved from Web of Science, PubMed and Scopus databases were systematically reviewed. RCTs involving physical exercise interventions in participants with OA were included. The 3 main outcomes considered in the systematic review were pain, functional capacity and inflammatory biomarkers. The effects of different types of interventions (aerobic, resistance, combined, neuromuscular and others) were analysed for each outcome. Systematic review and meta-analysis were conducted following the PRISMA Statement.</div></div><div><h3>Results</h3><div>21 studies were included in the systematic review and 11 in the meta-analysis. The meta-analysis was conducted on pain in training intervention subgroups, showing a larger effect size for neuromuscular training -2,26 (95 % CI -4,37 to -0,14). Functional capacity and inflammatory biomarkers were analysed only with a systematic review because it was not possible to estimate the efficacy of the different training protocols with a meta-analysis.</div></div><div><h3>Conclusion</h3><div>Neuromuscular training protocols seem to be the most effective in reducing pain in OA. Direct comparison of different training treatment options on functional capacity and inflammatory biomarkers for OA is not currently feasible in practice, due to the heterogeneity of the test and the small number of studies. High-quality physical exercise intervention studies are warranted to estimate their effectiveness more accurately on pain, functional capacity, and inflammatory status in OA.</div></div><div><h3>PROSPERO registration number</h3><div>CRD42023481061.</div></div>","PeriodicalId":56030,"journal":{"name":"Annals of Physical and Rehabilitation Medicine","volume":"68 3","pages":"Article 101909"},"PeriodicalIF":3.9,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are handheld dynamometers a valid alternative to isokinetic devices for assessing the shoulder rotators in neurogenic thoracic outlet syndrome?","authors":"Emmanuel Le Mercier,&nbsp;Christelle Darrieutort-Laffite,&nbsp;Benoit Le Goff,&nbsp;Germain Pomares,&nbsp;Pauline Daley,&nbsp;Pierre Menu,&nbsp;Marc Dauty,&nbsp;Alban Fouasson-Chailloux","doi":"10.1016/j.rehab.2024.101912","DOIUrl":"10.1016/j.rehab.2024.101912","url":null,"abstract":"","PeriodicalId":56030,"journal":{"name":"Annals of Physical and Rehabilitation Medicine","volume":"68 2","pages":"Article 101912"},"PeriodicalIF":3.9,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences and Interplay between serendipitous and theory-driven discoveries in treating disorders of consciousness","authors":"Jacques Luauté,&nbsp;Caroline Herault ,&nbsp;Daphné Rimsky Robert ,&nbsp;Abdulrahman Alnuaimi,&nbsp;Nathalie André-Obadia,&nbsp;Lionel Naccache,&nbsp;Hugo Ardaillon","doi":"10.1016/j.rehab.2024.101918","DOIUrl":"10.1016/j.rehab.2024.101918","url":null,"abstract":"","PeriodicalId":56030,"journal":{"name":"Annals of Physical and Rehabilitation Medicine","volume":"68 2","pages":"Article 101918"},"PeriodicalIF":3.9,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nitrous oxide analgesia for rehabilitation after anterior cruciate ligament reconstruction: A randomized controlled trial","authors":"Ziyang Wang ,&nbsp;Lingjun Zhou ,&nbsp;Fei Wang ,&nbsp;Xiaochen Jiang ,&nbsp;Weifeng Wang ,&nbsp;Xueling Qiu ,&nbsp;Yihui Xing ,&nbsp;Chongjian Fu ,&nbsp;Ping Zhong ,&nbsp;Lu Tang","doi":"10.1016/j.rehab.2024.101897","DOIUrl":"10.1016/j.rehab.2024.101897","url":null,"abstract":"<div><h3>Background</h3><div>Although there is increasing emphasis on rehabilitation training after ligament reconstruction, little is known about the pain induced by the procedure itself. Procedural success may be limited by pain and anxiety. Nitrous oxide is widely used to alleviate procedural pain. However, few studies have been conducted to show the efficacy and safety of nitrous oxide for rehabilitation training.</div></div><div><h3>Objectives</h3><div>To explore the short-term efficacy and safety of nitrous oxide for acute pain elicited by rehabilitation training.</div></div><div><h3>Methods</h3><div>A double-blinded randomized placebo-controlled trial was conducted in the department of rehabilitation medicine. People willing to participate in the trial and sign informed consent, ≥18 years old, who had acute pain (self-reported pain score ≥4) caused by rehabilitation training after anterior cruciate ligament reconstruction were recruited. Participants undergoing rehabilitation training were randomized to receive either 65 % nitrous oxide or 100 % oxygen. The primary outcome was the pain score. Secondary outcomes were sedation score, range of motion, vital signs, physician and participant satisfaction, acceptance, and side effects.</div></div><div><h3>Results</h3><div>120 people were enrolled; 60 received nitrous oxide and 60 received oxygen. The nitrous oxide group had a significantly lower pain score than the placebo group (<em>P</em> &lt; 0.001, median difference -3, 95 % CI -4 to -2, effect size <em>η²</em> = 0.369) and sedation scores (<em>P</em> &lt; 0.001, median difference 1, 95 % CI 1 to 1, <em>η²</em> = 0.263) during the procedure. Both physician (<em>P</em> &lt; 0.001) and participant (<em>P</em> &lt; 0.001) satisfaction were significantly higher in the intervention group than the placebo group. Acceptance (willingness to use the same gas next time) differed between groups (<em>P</em> &lt; 0.001). No serious side effects occurred.</div></div><div><h3>Conclusion</h3><div>This study provides evidence supporting the efficacy and safety of self-administered nitrous oxide to reduce procedural pain during rehabilitation training after anterior cruciate ligament reconstruction.</div></div>","PeriodicalId":56030,"journal":{"name":"Annals of Physical and Rehabilitation Medicine","volume":"68 2","pages":"Article 101897"},"PeriodicalIF":3.9,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combining therapeutic strategies with rehabilitation improves motor recovery in animal models of spinal cord injury: A systematic review and meta-analysis","authors":"Liang Zhang ,&nbsp;Shin Yamada ,&nbsp;Narihito Nagoshi ,&nbsp;Munehisa Shinozaki ,&nbsp;Tetsuya Tsuji ,&nbsp;Masaya Nakamura ,&nbsp;Hideyuki Okano ,&nbsp;Syoichi Tashiro","doi":"10.1016/j.rehab.2024.101911","DOIUrl":"10.1016/j.rehab.2024.101911","url":null,"abstract":"<div><h3>Background</h3><div>Despite the lack of clinically validated strategies for treating spinal cord injury (SCI), combining therapeutic strategies with rehabilitation is believed to promote recovery of motor function; however, current research findings are inconsistent.</div></div><div><h3>Objectives</h3><div>To explore whether combination therapy involving therapy and rehabilitative training (CIRT) has a synergistic effect on motor function recovery in animal models of SCI.</div></div><div><h3>Methods</h3><div>We conducted a systematic review and meta-analysis of studies identified in a keyword search of 6 databases and extracted open-field motor scores from the Basso Mouse Scale (BMS) and the Basso, Beattie, and Bresnahan Locomotor Rating Scale (BBB) for meta-analysis using a weighted mean difference (WMD) and 95 % CI. We also performed qualitative synthesis and analysis of secondary outcome measures related to histological improvements and adverse effects.</div></div><div><h3>Results</h3><div>Eighty-seven preclinical studies were included. Combination treatment with treadmill training resulted in a significant improvement in motor function (1.40, 95 % CI 0.82 to 1.98, <em>P</em> &lt; 0.01, I² = 49 %), especially when initiated 1–2 weeks post-injury (1.77, 95 % CI 1.10 to 2.45, <em>P</em> &lt; 0.01, I² = 33 %) in rats. In mice, CIRT lasting &lt;6 weeks may enhance recovery (0.95, 95 % CI 0.49 to 1.40, <em>P</em> &lt; 0.01, I² = 33 %). Although there is a trend toward better outcomes in the chronic phase, insufficient sample sizes prevent definitive conclusions from being drawn. Combined therapy also enhances the reorganization of inhibitory synaptic structures and functions, without aggravating allodynia or spasticity.</div></div><div><h3>Conclusions</h3><div>This systematic review and meta-analysis suggest that CIRT can lead to superior motor function recovery compared to single-modality therapy (SMT) in animal models of SCI, with no significant adverse effects on allodynia or spasticity. However, the efficacy of CIRT depends on various factors, and further research is needed to establish optimal treatment strategies and understand the underlying mechanisms of recovery.</div></div>","PeriodicalId":56030,"journal":{"name":"Annals of Physical and Rehabilitation Medicine","volume":"68 3","pages":"Article 101911"},"PeriodicalIF":3.9,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of exercise on quality of life in people with chronic obstructive pulmonary disease: A network meta-analysis of RCTs","authors":"Susana Priego-Jiménez ,&nbsp;Maribel Lucerón-Lucas-Torres ,&nbsp;Patricia Lorenzo-García ,&nbsp;Marta González-Molinero ,&nbsp;Alberto Bermejo-Cantarero ,&nbsp;Celia Álvarez-Bueno","doi":"10.1016/j.rehab.2024.101890","DOIUrl":"10.1016/j.rehab.2024.101890","url":null,"abstract":"<div><h3>Background</h3><div>Chronic obstructive pulmonary disease (COPD) is characterized by a gradual deterioration of respiratory capacity, with worsening fatigue, weakness, activity intolerance, and dyspnea, influencing the person's emotional state and quality of life (QoL).</div></div><div><h3>Objective</h3><div>A network meta-analysis (NMA) was performed to determine the effects of different physical activity interventions on overall QoL in people with COPD, followed by a meta-analysis on the effect of these interventions on the different domains of the QoL scales.</div></div><div><h3>Methods</h3><div>A literature search was performed from inception to December 2023. Randomized controlled trials on the effectiveness of exercise programs on QoL in people with COPD were included. We assessed the risk of bias using the Cochrane Risk of Bias (RoB 2.0) tool and used the Grading of Recommendations, Assessment, Development, and Evaluation tool (GRADE) to assess the quality of the evidence. Pairwise meta-analysis and NMA for direct and indirect evidence were performed.</div></div><div><h3>Results</h3><div>A total of 54 studies were included in the NMA. The largest effects were for active mind-body movement therapy (AMBMT) programs versus control interventions (usual practice) for total QoL (effect size [ES] 0.87; 95 % CI 0.65–1.09), followed by endurance (END) vs control (ES 0.75; 95 % CI 0.27–1.24) and combined (COMB) versus control (ES 0.73; 95 % CI 0.02–1.43). The results reflected an improvement in all subdomains of the QoL scales, except for social support.</div></div><div><h3>Conclusions</h3><div>AMBMT should be considered the most effective strategy to improve overall QoL in people with COPD, followed by END and COMB interventions. Physical activity interventions produce a positive effect in all the QoL domains studied, except for social support.</div></div><div><h3>PROSPERO registration number</h3><div>CRD42023393463.</div></div>","PeriodicalId":56030,"journal":{"name":"Annals of Physical and Rehabilitation Medicine","volume":"68 2","pages":"Article 101890"},"PeriodicalIF":3.9,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of high-intensity interval training on cardiorespiratory function in coronary artery disease: An overview of systematic reviews","authors":"Yingtian Yang ,&nbsp;Qianyu Lv ,&nbsp;Xirui Zhang ,&nbsp;Qian Wu ,&nbsp;Lanlan Li ,&nbsp;Xuejiao Ye ,&nbsp;Shihan Wang","doi":"10.1016/j.rehab.2024.101878","DOIUrl":"10.1016/j.rehab.2024.101878","url":null,"abstract":"<div><h3>Background</h3><div>Exercise-based cardiac rehabilitation has been identified as a crucial component in mitigating all-cause mortality among individuals diagnosed with coronary artery disease (CAD). Nevertheless, the optimal exercise prescription remains elusive.</div></div><div><h3>Objective</h3><div>The purpose of this overview is to conduct a systematic evaluation and synthesis of the evidence derived from systematic reviews/meta-analyses (SRs/MAs) regarding the effects on cardiorespiratory fitness and safety of high-intensity interval training (HIIT) compared to moderate-intensity continuous training (MICT) for CAD.</div></div><div><h3>Methods</h3><div>SRs/MAs were searched across 5 databases from inception until March 22, 2023. We assessed methodological quality using the Assessing the Methodological Quality of Systematic Reviews 2 (AMSTAR-2). The risk of bias, reporting, and evidence were evaluated using the Risk of Bias in Systematic Reviews (ROBIS) tool, the Preferred Reporting Item for Systematic Review and Meta-analysis (PRISMA) 2020, and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system, respectively.</div></div><div><h3>Results</h3><div>In total, 9 SRs/MAs were included. Based on the AMSTAR-2 criteria, 4 and 5 studies were considered low- and critically-low quality, respectively. None of the studies reported all 27 items outlined in the PRISMA 2020 checklist. Regarding the ROBIS evaluation, 4 reviews were rated as low risk, 4 as high risk, and 1 as unclear risk. The GRADE evaluation indicated 3 high-level evidence, 20 moderate-level evidence, 28 low-level evidence, and 34 very low-level evidence studies based on 85 indicators. Moderate- to high-quality evidence supported that HIIT is superior to MICT in improving VO₂peak for CAD.</div></div><div><h3>Conclusion</h3><div>The efficacy and time cost of developing cardiorespiratory fitness support HIIT as an adjunct or alternative to MICT. The evidence does not permit a definitive decision regarding the adverse effects of HIIT compared to MICT. Because of the insufficient quality of the evidence, future studies should focus more on the quality of randomized controlled trials and evidence for SRs/MAs to provide scientific and robust evidence for conclusions.</div></div><div><h3>Trial Registration</h3><div>The review was registered at PROSPERO: CRD42023420015</div></div>","PeriodicalId":56030,"journal":{"name":"Annals of Physical and Rehabilitation Medicine","volume":"68 2","pages":"Article 101878"},"PeriodicalIF":3.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of exercise interventions on oxygen uptake in people with chronic obstructive pulmonary disease: A network meta-analysis of randomized controlled trials","authors":"Susana Priego-Jiménez ,&nbsp;Maribel Lucerón-Lucas-Torres ,&nbsp;Marta Carolina Ruiz-Grao ,&nbsp;Mª José Guzmán-Pavón ,&nbsp;Patricia Lorenzo-García ,&nbsp;Felipe Araya-Quintanilla ,&nbsp;Celia Álvarez-Bueno","doi":"10.1016/j.rehab.2024.101875","DOIUrl":"10.1016/j.rehab.2024.101875","url":null,"abstract":"<div><h3>Background</h3><div>Although aerobic training leads to physiological improvements in people with chronic obstructive pulmonary disease (COPD), measured by the VO2 peak, there is no evidence as to which type of physical exercise intervention is the most effective in improving the VO₂ peak or max.</div></div><div><h3>Objective</h3><div>A network meta-analysis (NMA) was performed to determine the effects of different physical interventions on oxygen uptake in people with COPD.</div></div><div><h3>Methods</h3><div>A literature search was performed from database inception to February 2024. Randomized controlled trials on the effectiveness of exercise programs on oxygen uptake with COPD were included. We assessed the risk of bias using the Cochrane Risk of Bias (RoB 2.0) tool and the quality of the evidence using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) tool. Pairwise meta-analyses and NMAs were performed for direct and indirect evidence.</div></div><div><h3>Results</h3><div>A total of 22 studies were included in this NMA. The highest effects for improvement in oxygen uptake scores were for continuous, moderate-intensity endurance exercise versus a control (effect size [ES]: 1.17; 95% CI 0.59 to 1.74), followed by continuous, high-intensity endurance exercise versus a control (ES: 0.47; 95% CI 0.08 to 0.85), and combined exercise versus a control (ES: 0.41; 95% CI 0.18 to 0.64).</div></div><div><h3>Conclusions</h3><div>Continuous, moderate-intensity endurance exercise should be considered the most effective strategy to improve oxygen uptake in people with COPD, followed by continuous, high-intensity endurance exercise and combined exercise. Due to the importance of VO₂ as a predictor of quality of life and mortality in people with COPD, it is essential to include its assessment in clinical guidelines and to include the most effective physical activity interventions to improve it.</div></div><div><h3>Trial Registration</h3><div>PROSPERO database: CRD42023425893</div></div>","PeriodicalId":56030,"journal":{"name":"Annals of Physical and Rehabilitation Medicine","volume":"67 8","pages":"Article 101875"},"PeriodicalIF":3.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the French Arthritis Self-Efficacy Scale short form (ASES-8-F) in people with knee osteoarthritis","authors":"Shenhao Dai,&nbsp;Charlotte Lanhers,&nbsp;Nicolas Coste,&nbsp;Chloé Gay,&nbsp;Loic Bareyre,&nbsp;Bruno Pereira,&nbsp;Emmanuel Coudeyre","doi":"10.1016/j.rehab.2024.101888","DOIUrl":"10.1016/j.rehab.2024.101888","url":null,"abstract":"","PeriodicalId":56030,"journal":{"name":"Annals of Physical and Rehabilitation Medicine","volume":"67 8","pages":"Article 101888"},"PeriodicalIF":3.9,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142536141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A biopsychosocial approach to phenotyping people with knee osteoarthritis awaiting total knee arthroplasty: A secondary cohort analysis","authors":"Sophie Vervullens ,&nbsp;Lotte Meert ,&nbsp;Rob J.E.M. Smeets ,&nbsp;Gavin van der Nest ,&nbsp;Jonas Verbrugghe ,&nbsp;Peter Verdonk ,&nbsp;Frank Th.G. Rahusen ,&nbsp;Mira Meeus","doi":"10.1016/j.rehab.2024.101895","DOIUrl":"10.1016/j.rehab.2024.101895","url":null,"abstract":"<div><h3>Background</h3><div>Previous research showed chronic post-total knee arthroplasty (TKA) pain in 20% of people with knee osteoarthritis (KOA). Various preoperative biopsychosocial-related factors have been described, but phenotyping people with KOA awaiting TKA based on these factors is still lacking. This could be relevant to understanding differences in TKA surgery responses.</div></div><div><h3>Objective</h3><div>To identify phenotypes in people with KOA awaiting TKA and differences in post-TKA pain based on preoperative biopsychosocial factors.</div></div><div><h3>Methods</h3><div>People with KOA awaiting TKA in 4 hospitals in Belgium and the Netherlands were included. A cross-sectional latent profile analysis was conducted on structural, metabolic, functional, pain-related, psychological and social variables. Concurrent validity was tested using 3-step multinomial logistic regression. The difference in one-year post-TKA pain was examined with linear mixed model analysis.</div></div><div><h3>Results</h3><div>Two hundred and seventeen participants were included in the latent profile analysis with a mean (SD) age of 65.5 (7.7) years, including 109 women. A model with 2 phenotypes differed in 14 out of 21 variables. Participants with phenotype 2 (28%) had a higher body mass index (BMI), higher chance of having less structural damage (KOA grade), lower mean quadriceps strength and physical function (Knee Society Scoring System functional and 30-second chair stand test), higher pain intensity, number of pain locations, and indices of central sensitisation (temporal summation, central sensitisation inventory score, and lower pressure pain thresholds), higher pain catastrophising, anxiety and depression, and higher post-TKA pain intensity compared to phenotype 1 (72%). Concurrent validity was confirmed in 3 out of 4 variables.</div></div><div><h3>Conclusions</h3><div>Phenotype 2 (28%) with nociplastic pain characteristics in combination with worse psychological factors, BMI, functional and structural factors, and phenotype 1 (72%) not representing these characteristics were identified. Phenotype 2 had worse pain intensity scores after TKA compared to phenotype 1. Attention to the characteristics of phenotype 2 is warranted concerning post-TKA pain.</div></div><div><h3>Database registration</h3><div>The protocol is registered at ClinicalTrials.gov (NCT05380648).</div></div>","PeriodicalId":56030,"journal":{"name":"Annals of Physical and Rehabilitation Medicine","volume":"67 8","pages":"Article 101895"},"PeriodicalIF":3.9,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142536140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}