Cleft Palate-Craniofacial Journal最新文献

Jaw Surgery Workshop: Patient Preparation for Orthognathic Surgery. 颌骨手术研讨会：正颌外科手术的患者准备。

IF 1.2 4区医学

Cleft Palate-Craniofacial Journal Pub Date : 2024-09-01 Epub Date: 2023-04-25 DOI: 10.1177/10556656231172298

Nicole Kurnik, Kathryn Preston, Hannah Tolson, Laura Takeuchi, Carolynne Garrison, P Beals, Stephen P Beals, Davinder J Singh, Thomas J Sitzman

引用次数: 0

Persistent Buccopharyngeal Membrane - A Systematic Review of Case Reports and Case Series. 顽固性颊咽膜--病例报告和病例系列的系统回顾。

IF 1.2 4区医学

Cleft Palate-Craniofacial Journal Pub Date : 2024-09-01 Epub Date: 2023-05-17 DOI: 10.1177/10556656231175855

Nishreen M Parekh, Shivani P Bansal, Vini Mehta, Pankaj M Shirsat, Pooja Prasad, Rajiv S Desai

{"title":"Persistent Buccopharyngeal Membrane - A Systematic Review of Case Reports and Case Series.","authors":"Nishreen M Parekh, Shivani P Bansal, Vini Mehta, Pankaj M Shirsat, Pooja Prasad, Rajiv S Desai","doi":"10.1177/10556656231175855","DOIUrl":"10.1177/10556656231175855","url":null,"abstract":"Objective: Persistent buccopharyngeal membrane (PBM) is a rare anomaly associated with failure of ecto-endodermal resorption of the buccopharyngeal membrane on the 26th day of intrauterine life. The current literature has insufficient information about PBM.Design: Systematic Review.Patients, participants: Online electronic databases such as PubMed-MEDLINE, Embase, and Scopus were searched using appropriate keywords from the earliest available data until 30th August 2022, with no language restriction. Additional sources such as Google Scholar, major journals, gray literature, conference proceedings, and cross-referencing were also explored.Main outcome measures: The present systematic review evaluated and analysed the data available on PBM along with its treatment options and clinicopathological findings, prevalence, and prognosis of the patient.Results: Thirty-four publications with 37 reported cases were included in this systematic review. The majority of patients had dyspnea (n = 18), followed by dysphagia (n = 10). Approximately 16 patients suffering from PBM reported orofacial abnormalities. Seventeen patients reported complete PBM, and 18 patients had partial PBM. The treatment modality followed by most patients (n = 15) was surgical excision of the membrane, along with stent placement in four patients. Oropharyngeal reconstruction was performed in four cases. The overall prognosis and survival rate of this rare condition is good.Conclusion: This review suggests that PBM is poorly understood, and the diagnosis of partial PBM is confirmed only when the patient complains of difficulty in breathing or eating. In-depth analysis and follow-up of the reported cases should be performed to diagnose the disease early so that clinicians can provide adequate treatment to the patients.","PeriodicalId":55255,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9479130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes After Pharyngeal Flap Surgery in Children: A Comparison of Lined Versus Unlined Flaps. 儿童咽瓣手术后的效果：有衬里与无衬里皮瓣的比较。

IF 1.2 4区医学

Cleft Palate-Craniofacial Journal Pub Date : 2024-09-01 Epub Date: 2023-05-04 DOI: 10.1177/10556656231172642

Colin Fuller, J Reed Gardner, Olivia Speed, Ashlen Thomason, Isabella Zaniletti, Lisa Buckmiller, Adam Johnson, Larry Hartzell

{"title":"Outcomes After Pharyngeal Flap Surgery in Children: A Comparison of Lined Versus Unlined Flaps.","authors":"Colin Fuller, J Reed Gardner, Olivia Speed, Ashlen Thomason, Isabella Zaniletti, Lisa Buckmiller, Adam Johnson, Larry Hartzell","doi":"10.1177/10556656231172642","DOIUrl":"10.1177/10556656231172642","url":null,"abstract":"Objective: The addition of a uvular flap (PFU) was hypothesized to improve outcomes over standard pharyngeal flap (PF) for correction of velopharyngeal dysfunction. We report differences in outcomes of PF vs PFU at our institution.Design: Retrospective cohort study.Setting: Tertiary children's hospital.Patients: Children who underwent PF or PFU with the three highest-volume surgeons at our institution in 2004-2017.Outcome measures: We examined differences in complications between groups, frequency and type of revision surgery, and speech-related measures including nasometry, pressure-flow testing (PFT) and perceptual speech analysis (PSA).Results: 160 patients were included, 41 PF and 119 PFU (including 18 with Hogan technique). Patients undergoing PFU were older (7.6 yr vs 6.0 yr; p = 0.037) and more likely to have cleft palate (63/119 vs 14/41; p = 0.047). There was no significant difference in complications. With PFU, a decrease in airspace contracting revision surgeries was noted, (4/119 vs 8/41; p = 0.002) which drove a reduction in revision surgery of all types (7/119 vs 13/41; p = 0.033). However, patients that did undergo revision surgery after PFU underwent more revision procedures (p = 0.032). PSA scores were found to be lower (less hypernasal) after PFU (p = 0.009) compared to PF. Objective speech measures had varying results, with nasometry demonstrating a significant difference between groups (p = 0.001), while PFT (p = 0.525) did not demonstrate a statistical difference.Conclusion: The use of a uvular lining flap in pharyngeal flap surgery may be associated with improved long term surgical outcomes, including both improvements in subjective and objective testing and a lower rate of revision surgery, without increased complications.","PeriodicalId":55255,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9763552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incorporating Velopharyngeal MRI into the Clinical Decision-Making Process for a Patient Presenting with Velopharyngeal Dysfunction Following a Failed Palatoplasty. 腭成形术失败后出现腭咽功能障碍的患者，将腭咽MRI纳入临床决策过程。

IF 1.2 4区医学

Cleft Palate-Craniofacial Journal Pub Date : 2024-09-01 Epub Date: 2023-05-04 DOI: 10.1177/10556656231173500

Kazlin N Mason, Jonathan Black

引用次数: 0

Single-cell Transcriptome Landscape of DNA Methylome Regulators Associated with Orofacial Clefts in the Mouse Dental Pulp. 与小鼠牙髓口面裂有关的 DNA 甲基调控因子的单细胞转录组图谱

IF 1.2 4区医学

Cleft Palate-Craniofacial Journal Pub Date : 2024-09-01 Epub Date: 2023-05-09 DOI: 10.1177/10556656231172296

Badam Enkhmandakh, Pujan Joshi, Paul Robson, Anushree Vijaykumar, Mina Mina, Dong-Guk Shin, Dashzeveg Bayarsaihan

{"title":"Single-cell Transcriptome Landscape of DNA Methylome Regulators Associated with Orofacial Clefts in the Mouse Dental Pulp.","authors":"Badam Enkhmandakh, Pujan Joshi, Paul Robson, Anushree Vijaykumar, Mina Mina, Dong-Guk Shin, Dashzeveg Bayarsaihan","doi":"10.1177/10556656231172296","DOIUrl":"10.1177/10556656231172296","url":null,"abstract":"Objective: Significant evidence links epigenetic processes governing the dynamics of DNA methylation and demethylation to an increased risk of syndromic and nonsyndromic cleft lip and/or cleft palate (CL/P). Previously, we characterized mesenchymal stem/stromal cells (MSCs) at different stages of osteogenic differentiation in the mouse incisor dental pulp. The main objective of this research was to characterize the transcriptional landscape of regulatory genes associated with DNA methylation and demethylation at a single-cell resolution.Design: We used single-cell RNA sequencing (scRNA-seq) data to characterize transcriptome in individual subpopulations of MSCs in the mouse incisor dental pulp.Settings: The biomedical research institution.Patients/participants: This study did not include patients.Interventions: This study collected and analyzed data on the single-cell RNA expssion in the mouse incisor dental pulp.Main outcome measure(s): Molecular regulators of DNA methylation/demethylation exhibit differential transcriptional landscape in different subpopulations of osteogenic progenitor cells.Results: scRNA-seq analysis revealed that genes encoding DNA methylation and demethylation enzymes (DNA methyltransferases and members of the ten-eleven translocation family of methylcytosine dioxygenases), methyl-DNA binding domain proteins, as well as transcription factors and chromatin remodeling proteins that cooperate with DNA methylation machinery are differentially expressed within distinct subpopulations of MSCs that undergo different stages of osteogenic differentiation.Conclusions: These findings suggest some mechanistic insights into a potential link between epigenetic alterations and multifactorial causes of CL/P phenotypes.","PeriodicalId":55255,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9440176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stem Cell-Based Tissue Engineering for Cleft Defects: Systematic Review and Meta-Analysis. 基于干细胞的裂隙缺陷组织工程：系统回顾与元分析》。

IF 1.2 4区医学

Cleft Palate-Craniofacial Journal Pub Date : 2024-09-01 Epub Date: 2023-05-18 DOI: 10.1177/10556656231175278

Diandra S Natsir Kalla, Salem A Alkaabi, Faqi N Hendra, Nisrina E Nasrun, Muhammad Ruslin, Tymour Forouzanfar, Marco N Helder

{"title":"Stem Cell-Based Tissue Engineering for Cleft Defects: Systematic Review and Meta-Analysis.","authors":"Diandra S Natsir Kalla, Salem A Alkaabi, Faqi N Hendra, Nisrina E Nasrun, Muhammad Ruslin, Tymour Forouzanfar, Marco N Helder","doi":"10.1177/10556656231175278","DOIUrl":"10.1177/10556656231175278","url":null,"abstract":"This study aimed to analyze the efficacy of stem cell-based tissue engineering for the treatment of alveolar cleft (AC) and cleft palate (CP) defects in animal models.Systematic review and meta-analysis.Preclinical studies on alveolar cleft repair in maxillofacial practice.Electronic search was performed using PubMed, Embase, and Cochrane databases. Pre-clinical studies, where stem cell-based tissue engineering was used in the reconstruction of AC and CP in animal models were included. Quality of the selected articles was evaluated using SYRCLE (SYstematic Review Centre for Laboratory animal Experimentation).Review of alveolar cleft bone augmentation interventions in preclinical models.Outcome parameters registered were new bone formation (NBF) and/or bone mineral density (BMD).Thirteen large and twelve small animal studies on AC (21) and CP (4) reconstructions were included. Studies had an unclear-to-high risk of bias. Bone marrow mesenchymal stem cells were the most widely used cell source. Meta-analyses for AC indicated non-significant benefits in favor of: (1) scaffold + cells over scaffold-only (NBF P = .13); and (2) scaffold + cells over empty control (NBF P = .66; BMD P = .31). Interestingly, dog studies using regenerative grafts showed similar to superior bone formation compared to autografts. Meta analysis for the CP group was not possible.AC and CP reconstructions are enhanced by addition of osteogenic cells to biomaterials. Directions and estimates of treatment effect are useful to predict therapeutic efficacy and guide future clinical trials of bone tissue engineering.","PeriodicalId":55255,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11323438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9487514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overlapping Spectrum of Craniofacial Microsomia Phenotype in Cat-Eye Syndrome. 猫眼综合征颅面微畸形表型的重叠谱。

IF 1.2 4区医学

Cleft Palate-Craniofacial Journal Pub Date : 2024-09-01 Epub Date: 2023-05-14 DOI: 10.1177/10556656231174435

Samira Spineli-Silva, Isabella L Monlleó, Têmis M Félix, Vera L Gil-da-Silva-Lopes, Társis P Vieira

引用次数: 0

A Unique Case Report of Meningeal Hamartoma Within Alveolar Cleft. 一例独特的肺泡裂内脑膜脂肪瘤病例报告

IF 1.2 4区医学

Cleft Palate-Craniofacial Journal Pub Date : 2024-09-01 Epub Date: 2023-06-13 DOI: 10.1177/10556656231178439

Kelsey Eaton, Arlene Rozzelle

引用次数: 0

Prognosis of Maxillary Central Incisors in Patients with Bilateral Cleft Lip/Palate. 双侧唇腭裂患者上颌中切牙的预后。

IF 1.2 4区医学

Cleft Palate-Craniofacial Journal Pub Date : 2024-09-01 Epub Date: 2023-05-09 DOI: 10.1177/10556656231175337

Mark A Green, Collin Ritchie, Sarah Flanagan, Laura Nuzzi, Bonnie L Padwa

{"title":"Prognosis of Maxillary Central Incisors in Patients with Bilateral Cleft Lip/Palate.","authors":"Mark A Green, Collin Ritchie, Sarah Flanagan, Laura Nuzzi, Bonnie L Padwa","doi":"10.1177/10556656231175337","DOIUrl":"10.1177/10556656231175337","url":null,"abstract":"Evaluate periodontal bone support of maxillary central incisors (MCI) in patients with bilateral complete cleft lip and palate (BCCLP). Determine if syndromic diagnosis, age at time of alveolar bone graft (ABG), presence of maxillary lateral incisor (MLI), history of dentofacial orthopedics, maxillary expansion, and pre-maxillary osteotomy are associated with the periodontal bone support of MCI.Retrospective radiographic study.Tertiary care children's hospital.One hundred seventy-nine patients with BCCLP (22 syndromic) who had post-operative ABG cone beam computed tomography (CBCT) scans taken between 2002-2018.Crown to root (C/R) ratio of MCI measured on CBCT scans.The C/R ratio in 65% of MCI indicated periodontally compromised teeth. Presence of a MLI improved bone support on adjacent MCI when compared to those missing a MLI (51.4% vs 28.4%, P = .010). There was no significant difference in C/R ratios for syndromic diagnosis, age at ABG, history of dentofacial orthopedics, maxillary expansion, and pre-maxillary osteotomy.The majority of MCI in patients with BCCLP are periodontally compromised but bone support is improved when cleft adjacent lateral incisors are present.","PeriodicalId":55255,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9438529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patient Reported Outcome Following the Skoog Unilateral Cleft Lip Repair among Adults- a Long-Term Cohort Study and Comparison to a Non-cleft Population. 成人斯科格单侧唇裂修复术后患者报告结果--一项长期队列研究以及与非唇裂人群的比较。

IF 1.2 4区医学

Cleft Palate-Craniofacial Journal Pub Date : 2024-09-01 Epub Date: 2023-05-29 DOI: 10.1177/10556656231177139

Roshan Peroz, Malin Hakelius, Alberto Falk-Delgado, Yun Phua, Maria Mani

{"title":"Patient Reported Outcome Following the Skoog Unilateral Cleft Lip Repair among Adults- a Long-Term Cohort Study and Comparison to a Non-cleft Population.","authors":"Roshan Peroz, Malin Hakelius, Alberto Falk-Delgado, Yun Phua, Maria Mani","doi":"10.1177/10556656231177139","DOIUrl":"10.1177/10556656231177139","url":null,"abstract":"Objective: The study primarily aimed to compare satisfaction with lip appearance among adults treated for unilateral cleft lip and palate (UCLP) with Skoog's primary lip repair procedure to those without clefts. The secondary aim was to determine whether satisfaction with lip appearance and the desire to change the lip/face appearance correlated with the number of secondary lip revisions performed.Design: Long-term follow-up.Patients/settings: All UCLP patients treated at the Uppsala University Hospital born between 1960- and 1987 (n = 109) were invited. At an average of 37 years following the primary lip repair, the participation rate was 76% (n = 83). A control group of adults without cleft (n = 67) completed the same study protocol for comparison.Main outcome measures: Satisfaction with appearance was measured with The Satisfaction with Appearance Questionnaire (SWA) and a modified version of the Body Cathexis -Scale was used to assess the desire to change the lip and facial appearance.Results: UCLP patients were less satisfied with their lip, face, and overall appearance and reported a greater desire to change the appearance of their lips and face than non-cleft controls (p < 0.001). Dissatisfaction with lip appearance correlated to a greater willingness to change the appearance of the lip and face. No correlation was found between satisfaction with appearance and the number of the previously performed secondary lip revisions.Conclusion: Adults treated for UCLP are less satisfied with the appearance of their lips compared to the non-cleft population. The number of secondary revisions does not necessarily correlate to greater satisfaction with lip appearance.","PeriodicalId":55255,"journal":{"name":"Cleft Palate-Craniofacial Journal","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11323433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9586535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0