Indonesia Journal of Biomedical Science最新文献_第2页

Effects of virtual music therapy on Burnout Syndrome in health workers in Tertiary Hospitals 虚拟音乐治疗对三级医院医护人员职业倦怠综合征的影响

Indonesia Journal of Biomedical Science Pub Date : 2023-02-21 DOI: 10.15562/ijbs.v17i1.437

Yanuar Ardani, Rudi Putranto, E. Yunir, Sukamto Koesnoe, Muhadi, H. Shatri, M. Mansyur, Ivona Oliviera, Rendi Faris Anggono, Kezia Putri

{"title":"Effects of virtual music therapy on Burnout Syndrome in health workers in Tertiary Hospitals","authors":"Yanuar Ardani, Rudi Putranto, E. Yunir, Sukamto Koesnoe, Muhadi, H. Shatri, M. Mansyur, Ivona Oliviera, Rendi Faris Anggono, Kezia Putri","doi":"10.15562/ijbs.v17i1.437","DOIUrl":"https://doi.org/10.15562/ijbs.v17i1.437","url":null,"abstract":"Background: Health workers are vulnerable to experiencing psychological and physiological stress, including burnout syndrome (BOS). BOS can be measured using the Maslach Burnout Inventory (MBI) assessment. BOS can also affect heart rate variability (HRV). Music therapy is one of the BOS therapies in the recovery phase. This study aims to evaluate the effects of virtual music therapy on \"Burnout Syndrome\" in health workers in Tertiary Hospitals\u0000Methods: This research is a qualitative study and a randomized control trial using a pre-and post-test control group study design on healthcare workers at Dr. Kariadi Hospital and Dr. Cipto Mangunkusumo Hospital for three months. Subjects were divided into two groups, namely the intervention group and the control group, each consisting of 20 people. The instruments used were the MBI-HSS questionnaire and heart rate variability measuring devices for the pretest and posttest. Depending on the data distribution analysis performed using the Shapiro-Wilk test, data analysis was performed using either the Mann-Whitney test or the independent T-test. Data were analyzed using SPSS version 21.0 for Windows.\u0000Results: This study shows significant differences in the MBI-HSS scores between the intervention and control groups (p<0.05). In the HRV-SDNN scores, there were only significant differences in the control group (p<0.05), although there was an increase in the mean values in the intervention group.\u0000Conclusion: The use of music therapy according to culture and individual preferences can significantly affect the MBI-HSS score, which indicates burnout and increases the HRV value.","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75127867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of the COVID-19 pandemic on the readiness of last year's medical students for clinical rotation COVID-19大流行对去年医学生临床轮转准备程度的影响

Indonesia Journal of Biomedical Science Pub Date : 2023-01-16 DOI: 10.15562/ijbs.v17i1.438

I. Manuaba, M. Yani, I. S. Darmayani, I. G. A. H. Sundariyati, I. Supadmanaba, P. Wulandari, I. G. K. A. Sadeva, Anak Agung Bagus Putra Indrakusuma

{"title":"The impact of the COVID-19 pandemic on the readiness of last year's medical students for clinical rotation","authors":"I. Manuaba, M. Yani, I. S. Darmayani, I. G. A. H. Sundariyati, I. Supadmanaba, P. Wulandari, I. G. K. A. Sadeva, Anak Agung Bagus Putra Indrakusuma","doi":"10.15562/ijbs.v17i1.438","DOIUrl":"https://doi.org/10.15562/ijbs.v17i1.438","url":null,"abstract":"The coronavirus disease (COVID-19) pandemic affects various aspects of human life. To minimize the impact of lockdown, medical schools used online learning systems. However, online education also impacts student readiness, especially last year's medical students who will soon undergo clinical rotation. Therefore, this article aims to discuss the impact of the COVID-19 pandemic on the readiness of last year's medical students for clinical rotation. This study was a literature review that used several databases and online sources: Google Scholar, ScienceDirect, Pubmed (MEDLINE), and Cochrane Library, to search relevant journals related to the topic. Based on the literature search, the transition from student to doctor has been severely impacted by the COVID-19 pandemic, which had a substantial impact on medical student education, especially on interruptions of student assistantship that disturb students’ preparation, self-assurance and professional identity. The online education system in the last year of pre-clinical medical students involves changing the medical curriculum, duration of lectures, lecture schedules, and academic material loads, which are carried out through the implementation of online material sources or meeting platforms. However, the online education system also has several barriers that cause learning effectiveness that is not comparable to traditional face-to-face education systems, including the level of ability of both teachers and students to adapt online, time management, supporting infrastructure, integrated communication systems, and student engagement. This also had an impact on both students' theoretical and practical skills. Several factors also affect the student's readiness, including student assistantship interruption, OSCEs, written exams, competence, clerkship orientation, learning style, classroom environment, and mental health.","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"966 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77082063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Apoliprotein C-III (Apo C-III) inhibitors effect of antisense oligonucleotides in the management of dyslipidemia 载脂蛋白C-III(载脂蛋白C-III)抑制剂反义寡核苷酸在血脂异常管理中的作用

Indonesia Journal of Biomedical Science Pub Date : 2023-01-12 DOI: 10.15562/ijbs.v17i1.455

I. G. A. P. Sasmana, Putu Nindya Krisnadewi Rahadi, Anggi Amanda Triana Devy, Putu Ari Shanti Dewi, I. Supadmanaba, D. Wihandani

{"title":"Apoliprotein C-III (Apo C-III) inhibitors effect of antisense oligonucleotides in the management of dyslipidemia","authors":"I. G. A. P. Sasmana, Putu Nindya Krisnadewi Rahadi, Anggi Amanda Triana Devy, Putu Ari Shanti Dewi, I. Supadmanaba, D. Wihandani","doi":"10.15562/ijbs.v17i1.455","DOIUrl":"https://doi.org/10.15562/ijbs.v17i1.455","url":null,"abstract":"Introduction: Dyslipidemia is an abnormal condition of blood lipid levels with a global prevalence of 31.2% which can cause various complications including atherosclerosis that can develop into stroke. Therefore, it is necessary to develop therapeutic modalities. One of them is Antisense Oligonucleotides (ASO) which target Apo C-III, a protein that controls body fat metabolism.\u0000Purpose: This study aims to summarize the current progress, challenges, and potency of the apoliprotein C-III (Apo C-III) inhibitors effect of antisense oligonucleotides in the management of dyslipidemia\u0000Methods: This paper is a literature review that collects and selects data from credible sources using the keywords apoliprotein C-III, antisense oligonucleotides, and dyslipidemia\u0000Results: Antisense Oligonucleotides have high specificity and efficiency in inhibiting Apo C-III. Administration of ASO significantly reduced Apo C-III mRNA up to 98% and Apo C-III plasma protein up to 65% in experimental animals and reduced triglycerides up to 70.9% in clinical trials. A decrease in very low density lipoprotein (VLDL) of up to 69.2% was identified in the administration of ISIS 304801, spesific ASO in humans. The administration of ISIS 304801 also reduced the number of chylomicron particles as a source of cholesterol up to 61.1% and significantly increased the number of high-density lipoprotein (HDL) up to 45.7%, which represented the role of the modality as atheroprotection. Over time, an increase in the endosomal release, distribution, and half-life of ASO was achieved by modification of phosphorothioate linkages and lipid conjugation which represented an increase in ASO concentration. It also facilitates the interaction between ASO and intracellular spesific Apo C-III coding mRNA\u0000Conclusion: Antisense oligonucleotides have great potential to inhibit Apo C-III as a treatment for dyslipidemia.","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84177788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What are the common uropathogens susceptible antimicrobials for nephrostomy patients? 肾造口患者常见的尿路病原体敏感抗菌药有哪些?

Indonesia Journal of Biomedical Science Pub Date : 2022-12-31 DOI: 10.15562/ijbs.v16i2.416

Iwan Indra Putra, Tanaya Ghinorawa

{"title":"What are the common uropathogens susceptible antimicrobials for nephrostomy patients?","authors":"Iwan Indra Putra, Tanaya Ghinorawa","doi":"10.15562/ijbs.v16i2.416","DOIUrl":"https://doi.org/10.15562/ijbs.v16i2.416","url":null,"abstract":"Introduction: Surgical procedures, such as nephrostomy, prone the patient to postoperative infection. Moreover, multidrug-resistant uropathogens emerge due to the inappropriate use of antibiotics and are now a progressive problem worldwide. Distribution mapping of uropathogens and antimicrobial susceptibility patterns in nephrostomy patients gives urologists a clearer picture to aid in better management of their patients.\u0000Objectives: To identify the distribution of uropathogens and antimicrobial susceptibility patterns in nephrostomy patients.\u0000Materials & methods: We conducted a retrospective observational review of the medical records, including all adult patients undergoing nephrostomy from 1st January 2020 until 31st December 2021 in a tertiary hospital in Yogyakarta, Indonesia. In each patient with a positive urine culture result, uropathogens and antimicrobial susceptibility test reports were recorded and evaluated separately.\u0000Results: Of 100 patients, 76 demonstrated positive urine culture (76%), with 78 isolates from 23 strains. Almost all strains were bacterial (22/23; 95.65%), but one was fungi (1/23; 4.35%). Escherichia coli was the most common uropathogens from the isolates (31/78; 39.74%), followed by Pseudomonas aeruginosa (10/78; 12.82%) and Klebsiella pneumoniae (6/78; 7.69%). Antimicrobial susceptibility tests of 33 antibiotics and 2 antifungals were carried out. Most reports showed susceptibility to Meropenem (11.78%), followed by Gentamicin (10.21%), amikacin (8.12%), and Nitrofurantoin (7.07%).\u0000Conclusion: The common uropathogens in nephrostomy patients were Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae. The common susceptible antimicrobials included Meropenem, Gentamicin, amikacin, and Nitrofurantoin.","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89741868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MHC polymorphism in the immune system 免疫系统中的MHC多态性

Indonesia Journal of Biomedical Science Pub Date : 2022-12-30 DOI: 10.15562/ijbs.v16i2.458

K. Pinatih, I. Supadmanaba, D. Wihandani

引用次数: 0

Nano extract of Coriandrum sativum l (ketumbar seed) decrease malondialdehyde (MDA) and blood glucose, and increase superoxide dismutase (SOD) in hyperglycaemic wistar rats 芫荽籽纳米提取物可降低高血糖大鼠丙二醛(MDA)和血糖，提高超氧化物歧化酶(SOD)水平

Indonesia Journal of Biomedical Science Pub Date : 2022-12-30 DOI: 10.15562/ijbs.v16i2.442

Sri Wahjuni, Ida Ayu Raka Astitiasih, Ni Made Puspawati, Mustika Lahaya, A.A. Bawa Putra, Ida Bagus Putra Manuaba, Ahmad Fudholi

{"title":"Nano extract of Coriandrum sativum l (ketumbar seed) decrease malondialdehyde (MDA) and blood glucose, and increase superoxide dismutase (SOD) in hyperglycaemic wistar rats","authors":"Sri Wahjuni, Ida Ayu Raka Astitiasih, Ni Made Puspawati, Mustika Lahaya, A.A. Bawa Putra, Ida Bagus Putra Manuaba, Ahmad Fudholi","doi":"10.15562/ijbs.v16i2.442","DOIUrl":"https://doi.org/10.15562/ijbs.v16i2.442","url":null,"abstract":"Introduction: Coriandrum sativum L (ketumbar seeds) nano extract was prepared using chitosan as a nano extract framework and tripolyphosphate as a stabilizer by ionic gelatin method. This study aimed to reduce free radicals in streptozotocin-induced hyperglycaemic rats by administering Coriandrum sativum L nano extract as nano herbal.\u0000Methods: Characterization of the resulting nano extract was performed using Fourier Transformation Infra-Red (FTIR). The ability of nano extract as antihyperglycemic on streptozotocin-induced rats was tested using the randomized post-test only control group design research by observing the levels of blood glucose, MDA, and SOD as markers of oxidative stress.\u0000Results: The phytochemical test showed that Coriandrum sativum L extracts contained polyphenols, flavonoids, alkaloids, and terpenoids. Characterization with PSA strongly supports nano extract as a delivery system for bioactive substances with a zeta potential of -25.80 mV and a particle size of 455.20 nm. The result of the antihyperglycemic test showed that oral administration at a dose of 50 mg/Kg BW/day gave the best result for decreasing glucose blood and MDA, and increasing SOD level in hyperglycaemic rats. LCMS/MS analysis showed that in ethanol extract of Coriandrum sativum L are suspected to contain the 7 compounds: DL-Valine, indoline, 2-quinolinol, trans-tnrthole, luteolin, apigenin, linoliamide, and luteolinin are compounds known in to be able to lower blood glucose and malondialdehyde.\u0000Conclusion: Coriandrum sativum L (ketumbar seeds) nano extract was prepared using chitosan had potential to decrease MDA and blood glucose, and increase SOD level in hyperglycaemic rats.","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88893904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Simple clean water treatment with double pots diffuser method in Lumbung Kauh village, Selemadeg Barat, Tabanan district, Bali, Indonesia 印度尼西亚巴厘塔巴南区Selemadeg Barat的Lumbung Kauh村用双罐扩散器法进行简单的净水处理

Indonesia Journal of Biomedical Science Pub Date : 2022-12-30 DOI: 10.15562/ijbs.v16i2.427

Ni Made Marwati, Ni Ketut Rusminingsih, I. Mahayana, I. N. Suyasa, I. K. Aryana, Anysiah Elly Yulianti

{"title":"Simple clean water treatment with double pots diffuser method in Lumbung Kauh village, Selemadeg Barat, Tabanan district, Bali, Indonesia","authors":"Ni Made Marwati, Ni Ketut Rusminingsih, I. Mahayana, I. N. Suyasa, I. K. Aryana, Anysiah Elly Yulianti","doi":"10.15562/ijbs.v16i2.427","DOIUrl":"https://doi.org/10.15562/ijbs.v16i2.427","url":null,"abstract":"Introduction: The prevalence of improvement clean water services for urban areas yearly shows an increase of 40% to 50% in largest and 20%-30% in district. In other words, the level of water pollution is increasing. Alleviating poverty and unsafe water takes a strategic approach. Double pot diffuser method as a simple clean water treatment tool to improve water quality\u0000Aims: The objective of this study is analysing the double pot diffuser method as a simple clean water treatment tool to improve water quality\u0000Method and result: The data was collected two times (before- after) in control and double pot diffuser as an experiment. Statistical analysis, including univariate and bivariate analysis, was done using SPSS 23. A normality test was carried out, and the Mann-Whitney method was used to asses the difference in results between the experiment and control. The non-parametric test results showed that in the experimental group there was a difference between the results of the examination of biological parameters of the water (E.coli, coliform) and turbidity parameters, before and after the experiment with p-value 0.001. In the control group, the results revealed no difference between the results of the examination of water biological parameters and water turbidity before and after the experiment.\u0000Conclusion: Double pot diffuser is recommended to residents because it has been proven to improve the water quality in gumleng. Draining and cleaning gumleng once a week is also recommended to prevent sedimentation from dissolving and re-polluting the water.","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76973944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physiotherapy Rehabilitation Management on Phase I of Post Operative Anterior Cruciate Ligament Reconstruction: A Case Report 前交叉韧带重建术后一期理疗康复管理1例

Indonesia Journal of Biomedical Science Pub Date : 2022-12-30 DOI: 10.15562/ijbs.v16i2.435

I. Adhitya, Ari Wibawa, Abdurrasyid, I Gusti Ngurah Wien Aryana, Muhammad Adrian Putra Rachman, Ni Luh Veni Rahayu, Ni Komang Mega Junianti, Emily Devina Kartawijaya, Tabita Febyola Wijaya

{"title":"Physiotherapy Rehabilitation Management on Phase I of Post Operative Anterior Cruciate Ligament Reconstruction: A Case Report","authors":"I. Adhitya, Ari Wibawa, Abdurrasyid, I Gusti Ngurah Wien Aryana, Muhammad Adrian Putra Rachman, Ni Luh Veni Rahayu, Ni Komang Mega Junianti, Emily Devina Kartawijaya, Tabita Febyola Wijaya","doi":"10.15562/ijbs.v16i2.435","DOIUrl":"https://doi.org/10.15562/ijbs.v16i2.435","url":null,"abstract":"Background: An anterior cruciate ligament reconstruction (ACLR) phase I is critical for the patient to improve knee pain and range of motion (ROM), knee functions, and prevent excessive inflammation and muscle atrophy. This study aims to evaluate the physiotherapy interventions to improve the pain, ROM, muscle atrophy, and knee function following ACLR phase I.\u0000Case Description: In July 2022, a 22-year-old female basketball athlete injured her right knee while running-pivoting movement during practice. The patient received ACLR on September 22, 2022, following an MRI and physiotherapy examinations. On October 14, 2022, the patient began receiving three times physiotherapy programs weekly. Until November 11, 2022, she complained of having trouble bending and straightening her knee. Although there was no increment in leg muscle circumference of 20 cm above the right patella (RP), there were increments in muscle circumferences of 1.3 cm at 10 cm above the RP, 1.1 cm at 5 cm above the RP, 1.2 cm at 10 cm below the RP, and 1.5 cm at 20 cm below the RP. After three times interventions, we found changes 5o of knee flexion, 2 points of tenderness VAS, 5-28 points of KOOS score, and 10 points of Lysholm’s score.\u0000Conclusion: The physiotherapy interventions improved the pain, ROM, leg muscle circumference, and knee function in the ACLR phase I patient. This case report study could be a reference for further experimental study.","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73363264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overview of findings on radiographic examination of sialography in patients with sialolithiasis: case serial 涎石症患者涎腺造影x线检查结果综述:病例序列

Indonesia Journal of Biomedical Science Pub Date : 2022-12-29 DOI: 10.15562/ijbs.v16i2.407

Ida Ayu Kemala Wasita Manuaba, I Made Dwijaputra Ayusta, Putu Patriawan

{"title":"Overview of findings on radiographic examination of sialography in patients with sialolithiasis: case serial","authors":"Ida Ayu Kemala Wasita Manuaba, I Made Dwijaputra Ayusta, Putu Patriawan","doi":"10.15562/ijbs.v16i2.407","DOIUrl":"https://doi.org/10.15562/ijbs.v16i2.407","url":null,"abstract":"Background: Sialolithiasis is the most common salivary gland disease. Salivary gland disease usually occurs in middle age, with an incidence of 12 in 1000 in the adult population. The peak incidence is between the ages of 30 and 50. Sialolithiasis generally occurs in the submandibular gland. Sialoliths can be single or multiple. Diagnosis of sialolithiasis can be based on clinical examination or simple supporting examination in the form of sialography.\u0000Case Report: There were 3 patients with the main complaint of pain in the lower jaw area with similar symptoms, such as swelling and discomfort every time they chewed food. In all three patients, conventional plain radiographs were examined, namely Skull AP photos, followed by conventional radiological examinations using water-soluble contrast media known as sialography. \u0000Conclusion: Correct diagnosis and determine the appropriate treatment for the patient. Plain AP skull radiographs can be used as an early indication of the presence or absence of sialolith images, although they may not be visible if they are relatively small. Furthermore, sialography examination can become the gold standard in determining the location and size of sialoliths. In these three cases, an opacity or filling defect, accompanied by a dilatation of the proximal duct and even narrowing of the distal lumen of the duct, indicates either partial or total obstruction. An ultrasound examination was performed to confirm the diagnosis. In all three cases, it was found that there was indeed a hyperechoic surrounded by clear anechoic (saliva), thus suggesting a sialolithiasis.","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77825415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between the degree of medulla spinalis retraction and motor function in experimental animals 实验动物脊髓回缩程度与运动功能的关系

Indonesia Journal of Biomedical Science Pub Date : 2022-12-27 DOI: 10.15562/ijbs.v16i2.423

Novi Firman Syah, Nasrullah Mustamir, M. I. Kusuma, Willy Adhimarta, Joko Hendarto

{"title":"Relationship between the degree of medulla spinalis retraction and motor function in experimental animals","authors":"Novi Firman Syah, Nasrullah Mustamir, M. I. Kusuma, Willy Adhimarta, Joko Hendarto","doi":"10.15562/ijbs.v16i2.423","DOIUrl":"https://doi.org/10.15562/ijbs.v16i2.423","url":null,"abstract":"Introduction: Spinal cord trauma can cause partial or total damage to the brain's and spinal cord's connection. The effects of spinal cord injury will affect motor function even if there is a severe injury, and in a longer duration, it will cause death. Medulla spinalis retraction can cause clinical abnormalities, especially in motor function.\u0000Methods: This study consisted of three groups of male Wistar rats (Rattus norvegicus). Each group was subjected to 15%, 25% and 37.5% retractions for 1 minute, 3 minutes and 5 minutes, respectively. After that, an assessment was carried out with the footprint test and forced swim test. Data were analyzed with Fisher's exact test.\u0000Results: This study had 27 samples of male Wistar rats which were divided into 3 groups. In the 15%, 25% and 37.5% retractions treatment with a duration of 3 minutes and 5 minutes, all samples died. Retraction of 15% of the diameter of the medulla spinalis in 1 minute does not cause motor function disorders. Statistically, there is no significant difference in the degree of medulla spinalis retraction and motor function on the footprint test and forced swim test (p = 0.102).\u0000Conclusion: The medulla spinalis retraction of less than 15% with a duration of less than 1 minute will not cause motor function impairment. If more than 15% retraction with more than 1 minute will cause motor function impairment and death, this relationship is not statistically significant.","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"82 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88461874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0