American Journal of the Medical Sciences最新文献_第5页

LncRNA CYTOR knockdown inhibits tumor development via regulating miR-503-5p/PCSK9 in lung adenocarcinoma LncRNA CYTOR敲除通过调节 miR-503-5p/PCSK9 抑制肺腺癌的肿瘤发生

IF 2.3 4区医学

American Journal of the Medical Sciences Pub Date : 2024-07-06 DOI: 10.1016/j.amjms.2024.07.012

{"title":"LncRNA CYTOR knockdown inhibits tumor development via regulating miR-503-5p/PCSK9 in lung adenocarcinoma","authors":"","doi":"10.1016/j.amjms.2024.07.012","DOIUrl":"10.1016/j.amjms.2024.07.012","url":null,"abstract":"<div><h3>Background</h3><p>The intricate biological mechanism underlying lung adenocarcinoma (LUAD), characterized by a deficiency of distinctive biomarkers, remain elusive. The presence of Long non-coding RNAs (lncRNAs) have been established to play a role in carcinogenesis. Nevertheless, the regulatory effects and mechanisms of lncRNA CYTOR in LUAD have yet to be elucidated.</p></div><div><h3>Methods</h3><p>In this study, RT-qPCR and Western blot were adopted to examine gene mRNA and protein expression, respectively. Cell proliferation was evaluated by CCK-8 assays. Transwell was performed to assay cell migration and invasion. The function of CYTOR <em>in vivo</em> was investigated through a xenograft animal model.</p></div><div><h3>Results</h3><p>We observed an apparent upregulation of CYTOR in LUAD. Silencing CYTOR significantly reduced proliferation, migration, and invasion capabilities of LUAD cells. Mechanism analysis indicated that CYTOR targeted the miR-503-5p/PCSK9 axis. Additionally, inhibiting of miR-503-5p partially reversed the inhibitory effects of CYTOR silencing on the malignant progression of LUAD cells. Animal experiments revealed that CYTOR/miR-503-5p/PCSK9 curbed tumor formation of nude mice <em>in vivo</em>.</p></div><div><h3>Conclusion</h3><p>These findings demonstrated that lncRNA CYTOR acted as an oncogene in LUAD, regulating tumor malignant progression through the miR-503-5p/PCSK9 axis. This study unveiled a new regulation mechanism of LUAD progression, offering potential therapeutic targets for LUAD.</p></div>","PeriodicalId":55526,"journal":{"name":"American Journal of the Medical Sciences","volume":"368 4","pages":"Pages 382-391"},"PeriodicalIF":2.3,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0002962924013478/pdfft?md5=a5fc4e3921a8f416abbbb8cfe3c40a36&pid=1-s2.0-S0002962924013478-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141560667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expanding pulmonary artery pressure monitoring to racially and socially diverse populations: A pilot CardioMEMS program 将肺动脉压力监测扩展至种族和社会多元化人群：CardioMEMS 试点项目。

IF 2.3 4区医学

American Journal of the Medical Sciences Pub Date : 2024-07-06 DOI: 10.1016/j.amjms.2024.07.008

引用次数: 0

ACEI/ARB use within one year of kidney transplant is associated with less AKI and graft loss in elderly recipients 肾移植后一年内使用 ACEI/ARB 可减少老年受者的 AKI 和移植物丢失。

IF 2.3 4区医学

American Journal of the Medical Sciences Pub Date : 2024-07-05 DOI: 10.1016/j.amjms.2024.07.009

{"title":"ACEI/ARB use within one year of kidney transplant is associated with less AKI and graft loss in elderly recipients","authors":"","doi":"10.1016/j.amjms.2024.07.009","DOIUrl":"10.1016/j.amjms.2024.07.009","url":null,"abstract":"<div><h3>Background</h3><div>Optimizing long-term graft survival remains a major focus in transplant. Elderly kidney transplant recipients are vulnerable to acute kidney injury (AKI) and graft loss. This study assessed the safety and efficacy of ACEI/ARB in elderly kidney transplant recipients and impact on graft outcomes.</div></div><div><h3>Methods</h3><div>Retrospective, longitudinal, cohort study of 500 patients age ≥60 years, who underwent kidney transplantation between 2005 and 2015. Demographic, transplant, and outcomes data were collected. Manual chart abstraction was conducted to determine medication use at discharge, one, three, and five years post-transplant. Univariate and multivariable Cox regression modeling were used to analyze outcomes.</div></div><div><h3>Results</h3><div>Mean age of subjects was 66 years (range 60–81). 59% were males and 50% were African-American. 49% had chronic kidney disease (CKD) due to diabetes mellitus (DM). A total of 38, 134, 167, and 112 elderly kidney transplant recipients were on ACEI/ARB at discharge, one, three, and five years post-transplant respectively. ACEI/ARB initiated within one year of transplant was associated with lower risk of graft loss (HR=0.62, CI 0.38–0.99, <em>p</em> = 0.047). This was driven mainly by a lower risk of death (HR=0.41, CI 0.24–0.71, <em>p</em> = 0.002). ACEI/ARB use was associated with lower risk of AKI after 1 year (HR 0.70, CI 0.52–0.95, <em>p</em> = 0.02). ACEI/ARB was not associated with increased risk of acute rejection or hospitalization.</div></div><div><h3>Conclusion</h3><div>Initiation of ACEI/ARB within one year of transplant is associated with lower risk of AKI and graft loss, driven by lower risk of death in elderly kidney transplant recipients. Clinicians should maximize ACEI/ARB therapy early on after kidney transplant.</div></div>","PeriodicalId":55526,"journal":{"name":"American Journal of the Medical Sciences","volume":"368 5","pages":"Pages 432-437"},"PeriodicalIF":2.3,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141556328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term trends in lifestyle factors among respondents with dyslipidemia in the United States 美国血脂异常受访者生活方式因素的长期趋势。

IF 2.3 4区医学

American Journal of the Medical Sciences Pub Date : 2024-07-05 DOI: 10.1016/j.amjms.2024.06.025

Bingqing Bai MM , Quanjun Liu MM , Yuting Liu MD , Fengyao Liu MM , Yu Wang MD , Yilin Chen MM , Yanting Liang MM , Haochen Wang MM , Chao Wu PhD , Lan Guo PhD , Huan Ma PhD , Qingshan Geng PhD

{"title":"Long-term trends in lifestyle factors among respondents with dyslipidemia in the United States","authors":"Bingqing Bai MM , Quanjun Liu MM , Yuting Liu MD , Fengyao Liu MM , Yu Wang MD , Yilin Chen MM , Yanting Liang MM , Haochen Wang MM , Chao Wu PhD , Lan Guo PhD , Huan Ma PhD , Qingshan Geng PhD","doi":"10.1016/j.amjms.2024.06.025","DOIUrl":"10.1016/j.amjms.2024.06.025","url":null,"abstract":"<div><h3>Objectives</h3><div>To explore the long-term trends in unhealthy lifestyle factors and the risk sociodemographic subgroups among people with dyslipidemia.</div></div><div><h3>Methods</h3><div>Data extracted from the 1999 to 2018 National Health and Nutrition Examination Survey (NHANES). Lifestyle factors were smoking status, alcohol drinking, obesity, dietary quality, depression, physical activity, and sedentary behavior. A Joinpoint regression model was used to estimate trends in the log-transformed age-standardized prevalence. Multinomial logistic regression models adjusted for age, sex, and race/ethnicity were used to analyze subgroups by sociodemographic factors.</div></div><div><h3>Results</h3><div>Data for 33,680 respondents were extracted between 1999 and 2018. The prevalence of smoking and poor-quality diet decreased from 1999 to 2018 (<em>P</em><0.001), while obesity significantly increased (<em>P</em><0.001). The prevalence of depression marginally increased from 2005 to 2018 (<em>P</em>=0.074). We observed that non-Hispanic Black individuals, Hispanics, males, as well as those with lower family income-to-poverty ratios and education levels, unemployed individuals, or those lacking a spouse/live-in partner, were at elevated risk of unhealthy lifestyle factors when compared to the reference groups.</div></div><div><h3>Conclusions</h3><div>Among NHANES respondents from 1999 to 2018 with dyslipidemia, significant reductions in the prevalence of current smoking and poor diet were observed, while the prevalence of obesity was markedly increased. There were sociodemographic differences in the management of lifestyle factors. Further initiatives to encourage people with dyslipidemia are required to reduce potential adverse outcomes.</div></div>","PeriodicalId":55526,"journal":{"name":"American Journal of the Medical Sciences","volume":"368 6","pages":"Pages 600-609"},"PeriodicalIF":2.3,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141556330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2024 SSCI Founders’ Medal Presentation and acceptance: Dr. Don Rockey 2024 SSCI 创始人奖章颁发和接受：Don Rockey 博士。

IF 2.3 4区医学

American Journal of the Medical Sciences Pub Date : 2024-07-04 DOI: 10.1016/j.amjms.2024.07.006

引用次数: 0

Gut barrier dysfunction, endotoxemia and inflammatory response in STEMI patients and effect of primary PCI STEMI 患者肠道屏障功能障碍、内毒素血症和炎症反应以及初级 PCI 的影响。

IF 2.3 4区医学

American Journal of the Medical Sciences Pub Date : 2024-07-04 DOI: 10.1016/j.amjms.2024.07.004

{"title":"Gut barrier dysfunction, endotoxemia and inflammatory response in STEMI patients and effect of primary PCI","authors":"","doi":"10.1016/j.amjms.2024.07.004","DOIUrl":"10.1016/j.amjms.2024.07.004","url":null,"abstract":"<div><h3>Background</h3><div><span>Gut-derived bacterial and endotoxin<span> translocation induce systemic inflammation, which exerts a pivotal pathogenetic role in all phases of </span></span>atherosclerosis.</div></div><div><h3>Objectives</h3><div><span>To investigate prospectively the gut barrier function, endotoxin translocation and </span>inflammatory response<span> in ST-elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary artery intervention (PPCI).</span></div></div><div><h3>Methods</h3><div>Twenty-seven patients with STEMI that underwent successful PPCI were subjected to peripheral blood sampling<span> at 3-time points; before PPCI (day0), 24 h (day1) and 96 h (day4) after PPCI and were compared with 20 chronic coronary syndrome<span> (CCS) patients and 11 healthy controls. Serum ZO-1, I-FABP and endotoxin concentrations were determined by ELISA. Concentrations of cytokines IL-1β, -6, -8, -10 and TNF-α were determined by flow cytometry.</span></span></div></div><div><h3>Results</h3><div><span>Patients with STEMI before PPCI (day0) had increased serum ZO-1 and endotoxin, both at significantly higher levels compared to CCS patients. STEMI induced also significant increases of the cytokines IL-6, -8 and -10. After PPCI, a significant improvement of gut barrier integrity (ZO-1) and endotoxemia was observed from the first day. At day4 post PPCI, systemic endotoxin and cytokines IL-6, -8 and -10 levels were reduced to control levels. Serum ZO-1 levels were positively correlated with systemic IL-10 concentrations (</span><em>r</em> = 0.471).</div></div><div><h3>Conclusion</h3><div>STEMI is associated with gut barrier dysfunction, systemic endotoxemia and inflammatory response, which improve rapidly following successful PPCI.</div></div>","PeriodicalId":55526,"journal":{"name":"American Journal of the Medical Sciences","volume":"368 5","pages":"Pages 485-493"},"PeriodicalIF":2.3,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141539116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethical consumption of antimicrobial agents: A proposal for a new concept in promoting antimicrobial stewardship 抗菌剂的道德消费：促进抗菌药物管理的新概念提案。

IF 2.3 4区医学

American Journal of the Medical Sciences Pub Date : 2024-07-03 DOI: 10.1016/j.amjms.2024.07.002

引用次数: 0

Artificial intelligence in medicine: Between Saturn and Cronus 人工智能在医学中的应用：在土星和克洛诺斯之间

IF 2.3 4区医学

American Journal of the Medical Sciences Pub Date : 2024-07-02 DOI: 10.1016/j.amjms.2024.06.026

引用次数: 0

Is 90 the new 80? Temporal trends in nonagenarians undergoing percutaneous coronary interventions 90 岁是新的 80 岁吗？接受经皮冠状动脉介入治疗的非老年患者的时间趋势。

IF 2.3 4区医学

American Journal of the Medical Sciences Pub Date : 2024-07-02 DOI: 10.1016/j.amjms.2024.06.029

{"title":"Is 90 the new 80? Temporal trends in nonagenarians undergoing percutaneous coronary interventions","authors":"","doi":"10.1016/j.amjms.2024.06.029","DOIUrl":"10.1016/j.amjms.2024.06.029","url":null,"abstract":"<div><h3>Background</h3><div>Coronary artery disease<span> (CAD) is a leading cause of death in the elderly population. Data regarding percutaneous coronary interventions (PCIs) in nonagenarians are scarce, and differences in long term outcomes between generations remain unclear. We aimed to study the pattern and temporal trends of nonagenarians treated with PCI. Materials and Methods: A total of 14,695 patients underwent PCI between 2009-2020. We identified 2,034 (13.8%) octogenarians (age 80-89), and 222 (1.5%) nonagenarians (age 90-99). Endpoints included mortality and major adverse cardiac events (MACE) at 1 year.</span></div></div><div><h3>Materials and Methods</h3><div>A total of 14,695 patients underwent PCI between 2009-2020. We identified 2,034 (13.8%) octogenarians (age 80-89), and 222 (1.5%) nonagenarians (age 90-99). Endpoints included mortality and major adverse cardiac events (MACE) at 1 year.</div></div><div><h3>Results</h3><div>The number of nonagenarians undergoing PCI has increased substantially during the study time period, from 89 patients in the earlier time period (2009-2014) to 133 patients in the later time period (2015-2020). At 1-year, nonagenarians had significantly higher rates of both death (24.3% vs. 14.9%, p<0.01), and MACE (30.6% vs. 22.0%, p<0.01), as compared to octogenarians. The cumulative survival rate was higher among octogenarians both in the early and late time period (p<0.01 and p=0.039, respectively). A significant reduction in nonagenarian MACE rates were observed during the study time period, resulting in a non-significant difference in MACE rates in the later time period between both groups.</div></div><div><h3>Conclusion</h3><div>The number of nonagenarians who undergo PCI is on the rise. While their clinical outcomes are inferior as compared to younger age groups, improvement was noted in the late time period.</div></div>","PeriodicalId":55526,"journal":{"name":"American Journal of the Medical Sciences","volume":"368 5","pages":"Pages 462-468"},"PeriodicalIF":2.3,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141536308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare observation in a case of Williams-Campbell syndrome 威廉姆斯-坎贝尔综合症病例中的罕见观察结果。

IF 2.3 4区医学

American Journal of the Medical Sciences Pub Date : 2024-06-29 DOI: 10.1016/j.amjms.2024.06.031

Chun Ian Soo FCCP , Wai Ling Leong MRad (UM) , Leng Cheng Sia MRCP(UK)

引用次数: 0