American Journal of the Medical Sciences最新文献_第5页

59 Novel mutations of the cytochrome B5 reductase gene in a patient with recessive congenital methemoglobinemia type II

IF 2.3 4区医学

American Journal of the Medical Sciences Pub Date : 2025-02-01 DOI: 10.1016/S0002-9629(25)00068-0

R Mayo, G Aixa, D Fry, JM Mack, JE Farrar

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60 Acute urinary retention in a 17-year-old male

IF 2.3 4区医学

American Journal of the Medical Sciences Pub Date : 2025-02-01 DOI: 10.1016/S0002-9629(25)00069-2

T Le

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82 Hypertrophic obstructive cardiomyopathy mimicking aortic stenosis: diagnostic challenges and therapeutic outcomes

IF 2.3 4区医学

American Journal of the Medical Sciences Pub Date : 2025-02-01 DOI: 10.1016/S0002-9629(25)00091-6

M Abubaker, P Adrejiya, RN Khouzam

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76 When the lumps aren't mumps

IF 2.3 4区医学

American Journal of the Medical Sciences Pub Date : 2025-02-01 DOI: 10.1016/S0002-9629(25)00085-0

EL Nichols, JI Hampton, CL Wu

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63 PCR vs. clinical judgment: is my tool accurate?

IF 2.3 4区医学

American Journal of the Medical Sciences Pub Date : 2025-02-01 DOI: 10.1016/S0002-9629(25)00072-2

C Johnson, S Khan, K Parsell, B Estrada

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Systemic investigation of the mechanism underlying the therapeutic effect of Astragalus membranaceus in ulcerative colitis 系统研究黄芪对溃疡性结肠炎的治疗作用机制。

IF 2.3 4区医学

American Journal of the Medical Sciences Pub Date : 2025-02-01 DOI: 10.1016/j.amjms.2024.07.019

Jingxin Mao PhD , Lihong Tan MD , Cheng Tian MD , Wenxiang Wang PhD , YanLin Zou MD , Zhaojing Zhu PhD , Yan Li MD

{"title":"Systemic investigation of the mechanism underlying the therapeutic effect of Astragalus membranaceus in ulcerative colitis","authors":"Jingxin Mao PhD , Lihong Tan MD , Cheng Tian MD , Wenxiang Wang PhD , YanLin Zou MD , Zhaojing Zhu PhD , Yan Li MD","doi":"10.1016/j.amjms.2024.07.019","DOIUrl":"10.1016/j.amjms.2024.07.019","url":null,"abstract":"<div><h3>Background</h3><div>Whether <em>Astragalus membranaceus</em> is an effective drug in the treatment of ulcerative colitis (UC) is unknown and how it exhibits activity in UC is unclear.</div></div><div><h3>Methods</h3><div>TCMSP, GeneCards, String, and DAVID databases were used to screen target genes in PPI network and we performed GO and KEGG pathway enrichment analysis. Molecular docking and animal experiments were performed. The body weight and disease activity index (DAI) of mice were recorded. ELISA kits were used to detect the levels of CAT, SOD, MDA and IL-6, IL-10, TNF-α in the blood of mice. Western blot kits were utilized to measure the expression of MAPK14, RB1, MAPK1, JUN, ATK1, and IL2 proteins.</div></div><div><h3>Results</h3><div>The active components of <em>Astragalus membranaceus</em> mainly include 7-O-methylisomucronulatol, quercetin, kaempferol, formononetin and isrhamnetin. <em>Astragalus membranaceus</em> may inhibit the expression of TNF-α, IL-6, MDA, while promoting the expression of CAT, SOD, and IL-10. The expression levels of MAPK14, RB1, MAPK1, JUN and ATK1 proteins were significantly decreased while IL2 protein increased after administration of <em>Astragalus membranaceus.</em></div></div><div><h3>Conclusions</h3><div><em>Astragalus membranaceus</em> may be an effective drug in the treatment of UC by acting on targets with anti-UC effect <em>via</em> its antioxidant action and by regulating the balance of pro-inflammatory and anti-inflammatory factors.</div></div>","PeriodicalId":55526,"journal":{"name":"American Journal of the Medical Sciences","volume":"369 2","pages":"Pages 238-251"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141622080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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29 From throat to thorax: an unusual case of mediastinitis after streptococcal pharyngitis infection

IF 2.3 4区医学

American Journal of the Medical Sciences Pub Date : 2025-02-01 DOI: 10.1016/S0002-9629(25)00038-2

A Anderson, T Tran, MK Olejniczak, V Nijjar, O Ajibola, S Sanne, B DeBoisblanc

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Effect of different shock conditions on mesenteric hemodynamics 不同冲击条件对肠系膜血液动力学的影响。

IF 2.3 4区医学

American Journal of the Medical Sciences Pub Date : 2025-02-01 DOI: 10.1016/j.amjms.2024.08.018

Hao Pu MSc, Wen Li MSc, Gui Wang MSc, ShuJun Zhou MSc

{"title":"Effect of different shock conditions on mesenteric hemodynamics","authors":"Hao Pu MSc, Wen Li MSc, Gui Wang MSc, ShuJun Zhou MSc","doi":"10.1016/j.amjms.2024.08.018","DOIUrl":"10.1016/j.amjms.2024.08.018","url":null,"abstract":"<div><h3>Background</h3><div>Reduced effective circulating blood volume and impaired peripheral tissue perfusion play an important role in the pathophysiology of shock. However, there have been no studies examining the relationship between Doppler ultrasound of the superior mesenteric artery (SMA) under different shock conditions.</div></div><div><h3>Methods</h3><div>We evaluated a total of 85 patients, including 63 patients with different types of shock and 22 in the control group. we included patients who were diagnosed with shock upon admission or developed shock during their hospital stay. At the same time, patients with stable hemodynamics, no use of vasoactive drugs and normal lactate levels were used as a control group. We collected SMA Doppler ultrasound parameters, including Peak Systolic Velocity (PSV), End Diastolic Velocity (EDV), Resistance Index (RI), pulsatility index (PI), Time-Averaged Mean Velocity (TAMV), and Blood Flow (BF).</div></div><div><h3>Results</h3><div>In the cardiac shock group, SMA PSV, TAMV, and BF were lower compared to the other groups. There was no significant difference in SMA RI and PI between the different types of shock groups, but both were significantly lower than the control group. Cardiac index (CI) is correlated with SMA PSV (<em>r</em> = 0.487, <em>P</em> = 0.000) and TAMV (<em>r</em> = 0.538, <em>P</em> = 0.000), whereas SVRI is not correlated with SMA RI and PI. Lactate levels was correlation with SMA RI (<em>r</em> = -0.307, <em>P</em> = 0.000) and PI (<em>r</em> = -0.287, <em>P</em> = 0.000). The area under the ROC curve of SMA RI and PI to predict hyperlactatemia was 0.85[0.78–0.91] and 0.83[0.76–0.90].</div></div><div><h3>Conclusions</h3><div>The velocity parameters of SMA Doppler ultrasound such as TAMV and PSV can reflect cardiac function. The measurements of SMA RI and PI are correlated with lactate levels, having a positive predictive value for hyperlactatemia and provide guidance for fluid resuscitation in patients with shock in the future.</div></div>","PeriodicalId":55526,"journal":{"name":"American Journal of the Medical Sciences","volume":"369 2","pages":"Pages 208-217"},"PeriodicalIF":2.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142020036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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70 A complex case of gastroparesis, severe feeding intolerance, and malnutrition in a 2-month-old

IF 2.3 4区医学

American Journal of the Medical Sciences Pub Date : 2025-02-01 DOI: 10.1016/S0002-9629(25)00079-5

P Escalona, A Sarkar, S Prudencio

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7 La ribonucleoprotein 6 regulates skeletal muscle fibrotic response in congestive heart failure

IF 2.3 4区医学

American Journal of the Medical Sciences Pub Date : 2025-02-01 DOI: 10.1016/S0002-9629(25)00016-3

CS Lott, S Sukhanov, P Delafontaine, T Yoshida

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