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Trends in Glycoscience and Glycotechnology最新文献

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超分子グライコポリマーの合成と応用 超分子糖聚合物的合成与应用。
IF 0.3 4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-11-25 DOI: 10.4052/tigg.2301.1j
Norihiko Sasaki
{"title":"超分子グライコポリマーの合成と応用","authors":"Norihiko Sasaki","doi":"10.4052/tigg.2301.1j","DOIUrl":"https://doi.org/10.4052/tigg.2301.1j","url":null,"abstract":"","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139236957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
呼吸上皮細胞へのB3GAT1導入による糖鎖発現変化がウィルス感染を防ぐ 通过 B3GAT1 转导呼吸道上皮细胞，改变糖的表达可防止病毒感染。
IF 0.3 4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-11-25 DOI: 10.4052/tigg.2330.6j
Jyoji Morise
{"title":"呼吸上皮細胞へのB3GAT1導入による糖鎖発現変化がウィルス感染を防ぐ","authors":"Jyoji Morise","doi":"10.4052/tigg.2330.6j","DOIUrl":"https://doi.org/10.4052/tigg.2330.6j","url":null,"abstract":"","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139237099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alternation of Glycan Expression by Introducing B3GAT1 into the Respiratory Epithelium Restricts Viral Infections 通过在呼吸道上皮细胞中引入 B3GAT1 来交替表达糖，从而抑制病毒感染
IF 0.3 4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-11-25 DOI: 10.4052/tigg.2330.6e
Jyoji Morise
{"title":"Alternation of Glycan Expression by Introducing B3GAT1 into the Respiratory Epithelium Restricts Viral Infections","authors":"Jyoji Morise","doi":"10.4052/tigg.2330.6e","DOIUrl":"https://doi.org/10.4052/tigg.2330.6e","url":null,"abstract":"","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139237107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
<i>N</i>-グリコシル化VHH抗体 &爱尔蒂;i & gt;n &爱尔蒂;/ i & gt;糖基化VHH抗体
4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-09-25 DOI: 10.4052/tigg.2327.6j
Takahiko Matsushita
{"title":"&lt;i&gt;N&lt;/i&gt;-グリコシル化VHH抗体","authors":"Takahiko Matsushita","doi":"10.4052/tigg.2327.6j","DOIUrl":"https://doi.org/10.4052/tigg.2327.6j","url":null,"abstract":"","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135859649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural Analysis of GPI-glycans from GPI-anchored Proteins by Mass Spectrometry 质谱法分析gpi锚定蛋白中gpi聚糖的结构
4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-09-25 DOI: 10.4052/tigg.2209.1e
Miyako Nakano
{"title":"Structural Analysis of GPI-glycans from GPI-anchored Proteins by Mass Spectrometry","authors":"Miyako Nakano","doi":"10.4052/tigg.2209.1e","DOIUrl":"https://doi.org/10.4052/tigg.2209.1e","url":null,"abstract":"Glycosylphosphatidylinositol-anchored proteins (GPI-APs) are a group of proteins anchored to glycolipid on the cell membrane and are ubiquitous in eukaryotes. The basic structure of the glycosylphosphatidylinositol (GPI) moiety comprises ethanolamine phosphate, three mannose residues, glucosamine and phosphatidylinositol (PI). This basic structure and the mechanism by which proteins are anchored to membranes via the structure are conserved among organisms. After the identification of paroxysmal nocturnal hemoglobinuria (PNH), diseases derived from GPI anchor deficiencies were discovered. To comprehend these diseases fully, a comprehensive understanding of GPI anchor biosynthesis, encompassing the intricate remodeling of glycans and lipids, becomes imperative. We used mutant strains of Saccharomyces cerevisiae in which the gene encoding the enzyme that catalyzes remodeling was knocked out and a model molecule for GPI-APs to observe the remodeling process. Herein, we introduce a method for analyzing and identifying glycan structures in GPI anchors using liquid chromatography-electrospray ionization mass spectrometry (LC-ESI MS).","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135859812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
<i>N</i>-glycosylated VHH Antibodies &lt;i&gt;N&lt;/i&gt;-糖基化VHH抗体
4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-09-25 DOI: 10.4052/tigg.2327.6e
Takahiko Matsushita
{"title":"&lt;i&gt;N&lt;/i&gt;-glycosylated VHH Antibodies","authors":"Takahiko Matsushita","doi":"10.4052/tigg.2327.6e","DOIUrl":"https://doi.org/10.4052/tigg.2327.6e","url":null,"abstract":"","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135859506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
アラビノキシランの生合成機構と健康機能性に関する研究動向 阿拉伯昔兰的生物合成机制和健康功能研究趋势
4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-09-25 DOI: 10.4052/tigg.2116.1j
Shiro Suzuki, Seichi Suzuki, Kouki Yoshida
{"title":"アラビノキシランの生合成機構と健康機能性に関する研究動向","authors":"Shiro Suzuki, Seichi Suzuki, Kouki Yoshida","doi":"10.4052/tigg.2116.1j","DOIUrl":"https://doi.org/10.4052/tigg.2116.1j","url":null,"abstract":"アラビノキシラン（AX）は、イネ科植物細胞壁の主要なヘミセルロースで、地上で最も多い賦存量と生産量を有するリグノセルロース系バイオマス成分の一つである。AXは、イネ科エネルギー作物の支持組織（茎・葉）では、リグニンと結合した構造多糖としてバイオマス糖化の障壁となる一方、穀物の可食組織（種皮・胚乳）では食物繊維として免疫賦活機能やプレバイオティクス機能などの生理活性を有する。このように、AXはカーボンニュートラルな再生可能エネルギー資源と大麦β-グルカンに続く第二の穀物由来機能性多糖という観点から興味深い特徴を持ち、その詳細な化学構造と生合成機構の解明は、イネ科エネルギー作物や穀物の品種特性の評価や機能性食品の開発に寄与し得る。本稿では、その化学構造や生合成機構と利用展開に関する研究動向を概説する。","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135770785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Significance of Sulfated Glycans on Mucins in the Gut 硫酸甘聚糖对肠道黏蛋白的影响
4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-09-25 DOI: 10.4052/tigg.2219.1e
Hirohito Abo, Hiroto Kawashima
{"title":"Significance of Sulfated Glycans on Mucins in the Gut","authors":"Hirohito Abo, Hiroto Kawashima","doi":"10.4052/tigg.2219.1e","DOIUrl":"https://doi.org/10.4052/tigg.2219.1e","url":null,"abstract":"In the intestine, mucins function as a physical barrier separating the gut bacteria and the host. MUC2 mucin is a highly O-glycosylated glycoprotein, and its glycans are an essential post-translational modification for MUC2 function. In recent years, it has been discovered that specific structural units of the complex MUC2 glycans play distinct physiological functions. In particular, the sulfation of GlcNAc and Galactose in MUC2 glycans is essential for intestinal barrier function. Furthermore, gut bacteria utilize mucin sugar chains as a nutrient source by employing specific sulfatase enzymes, allowing them to colonize in the intestine. On the other hand, gut bacteria regulate host glycosylation through the induction of glycosyltransferase expression. In the light of recent studies on the structure and function of MUC2 glycans, mucins are not only functioning as a physical barrier but also as molecules that mediate complex interactions with gut microbiota. In this article, we discuss the function of MUC2 mucin and its glycosylation, with a particular focus on sulfated glycans.","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135859490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
<i>Xenopus</i> Galectin: Molecular Function and Evolution & lt; i&gt Xenopus&lt; / i&gt;凝集素:分子功能和进化
4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-09-25 DOI: 10.4052/tigg.2224.1e
Takashi Ogawa, Yasuhiro Nonaka, Takanori Nakamura
{"title":"&lt;i&gt;Xenopus&lt;/i&gt; Galectin: Molecular Function and Evolution","authors":"Takashi Ogawa, Yasuhiro Nonaka, Takanori Nakamura","doi":"10.4052/tigg.2224.1e","DOIUrl":"https://doi.org/10.4052/tigg.2224.1e","url":null,"abstract":"Galectins are carbohydrate-binding proteins that do not require metals, and are widely distributed in vertebrates. The basic specificity of galectins for β-galactosides is conserved in their carbohydrate recognition domains (CRDs). Although galectins have been implicated in important biological functions, there is limited evidence that galectin-galactoside binding is directly linked to such functions. Extensive functional analysis of galectins in a large number of species is necessary to understand the broad range of evolutionarily conserved functions. Therefore, we focused on Xenopus galectins and identified and analyzed 12 species of Xenopus laevis galectins. The only non-mammalian vertebrate that has been comprehensively analyzed for galectins is the Xenopus laevis, which we use as a model for galectin research. In this review, we introduce the types of galectins and the functions of Xenopus galectins available to date.","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135859653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a glycoRNA Detection Tool and Biological Roles of glycoRNA glycoRNA检测工具的开发及glycoRNA的生物学作用
4区 生物学
Trends in Glycoscience and Glycotechnology Pub Date : 2023-09-25 DOI: 10.4052/tigg.2326.6j
Haruhiko Fujihira
{"title":"Development of a glycoRNA Detection Tool and Biological Roles of glycoRNA","authors":"Haruhiko Fujihira","doi":"10.4052/tigg.2326.6j","DOIUrl":"https://doi.org/10.4052/tigg.2326.6j","url":null,"abstract":"","PeriodicalId":55609,"journal":{"name":"Trends in Glycoscience and Glycotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135859508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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