{"title":"The Second European Carotid Surgery Trial (ECST-2): Clinical Implications and Future Directions.","authors":"Paul J Nederkoorn, Gert J de Borst","doi":"10.1016/j.ejvs.2025.05.003","DOIUrl":"https://doi.org/10.1016/j.ejvs.2025.05.003","url":null,"abstract":"","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The European Society for Vascular Surgery 2025 Guidelines on the Management of Diseases of the Mesenteric and Renal Arteries and Veins. Known Knowns and Known Unknowns: A Call For Collaboration.","authors":"Anastasia Dean, Meg Beaumont, Manar Khashram","doi":"10.1016/j.ejvs.2025.05.007","DOIUrl":"https://doi.org/10.1016/j.ejvs.2025.05.007","url":null,"abstract":"","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Additional Considerations in Assessing Mesenteric Artery Stenosis as a Risk Factor for Anastomotic Leakage.","authors":"Wenhan Wu","doi":"10.1016/j.ejvs.2025.03.039","DOIUrl":"https://doi.org/10.1016/j.ejvs.2025.03.039","url":null,"abstract":"","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Strengthening Clinical Interpretation of SurVeil Paclitaxel Coated Balloon in Femoropopliteal Disease.","authors":"Xiaoliang Yin","doi":"10.1016/j.ejvs.2025.04.069","DOIUrl":"https://doi.org/10.1016/j.ejvs.2025.04.069","url":null,"abstract":"","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intramural Haematoma of the Brachiocephalic Artery.","authors":"Lingxi Zhu, Tan Li","doi":"10.1016/j.ejvs.2025.05.010","DOIUrl":"https://doi.org/10.1016/j.ejvs.2025.05.010","url":null,"abstract":"","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katharina Kurzmann-Guetl, Marianne Brodmann, Peter A Schneider
{"title":"Expanding the View: Insights into Methodological and Clinical Aspects of the TRANSCEND Study.","authors":"Katharina Kurzmann-Guetl, Marianne Brodmann, Peter A Schneider","doi":"10.1016/j.ejvs.2025.05.008","DOIUrl":"https://doi.org/10.1016/j.ejvs.2025.05.008","url":null,"abstract":"","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Expanding Possibilities in Fenestrated Endovascular Aneurysm Repair: Early Insights from the Treo Experience.","authors":"Artur Rebelo, Jörg Ukkat","doi":"10.1016/j.ejvs.2025.04.056","DOIUrl":"https://doi.org/10.1016/j.ejvs.2025.04.056","url":null,"abstract":"","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiaolu Li, Chenglong Fang, Shang Gao, Zhiyuan Wu, Lihong Du, Xinping Tian, Jing Li, Zuoguan Chen, Yongpeng Diao, Yongjun Li
{"title":"Association between Pre-operative Disease Activity and Long Term Outcomes of Revascularisation in Patients with Takayasu's Arteritis: A Multicentre Retrospective Cohort Study.","authors":"Xiaolu Li, Chenglong Fang, Shang Gao, Zhiyuan Wu, Lihong Du, Xinping Tian, Jing Li, Zuoguan Chen, Yongpeng Diao, Yongjun Li","doi":"10.1016/j.ejvs.2025.04.068","DOIUrl":"https://doi.org/10.1016/j.ejvs.2025.04.068","url":null,"abstract":"<p><strong>Objective: </strong>Current guidelines recommend postponing surgical intervention in patients with Takayasu's arteritis (TAK) until the disease becomes quiescent, which could exacerbate the incidence of pre-operative adverse events. Considering advances in peri-operative management, the association between pre-operative disease activity and long term prognosis after revascularisation requires re-evaluation.</p><p><strong>Methods: </strong>This was a multicentre, retrospective cohort study conducted across six tertiary Chinese centres, including patients receiving revascularisation procedures for arterial stenosis or occlusion due to TAK between August 2016 and January 2024. Kaplan-Meier survival analyses, Cox proportional hazards regression, and subgroup analyses were performed to evaluate the relationship between pre-operative disease activity and long term outcomes. Potential prognostic risk factors associated with clinical outcomes were identified using Cox regression analysis and receiver operating characteristic curve analysis.</p><p><strong>Results: </strong>The outcomes of 165 consecutive patients with TAK who underwent 201 surgical interventions, including 94 (46.8%) endovascular revascularisations (EVRs) and 107 (53.2%) open surgical revascularisations (OSRs), were analysed. Interestingly, pre-operative disease activity parameters (active state defined by the 2018 European Alliance of Associations for Rheumatology consensus, Kerr score, and biological inflammation) were poorly relevant to the incidence of poor long term outcomes among patients undergoing either EVR or OSR. Moreover, peri-operative immunosuppressive treatment was a prognostic factor for favourable outcomes after EVR (hazard ratio [HR] 3.10, 95% confidence interval [CI] 1.20 - 8.75, p = .009), whereas pre-operative thrombin time showed a statistically significant negative correlation with the risk of poor long term outcomes following OSR during the eight year follow up (HR 0.81, 95% CI 0.70 - 0.94, p = .004; p of non-linearity = .42), with an optimal cutoff value of 13 seconds.</p><p><strong>Conclusion: </strong>These data indicated a lack of correlation between pre-operative disease activity and long term prognosis. Peri-operative immunosuppressive treatment and thrombin time should be adequately considered in clinical decision making and peri-operative management for patients undergoing EVR and OSR, respectively.</p>","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Barend M Mol, Tetiana Motsak, Joost K R Hoekstra, Valentina Osorio Zuluaga, Saskia Rumpff-Derksen, Ioanna Paspali-Strik, Sofong Cam Ngan, Gerard Pasterkamp, Gert J de Borst, Siu Kwan Sze, Dominique P V de Kleijn
{"title":"High Levels of Plasma and Plaque IsoDGR-Modified Fibronectin are Associated with Rupture Prone Plaque Characteristics in Carotid Endarterectomy Patients.","authors":"Barend M Mol, Tetiana Motsak, Joost K R Hoekstra, Valentina Osorio Zuluaga, Saskia Rumpff-Derksen, Ioanna Paspali-Strik, Sofong Cam Ngan, Gerard Pasterkamp, Gert J de Borst, Siu Kwan Sze, Dominique P V de Kleijn","doi":"10.1016/j.ejvs.2025.04.067","DOIUrl":"https://doi.org/10.1016/j.ejvs.2025.04.067","url":null,"abstract":"<p><strong>Objective: </strong>Macrophage influx is an important feature of human plaque destabilisation. Studies in mice suggest a role of the isoD(Asp)G(Gly)R(Arg) three amino acid motif in fibronectin (isoDGR fibronectin) in macrophage influx. The association of isoDGR fibronectin in human plasma and plaque with plaque macrophage influx and vulnerable plaque characteristics has not been investigated in large human cohorts.</p><p><strong>Methods: </strong>Levels of isoDGR fibronectin were measured in individual plasma and plaques from carotid endarterectomy (CEA) patients from the Athero-Express biobank and associated with macrophage content and other vulnerable plaque characteristics in the carotid plaque of the same patient. Levels of isoDGR fibronectin were measured using an enzyme linked immunosorbent assay. Carotid plaque characteristics were visualised with immunohistochemistry staining and scored semi-quantitatively. Baseline characteristics were analysed with Pearson's chi squared test and Mann-Whitney U test when applicable. Univariate and multivariate logistics regression analyses were used to identify associations with adverse plaque characteristics.</p><p><strong>Results: </strong>Plasma isoDGR fibronectin was measured in 730 CEA patients (12.3% asymptomatic). Patients with moderate/heavy plaque macrophage staining had higher levels of isoDGR fibronectin than patients with no/minor macrophage staining (multivariate odds ratio [OR] 1.40, 95% confidence interval [CI] 1.04 - 1.90; p = .028). Of the 730 CEA patients, 348 had plaque samples available for isoDGR fibronectin measurements. In the multivariate analysis, higher plaque levels of isoDGR fibronectin were associated with moderate/high plaque macrophage staining (OR 1.22, 95% CI 1.00 - 1.56; p = .049), > 40% plaque area of fat (OR 1.1.44, 95% CI 1.14 - 1.86; p = .004), and intraplaque haemorrhage (OR 1.38, 95% 1.12 - 1.72; p = .003).</p><p><strong>Conclusion: </strong>In this large human cohort study, high plasma and plaque levels of isoDGR fibronectin were associated with more plaque macrophages and other adverse plaque characteristics. This suggests the involvement of isoDGR fibronectin in human plaque destabilisation and blocking isoDGR modifications as a potential treatment modality.</p>","PeriodicalId":55160,"journal":{"name":"European Journal of Vascular and Endovascular Surgery","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}