Yichen Wang , Huiyun Lv , Yuhua Song , Die Sang , Zheng Lv , Tianyi Ma , Ning Li , Chen Song , Man Li
{"title":"Low-dose vs standard-dose everolimus combined with endocrine therapy in patients with HR-positive, HER2-negative advanced breast cancer: A multicenter real-world study","authors":"Yichen Wang , Huiyun Lv , Yuhua Song , Die Sang , Zheng Lv , Tianyi Ma , Ning Li , Chen Song , Man Li","doi":"10.1016/j.asjsur.2024.11.135","DOIUrl":"10.1016/j.asjsur.2024.11.135","url":null,"abstract":"<div><h3>Background</h3><div>Everolimus (EVE) has been approved by the FDA for hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer patients. However, in clinical practice, the toxicity of the standard dose (10 mg/d) limits its use.</div></div><div><h3>Method</h3><div>This study aimed to compare the efficacy, safety, and compliance of 5 mg/d and 10 mg/d EVE in combination with endocrine therapy in btreast cancer patients.</div></div><div><h3>Results</h3><div>Compared with the 5 mg/d group, the 10 mg/d group included more primary endocrine-resistant patients (46.7 % vs. 24.6 %; <em>P</em> = 0.036). There was no significant difference in overall ORR and DCR between the two groups and the difference in median PFS and OS was not statistically significant (PFS: 7.07 m vs. 8.07 m, <em>P</em> = 0.663; OS: 29.47 m vs. 30.53 m, <em>P</em> = 0.615). In the subgroup of patients with primary endocrine resistance and premenopausal patients, the PFS benefit of the 10 mg/d group was more significant. In the safety analysis, the 5 mg/d group had lower rates of fatigue (29.2 % vs. 53.3 %; <em>P</em> = 0.038) and diarrhea (10.8 % vs. 33.3 %; <em>P</em> = 0.011). In the compliance analysis, the 5 mg/d group had a lower treatment interruption rate, and fewer patients stopped treatment due to adverse reactions. For most patients, 5 mg/d and 10 mg/d EVE combined with endocrine therapy showed comparable efficacy, but the safety and compliance of 5 mg/d were better.</div></div><div><h3>Conclusions</h3><div>For patients with primary endocrine resistance and premenopausal patients, using standard-dose EVE resulted in greater PFS benefit.</div></div>","PeriodicalId":55454,"journal":{"name":"Asian Journal of Surgery","volume":"48 4","pages":"Pages 2286-2294"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143833882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cryopreserved oocyte utilization in paroxysmal nocturnal hemoglobinuria: A case report on successful pregnancy after hematopoietic stem cell transplantation","authors":"Juan Yang, Qi Wan, Xue-jiao Wang","doi":"10.1016/j.asjsur.2024.10.041","DOIUrl":"10.1016/j.asjsur.2024.10.041","url":null,"abstract":"","PeriodicalId":55454,"journal":{"name":"Asian Journal of Surgery","volume":"48 4","pages":"Pages 2448-2449"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A case of perianal dermatoid cyst misdiagnosed as recurrent anal fistula","authors":"Shijiang Zhong, Feng Qiu, cheng Huang","doi":"10.1016/j.asjsur.2024.10.169","DOIUrl":"10.1016/j.asjsur.2024.10.169","url":null,"abstract":"","PeriodicalId":55454,"journal":{"name":"Asian Journal of Surgery","volume":"48 4","pages":"Pages 2395-2396"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Causal relationship between diet and intervertebral disc degeneration: A Mendelian randomization analysis","authors":"Deyang Liu , Xi Wang , Xiaolu Fang","doi":"10.1016/j.asjsur.2024.10.054","DOIUrl":"10.1016/j.asjsur.2024.10.054","url":null,"abstract":"","PeriodicalId":55454,"journal":{"name":"Asian Journal of Surgery","volume":"48 4","pages":"Pages 2478-2480"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Application of the “Hand-as-Foot” teaching method in preoperative notification for carpal tunnel syndrome","authors":"Yiran Zhang, Dewei Zou, Rui Liu, Xu Bai","doi":"10.1016/j.asjsur.2024.10.130","DOIUrl":"10.1016/j.asjsur.2024.10.130","url":null,"abstract":"","PeriodicalId":55454,"journal":{"name":"Asian Journal of Surgery","volume":"48 4","pages":"Pages 2322-2323"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of formononetin on osteoporosis in ovariectomized rats","authors":"Shile Cheng, Jiarui Cao, Zewen Jiang, Hao Peng","doi":"10.1016/j.asjsur.2024.10.177","DOIUrl":"10.1016/j.asjsur.2024.10.177","url":null,"abstract":"","PeriodicalId":55454,"journal":{"name":"Asian Journal of Surgery","volume":"48 4","pages":"Pages 2409-2411"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Is recruitment maneuver a risk factor for postoperative air leak?","authors":"Hao Zhu , Jianping Kong , Yaling Liu, Jie Zhou","doi":"10.1016/j.asjsur.2024.10.171","DOIUrl":"10.1016/j.asjsur.2024.10.171","url":null,"abstract":"","PeriodicalId":55454,"journal":{"name":"Asian Journal of Surgery","volume":"48 4","pages":"Pages 2399-2400"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exploring the relationship between sodium intake and coronary artery disease severity in hypertensive patients","authors":"Li Wang, Yingzhu Xie, Yaqi Liu, Liangbang Zeng","doi":"10.1016/j.asjsur.2024.10.190","DOIUrl":"10.1016/j.asjsur.2024.10.190","url":null,"abstract":"","PeriodicalId":55454,"journal":{"name":"Asian Journal of Surgery","volume":"48 4","pages":"Pages 2446-2447"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}