{"title":"Master Clinician Editorial.","authors":"Henry Takei, Jonathan H Do","doi":"10.1002/cap.10337","DOIUrl":"https://doi.org/10.1002/cap.10337","url":null,"abstract":"","PeriodicalId":55950,"journal":{"name":"Clinical Advances in Periodontics","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Apical horizontal incision with periosteum graft wall technique for periodontal regeneration: A case study.","authors":"Kazuhito Shiraishi, Lan-Lin Chiou, Takeshi Haga, Yusuke Hamada, Pierpaolo Cortellini","doi":"10.1002/cap.10339","DOIUrl":"https://doi.org/10.1002/cap.10339","url":null,"abstract":"<p><strong>Background: </strong>The periosteum consists of an outer fibrous layer and an inner cellular layer, where bone cells reside. Hence, it has been suggested that applying periosteum to a periodontal defect may help new bone formation. The purpose of this case study is to present the clinical and radiographic outcomes of a vestibular regenerative approach and the application of a connective tissue graft (CTG) with periosteum to improve the periodontal prognosis of a pathologically migrated hopeless tooth with an endo-periodontal lesion (EPL).</p><p><strong>Methods: </strong>A 35-year-old female presented with a hopeless tooth with EPL on #9. To preserve the papilla, a horizontal incision with two vertical releasing incisions was made on the buccal vestibule where the buccal bone was present. A CTG with periosteum was harvested from the tuberosity area. After applying enamel matrix derivative (EMD) and freeze-dried bone allograft (FDBA), the CTG was placed over the defect and stabilized with absorbable sutures. The flap was replaced and sutured, achieving primary closure and healing by primary intention.</p><p><strong>Results: </strong>Following regenerative procedure, a localized orthodontic treatment was applied. A minimal ridge resorption, shallow probing depth, and radiographic stability of periodontal bone level were observed.</p><p><strong>Conclusion: </strong>This case study shows the successful application of a multidisciplinary approach to save a hopeless tooth with severe bone destruction and a non-contained periodontal defect.</p><p><strong>Key points: </strong>Multi-disciplinary approach including endodontic, orthodontic, and periodontal regenerative procedure can improve the prognosis of natural teeth. It would be beneficial to maintain the blood supply to the crestal part of the flap with apical incision. Connective tissue graft with periosteum could enhance the healing potential when used in adjunct with periodontal regeneration.</p><p><strong>Plain language summary: </strong>The apical horizontal incision combined with periosteum graft could successfully save a tooth with severe bone destruction and a non-contained periodontal defect. The importance of wound stability on the papillae area was achieved with the vestibular approach with application of the room concept. This method would be beneficial to improve the periodontal prognosis of a severely periodontally compromised tooth.</p>","PeriodicalId":55950,"journal":{"name":"Clinical Advances in Periodontics","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carola B Bozal, Marina Sosa, Sofía Aguirre, Cristina Rodríguez, Mariano Adrados, Mariel Gómez, Hugo J Romanelli
{"title":"Regenerative surgical therapy in a frequent cannabis consumer: A case study.","authors":"Carola B Bozal, Marina Sosa, Sofía Aguirre, Cristina Rodríguez, Mariano Adrados, Mariel Gómez, Hugo J Romanelli","doi":"10.1002/cap.10325","DOIUrl":"https://doi.org/10.1002/cap.10325","url":null,"abstract":"<p><strong>Background: </strong>There is substantial evidence that smokers present a less favorable response following regenerative periodontal surgery. However, there are no reports to date on the response to regenerative procedures in chronic cannabis smokers. In the present case study, we discuss the periodontal outcomes of reparative and regenerative surgical treatment in a cannabis consumer patient with generalized stage III grade C periodontitis.</p><p><strong>Methods and results: </strong>We report the case of a young adult cannabis consumer patient diagnosed with generalized stage III grade C periodontitis who had a probing depth (PD) of ≥ 4 at 18% of sites and of ≥ 7 mm at 12% of sites and radiographically confirmed generalized interproximal bone loss with horizontal and angular defects that reached the middle and apical third of the roots. An appropriate sequence of therapy based on the recommendations in the Clinical Practice Guideline (CPG) involving reparative and regenerative surgical procedures (steps 1-3) was followed. Clinical outcomes at 6 months included a decrease in PD of up to 7 mm and radiographic evidence of newly formed bone in the bony defects.</p><p><strong>Conclusion: </strong>The present case study demonstrates the use of regenerative periodontal procedures as part of a stepwise treatment approach, with different interventions at each step, to successfully manage intrabony periodontal defects in a healthy young adult male cannabis consumer.</p><p><strong>Key points: </strong>Smoking is a well-documented dose-dependent risk factor for periodontal disease, with a demonstrated negative effect on periodontal therapy outcomes. However, the usefulness of regenerative periodontal therapy in cannabis smokers has not been established to date. This case presents new information in that it is the first report to show that appropriate periodontal treatment can stabilize the periodontal disease and that regenerative therapies were successful in healing intrabony periodontal defects in a healthy young adult cannabis user. The keys to successful management of this case are: -Attention to detail in all aspects of therapy. -Patient compliance as a co-therapist by maintaining effective plaque control. -Patient acceptance of supportive care recommendations. The primary limitations of this case study are: -The main limitation of this study is that a single clinical case study is too small to draw conclusions about regenerative treatment in patients who use cannabis. -The follow-up assessment times were not sufficient to determine the long-term success of regenerative surgery. -Patient compliance with oral hygiene recommendations and supportive care are key to achieving long-term success in regenerative therapy.</p><p><strong>Plain language summary: </strong>Background: Smokers have a worse response to regenerative periodontal surgery. There are no reports on how cannabis smokers respond to regenerative procedures. This case study discuss","PeriodicalId":55950,"journal":{"name":"Clinical Advances in Periodontics","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Surgical treatment for severe endodontic-periodontal lesion: A case report with 2-year follow-up.","authors":"Yoshitaka Nara, Lorenzo Tavelli, Shogo Maekawa","doi":"10.1002/cap.10341","DOIUrl":"https://doi.org/10.1002/cap.10341","url":null,"abstract":"<p><strong>Background: </strong>Various surgical techniques have recently been developed for periodontal tissue regeneration, especially those do not involve any incisions in the interdental papillae at the regeneration site. These techniques have significant advantages for obtaining clinical attachment gain with least amount of gingival recession, however, may also have disadvantages such as limited field of surgical view, difficulty in debridement, and limited access only from the buccal side. This case report addresses a 2-year follow-up with a novel surgical approach to achieve periodontal regeneration that overcomes these limitations: the flexible tunnel technique (FTT).</p><p><strong>Methods: </strong>In a 66-year-old patient, in an enclosing infrabony defect extending to the root apex on the palatal side, which appeared to be an endodontic-periodontal lesion on tooth #5, four vertical incisions and a periosteal releasing incision were performed in order to make the interdental papillae easier to translocate over the abutment teeth, which led to obtain clearer operative field. After debridement, the enamel matrix derivative was applied to the root surface and the infrabony defect was filled with deproteinized bovine bone mineral. The flaps were relocated, and simple interrupted sutures were performed.</p><p><strong>Results: </strong>One year later, pocket closure and improvement of bone defects were observed without gingival recession. After confirmation with improved mobility, a full zirconia crown was placed. During 2-year follow-up, periodontal tissue was maintained well without any complication.</p><p><strong>Conclusions: </strong>The FTT can be used to approach endodontic-periodontal lesions and infrabony defects extending to the root apex without incision of the interdental papillae.</p><p><strong>Key points: </strong>A more accessible tunnel technique can be performed by using four vertical incisions. If the tooth is abutment, interdental papillae can be flexible to translocate due to this tunnel technique with vertical incisions. Ensuring root surface debridement, application of regenerative materials, and wound stability are the keys to this regenerative procedure. The patient needs to understand the risks associated with the proposed periodontal regenerative surgery and the prognosis of tooth.</p><p><strong>Plain language summary: </strong>Various surgical techniques have been developed recently to help regenerate the tissues that support teeth, especially methods that avoid making cuts in the gum tissue between the teeth at the treatment site. However, these techniques may have some drawbacks, such as limited visibility during surgery, difficulty cleaning the area, and access only from the outer side of the teeth. This case report addresses a 2-year follow-up of a new surgical method aimed at overcoming these challenges: the flexible tunnel technique (FTT). In a deep bone defect extending to the tip of the tooth root on the roof ","PeriodicalId":55950,"journal":{"name":"Clinical Advances in Periodontics","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Double-vestibular incision subperiosteal tunnel access (double-VISTA) with connective tissue graft for treating multiple gingival recessions: 2-year follow-up.","authors":"Guo-Hao Lin","doi":"10.1002/cap.10333","DOIUrl":"https://doi.org/10.1002/cap.10333","url":null,"abstract":"<p><strong>Background: </strong>Gingival recession has a multifactorial etiology, involving various predisposing and precipitating factors. Non-carious cervical lesions (NCCLs) are often associated with gingival recession and pose challenges due to their complex pathodynamics. There is limited evidence regarding tunnel-based procedures combined with connective tissue grafts (CTGs) for treating recession-associated NCCLs. This case study illustrates a periodontal-restorative approach for addressing multiple adjacent recession-associated NCCLs.</p><p><strong>Methods: </strong>A healthy, non-smoking 55-year-old Asian male presented with generalized mucogingival conditions, including gingival recessions and lack of keratinized tissue on the facial aspect of the maxillary right first molar through the left first molar, accompanied by physiological gingival pigmentation. The recessions were classified as Cairo RT I. NCCLs were evident in all six maxillary anterior teeth. After restoring the NCCLs to the maximum root coverage (MRC) level with composite resin, the patient underwent a mucogingival procedure via a double-vestibular incision subperiosteal tunnel access (double-VISTA) approach with autogenous CTG for treating the recession defects. Due to limited CTG availability, the maxillary left side was treated first, followed by the right side 3 months later.</p><p><strong>Results: </strong>Post-surgical healing was uneventful, except for mild facial swelling for 5 days, which subsided within a week. After 12 months, all treated teeth exhibited complete coverage to the predetermined MRC level, with a thick gingival phenotype. At the 2-year follow-up, all treated teeth maintained a stable root coverage outcome with harmonious gingival margins.</p><p><strong>Conclusion: </strong>This case study demonstrates that the double-VISTA technique for treating recession-associated NCCLs is promising in achieving complete coverage at sites where the MRC level was predetermined.</p><p><strong>Key points: </strong>This case study introduces a modified vestibular incision subperiosteal tunnel access (VISTA) technique, termed double-VISTA, which employs two distant vestibular incisions to enhance access for instrumentation and recipient site preparation in the treatment of multiple adjacent recession defects. A periodontal-restorative approach is detailed in this case study, demonstrating a step-by-step process for managing multiple adjacent recession-associated non-carious cervical lesions using the double-VISTA technique with a promising treatment outcome. The advantages and disadvantages of the double-VISTA technique are further discussed in this case study. Limitations of this technique include shallow vestibular depth and close proximity to the mental nerve, necessitating careful attention during recipient site preparation under these conditions.</p><p><strong>Plain language summary: </strong>Gingival recession, where gums recede and expose tooth roots, can resul","PeriodicalId":55950,"journal":{"name":"Clinical Advances in Periodontics","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Vitamin C mesotherapy with microneedling for gingival depigmentation: A case study.","authors":"Anika Dawar, Razia Haidrus, Sumit Kumar Das","doi":"10.1002/cap.10327","DOIUrl":"https://doi.org/10.1002/cap.10327","url":null,"abstract":"<p><strong>Background: </strong>Surgical methods of gingival depigmentation can be challenging, particularly if the gingival phenotype is thin due to the risk of gingival recession and bone exposure. Thus, exploring alternative, non-surgical, minimally invasive treatment modalities is warranted. In dermatology, vitamin C is extensively used for depigmentation and microneedling for collagen induction, with limited literature about its usage for improving gingival esthetics. The present preliminary case study aims to explore the synergistic use of vitamin C mesotherapy with microneedling for the esthetic management of physiologic melanin gingival hyperpigmentation.</p><p><strong>Methods: </strong>Eleven arches from six patients having anterior physiologic melanin hyperpigmentation were recruited. Microneedling was done with a lancet, followed by intra-epidermal administration of 1.5-2 mL of vitamin C in pigmented gingiva (once weekly/four sessions). Dummett oral pigmentation index (DOPI), gingival pigmentation index (GPI), pigmented surface area (PSA), and gingival luminescence (L*) were assessed at baseline and follow-up visits of 1 week, 1 month, and 3 months. Gingival thickness (GT) was recorded at baseline and 3 months. Pain, itching, and gingival color were also assessed.</p><p><strong>Results: </strong>A significant reduction (p < 0.05) in mean DOPI, GPI, and PSA was observed from baseline to 3 months, while L* and GT increased significantly within that timeframe. Patients reported an improvement in gingival color at 1 and 3 months. Low pain and itching scores were obtained post-treatment.</p><p><strong>Conclusion: </strong>Vitamin C mesotherapy with microneedling is a newer, minimally invasive approach that can effectively reduce gingival melanin pigmentation intensity and extent, and can potentially increase the gingival thickness.</p><p><strong>Key points: </strong>Vitamin C mesotherapy (intra-epidermal injection) is an effective and minimally invasive treatment modality for gingival depigmentation. The adjunctive use of microneedling with vitamin C mesotherapy can potentially increase gingival thickness non-surgically. Non-surgical methods for gingival depigmentation can be chosen as an alternative to surgical methods for esthetic management of physiologic melanin hyperpigmentation in cases with thin gingival phenotype.</p><p><strong>Plain language summary: </strong>Patients seek treatment for hyperpigmented gingiva caused by increased melanin to improve the smile esthetics. Conventional surgical methods for gingival depigmentation, however, are challenging to perform in areas of thin gingiva as there is an increased risk of gingival damage and bone exposure. Thus, exploring alternative, non-surgical, minimally invasive options will be advantageous. In dermatology, vitamin C is a popular agent for treating skin hyperpigmentation, and microneedling is a technique used for collagen induction. This preliminary case study synergistically used","PeriodicalId":55950,"journal":{"name":"Clinical Advances in Periodontics","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Novel triangle papilla access approach for interdental bone defect regeneration: A case study.","authors":"Yuichiro Ihara, Shunichi Shibazaki, Satoru Morikawa, Taneaki Nakagawa","doi":"10.1002/cap.10335","DOIUrl":"https://doi.org/10.1002/cap.10335","url":null,"abstract":"<p><strong>Background: </strong>Successful periodontal regeneration depends on primary wound closure and interdental papilla preservation. In this case study, we introduce a novel triangle papilla access approach (T-PAA) performed under a surgical microscope for treating interdental bone defects. In this novel approach, buccal incisions were used to access root surfaces and bone defects, avoiding interdental papilla incisions and preventing papillary collapse and necrosis.</p><p><strong>Methods: </strong>Nine patients with a mean age of 56 years were enrolled in this study. Incisions were made to create a triangular flap, which was reflected using a micro-periosteal elevator to expose the bone defect and granulation tissue. Subsequently, the granulation tissue was removed from the bone defect using a microsurgical blade, followed by root debridement using ultrasonic and micro-hand scalers and root conditioning. Thereafter, a mixture of fibroblast growth factor-2 and carbonated apatite granules was applied to the bone defect. The triangular flap was repositioned to ensure that the apex was not lifted by the graft material, and from the flap apex, 7-0 nylon sutures were used, followed by the addition of mesial and distal sutures. Adjacent teeth were splinted using wire and resin cement.</p><p><strong>Results: </strong>Postoperatively, clinical and radiographic evaluations at 6 months and 1 year showed significant improvements in periodontal parameters and bone filling. All patients achieved primary wound closure with no postoperative complications.</p><p><strong>Conclusions: </strong>T-PAA is a promising approach for periodontal regeneration, providing adequate surgical access under a surgical microscope while preserving the papilla and potentially improving clinical outcomes in patients with interdental bone defects.</p><p><strong>Key points: </strong>Triangle papilla access approach (T-PAA) provides adequate surgical access, preserves the interdental papillae, and improves clinical outcomes in cases of interdental bone defects. Triangular incisions made in areas with abundant blood flow and thicker gingiva at the base of the papilla are less likely to impair blood supply to the interdental papillae. T-PAA facilitates effective debridement, precise placement of regenerative materials, and accurate flap repositioning regardless of the defect morphology in localized interdental areas.</p><p><strong>Plain language summary: </strong>Successful periodontal treatment often requires surgical procedures for bone regeneration in patients with bone defects. However, traditional surgical approaches may damage the interdental papillae, leading to esthetic concerns and compromised healing. In this study, we introduced a new surgical technique called the triangle papilla access approach, which uses a specially designed triangular incision to access and treat bone defects under a surgical microscope while preserving the interdental papillae. Our results from nin","PeriodicalId":55950,"journal":{"name":"Clinical Advances in Periodontics","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Biologically-oriented alveolar ridge preservation to correct bone dehiscence at immediate implant placement.","authors":"Leonardo Trombelli, Tommaso Grenzi","doi":"10.1002/cap.10334","DOIUrl":"https://doi.org/10.1002/cap.10334","url":null,"abstract":"<p><strong>Background: </strong>The purpose of the present case study is to describe the application of a modification of the Biologically-oriented Alveolar Ridge Preservation (BARP) principles in cases of peri-implant bone dehiscence (PIBD) due to a compromised alveolus at immediate implant placement (IIP).</p><p><strong>Methods: </strong>The technique is based on the stratification of three layers: a deep layer with a collagen sponge (CS) in the apical part of the alveolus (where the buccal bone plate was still present) to support the blood clot; a graft layer to correct the PIBD; and a superficial collagen layer to cover the graft thus providing space and enhancing clot/graft stability. Healing was obtained by primary closure.</p><p><strong>Results: </strong>At the re-entry procedure for implant uncovering, a complete PIBD correction with newly formed peri-implant bone up to the level of the polished collar was observed in both cases.</p><p><strong>Conclusions: </strong>These observations suggest that BARP based on the combined use of CS and deproteinized bovine bone mineral may be regarded as a simplified treatment option to correct a PIBD at IIP.</p><p><strong>Key points: </strong>Why treat a Peri-Implant Bone Dehiscence (PIBD)? PIBD should be treated to avoid biological and esthetic complications over time. What plays a key role in this case? The stability of both the graft and the cloth is essential for providing space for bone formation to correct the PIBD; the extraction socket supports angiogenic and osteogenic properties; Primary intention closure is crucial to prevent potential infection.</p><p><strong>Limitation: </strong>the efficacy of the technique must be assessed.</p><p><strong>Plain language summary: </strong>This case study described the potential to correct a post-extraction osseous defect associated with a substantial portion of a dental implant which resulted exposed and without bone support on its buccal aspect. The application of a novel bone augmentation technique, namely the biologically oriented Alveolar Ridge Preservation, has been described. This simplified procedure is based on the stratification of i) a deep collagen layer in the apical part of the socket to support the blood clot and spontaneous bone formation, ii) a graft of bone substitute to correct the missing bone, and iii) a superficial collagen layer to protect the graft and the wound. After 5 months, a complete correction of the osseous defect with newly formed bone up to the head of the implant was observed in both treated cases.</p>","PeriodicalId":55950,"journal":{"name":"Clinical Advances in Periodontics","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alcione Maria Soares Dutra Oliveira, Peterson Antônio Dutra Oliveira, Tarcísio Junqueira Pereira, Fernando Oliveira Costa
{"title":"Clinical management of hereditary gingival fibromatosis: Case report with 13 years follow-up.","authors":"Alcione Maria Soares Dutra Oliveira, Peterson Antônio Dutra Oliveira, Tarcísio Junqueira Pereira, Fernando Oliveira Costa","doi":"10.1002/cap.10331","DOIUrl":"https://doi.org/10.1002/cap.10331","url":null,"abstract":"<p><strong>Background: </strong>Hereditary gingival fibromatosis (HGF) is one of the categories of non-plaque-induced gingival diseases of genetic origin. Current studies show high genetic heterogeneity and suggest that not all forms of HGF are the same and that more than one biological mechanism may result in gingival growth. This report presents a case of syndromic HGF with generalized and complex clinical manifestations associated with other conditions such as body hypertrichosis and hearing deficit.</p><p><strong>Methods: </strong>This is a case report of a male patient with HGF, detailing the orthodontic and periodontal management that began at the age of 8 and was completed by 21.</p><p><strong>Results and conclusions: </strong>The results of this case report demonstrated the importance of early diagnosis and the establishment of a correct treatment plan that provided, in the long-term, highly positive effects, minimizing impacts affecting the oral health-related quality of life of individuals with HGF.</p><p><strong>Key points: </strong>This is a case report of a male patient with HGF, detailing the orthodontic and periodontal management that began at age 8 and was completed by age 21. Clinical, genetic, and histological data are reported over the 13 years of follow-up. Due to the numerous complications caused by HGF, early diagnosis and the establishment of an appropriate treatment plan are imperative.</p>","PeriodicalId":55950,"journal":{"name":"Clinical Advances in Periodontics","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}