Analytical and Quantitative Cytopathology and Histopathology最新文献

Effects of Cyclooxygenase on the Urothelium of the Urinary Bladder of Mice Exposed to Pelvic Radiation. 环氧化酶对盆腔辐射小鼠膀胱尿路上皮的影响。

IF 0.1 4区医学

Analytical and Quantitative Cytopathology and Histopathology Pub Date : 2016-04-01

M Kemal Ozbilgin, Tuna Onal, Cemil Ozcan, Merve Temel, Caner Aktas, Manuchehr Salehi Gareveran, Elgin Turkoz Uluer, Sevinc Inan, Cengiz Kurtman

{"title":"Effects of Cyclooxygenase on the Urothelium of the Urinary Bladder of Mice Exposed to Pelvic Radiation.","authors":"M Kemal Ozbilgin, Tuna Onal, Cemil Ozcan, Merve Temel, Caner Aktas, Manuchehr Salehi Gareveran, Elgin Turkoz Uluer, Sevinc Inan, Cengiz Kurtman","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To determine the role of cyclooxygenase (COX) expression in the urothelium of the urinary bladder during radiation injury caused by pelvic radiotherapy for cancer therapy.Study design: Twenty-four male Swiss Albino mice were separated into 4 groups. The first group was the control group (Group 1) and the second, third, and fourth groups were euthanized after 24 hours (Group 2), 48 hours (Group 3), and 7 days (Group 4), respectively. A single-fractioned 10 Gy of ionizing radiation was applied to all mice's pelvic zone with Co-60. Bladders were removed completely from the pelvic region. Histochemical analysis using hematoxylin and eosin and immunohistochemical analysis using anti-COX-1 and COX-2 antibodies were performed on tissue samples. The immunoreactivities of the urinary bladder were quantified using H-score measurement, and statistical comparison was performed.Results: In the immunohistochemical examination the COX-1 immunoreactivities were found to be higher in the urothelium of the bladder in the radiation exposed groups than in the normal control group (group 1) (p < 0.005). Additionally, high immunoreactivity of COX-2 molecule was established in groups 2, 3, and 4 of radiation groups as compared to group 1 (p < 0.005) in examination of the urothelium. COX-1 and COX-2 immunoreactivities in the submucosa were detected higher in group 4 than in the other groups (p < 0.005).Conclusion: COX-1 and COX-2 expressions in the urothelium and subepithelium of the urinary bladder were investigated in mice during the acute radiation response. The expression of COX-1 and COX-2 in the urothelium seems to prevent bladder damage from radiation, supplying differentiation and restoration of the urothelium.","PeriodicalId":55517,"journal":{"name":"Analytical and Quantitative Cytopathology and Histopathology","volume":"38 2","pages":"103-10"},"PeriodicalIF":0.1,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34709781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Automated Region-based Prostate Cancer Cell Nuclei Localization. Part of a Prognostic Modality Tool for Prostate Cancer Patients. 基于区域的前列腺癌细胞核自动定位。前列腺癌患者预后模式工具的一部分。

IF 0.1 4区医学

Analytical and Quantitative Cytopathology and Histopathology Pub Date : 2016-04-01

Nilgoon Zarei, Amir Bakhtiari, Jagoda Korbelik, Anita Carraro, Mira Keyes, Martial Guillaud, Calum MacAulay

{"title":"Automated Region-based Prostate Cancer Cell Nuclei Localization. Part of a Prognostic Modality Tool for Prostate Cancer Patients.","authors":"Nilgoon Zarei, Amir Bakhtiari, Jagoda Korbelik, Anita Carraro, Mira Keyes, Martial Guillaud, Calum MacAulay","doi":"","DOIUrl":"","url":null,"abstract":"Background: Prostate cancer is a disease of disrupted cell genomes. Quantification of DNA from cytology preparations can yield prognostic information about tissue biological behaviors; however, this process is very labor-intensive to perform. Quantitative digital pathology can measure the structural chromatin changes associated with neoplasia and can enable prognostic and predictive assays based on imaging of sectioned prostate tissue.Objective: To design an automated system to recognize and localize cell nuclei in images of stained sectioned tissue (first step in enabling quantitative digital pathology).Study design: Images of Feulgen-thionin-stained prostate cancer tissue microarray constructed from the surgical specimens of 33 prostate cancer patients were acquired for this study. We implemented a new image segmentation technique to overcome tissue complexity, cell clusters, background noise, image and tissue inhomogeneities, and other imaging issues that introduce uncertainties into the segmentation method and developed a fully automated system to localized prostate cell nuclei.Results: We applied our algorithm on our dataset and obtained a 96.6% true-positive rate and a 12% false-positive rate.Conclusion: In this paper we present a new method to automatically localize thionin-stained prostate cancer cells, enabling the extraction of various nuclear and cell sociology features with high precision.","PeriodicalId":55517,"journal":{"name":"Analytical and Quantitative Cytopathology and Histopathology","volume":"38 2","pages":"59-69"},"PeriodicalIF":0.1,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34546359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gentian Violet Used as an Epithelial Cell Monolayer Stain in the Scratch Wound Healing Assay. 龙胆紫在抓伤愈合试验中用作上皮细胞单层染色剂。

IF 0.1 4区医学

Analytical and Quantitative Cytopathology and Histopathology Pub Date : 2016-04-01

César Rivera

引用次数: 0

Immunohistochemical Expression and Clinical Significance of Wnt11 and BCL2A1 in Complete Moles. Wnt11和BCL2A1在完整痣组织中的免疫组织化学表达及临床意义

IF 0.1 4区医学

Analytical and Quantitative Cytopathology and Histopathology Pub Date : 2016-04-01

Zhimin Hao, Weiguo Lü, Xiaodong Cheng, Caiyun Zhou

{"title":"Immunohistochemical Expression and Clinical Significance of Wnt11 and BCL2A1 in Complete Moles.","authors":"Zhimin Hao, Weiguo Lü, Xiaodong Cheng, Caiyun Zhou","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To investigate Wnt11 and BCL2A1 immunohistochemical expression in complete moles and normal villi.Study design: The expression of Wnt11 and BCL2A1 in 84 complete moles and 30 normal first-trimester villi were detected by Envision immunohistochemistry. Quantitative evaluation according to color deconvolution and immunoreactive score was performed. Data was analyzed using Kruskal-Wallis test, Pearson test, and ROC curve.Results: Of 84 complete moles, 14 developed to post-molar gestational trophoblastic neoplasia, and the others regressed spontaneously. Both proteins showed cytoplasmic pattern, whereas the DAB wt% of BCL2A1 and Wnt11 expression was highest in moles that developed to GTN, gradually reduced in spontaneously regressed moles and normal villi (all p < 0.01). We considered a 23.17% cutoff valuefor Wnt11 DAB wt% and 16.31% for BCL2A1 DAB wt% to assess molar progression to GTN. There was positive correlation between expressions of the 2 proteins (r = 0.403).Conclusion: Our findings demonstrated immunohistochemical expression of Wnt11 and BCL2A1 in complete moles and normal villi. Both proteins may be included as part of an immunohistochemical panel to identify postmolar outcome when other trophoblastic markers yield ambiguous results.","PeriodicalId":55517,"journal":{"name":"Analytical and Quantitative Cytopathology and Histopathology","volume":"38 2","pages":"79-86"},"PeriodicalIF":0.1,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34546362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective Effects of Vitamin E on Methotrexate-Induced Jejunal Mucosal Damage in Rats. 维生素E对甲氨蝶呤诱导的大鼠空肠黏膜损伤的保护作用。

IF 0.1 4区医学

Analytical and Quantitative Cytopathology and Histopathology Pub Date : 2016-04-01

Busra Burcu, Mehmet Kanter, Zeynep Nur Orhon, Oguzhan Yarali, Rukiye Karabacak

{"title":"Protective Effects of Vitamin E on Methotrexate-Induced Jejunal Mucosal Damage in Rats.","authors":"Busra Burcu, Mehmet Kanter, Zeynep Nur Orhon, Oguzhan Yarali, Rukiye Karabacak","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To investigate the possible protective effects of Vitamin E (Vit E) on oxidative stress and jejunal damage in the rat intestinal mucosa after methotrexate (MTX)-induced enterotoxicity.Study design: Rats were divided into 3 groups: control, MTX, and MTX+ Vit E; each group contained 8 animals. The control group was given physiological serum in addition to sunflower oil for 3 days. The second group was given sunflower oil with intragastric tube daily, followed by MTX injection (20 mg/kg intraperitoneally). To the third group, starting 3 days before injection, Vit E was given dissolved in sunflower oil (600 mg/kg orally) in addition to MTX injection. Four days after MTX injection the anesthetized rats were sacrificed, and the tissue samples obtained from their jejunums were investigated for histological and biochemical analysis.Results: Vit E treatment significantly decreased the elevated tissue malondialdehyde levels and increased the reduced glutathione peroxidase and superoxide dismutase activities in comparison to the MTX-treated group. MTX treatment caused severe histopathological injury including mucosal erosions, inflammatory cell infiltration, necrosis, hemorrhage, and villous congestion. Vit E treatment significantly attenuated the severity of intestinal injury caused by MTX via inhibiting induced nitric oxide synthase levels and NF-κB p65 activation.Conclusion: Because of its reconstructing and antioxidant effects, Vit E pretreatment may have protective effects in the intestinal tissue of MTX-treated rats.","PeriodicalId":55517,"journal":{"name":"Analytical and Quantitative Cytopathology and Histopathology","volume":"38 2","pages":"87-94"},"PeriodicalIF":0.1,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34709779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of Radiation Exposure During Radiotherapy. Evidence for the Increase of Versican and Heparin-Binding EGF-like Growth Factor Concentrations. 放射治疗期间辐射暴露的影响。肝素结合egf样生长因子浓度升高的证据。

IF 0.1 4区医学

Analytical and Quantitative Cytopathology and Histopathology Pub Date : 2016-04-01

Mahmut Kemal Ozbilgin, Caner Aktas, Elgin Turkoz Uluer, Mustafa Cagatay Buyukuysal, Manuchehr Salehi Gareveran, Cengiz Kurtman

{"title":"Influence of Radiation Exposure During Radiotherapy. Evidence for the Increase of Versican and Heparin-Binding EGF-like Growth Factor Concentrations.","authors":"Mahmut Kemal Ozbilgin, Caner Aktas, Elgin Turkoz Uluer, Mustafa Cagatay Buyukuysal, Manuchehr Salehi Gareveran, Cengiz Kurtman","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To investigate the reaction of versican and heparin-binding EGF-like growth factor (HB-EGF) molecule concentrations to acute radiation exposure in normal bladder and rectal tissue samples in order to gain more insight into the effects of cancer radiotherapy.Study design: Four groups with 6 male adult Swiss Albino mice per group were investigated. The mice bladder and rectum tissue samples were subjected to a 10-Gy single-dose radiation exposure in the pelvic region with a Co-60 teletherapy device and investigated 1, 2, and 7 days after radiation exposure, with 1 reference group which was not exposed to radiation.Results: In the immunohistochemical examination of the tissue samples with anti-versican and anti-HB-EGF primary antibodies was observed a statistically significant increase 7 days after radiation exposure.Conclusion: The observed increase of versican and HB-EGF concentrations in the normal tissue matrix after radiation exposure may play a role in the side effects of radiotherapy.","PeriodicalId":55517,"journal":{"name":"Analytical and Quantitative Cytopathology and Histopathology","volume":"38 2","pages":"126-32"},"PeriodicalIF":0.1,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34709784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distribution and Developmental Changes of Neuropeptide Y and Its Y1 Receptor-like Immunoreactive Cells in the Duck Thymus. 神经肽Y及其Y1受体样免疫反应细胞在鸭胸腺的分布和发育变化。

IF 0.1 4区医学

Analytical and Quantitative Cytopathology and Histopathology Pub Date : 2016-04-01

Min Jiang, Chunyu Liu, Jing Fang, Xi Peng, Junde Fan, Hengmin Cui, Heng Yin

{"title":"Distribution and Developmental Changes of Neuropeptide Y and Its Y1 Receptor-like Immunoreactive Cells in the Duck Thymus.","authors":"Min Jiang, Chunyu Liu, Jing Fang, Xi Peng, Junde Fan, Hengmin Cui, Heng Yin","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To investigate the distribution and developmental changes of Neuropeptide-Y (NPY) and its Y1 receptor (NPYY1)-like immunoreactivity cells in the duck thymus using immunohistochemistry associated with morphological analysis.Study design: Studies were carried out on Tianfu ducks on days 14, 18, 22, and 26 of embryogenesis (E14, E18, E22, and E26) as well as at 0 (neonatal stage), 1, 3, 5, 8, 11, 14, 17, 20, 26, 29, and 32 weeks of postnatal development (P0, P1, P3, P5, P8, P11, P14, P17, P20, P26, P29, and P32).Results: NPY-like immunoreactivity (NPY-ir) was detected mainly in the epithelial reticular cells and vascular smooth muscles, slightly in the lymphocytes from E26 onwards. On E26, NPY-ir was restricted to the epithelial reticular cells of diffuse forms of Hassall's corpuscle (DHC). The integral optical density (IOD) values of NPY-ir cells in the cortex and medulla did not significantly change from P0 to P17, but then dramatically rose from P20 to P32. NPYY1-like immunoreactivity (NPYY1-ir) was observed mainly in the lymphocytes, slightly in the epithelial reticular cells of DHC and the vascular smooth muscles from E18 onwards. The IOD values of NPYY1-ir cells significantly increased from E18 to E22, then kept unchanged until P0, greatly increased on P3, and then remained stable until P17 but dramatically increased from P20 to P32.Conclusion: These results suggest that the possible interaction between NPY and NPYY1 may take place within the duck thymus chiefly during postembryonic development, which might be of great importance for the function of thymocytes, as well as duck thymus involution.","PeriodicalId":55517,"journal":{"name":"Analytical and Quantitative Cytopathology and Histopathology","volume":"38 2","pages":"70-8"},"PeriodicalIF":0.1,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34546361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Malignant Bilateral Basifrontal Solitary Fibrous Tumor. A Case Report. 恶性双侧基底额单发纤维性肿瘤。一个病例报告。

IF 0.1 4区医学

Analytical and Quantitative Cytopathology and Histopathology Pub Date : 2016-04-01

Nidhi Mahajan, Kavite Gaur, Shramana Mandal, Ravindra Kumar Saran, Hukum Singh

{"title":"Malignant Bilateral Basifrontal Solitary Fibrous Tumor. A Case Report.","authors":"Nidhi Mahajan, Kavite Gaur, Shramana Mandal, Ravindra Kumar Saran, Hukum Singh","doi":"","DOIUrl":"","url":null,"abstract":"Background: Solitary fibrous tumors are rare benign mesenchymal neoplasms characterized by involvement of many sites all over the body with uncommon presentation within the cranium. Furthermore, malignant bilateral basifrontal solitary fibrous tumor is extremely rare. Although uncommon, this rare entity may be included in the differential diagnosis of frontal tumors in adults, to ensure complete surgical resection. The tumor falls under the spectrum of fibroblastic proliferation and shares close morphological overlap with meningiomas and hemangiopericytomas, posing a diagnostic challenge for the histopathologist.Case: We report a case of a malignant solitary fibrous tumor in the bilateral basifrontal region in a 50-year-old woman who presented with intermittent headache and vomiting and was clinicoradiologically diagnosed with meningioma.Conclusion: Clinicoradiological and pathological correlation is required for recognizing the aggressive behavior of this tumor and aiding the clinician for appropriate surgical management (complete surgical resection) and close sequential follow-up.","PeriodicalId":55517,"journal":{"name":"Analytical and Quantitative Cytopathology and Histopathology","volume":"38 2","pages":"133-6"},"PeriodicalIF":0.1,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34643881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Low-Intensity Treadmill Exercise on Sciatic Nerve in Experimental Diabetic Neuropathy. 低强度跑步机运动对实验性糖尿病神经病变坐骨神经的影响。

IF 0.1 4区医学

Analytical and Quantitative Cytopathology and Histopathology Pub Date : 2016-04-01

Ismail Gulsen, Murat Demiroglu, Abdurrahman Aycan, Rifki Ucler, Ilker Alaca, Zeynep Nur Orhon, Mehmet Kanter

{"title":"Effects of Low-Intensity Treadmill Exercise on Sciatic Nerve in Experimental Diabetic Neuropathy.","authors":"Ismail Gulsen, Murat Demiroglu, Abdurrahman Aycan, Rifki Ucler, Ilker Alaca, Zeynep Nur Orhon, Mehmet Kanter","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To investigate the potential beneficial effects of low-intensity exercise on histopathological changes of sciatic nerves in streptozotocin (STZ)-induced diabetic rats.Study design: The rats were allotted randomly into 3 experimental groups: A (control), B (diabetic untreated), and C (diabetic treated with low-intensity exercise); each group contained 8 animals. Groups B and C received STZ. Diabetes was induced in 2 groups by a single intraperitoneal injection of STZ (40 mg/kg, freshly dissolved in 0.1 M citrate buffer, pH 4.2). Two days after STZ treatment, diabetes in 2 experimental groups was confirmed by measuring blood glucose levels. Rats with blood glucose levels ≥ 250 mg/dL were considered to be diabetic. Animals in the exercise group were made to run the treadmill once a day for 4 consecutive weeks. Exercise started 3 days prior to STZ administration.Results: The treatment of low-intensity exercise caused a sharp decrease in the elevated serum glucose and an increase in the lowered serum insulin concentrations in STZ-induced diabetic rats. STZ induced a significant decrease in the area of insulin-immunoreactive β cells. Low-intensity exercise treatment resulted in increased area of insulin-immunoreactive β cells signficantly. Myelin breakdown decreased significantly after treatment with low intensity exercise. The ultrastructural features of degenerated axons also showed remarkable improvement.Conclusion: We believe that further preclinical research into low-intensity exercise may indicate its usefulness as a potential treatment for peripheral neuropathy in STZ-induced diabetic rats.","PeriodicalId":55517,"journal":{"name":"Analytical and Quantitative Cytopathology and Histopathology","volume":"38 2","pages":"95-102"},"PeriodicalIF":0.1,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34709780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Potentilla fulgens as a Prophylactic Agent in Tibial Defects in Rats. 麻陵草对大鼠胫骨缺损的预防作用。

IF 0.1 4区医学

Analytical and Quantitative Cytopathology and Histopathology Pub Date : 2016-04-01

Mahmut Koparal, Sevgi Ïrtegün, Hilal Alan, Engin Deveci, Belgin Gülsün, Ugur Seker

{"title":"Effects of Potentilla fulgens as a Prophylactic Agent in Tibial Defects in Rats.","authors":"Mahmut Koparal, Sevgi Ïrtegün, Hilal Alan, Engin Deveci, Belgin Gülsün, Ugur Seker","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To investigate the effects of Potentilla fulgens as a prophylactic agent on tibial defects in the rat.Study design: Twenty-eight male Wistar albino rats weighing 200-215 g each were divided into 3 experimental groups. The tibial bone defect group served as the control group. The experimental groups were Potentilla fulgens with tibial defect (14 days) and Potentilla fulgens with tibial defect (28 days). Extract of Potentilla fulgens was mixed with water (400 mg/kg/day) and given to groups 14 and 28 as drinking water. The histopathological and immunohistochemical characteristics of each tibial bone cavity within each group were observed. The trabecular new bone formation was evaluated by expression rate of osteonectin and osteopontin.Results: In the Potentilla fulgens + tibial defect group (14 days), trabecular bone had started combining extensive new bone formation, osteocyte cells were evident, and lamellar bone was formed. Osteoblasts showed a positive reaction with osteonectin. Osteopontin expression was positively observed between fibrous structures and in the osteoblast and osteocyte cells. This can be considered indicative of new bone formation. In the Potentilla fulgens + tibial defect group (28 days), an increase in expansion in trabecular bone and myeloid tissue was observed. Osteoblastic activity and osteocyte cells began to be observed in new bone fragments.Conclusion: In our study we show that Potentilla fulgens extract provided a protective effect on new bone formation and aided in the development of osteocytes and secretion of matrix in osteoblasts. Additionally, we show the inductive effect of the extract on new bone formation. In particular, the expression of osteopontin and osteonectin was also supported with the Western blot technique on the development of osteoblasts and osteocytes, showing a similar trend with our results.","PeriodicalId":55517,"journal":{"name":"Analytical and Quantitative Cytopathology and Histopathology","volume":"38 2","pages":"111-6"},"PeriodicalIF":0.1,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34709782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0