Archives of Facial Plastic Surgery最新文献

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Orbitomaxillary reconstruction using the layered fibula osteocutaneous flap. 层状腓骨骨皮瓣重建眶上颌部。
Archives of Facial Plastic Surgery Pub Date : 2012-03-01 DOI: 10.1001/archfacial.2011.1329
Taha Z Shipchandler, Heather H Waters, P Daniel Knott, Michael A Fritz
{"title":"Orbitomaxillary reconstruction using the layered fibula osteocutaneous flap.","authors":"Taha Z Shipchandler,&nbsp;Heather H Waters,&nbsp;P Daniel Knott,&nbsp;Michael A Fritz","doi":"10.1001/archfacial.2011.1329","DOIUrl":"https://doi.org/10.1001/archfacial.2011.1329","url":null,"abstract":"<p><strong>Objective: </strong>To describe a surgical technique for total palatomaxillary and orbital reconstruction using a fibula osteocutaneous free flap in a layered fashion.</p><p><strong>Methods: </strong>Case series from a tertiary care facial plastic and reconstructive surgical practice including patients with postextirpative Brown 3a and 3b orbitopalatomaxillary defects undergoing immediate microvascular reconstruction. Application of the layered fibula free flap to composite maxillary defects permits single-stage, optimal reconstruction of contiguous orbitomaxillary defects, reconstitution of midface 3-dimensional contour, and restoration of the anterior alveolar arch with robust bone, thereby providing for potential sequential dental rehabilitation with osseointegrated implants.</p><p><strong>Results: </strong>This technique demonstrates excellent long-term symmetry, support, function, and aesthetic contour. Although patients may need minor, adjunctive procedures, this technique is flexible in design and offers reliable outcomes with a minimum of morbidity.</p><p><strong>Conclusion: </strong>The fibula osteocutaneous free flap, because of its design flexibility and ability to provide structural support, is an excellent reconstructive option for total maxillary defects, including those that involve the orbit.</p>","PeriodicalId":55470,"journal":{"name":"Archives of Facial Plastic Surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archfacial.2011.1329","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30513929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 37
Leonardo da Vinci's Portrait of a Young Woman in Profile: studies of beauty and "ideal" proportions. 列奥纳多·达·芬奇的年轻女子侧面肖像:对美和“理想”比例的研究。
Archives of Facial Plastic Surgery Pub Date : 2012-03-01 DOI: 10.1001/archfacial.2011.1553
Farhad B Naini
{"title":"Leonardo da Vinci's Portrait of a Young Woman in Profile: studies of beauty and \"ideal\" proportions.","authors":"Farhad B Naini","doi":"10.1001/archfacial.2011.1553","DOIUrl":"https://doi.org/10.1001/archfacial.2011.1553","url":null,"abstract":"L EONARDO DA VINCI (1452-1519), the most fascinating figure of the Renaissance, was born onApril15,1452, inthe Tuscan hill town of Vinci, near Florence, Italy.Hewas the illegitimateson of Piero d’Antonio, a Florentine notary, andayoungpeasantwoman,Caterina. Illegitimacy meant he was not permitted to learn Greek or Latin as a child, which forced the young Leonardoto learn to think forhimself and withdraw into a private world of observation and invention. Leonardo’s artistic aptitude appeared relatively early. When he was 15 years old, his father apprenticed him to Andrea del Verrochio, in whose workshop Leonardo received training in painting and sculpture. Leonardo’s genius was dominated by one ruling passion—unquenchable curiosity. Everything he observed made him ask why and how, particularly how. His relentless curiosity was matched by his indefatigable energy in attempting to find answers to his questions. His drawings, sketches, and notes are almost all answers to questions, in particular concerning man as a mechanism, whether in anatomy, physiology or beauty and “ideal” proportions. The Royal Collection is the art collection of the British Royal Family. The works are dispersed between a number of locations, but the nearly 600 drawings, arguably the finest collection of Leonardo drawings in the world, are housed in The Royal Library at Windsor Castle, Windsor, England, the largest inhabited castle in the world. This great miscellaneous collection contains drawings and textual notes by Leonardo. It was created by the sculptor Pompeo Leoni, who purchased in Milan a large quantity of Leonardo’s manuscripts, which he took to Spain in 1590. The volume in The Royal Collection was bound in red leather and bore the gilt characters, “Drawings of Leonardo da Vinci restored by Pompeo Leoni.” Unfortunately, Leoni’s destructive “restoration” involved cutting out parts of the original manuscripts and redistributing and reassembling the fragments. A modern restoration was begun in the late 19th century and completed in 1994, separating the volume into loose folios, each placed between 2 sheets of Perspex (Plexiglas). The folios have been divided into 5 thematic sections: anatomy; landscapes, plants, and water studies; horses and other animals; figure studies; and miscellaneous papers. The fourth section of The Royal Collection includes the Portrait of a Young Woman in Profile (Figure). It is thought to have been bequeathed to Francesco Melzi, from whose heirs itwaspurchasedbyPompeoLeoni(ca 1582-90). Thomas Howard, Second Earl of Arundel, obtained it in 1630. After the defeat of his father, Charles II (1630-1685) spent his 20s mostly in exile on the continent, which no doubt added to his love of art. On his return to England at the Restoration in 1660, King Charles acquired the volumes containing the 600 drawings by Leonardo and 80 drawings by Hans Holbein the Younger. Leonardo executed several portrait paintings during his career, yet this profile of a young","PeriodicalId":55470,"journal":{"name":"Archives of Facial Plastic Surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archfacial.2011.1553","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30514995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Induction of dermal collagenesis, angiogenesis, and adipogenesis in human skin by injection of platelet-rich fibrin matrix. 通过注射富含血小板的纤维蛋白基质诱导皮肤胶原、血管生成和脂肪生成。
Archives of Facial Plastic Surgery Pub Date : 2012-03-01 Epub Date: 2011-10-17 DOI: 10.1001/archfacial.2011.784
Anthony P Sclafani, Steven A McCormick
{"title":"Induction of dermal collagenesis, angiogenesis, and adipogenesis in human skin by injection of platelet-rich fibrin matrix.","authors":"Anthony P Sclafani,&nbsp;Steven A McCormick","doi":"10.1001/archfacial.2011.784","DOIUrl":"https://doi.org/10.1001/archfacial.2011.784","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the histological changes induced in human skin by injection of autologous platelet-rich fibrin matrix (PRFM).</p><p><strong>Methods: </strong>Four healthy adult volunteers were included in the study. Platelet-rich fibrin matrix was prepared from 9 mL of autologous blood using a proprietary system (Selphyl; Aesthetic Factors, Wayne, New Jersey) and injected into the deep dermis and immediate subdermis of the upper arms of subjects. Full-thickness skin biopsy specimens were taken from the treated areas over a 10-week period, and the specimens were processed for histological evaluation.</p><p><strong>Results: </strong>Findings from histological examination supported the clinical observation of soft-tissue augmentation. As early as 7 days after treatment, activated fibroblasts and new collagen deposition were noted and continued to be evident throughout the course of the study. Development of new blood vessels was noted by 19 days; also at this time, intradermal collections of adipocytes and stimulation of subdermal adipocytes were noted. These findings became more pronounced over the duration of the study, although the fibroblastic response became much less pronounced. No abnormal mitotic figures were observed at any point, and a very mild chronic inflammatory response was noted only at the earliest time points of the study.</p><p><strong>Conclusions: </strong>Injection of PRFM into the deep dermis and subdermis of the skin stimulates a number of cellular changes that can be harnessed for use. Coupled with prior in vitro and in vivo studies, we now have a much clearer picture of the cellular effects of PRFM and its potential uses in facial plastic surgery. Further work is planned to more clearly elucidate the potential role of PRFM in aesthetic and reconstructive surgery.</p>","PeriodicalId":55470,"journal":{"name":"Archives of Facial Plastic Surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archfacial.2011.784","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30213739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 81
Recent advances in surgical pharyngeal modification procedures for the treatment of velopharyngeal insufficiency in patients with cleft palate. 腭裂腭咽功能不全手术咽改良术的最新进展。
Archives of Facial Plastic Surgery Pub Date : 2012-03-01 DOI: 10.1001/archfacial.2011.1394
Masoud Saman, Sherard A Tatum
{"title":"Recent advances in surgical pharyngeal modification procedures for the treatment of velopharyngeal insufficiency in patients with cleft palate.","authors":"Masoud Saman,&nbsp;Sherard A Tatum","doi":"10.1001/archfacial.2011.1394","DOIUrl":"https://doi.org/10.1001/archfacial.2011.1394","url":null,"abstract":"<p><p>Background To review recent advances in pharyngeal modification procedures for the treatment of velopharyngeal insufficiency (VPI) in patients with cleft palate after primary repair. In addition, we discuss some of the advantages and disadvantages of the various pharyngoplasty techniques, as well as their safety and efficacy. Methods A review of frequently used pharyngeal modification techniques in correction of VPI was performed, and their advantages and disadvantages are outlined. Several techniques in pharyngoplasty most recently described in the literature are compared and contrasted. Results The goal of surgical pharyngeal modification procedures is to correct the abnormal failure of velopharyngeal closure. Multiple techniques used in VPI surgery have proven to be effective. They have similar adverse effect profiles, but what distinguishes them is likely their effectiveness in cases of severe VPI. Conclusions Velopharyngeal insufficiency is a problematic issue both for the patient and the treating surgeon. The negative effect of VPI on patients' quality of life has long been known, and over the years numerous techniques have been described to correct or improve this problem. Pharyngoplasty and pharyngeal flap or combination procedures are most effective in cases of severe VPI.</p>","PeriodicalId":55470,"journal":{"name":"Archives of Facial Plastic Surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archfacial.2011.1394","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30513927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
A retrospective review of the use of autologous platelet gels for rhytidectomy. 自体血小板凝胶用于除皱术的回顾性研究。
Archives of Facial Plastic Surgery Pub Date : 2012-03-01 DOI: 10.1001/archfacial.2011.1462
Edward Farrior, Keith Ladner
{"title":"A retrospective review of the use of autologous platelet gels for rhytidectomy.","authors":"Edward Farrior,&nbsp;Keith Ladner","doi":"10.1001/archfacial.2011.1462","DOIUrl":"https://doi.org/10.1001/archfacial.2011.1462","url":null,"abstract":"Tissue sealants exist in 2 forms: platelet-rich plasma (PRP) and platelet-rich fibrin matrix (PRFM). They both result in activation of fibrinogen to fibrin, but PRFM contains a higher concentration of fibrinogen. PRFM products, otherwise known as fibrin sealants, make use of pooled human donor fibrinogen, factor XIII, and fibronectin. When they are mixed with thrombin, calcium chloride, and aprotinin, a fibrin clot is formed. Fibrin sealants are available as single-use kits. As an example, Evicel (Ethicon 360) comes in a triluminal catheter. One lumen contains the fibrinogen solution; one contains the thrombin solution; and one is filled with air to allow the spray application. On spraying, the fibrinogen and thrombin solutions are mixed, and a fibrin clot is created within seconds. In 2001, our facility compared the severity of edema and ecchymosis with and without the use of autologous PRP in 8 healthy women after standard deep-plane rhytidectomy. Unilateral application of the PRP was performed on closure of the superficial musculoaponeurotic system and skin flaps (Figure). The conclusion from this prospective, randomized, controlled pilot study was that there was a trend toward decreased postoperative ecchymosis and edema on the side of PRP application. The trend was more apparent early in the postoperative period (days 3-12) and more so for ecchymosis than edema. Because of the limited power of the study, however, a statistically significant difference could not be elucidated. In 2009, Lee et al published their results using the fibrin sealant Crosseal (Ethicon Inc) in 9 patients who were undergoing rhytidectomy. The sealant was applied unilaterally at random, and the contralateral side served as the control. The severity of ecchymosis for each side was scored 1 (minimal) to 10 (severe) by 5 blinded observers at postoperative days 3 and 7. The authors found a statistically lower level of ecchymosis for the fibrin sealant side (4.5) as compared with the control (6.2). Zoumalan and Rizk investigated hematoma occurrence with fibrin glue in both deep-plane and lateral superficial musculoaponeurotic system rhytidectomies. In their study, 459 patients underwent skin flap closure with fibrin glue, and 146 patients underwent standard closure. The authors concluded that there was a statistically significant reduction in hematoma rate when fibrin glue was applied to the skin flap. The hematoma rate was 3.4% in the control group and 0.4% in the fibrin sealant group (P=.01). Based on these studies, it seems likely that tissue sealants reduce the severity of ecchymosis in the acute postoperative period and may also minimize hematoma occurrence. It should be noted, however, that many other studies have not been able to corroborate these findings. Perhaps one of the more important and less frequently discussed advantages of fibrin sealants is the reduced operative time to achieve hemostasis and wound closure. Clearly, patients stand to benefit from reduced ","PeriodicalId":55470,"journal":{"name":"Archives of Facial Plastic Surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archfacial.2011.1462","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30513926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Alternative 1-step nasal reconstruction technique. 可选择的一步鼻部重建技术。
Archives of Facial Plastic Surgery Pub Date : 2012-03-01 DOI: 10.1001/archfacial.2011.1402
Kazuo Kishi, Nobuaki Imanishi, Yusuke Shimizu, Ruka Shimizu, Keisuke Okabe, Hideo Nakajima
{"title":"Alternative 1-step nasal reconstruction technique.","authors":"Kazuo Kishi,&nbsp;Nobuaki Imanishi,&nbsp;Yusuke Shimizu,&nbsp;Ruka Shimizu,&nbsp;Keisuke Okabe,&nbsp;Hideo Nakajima","doi":"10.1001/archfacial.2011.1402","DOIUrl":"https://doi.org/10.1001/archfacial.2011.1402","url":null,"abstract":"<p><strong>Objective: </strong>To describe a 1-step nasal reconstruction technique for use in lieu of a paramedian forehead flap that is usually raised at the location of the supratrochlear artery.</p><p><strong>Methods: </strong>Using angiography in 10 fresh cadavers, we confirmed the arterial anatomy of the nasal and forehead regions to refine the paramedian forehead flap. Based on the anatomical data, we performed nasal reconstruction in 6 patients who had a full-thickness defect of the nasal ala or who needed alar base reconstruction with an island paramedian forehead flap based on the angular artery.</p><p><strong>Results: </strong>From the anatomical study, we confirmed a rich network among the supratrochlear, dorsonasal, and angular arteries around the medial canthus. In the clinical cases, the subcutaneous pedicle was tunneled beneath the skin, without conspicuous bulkiness. For all patients, the operation was completed in 1 stage, and the flaps healed without evidence of necrosis.</p><p><strong>Conclusions: </strong>By moving the pedicle downward, a full-thickness nasal defect can be reconstructed in 1 stage that includes the alar lining or alar base with the paramedian forehead flap. This avoids restriction of the rotation arc, particularly when the alar lining or alar base is also needed for reconstruction.</p>","PeriodicalId":55470,"journal":{"name":"Archives of Facial Plastic Surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archfacial.2011.1402","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30513933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
In Memoriam: D. Ralph Millard Jr, MD 纪念:拉尔夫·米勒德博士,医学博士
Archives of Facial Plastic Surgery Pub Date : 2012-03-01 DOI: 10.1001/ARCHFACIAL.2011.1557
Sydney C. Butts, S. Tatum
{"title":"In Memoriam: D. Ralph Millard Jr, MD","authors":"Sydney C. Butts, S. Tatum","doi":"10.1001/ARCHFACIAL.2011.1557","DOIUrl":"https://doi.org/10.1001/ARCHFACIAL.2011.1557","url":null,"abstract":"","PeriodicalId":55470,"journal":{"name":"Archives of Facial Plastic Surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/ARCHFACIAL.2011.1557","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50617929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simultaneous anterolateral thigh flap and temporalis tendon transfer to optimize facial form and function after radical parotidectomy. 同时转股前外侧皮瓣和颞肌肌腱以优化腮腺根治术后面部形态和功能。
Archives of Facial Plastic Surgery Pub Date : 2012-03-01 DOI: 10.1001/archfacial.2011.1263
Peter C Revenaugh, P Daniel Knott, Joseph Scharpf, Michael A Fritz
{"title":"Simultaneous anterolateral thigh flap and temporalis tendon transfer to optimize facial form and function after radical parotidectomy.","authors":"Peter C Revenaugh,&nbsp;P Daniel Knott,&nbsp;Joseph Scharpf,&nbsp;Michael A Fritz","doi":"10.1001/archfacial.2011.1263","DOIUrl":"https://doi.org/10.1001/archfacial.2011.1263","url":null,"abstract":"<p><p>Background Extirpation of aggressive parotid or cutaneous facial tumors often involves facial nerve sacrifice and the creation of a large soft-tissue defect. We describe a method for single-stage reconstruction during radical parotidectomy to restore facial form and function without additional morbidity. Methods We conducted a review of immediate reconstruction/reanimation of radical parotidectomy defects with the use of anterolateral thigh (ALT) fat and fascia flaps for facial contouring, orthodromic temporalis tendon transfer (OTTT), cable grafting of the facial nerve, and fascia lata lower lip suspension. Results Five patients (mean age, 67.4 years) underwent extirpation of malignant tumors with facial nerve sacrifice resulting in large soft-tissue deficits. All patients had ALT free tissue transfer to correct facial contour defects and OTTT to restore facial form and function. Four patients underwent cable grafting of facial nerve branches. Branches of the motor nerve to the vastus lateralis harvested from the ALT surgical site were used for cable nerve grafting in 3 patients. Fascia lata from the same ALT harvest site was used for lower lip suspension to the OTTT in 4 patients. There were no donor site complications. All patients achieved midfacial symmetry at rest, oral competence with dynamic corner-of-mouth movement, and full eye closure. Conclusions Tumor clearance, symmetric facial appearance, as well as dynamic facial rehabilitation were accomplished in a single-stage procedure using the method described herein. The ALT free flap provides versatile options for soft-tissue defects as well as access to motor nerves optimal for grafting without additional morbidity. Patients undergoing extirpation of malignant tumors requiring facial nerve sacrifice can undergo immediate free tissue contour reconstruction and facial reanimation procedures with no additional morbidity.</p>","PeriodicalId":55470,"journal":{"name":"Archives of Facial Plastic Surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archfacial.2011.1263","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30513928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 36
Larger osteotomies result in larger ostia in external dacryocystorhinostomies. 在外部泪囊鼻腔造口术中,更大的截骨导致更大的开口。
Archives of Facial Plastic Surgery Pub Date : 2012-03-01 Epub Date: 2011-10-17 DOI: 10.1001/archfacial.2011.73
Guy J Ben Simon, Chris Brown, Alan A McNab
{"title":"Larger osteotomies result in larger ostia in external dacryocystorhinostomies.","authors":"Guy J Ben Simon,&nbsp;Chris Brown,&nbsp;Alan A McNab","doi":"10.1001/archfacial.2011.73","DOIUrl":"https://doi.org/10.1001/archfacial.2011.73","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate whether final ostium size is determined by the osteotomy created during dacryocystorhinostomy (DCR).</p><p><strong>Design: </strong>Prospective nonrandomized study. Intraoperative measurements of bony osteotomy were taken during external DCR. Endonasal endoscopy with functional endoscopic dye testing and internal ostium photography were performed 3 months after surgery.</p><p><strong>Results: </strong>Fifty patients (mean age, 63 years) underwent 55 DCRs. Postoperative nasal endoscopy with functional endoscopic dye testing was performed in 27 cases (49%), and measurements of intranasal ostia were feasible in 24 of them (86%). The mean follow-up time was 7 months (range, 3-12 months). Surgical success was achieved in 25 of 27 patients (93%) who underwent postoperative nasal endoscopy. There was no difference in either the intraoperative osteotomy size or the postoperative ostium size between failed and successful cases. The mean (SD) intraoperative osteotomy size was 256.3 (89.0) mm(2), and the mean (SD) postoperative ostium size was 9.6 (6.7) mm(2). The intraoperative osteotomy size correlated positively with the postoperative intranasal ostium size (r = 0.45; P = .03, Pearson bivariate correlation).</p><p><strong>Conclusions: </strong>Larger osteotomies created during external DCR are correlated with larger postoperative ostia as measured by endonasal endoscopy and image analysis software. There is a trend toward greater success with larger osteotomies; however, failed cases in this series were not associated with smaller-sized intraoperative osteotomies.</p>","PeriodicalId":55470,"journal":{"name":"Archives of Facial Plastic Surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archfacial.2011.73","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30213738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 33
Effects of botulinum toxin a on cytokine synthesis in a cell culture model of cutaneous scarring. 肉毒毒素a对皮肤瘢痕细胞培养模型中细胞因子合成的影响。
Archives of Facial Plastic Surgery Pub Date : 2012-03-01 Epub Date: 2011-10-17 DOI: 10.1001/archfacial.2011.734
Frank Haubner, Elisabeth Ohmann, Uwe Müller-Vogt, Peter Kummer, Juergen Strutz, Holger G Gassner, Holger Gassner
{"title":"Effects of botulinum toxin a on cytokine synthesis in a cell culture model of cutaneous scarring.","authors":"Frank Haubner,&nbsp;Elisabeth Ohmann,&nbsp;Uwe Müller-Vogt,&nbsp;Peter Kummer,&nbsp;Juergen Strutz,&nbsp;Holger G Gassner,&nbsp;Holger Gassner","doi":"10.1001/archfacial.2011.734","DOIUrl":"https://doi.org/10.1001/archfacial.2011.734","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate possible botulinum toxin A effects in a cell culture model.</p><p><strong>Methods: </strong>In a cell culture model with dermal fibroblasts and microvascular endothelial cells, possible botulinum toxin A effects were evaluated. Cell proliferation and cytokine expression were analyzed using viability assays and enzyme-linked immunosorbent assay techniques.</p><p><strong>Results: </strong>Neither cell proliferation nor cytokines and growth factors (interleukin 6, monocyte chemoattractant protein 2, fibroblast growth factor, macrophage colony-stimulating factor, and vascular endothelial growth factor) were affected by botulinum toxin A incubation.</p><p><strong>Conclusions: </strong>The present data do not add evidence to suggest a significant therapeutic role of botulinum toxin A injections for cutaneous wound healing beyond chemoimmobilization. Further studies that include patient-specific cells of hypertrophic scars are required to better understand what role botulinum toxin A can play in the treatment of mature scar tissue.</p>","PeriodicalId":55470,"journal":{"name":"Archives of Facial Plastic Surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archfacial.2011.734","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30215517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
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