Influence of Radiation Exposure During Radiotherapy. Evidence for the Increase of Versican and Heparin-Binding EGF-like Growth Factor Concentrations.

IF 0.1 4区医学 Q4 Medicine

Analytical and Quantitative Cytopathology and Histopathology Pub Date : 2016-04-01

Mahmut Kemal Ozbilgin, Caner Aktas, Elgin Turkoz Uluer, Mustafa Cagatay Buyukuysal, Manuchehr Salehi Gareveran, Cengiz Kurtman

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引用次数: 0

Abstract

Objective: To investigate the reaction of versican and heparin-binding EGF-like growth factor (HB-EGF) molecule concentrations to acute radiation exposure in normal bladder and rectal tissue samples in order to gain more insight into the effects of cancer radiotherapy.

Study design: Four groups with 6 male adult Swiss Albino mice per group were investigated. The mice bladder and rectum tissue samples were subjected to a 10-Gy single-dose radiation exposure in the pelvic region with a Co-60 teletherapy device and investigated 1, 2, and 7 days after radiation exposure, with 1 reference group which was not exposed to radiation.

Results: In the immunohistochemical examination of the tissue samples with anti-versican and anti-HB-EGF primary antibodies was observed a statistically significant increase 7 days after radiation exposure.

Conclusion: The observed increase of versican and HB-EGF concentrations in the normal tissue matrix after radiation exposure may play a role in the side effects of radiotherapy.

本刊更多论文

放射治疗期间辐射暴露的影响。肝素结合egf样生长因子浓度升高的证据。

目的:探讨肝素结合型egf样生长因子(HB-EGF)分子浓度对正常膀胱和直肠组织急性辐射暴露的影响，以进一步了解肿瘤放疗的影响。研究设计:分为4组，每组6只雄性成年瑞士白化小鼠。用Co-60远程治疗仪对小鼠膀胱和直肠组织样本进行10 gy单剂量骨盆辐射照射，并在照射后1、2和7天进行研究，其中1个对照组未接受辐射照射。结果:在免疫组化检查中，抗versican和抗hb - egf一抗的组织样本在辐射照射7天后有统计学意义的升高。结论:放疗后正常组织基质中versican和HB-EGF浓度升高可能与放疗副反应有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Analytical and Quantitative Cytopathology and Histopathology CELL BIOLOGY-

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0.00%

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审稿时长

1 months

期刊介绍： AQCH is an Official Periodical of The International Academy of Cytology and the Italian Society of Urologic Pathology.