Indonesia Journal of Biomedical Science最新文献

{"title":"Immune regulation in obesity: a narrative review","authors":"I. Manuaba, D. A. Sindhughosa","doi":"10.15562/ijbs.v17i1.459","DOIUrl":"https://doi.org/10.15562/ijbs.v17i1.459","url":null,"abstract":"Obesity is a condition triggered by many risk factors, but the main one is due to high calorie intake and low physical activity. Various studies have explored the relationship between obesity and metabolic complications, namely chronic degenerative disorders. In the condition of obesity, there are biochemical changes including chronic inflammation. This condition mainly occurs due to the load on the metabolic tissue due to weight gain and fat tissue dysfunction. These changes result in changes in the distribution of leukocytes, lymphocyte activity, and in general the immune defense system. The changes that occur include the occurrence of a chronic inflammatory process. Among the various inflammatory mediators, there are three mediators that play an important role in the regulation of the immune system due to obesity, namely TNF-α, IL-6, and adiponectin. In addition, the accumulation of free fatty acids in obesity can activate a cascade of a series of pro-inflammatory kinases, such as IkB kinase and c-Jun N-terminal kinase, which triggers fatty tissue to release IL-6. Other effects include activation of the inflammasome, and hyperleptinemia. Leptin is then associated with cell survival, cytokine release, and chemotaxis. In addition, leptin can also be related to the proliferation of T cells.","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90779405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and quantification of Roseburia intestinalis and Escherichia coli in hypertensive patients in Denpasar","authors":"K. Pinatih, D. Wihandani, A. E. Darwinata, Gede Setula Narayana, I Putu Gede Septiawan Saputra, I Gede Putu Supadmanaba","doi":"10.15562/ijbs.v17i1.457","DOIUrl":"https://doi.org/10.15562/ijbs.v17i1.457","url":null,"abstract":"Background: Low-grade chronic inflammation may contribute to the development of atherosclerosis as well as hypertension by inducing the production of pro-inflammatory cytokines. Several studies have revealed a relationship between the microbiota living in the gut and the incidence of hypertension. Two of several gut microbiota that contributed, in this case, are Escherichia coli (E. coli) and Roseburia intestinalis (R. intestinalis). Therefore this study aimed to identify and quantify gut microbes namely R. intestinalis and E.coli in hypertensive patients in Bali, especially in Denpasar City.\u0000Methods: This research is a cross-sectional study located at South Denpasar Health Center I, Bali, and the Integrated Biomedical Laboratory, Faculty of Medicine, Universitas Udayana. The sample in this study were hypertensive patients who had been registered at South Denpasar Health Center I and who met the inclusion criteria and did not meet the exclusion criteria. The E. coli and R. intestinalis concentrations were assessed by conducting DNA isolation and RT-qPCR. Statistical analysis using univariate analysis, bivariate analysis using the Independent T-Test; Mann-Whitney Test; Chi-Square, and ROC analysis\u0000Results: There were 70 subjects included in this study. Thirty-one subjects were hypertensive patients and the other 39 patients were not hypertensive. The age of the subjects between the two groups was found statistically significant (p=0.007). We also found that comorbid were found mostly in hypertensive patients (p=0.009). Most of the comorbid experienced among them were cardiovascular diseases and diabetes mellitus. Hypertensive subjects had more E. coli concentration in their gut compared with non-hypertensive subjects (p=0.048), while R. intestinalis concentrations were similar in both groups (p>0.05). From the multivariate analysis, it was found that hypertensive patients tended to have a higher concentration of E. coli than non-hypertensive patients (p=0.012; 95% CI:0.055–0.417).\u0000Conclusion: E. coli concentration in the gut is independently associated with the incidence of hypertension, while R. intestinalis concentration is not.","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81078049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Change of ABO blood group in a patient with Acute Myelocytic Leukemia (AML): a case report","authors":"Ni Ketut Puspa Sari, N. Mulyantari, S. Herawati, A. A. Lestari, Ni Nyoman Mahartini, I. Wande","doi":"10.15562/ijbs.v17i1.428","DOIUrl":"https://doi.org/10.15562/ijbs.v17i1.428","url":null,"abstract":"Background: ABO and Rhesus blood groups are clinically important, especially in blood transfusion. Blood groups are determined by the antigens found on the erythrocyte membrane. In patients with hematologic malignancies, especially from the myeloid lineage, changes in blood group can occur in the ABO system mainly due to weakness or loss of some ABO antigens.\u0000Case Description: A nine-year-old girl was admitted to the hospital with a chief complaint of high fever three days before admission. The patient had been diagnosed with acute non-lymphoblastic leukemia three months ago. From medical history, the patient had undergone chemotherapy and received 22 bags of PRC transfusion with blood group O (+) from February 27th until May 28th 2018. On July 21st 2018, the transfusion procedure was repeated, and the blood group showed B (+). The procedure was repeated using a new sample but the result remained the same. The crossmatch was performed with five blood groups O (+) and two blood groups B (+) showed mayor: negative, minor:+weak, AC:+weak, mayor: negative, minor:+weak, AC:+weak, respectively.\u0000Conclusion: Changes in blood group antigens in hematologic malignancies that experience ABO antigen alternation and return to the original blood group reflect the remission from the disease. The expression of H antigen in blood groups A and B may revert to normal with an improvement from the underlying disease.","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78355811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiorenal Syndrome: revisiting its pathophysiology and classification","authors":"I. M. F. Wikananda, I. Widiana, D. A. Sindhughosa","doi":"10.15562/ijbs.v17i1.441","DOIUrl":"https://doi.org/10.15562/ijbs.v17i1.441","url":null,"abstract":"Heart failure remain as major health problem worldwide, causing severe morbidity and high mortality. Strong relationship between cardiac disorders and kidney disorders that affect the patient's prognosis. Cardiorenal syndrome (CRS) is a group of symptoms due to acute or chronic damage to one of the organs, including the heart or kidneys, which will affect the function of other organs. The heart and kidney each play a role as a regulator of the body's hemodynamic balance. The kidneys produce urine based on that produced by glomerular filtration which depends on the level of renal perfusion and arteriolar blood pressure. CRS classified into five. The classification is based on the primary and secondary damage from CRS occurs in the heart, kidney or outside the heart and/or kidney. Understanding the pathophysiology of CRS benefit to comprehensively manage patients with such condition.","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84187652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectivity and safety of cisternostomy and decompressive craniectomy as management of brain trauma: a systematic review and meta-analysis","authors":"Agung B S Satyarsa, D. P. W. Wardhana, I. B. Y. Brahmantya, Rohadi Muhammad Rosyid, S. Maliawan","doi":"10.15562/ijbs.v17i1.448","DOIUrl":"https://doi.org/10.15562/ijbs.v17i1.448","url":null,"abstract":"Introduction: Traumatic brain injury (TBI) is the disease that causes the most common disability globally. The cisternostomy as adjuvant management of TBI lacks documentation. We aim to prove the effectiveness and safety of cisternostomy and decompressive craniectomy in managing traumatic brain injury.\u0000Methods: The search for published scientific articles using the Preferred Reporting, Items for Systematic Reviews, and Meta-Analysis (PRISMA) method. The search was conducted using the PubMed, Cochrane library, and Medline databases published in English for the last ten years until June 2022, evaluating the effectiveness and safety of cisternostomy and decompressive craniectomy in managing traumatic brain injury. The Oxford Center for Evidence-based medicine assessed the evidence levels of each study. Data analysis with RevMan version 5.3.\u0000Results: Four studies were included in this meta-analysis, two RCTs, and two observational studies. We find a total of 1000 patients with; 596 cisternostomies and 404 decompressive craniectomies. These primary points show that mean GOS at six weeks is 0.93 (I2:52%; 95%CI: 0.70 to 1.17; p<0,01), decrease in intracranial pressure post-operation is -3.20 mmHg (I2:97%; 95%CI: -3.84 to -2.56; p<0,01), duration of ICU stay is -2.37 days (I2:37%; 95%CI: -4.54 to -0.21; p<0,03), and mortality is 0.51 (I2:21%; 95%CI: 0.42 to 0.63; p<0,01).\u0000Conclusion: Cisternostomy is a beneficial procedure in TBI, leading to survival benefits and better clinical outcomes. Hopefully, more studies will examine its role in TBI patients critically in the future.","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85332026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between shear wave liver elastography and fibrosis index in chronic viral hepatitis B patients","authors":"H. Septian, Nyoman Srie Laksminingsih, M. Asih, I. Widiana, I. K. Mariadi","doi":"10.15562/ijbs.v17i1.415","DOIUrl":"https://doi.org/10.15562/ijbs.v17i1.415","url":null,"abstract":"Background: Chronic viral hepatitis B causes chronic inflammatory process, hepatocyte damage, progressive fibrosis, and irreversible liver damage, leading to high morbidity. There are two methods of diagnosing liver fibrosis, invasive (biopsy) and non-invasive, including radiological examination using the elastography method and hematological examination. This study aims to determine the relationship between the elasticity of liver parenchyma using the Shear Wave Elastography (SWE) method and fibrosis index in chronic viral hepatitis B patients.\u0000Methods: This research is a cross-sectional study using 68 samples that met the inclusion criteria. The 2D-SWE examination was blindly performed by two observers using a convex transducer probe with frequencies ranging from 1.2 to 6 MHz. Data were analyzed using SPSS version 20.0 for Windows.\u0000Results: In our study, there was a significant moderate positive correlation between the elasticity of liver parenchyma and the fibrosis index performed by both observers (r=0.52; p < 0.001). After controlling confounding variables, a higher correction was obtained (r=0.61), suggesting a change from moderate to strong correlation (p<0.05).\u0000Conclusion: There was a positive and significant correlation between the elasticity of liver parenchyma and fibrosis index.","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88797427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Characteristics of Pediatric Abdominal Mass in Radiology Department Prof. Ngoerah General Hospital Bali, From January 2018 to December 2020","authors":"Ni Nyoman Margiani","doi":"10.15562/ijbs.v17i1.440","DOIUrl":"https://doi.org/10.15562/ijbs.v17i1.440","url":null,"abstract":"Introduction: Abdominal mass is one of the common pediatric tumors that can manifest as abdominal pain or a distended abdomen, and it requires immediate management. Some of them can often be incidentally discovered by parents, during routine pediatric examination in an outpatient clinic, or detected on imaging multimodalities. This study is aimed to evaluate the prevalence of pediatric abdominal mass and to demonstrate tumor characteristics by radiology imaging findings in Prof. I G. N. G. Ngoerah Hospital Denpasar.\u0000Methods: We conducted a descriptive, cross-sectional study of patients with abdominal masses\u0000discovered by Abdominal CT scan in the Radiology Department of Prof. I G. N. G. Ngoerah Hospital from January 2018 to December 2020. Medical record review and data analysis were done retrospectively.\u0000Results: We identified 143 pediatric patients diagnosed with abdominal masses discovered by a CT scan in the Radiology Department of Prof. I G. N. G. Ngoerah Hospital from January 2018 to December 2020. Female patients were found more than male patients (77 vs. 66 patients). Out of all patients, the majority of age were 1 to 9 years old (65 patients, 45%), while the second were 10 to 18 years old (52 patients, 35%), and the rest were one month – 11 months (17 patients, 12%) and <1 month (5 patients, 4%) respectively. The average age was 7.44 years old.\u0000Conclusion: The abdominal imaging and histopathological findings help evaluate abdominal mass in children. An accurate diagnosis is essential for proper management.","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78926708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Making tinnitus songs according to the frequency and amplitude of the sound of tinnitus sufferers that are safe and comfortable for sufferers","authors":"M. Rahayu, E. Setiawan, I. K. Sumerjana, Ida Bagus Made Suryatika, I. W. G. A. E. Putra, Ketut Tadeus Max Nurcahya Pinatih, Idola Pratiwi, I. M. N. Arthana, I. G. A. S. Widiantari","doi":"10.15562/ijbs.v17i1.422","DOIUrl":"https://doi.org/10.15562/ijbs.v17i1.422","url":null,"abstract":"Background: Tinnitus is the perception of sound heard by a person without an external stimulus. About 10-14.5% of the world's population experience tinnitus, with the most common age group being 40-60. The management of tinnitus is still a challenge for researchers. Until now, there has been no effective management of tinnitus. The last therapy available is to make artificial sounds that imitate the tinnitus sound so that it can mask the actual tinnitus sound. In addition, music therapy is expected to reduce the stress level of tinnitus patients.\u0000Methods: This research is a follow-up study from previous research with 26 subjects. After getting the frequency and amplitude of tinnitus, a sound stimulus is made by combining tone variations and good generators obtained from audiometric masking. Tone variations are made using a basic tone that matches the patient's tinnitus frequency. After that, the patient will assess the results of the merger. Then all the participants will listen to dan evaluate the mixing song.\u0000Results: Of all subjective tinnitus sound generators, 3-5% have frequencies below 20 Hz and above 20,000 Hz. Songs made by recording in a soundproof room also have a frequency of 20 Hz and above 20,000 Hz, about 5 – 7%, where the song has an unnecessary frequency. The subjective tinnitus sound generator with the created song has an amplitude of < 85dB so that it can be adjusted with the volume control on the speaker.\u0000Conclusion: Tinnitus songs were made with the addition of Piano and Violin and Flute music, and Guitar, Bass and Balinese gamelan had a frequency of 20 – 20,000 Hz with an amplitude of < 85 dB, which can be adjusted with the volume so that it is safe and comfortable for tinnitus sufferers.","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79656196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated with the incidence of perinatal asphyxia at Sanjiwani Regional General Hospital, Gianyar, Bali, Indonesia","authors":"Kadek Enny Pradnyaswari, Romy Windiyanto","doi":"10.15562/ijbs.v17i1.446","DOIUrl":"https://doi.org/10.15562/ijbs.v17i1.446","url":null,"abstract":"Background: perinatal asphyxia is the second-highest cause of neonatal death in Indonesia. According to the World Health Organization (WHO), perinatal asphyxia is when a baby experiences spontaneous and regular breathing failure immediately after birth. Various risk factors may cause perinatal asphyxia, including maternal, fetal, and placental factors. This study aims to identify the risk factors associated with the incidence of perinatal asphyxia at the Sanjiwani Regional General Hospital, Gianyar.\u0000Methods: This research was an observational analytic study with a case-control design involving 114 samples of newborns from January 1 to December 31, 2022, at the Sanjiwani Gianyar Hospital. The case group was selected using a total sampling technique, and the control group using a simple random sampling technique. Data were extracted from the medical records and analyzed using univariate, bivariate, and multivariate methods. Bivariate analysis used Chi-square or Fisher's exact tests, while multivariate analysis used logistic regression. The P-value of <0.05 is considered significant.\u0000Results: A total of 57 cases and 57 controls were included in this study. The bivariate analysis found the factors associated with perinatal asphyxia were meconium-stained amniotic fluid (p=0.021; OR=2.742; 95%CI=1.150-6.539), mode of delivery (p=0.003; OR=3.203; 95%CI=1.484-6.913), low birth weight (p=0.002; OR=4.595; 95%CI=1.681-12.561), and prematurity (p=0.006; OR=4.732; 95%CI=1.462-15.322). In multivariate analysis, it was found that meconium-stained amniotic fluid has the strongest association with perinatal asphyxia.\u0000Conclusion: There is a significant relationship between meconium-stained amniotic fluid, method of delivery, low birth weight, and prematurity with the incidence of perinatal asphyxia.","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81914833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristic and risk factors of retinopathy of prematurity in Sanglah Hospital Denpasar: 3-years retrospective study","authors":"I. K. Sutyawan, Maria Vinsensia Lie, Intan Ade Indraputri, Made Ayu Surasmiati, Ariani Andayani, Ni Made Ari Suryati","doi":"10.15562/ijbs.v17i1.434","DOIUrl":"https://doi.org/10.15562/ijbs.v17i1.434","url":null,"abstract":"Introduction: Retinopathy of prematurity (ROP) is one of the important causes of blindness in children. ROP is characterized by abnormal retinal neovascularization of premature infants.\u0000Purpose: This study aimed to estimate the prevalence of ROP in preterm infants at Sanglah Hospital Bali from 2015-2017 and identify the risk factors predisposing them to ROP.\u0000Methods: This was a retrospective study, observational analysis on premature infants diagnosed as ROP at Sanglah Hospital Bali from January 2015 to December 2017, with a gestational age of 30 weeks or less at birth and a birth weight of 1500 grams or less. Infants whose gestational age was >30 weeks or whose birth weight was >1500 grams were also included. The ophthalmological examinations were initiated between the fourth and sixth weeks of chronological age or 34 weeks of corrected age, whichever was earlier, and were repeated weekly or biweekly as per Indonesian guidelines for ROP screening, until full vascularization of the retina reached zone 3.\u0000Results: Out of 31 infants diagnosed as ROP, 3 (9.7%) cases developed ROP in one eye, and 28 (90,3%) cases in both eyes. They were classified as 23 (74.2%) cases stage 1, and 8 (25,8%) cases stage 2. None of the studied infants presented ROP at stage 3, 4, or 5. The risk for ROP was not significantly associated with birth weight (OR 0.375; 95% CI 0.030 – 4.635), gestational age (OR 0.897; 95% CI 0.792 – 1.015), sepsis (OR 1.111; 95% CI 0.089 – 13.835), blood transfusion (OR 1.111; 95% CI 0.089 – 13.835), and HMD (OR 1.118; 95% CI 0.977 – 1.443).\u0000Conclusions: The data of this study showed that low gestational age, low birth weight, sepsis, oxygen therapy, and blood transfusion may be contribute to the development of ROP, but not significant statistically. Clinicians should be aware of the presence of the additional risk factors when monitoring preterm infants,especially when giving supplemental oxygen therapy.","PeriodicalId":55769,"journal":{"name":"Indonesia Journal of Biomedical Science","volume":"86 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83690853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}