Clinical Advances in Periodontics最新文献

{"title":"Double-vestibular incision subperiosteal tunnel access (double-VISTA) with connective tissue graft for treating multiple gingival recessions: 2-year follow-up.","authors":"Guo-Hao Lin","doi":"10.1002/cap.10333","DOIUrl":"https://doi.org/10.1002/cap.10333","url":null,"abstract":"<p><strong>Background: </strong>Gingival recession has a multifactorial etiology, involving various predisposing and precipitating factors. Non-carious cervical lesions (NCCLs) are often associated with gingival recession and pose challenges due to their complex pathodynamics. There is limited evidence regarding tunnel-based procedures combined with connective tissue grafts (CTGs) for treating recession-associated NCCLs. This case study illustrates a periodontal-restorative approach for addressing multiple adjacent recession-associated NCCLs.</p><p><strong>Methods: </strong>A healthy, non-smoking 55-year-old Asian male presented with generalized mucogingival conditions, including gingival recessions and lack of keratinized tissue on the facial aspect of the maxillary right first molar through the left first molar, accompanied by physiological gingival pigmentation. The recessions were classified as Cairo RT I. NCCLs were evident in all six maxillary anterior teeth. After restoring the NCCLs to the maximum root coverage (MRC) level with composite resin, the patient underwent a mucogingival procedure via a double-vestibular incision subperiosteal tunnel access (double-VISTA) approach with autogenous CTG for treating the recession defects. Due to limited CTG availability, the maxillary left side was treated first, followed by the right side 3 months later.</p><p><strong>Results: </strong>Post-surgical healing was uneventful, except for mild facial swelling for 5 days, which subsided within a week. After 12 months, all treated teeth exhibited complete coverage to the predetermined MRC level, with a thick gingival phenotype. At the 2-year follow-up, all treated teeth maintained a stable root coverage outcome with harmonious gingival margins.</p><p><strong>Conclusion: </strong>This case study demonstrates that the double-VISTA technique for treating recession-associated NCCLs is promising in achieving complete coverage at sites where the MRC level was predetermined.</p><p><strong>Key points: </strong>This case study introduces a modified vestibular incision subperiosteal tunnel access (VISTA) technique, termed double-VISTA, which employs two distant vestibular incisions to enhance access for instrumentation and recipient site preparation in the treatment of multiple adjacent recession defects. A periodontal-restorative approach is detailed in this case study, demonstrating a step-by-step process for managing multiple adjacent recession-associated non-carious cervical lesions using the double-VISTA technique with a promising treatment outcome. The advantages and disadvantages of the double-VISTA technique are further discussed in this case study. Limitations of this technique include shallow vestibular depth and close proximity to the mental nerve, necessitating careful attention during recipient site preparation under these conditions.</p><p><strong>Plain language summary: </strong>Gingival recession, where gums recede and expose tooth roots, can resul","PeriodicalId":55950,"journal":{"name":"Clinical Advances in Periodontics","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin C mesotherapy with microneedling for gingival depigmentation: A case study.","authors":"Anika Dawar, Razia Haidrus, Sumit Kumar Das","doi":"10.1002/cap.10327","DOIUrl":"https://doi.org/10.1002/cap.10327","url":null,"abstract":"<p><strong>Background: </strong>Surgical methods of gingival depigmentation can be challenging, particularly if the gingival phenotype is thin due to the risk of gingival recession and bone exposure. Thus, exploring alternative, non-surgical, minimally invasive treatment modalities is warranted. In dermatology, vitamin C is extensively used for depigmentation and microneedling for collagen induction, with limited literature about its usage for improving gingival esthetics. The present preliminary case study aims to explore the synergistic use of vitamin C mesotherapy with microneedling for the esthetic management of physiologic melanin gingival hyperpigmentation.</p><p><strong>Methods: </strong>Eleven arches from six patients having anterior physiologic melanin hyperpigmentation were recruited. Microneedling was done with a lancet, followed by intra-epidermal administration of 1.5-2 mL of vitamin C in pigmented gingiva (once weekly/four sessions). Dummett oral pigmentation index (DOPI), gingival pigmentation index (GPI), pigmented surface area (PSA), and gingival luminescence (L*) were assessed at baseline and follow-up visits of 1 week, 1 month, and 3 months. Gingival thickness (GT) was recorded at baseline and 3 months. Pain, itching, and gingival color were also assessed.</p><p><strong>Results: </strong>A significant reduction (p < 0.05) in mean DOPI, GPI, and PSA was observed from baseline to 3 months, while L* and GT increased significantly within that timeframe. Patients reported an improvement in gingival color at 1 and 3 months. Low pain and itching scores were obtained post-treatment.</p><p><strong>Conclusion: </strong>Vitamin C mesotherapy with microneedling is a newer, minimally invasive approach that can effectively reduce gingival melanin pigmentation intensity and extent, and can potentially increase the gingival thickness.</p><p><strong>Key points: </strong>Vitamin C mesotherapy (intra-epidermal injection) is an effective and minimally invasive treatment modality for gingival depigmentation. The adjunctive use of microneedling with vitamin C mesotherapy can potentially increase gingival thickness non-surgically. Non-surgical methods for gingival depigmentation can be chosen as an alternative to surgical methods for esthetic management of physiologic melanin hyperpigmentation in cases with thin gingival phenotype.</p><p><strong>Plain language summary: </strong>Patients seek treatment for hyperpigmented gingiva caused by increased melanin to improve the smile esthetics. Conventional surgical methods for gingival depigmentation, however, are challenging to perform in areas of thin gingiva as there is an increased risk of gingival damage and bone exposure. Thus, exploring alternative, non-surgical, minimally invasive options will be advantageous. In dermatology, vitamin C is a popular agent for treating skin hyperpigmentation, and microneedling is a technique used for collagen induction. This preliminary case study synergistically used","PeriodicalId":55950,"journal":{"name":"Clinical Advances in Periodontics","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel triangle papilla access approach for interdental bone defect regeneration: A case study.","authors":"Yuichiro Ihara, Shunichi Shibazaki, Satoru Morikawa, Taneaki Nakagawa","doi":"10.1002/cap.10335","DOIUrl":"https://doi.org/10.1002/cap.10335","url":null,"abstract":"<p><strong>Background: </strong>Successful periodontal regeneration depends on primary wound closure and interdental papilla preservation. In this case study, we introduce a novel triangle papilla access approach (T-PAA) performed under a surgical microscope for treating interdental bone defects. In this novel approach, buccal incisions were used to access root surfaces and bone defects, avoiding interdental papilla incisions and preventing papillary collapse and necrosis.</p><p><strong>Methods: </strong>Nine patients with a mean age of 56 years were enrolled in this study. Incisions were made to create a triangular flap, which was reflected using a micro-periosteal elevator to expose the bone defect and granulation tissue. Subsequently, the granulation tissue was removed from the bone defect using a microsurgical blade, followed by root debridement using ultrasonic and micro-hand scalers and root conditioning. Thereafter, a mixture of fibroblast growth factor-2 and carbonated apatite granules was applied to the bone defect. The triangular flap was repositioned to ensure that the apex was not lifted by the graft material, and from the flap apex, 7-0 nylon sutures were used, followed by the addition of mesial and distal sutures. Adjacent teeth were splinted using wire and resin cement.</p><p><strong>Results: </strong>Postoperatively, clinical and radiographic evaluations at 6 months and 1 year showed significant improvements in periodontal parameters and bone filling. All patients achieved primary wound closure with no postoperative complications.</p><p><strong>Conclusions: </strong>T-PAA is a promising approach for periodontal regeneration, providing adequate surgical access under a surgical microscope while preserving the papilla and potentially improving clinical outcomes in patients with interdental bone defects.</p><p><strong>Key points: </strong>Triangle papilla access approach (T-PAA) provides adequate surgical access, preserves the interdental papillae, and improves clinical outcomes in cases of interdental bone defects. Triangular incisions made in areas with abundant blood flow and thicker gingiva at the base of the papilla are less likely to impair blood supply to the interdental papillae. T-PAA facilitates effective debridement, precise placement of regenerative materials, and accurate flap repositioning regardless of the defect morphology in localized interdental areas.</p><p><strong>Plain language summary: </strong>Successful periodontal treatment often requires surgical procedures for bone regeneration in patients with bone defects. However, traditional surgical approaches may damage the interdental papillae, leading to esthetic concerns and compromised healing. In this study, we introduced a new surgical technique called the triangle papilla access approach, which uses a specially designed triangular incision to access and treat bone defects under a surgical microscope while preserving the interdental papillae. Our results from nin","PeriodicalId":55950,"journal":{"name":"Clinical Advances in Periodontics","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biologically-oriented alveolar ridge preservation to correct bone dehiscence at immediate implant placement.","authors":"Leonardo Trombelli, Tommaso Grenzi","doi":"10.1002/cap.10334","DOIUrl":"https://doi.org/10.1002/cap.10334","url":null,"abstract":"<p><strong>Background: </strong>The purpose of the present case study is to describe the application of a modification of the Biologically-oriented Alveolar Ridge Preservation (BARP) principles in cases of peri-implant bone dehiscence (PIBD) due to a compromised alveolus at immediate implant placement (IIP).</p><p><strong>Methods: </strong>The technique is based on the stratification of three layers: a deep layer with a collagen sponge (CS) in the apical part of the alveolus (where the buccal bone plate was still present) to support the blood clot; a graft layer to correct the PIBD; and a superficial collagen layer to cover the graft thus providing space and enhancing clot/graft stability. Healing was obtained by primary closure.</p><p><strong>Results: </strong>At the re-entry procedure for implant uncovering, a complete PIBD correction with newly formed peri-implant bone up to the level of the polished collar was observed in both cases.</p><p><strong>Conclusions: </strong>These observations suggest that BARP based on the combined use of CS and deproteinized bovine bone mineral may be regarded as a simplified treatment option to correct a PIBD at IIP.</p><p><strong>Key points: </strong>Why treat a Peri-Implant Bone Dehiscence (PIBD)? PIBD should be treated to avoid biological and esthetic complications over time. What plays a key role in this case? The stability of both the graft and the cloth is essential for providing space for bone formation to correct the PIBD; the extraction socket supports angiogenic and osteogenic properties; Primary intention closure is crucial to prevent potential infection.</p><p><strong>Limitation: </strong>the efficacy of the technique must be assessed.</p><p><strong>Plain language summary: </strong>This case study described the potential to correct a post-extraction osseous defect associated with a substantial portion of a dental implant which resulted exposed and without bone support on its buccal aspect. The application of a novel bone augmentation technique, namely the biologically oriented Alveolar Ridge Preservation, has been described. This simplified procedure is based on the stratification of i) a deep collagen layer in the apical part of the socket to support the blood clot and spontaneous bone formation, ii) a graft of bone substitute to correct the missing bone, and iii) a superficial collagen layer to protect the graft and the wound. After 5 months, a complete correction of the osseous defect with newly formed bone up to the head of the implant was observed in both treated cases.</p>","PeriodicalId":55950,"journal":{"name":"Clinical Advances in Periodontics","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical management of hereditary gingival fibromatosis: Case report with 13 years follow-up.","authors":"Alcione Maria Soares Dutra Oliveira, Peterson Antônio Dutra Oliveira, Tarcísio Junqueira Pereira, Fernando Oliveira Costa","doi":"10.1002/cap.10331","DOIUrl":"https://doi.org/10.1002/cap.10331","url":null,"abstract":"<p><strong>Background: </strong>Hereditary gingival fibromatosis (HGF) is one of the categories of non-plaque-induced gingival diseases of genetic origin. Current studies show high genetic heterogeneity and suggest that not all forms of HGF are the same and that more than one biological mechanism may result in gingival growth. This report presents a case of syndromic HGF with generalized and complex clinical manifestations associated with other conditions such as body hypertrichosis and hearing deficit.</p><p><strong>Methods: </strong>This is a case report of a male patient with HGF, detailing the orthodontic and periodontal management that began at the age of 8 and was completed by 21.</p><p><strong>Results and conclusions: </strong>The results of this case report demonstrated the importance of early diagnosis and the establishment of a correct treatment plan that provided, in the long-term, highly positive effects, minimizing impacts affecting the oral health-related quality of life of individuals with HGF.</p><p><strong>Key points: </strong>This is a case report of a male patient with HGF, detailing the orthodontic and periodontal management that began at age 8 and was completed by age 21. Clinical, genetic, and histological data are reported over the 13 years of follow-up. Due to the numerous complications caused by HGF, early diagnosis and the establishment of an appropriate treatment plan are imperative.</p>","PeriodicalId":55950,"journal":{"name":"Clinical Advances in Periodontics","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgically facilitated orthodontics with clear aligners for severe malocclusion and gingival recessions.","authors":"Elli Anna Kotsailidi, Lucy Johnson, Christopher Burns, Paul Emile Rossouw, Dimitrios Michelogiannakis","doi":"10.1002/cap.10324","DOIUrl":"https://doi.org/10.1002/cap.10324","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Gingival recession defects (GRDs) pose functional and esthetic concerns and may be associated with unfavorable tooth positions. Surgically facilitated orthodontic treatment (SFOT) with clear aligners can be a valuable option for adults with severe malocclusion and GRDs.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A 28-year-old male presented with severe dental crowding, Class III dental malocclusion, localized tooth crossbites, and tapered maxillary arch. He exhibited multiple gingival recessions type I up to 6 mm in depth, at least 2 mm of keratinized tissue throughout, and a thick scalloped gingival phenotype. Clear aligner SFOT was performed including buccal corticotomies and bone augmentation with demineralized allograft between the first molars on both arches, dental expansion, interproximal enamel reduction, and use of intermaxillary elastics. Progress of the aligners occurred every 3 days for the first 6 months; and every 5 days thereafter, for a total duration of 10.5 months.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Clear aligner SFOT led to tooth alignment, Class I occlusion, and improvement in smile esthetics. Complete root coverage was achieved on 50% of the teeth and the mean root coverage was 81.6%, ranging from 1 to 6 mm, while residual GRDs ranged from 1 to 2 mm.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Clear aligner SFOT can be a valuable interdisciplinary approach for the management of adults with multiple GRDs and severe malocclusion.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Plain language summary: &lt;/strong&gt;Recession of the gingiva creates functional and esthetic concerns and is often related to unfavorable tooth position and tooth crowding. A surgical procedure called \"surgically facilitated orthodontic treatment\" (SFOT) with clear aligners instead of metal braces is a valuable treatment option for adults with receding gingiva and unfavorable tooth position. This report presents a 28-year-old male with severe tooth crowding and narrow tooth arches. He had several areas with thick, receding gingiva on the upper and lower jaws. The surgery involved the creation of bony cuts in between the roots, followed by bone grafting over the roots and cuts, on both jaws. The orthodontic treatment was executed with clear aligners and elastics. The patient was switching aligners every 3 days for the first 6 months and every 5 days thereafter. The total treatment duration was 10.5 months. Eventually, clear aligner SFOT led to the alignment of all teeth and improved the appearance of the smile. Receding gingiva was completely reversed on 50% of the teeth and improved by a mean of 81.6% (1-6 mm gain in gingiva). This report exhibits that this technique can be a valuable treatment approach for patients with multiple areas of receding gingiva, unfavorable tooth position, and crowding.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Key points: &lt;/strong&gt;This case is the first to illustrate the successful management of multiple and severe gingival recession defects along with severe malocclusion with clea","PeriodicalId":55950,"journal":{"name":"Clinical Advances in Periodontics","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142959421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Saving a hopeless tooth with a four-wall bone defect: A case report.","authors":"Takayoshi Nagahara, Tomoyuki Iwata, Keinoshin Wada, Tomoya Ueda, Shoko Kono, Kazuhisa Ouhara, Noriyoshi Mizuno","doi":"10.1002/cap.10329","DOIUrl":"https://doi.org/10.1002/cap.10329","url":null,"abstract":"<p><strong>Background: </strong>Recombinant human fibroblast growth factor-2 (rhFGF-2) has been shown to effectively promote the formation of new periodontal tissues, and its efficacy has been demonstrated in clinical settings. Moreover, the clinical and radiographic outcomes in the treatment of periodontal infrabony defects can be improved by using rhFGF-2 in combination with a bone substitute. Here, we present a case of four-wall bone defect in a tooth treated by combination regenerative therapy using rhFGF-2 and beta-tricalcium phosphate (β-TCP).</p><p><strong>Methods: </strong>A 43-year-old male with a four-wall bone defect in tooth #28 was subjected to combination therapy with rhFGF-2 and β-TCP. Periodontal clinical parameters and radiographic images were evaluated at the first visit, after the initial periodontal treatment, and after 4 months and 4 years postoperation.</p><p><strong>Results: </strong>Although gingival recession and nonvital pulp were observed postoperation, improvements in the periodontal parameters and radiographic outcomes were subsequently recorded.</p><p><strong>Conclusion: </strong>Periodontal regenerative therapy with a combination of rhFGF-2 and β-TCP showed great potential in the treatment of four-wall bone defects of teeth.</p><p><strong>Key points: </strong>Periodontal regenerative therapy using recombinant human fibroblast growth factor-2 (rhFGF-2) and beta-tricalcium phosphate (β-TCP) showed immense potential in the treatment of four-wall bone defect in teeth. In addition to using computed tomography for assessing bone defects and root morphologies, an evaluation of root canal morphology and pulp diagnosis is essential for understanding the internal and external aspects of the defect, which would aid in tooth preservation. Appropriate periodontal and endodontic treatments enabled tooth preservation following apical periodontitis after periodontal regenerative therapy.</p><p><strong>Plain language summary: </strong>This case report focuses on a new approach for the treatment of a four-wall bone defect, a significant dental issue in which the bone around the tooth is damaged, thereby decreasing the stability of the tooth. We treated a 43-year-old male patient with a combination of two key components: the growth factor rhFGF-2, which helps promote the growth of new tissues, and the synthetic bone graft substitute β-TCP, which acts as a substitute for the missing bone. Over the course of 4 years, we monitored the patient's progress using dental exams and X-ray photos. Despite some minor side effects, such as gum recession and the loss of tooth vitality, the overall condition of the tooth and surrounding bone showed significant improvement. This combination therapy shows promise in repairing similar bone defects, which would help save teeth that might otherwise be lost.</p>","PeriodicalId":55950,"journal":{"name":"Clinical Advances in Periodontics","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Odontogenic keratocyst management using guided tissue regeneration: Literature review - Two case reports.","authors":"Bassam M Kinaia, Mirranda Kinaia, Joshua Graham, Naiomy Perez Villaneuva, David Van Winkle, Anmar Dawood, Anthony L Neely","doi":"10.1002/cap.10316","DOIUrl":"https://doi.org/10.1002/cap.10316","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Odontogenic cysts of the jaws are pathologies that require timely recognition and management. The initial diagnosis is based on clinical and radiographic appearance and dental history. A variety of surgical treatments are used for odontogenic keratocyst (OKC) depending on the clinical and radiographic presentation. The aim of this report and literature review is to highlight methods to treat OKC combined with guided tissue regeneration (GTR).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Two cases with similar clinical presentations are included. Case 1 was a 60-year-old healthy Caucasian female who presented with jaw expansion around teeth #'s 21 and 22. Initial exam revealed clinical gingival health on an intact periodontium. The patient presented with enlarged gingival tissue between teeth #'s 21 and 22 measuring 9 × 12 mm and vital teeth without root displacement radiographically. Case 2 had a similar clinical and radiographic presentation located between teeth #'s 5-6.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Case 1 treatment included excisional biopsy with complete enucleation of the cystic lesion. Thereafter, GTR was performed using allograft internally then covered with a xenograft externally, resorbable collagen membrane (RCM), and primary closure. Case 2 was managed with excisional biopsy with lesion enucleation, GTR with allogenic bone graft, enamel matrix derivative and RCM, and primary closure.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;OKC enucleation combined with GTR using mineralized allograft, enamel matrix derivative, and collagen membrane or a layering technique of allograft internally and xenograft externally covered by a collagen membrane showed proper regeneration with stable periodontium at 6-36 months.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Key points: &lt;/strong&gt;Guided tissue regeneration is an acceptable treatment for management of OKC. Complete enucleation of an OKC lesion is important to reduce recurrence. The use of allograft with xenograft or allograft with enamel matrix derivative and RCM can provide proper bone fill after OKC removal.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Plain language summary: &lt;/strong&gt;Odontogenic cysts are growths that can form in the jaw or soft tissues around the teeth. If not treated, they can grow larger, damage the bone, and even push teeth out of place. To prevent this, it's important to diagnose and remove them early. The most common way to treat these cysts is through a surgical method called enucleation, where the cyst is carefully removed. In these two cases, enucleation was used along with guided tissue regeneration, a technique to help the bone and tissue heal better after surgery. In the first case, a bone graft (made from human and animal bone) and a special material called a resorbable collagen membrane were used to protect and support the healing area. In the second case, a mineralized bone graft along with a substance that helps repair tissues called an enamel matrix derivative, and the same collagen membrane were used. Both p","PeriodicalId":55950,"journal":{"name":"Clinical Advances in Periodontics","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone dimensions relationship with gingival phenotype in smokers and nonsmokers using cone-beam computed tomography.","authors":"Shiva Barmar, Azadeh Torkzadeh, Roshanak Ghaffari, Shirin Zahra Farhad, Seyed Sasan Aryanezhad","doi":"10.1002/cap.10326","DOIUrl":"https://doi.org/10.1002/cap.10326","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to assess the relationship of maxillary alveolar bone thickness (BT) and height (BH) with gingival phenotype (GP) in smokers and nonsmokers using cone-beam computed tomography (CBCT).</p><p><strong>Methods: </strong>This cross-sectional study was conducted on 60 participants. The participants underwent periodontal examination, and their GP was determined by placing a periodontal probe in the gingival sulcus at the midline and observing the transparency. The participants were then assigned to four groups (n = 15) based on their smoking status and GP: thin phenotype/smoker, thick phenotype/smoker, thin phenotype/nonsmoker, and thick phenotype/nonsmoker. BT and BH of the participants were measured in the sagittal plane on CBCT scans at the bone crest and at 2, 4, and 6 mm apical to the crest at the site of maxillary central and lateral incisors. Data were analyzed by two-way ANOVA and LSD test (alpha = 0.05).</p><p><strong>Results: </strong>The distance between the cementoenamel junction (CEJ) of maxillary central and lateral incisors and alveolar bone crest in smokers was significantly greater than that in nonsmokers (p < 0.001). Smoking had no significant effect on alveolar BT at the crestal level or 2, 4, and 6 mm apical to the crest. BT at the crest and 2, 4, and 6 mm apical to the crest was significantly greater in thick, versus thin, GP (p < 0.001).</p><p><strong>Conclusion: </strong>Smoking significantly increased the distance between the CEJ and alveolar crest at the site of central and lateral incisors but had no significant effect on BT.</p><p><strong>Plain language summary: </strong>This study found that smoking significantly increased the distance between the cementoenamel junction and the alveolar bone crest in maxillary incisors but did not affect alveolar bone thickness, which was greater in individuals with a thick gingival phenotype compared to those with a thin gingival phenotype.</p>","PeriodicalId":55950,"journal":{"name":"Clinical Advances in Periodontics","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro ultrastructure and biodegradation of activated plasma albumin gel derived from human samples: A prospective observational study.","authors":"Behzad Houshmand, Mohammadreza Talebi Ardakani, Farshad Armandei, Anahita Moscowchi, Ahmad Nazari, Jafar Ai, Mehdi Ekhlasmand Kermani, Hamoun Sabri","doi":"10.1002/cap.10330","DOIUrl":"https://doi.org/10.1002/cap.10330","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;In soft tissue regeneration, the clinical efficacy of fibrin membranes has been a pressing concern. The key to this efficacy lies in the stability of membrane and its controlled absorption. Human serum albumin, with its influence on the formation and stability of fibrin networks, could hold the key to developing a more stable alternative. This study investigates the ultrastructure and biodegradability of plasma albumin-activated gel, a potential game-changer in the field.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Blood samples were collected from the participants and centrifuged to obtain the concentrated growth factor. The poor platelet plasma syringe was placed inside the activated plasma albumin gel device. The ultrastructure of the membrane was examined using a scanning electron microscope (SEM). The weight difference was measured over 21 days to investigate the biodegradability of the samples.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Twenty-two samples were prepared from six individuals (three males and three females). Based on SEM images, activated albumin gel after 21 days in Hank's solution exhibited a significant decrease in density and evident signs of surface degradation. The weight was significantly reduced after 21 days (p &lt; 0.05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;In the present study, the investigation of the ultrastructure and biodegradability of activated albumin gel showed that, based on the observed weight difference, the amount of biodegradation is high, and it may be necessary to use a thicker membrane compared to the conventional thickness of the connective tissue graft.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Key points: &lt;/strong&gt;Enhanced stability and biocompatibility: The study highlights plasma albumin-activated gel's potential as a soft tissue scaffold, demonstrating significant biodegradation and structural changes that support cell infiltration and nutrient exchange, essential for tissue regeneration. Controlled degradation profile: Plasma albumin gel offers a prolonged biodegradation period compared to conventional fibrin membranes, making it suitable for applications requiring stable, long-lasting scaffolds in soft tissue regeneration. Future clinical applications: Findings suggest that thicker plasma albumin membranes may be needed for optimal effectiveness, paving the way for further exploration in clinical trials and animal models to validate this approach in soft tissue grafting.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Plain language summary: &lt;/strong&gt;This study investigates plasma albumin-activated gel as a promising material for supporting soft tissue repair, particularly in periodontal regeneration. Traditional materials, such as fibrin membranes, are often used to aid healing, but their rapid breakdown can limit effectiveness in the body. Plasma albumin, a protein naturally found in human blood, might offer a more stable alternative by forming a longer-lasting structure. In this study, researchers processed blood samples from participants to cre","PeriodicalId":55950,"journal":{"name":"Clinical Advances in Periodontics","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}